Review
Chemistry, Multidisciplinary
Nathalie Hock, Giuseppe Francesco Racaniello, Sam Aspinall, Nunzio Denora, Vitaliy V. Khutoryanskiy, Andreas Bernkop-Schnuerch
Summary: This review discusses the interface between thiol chemistry and nanoparticles, highlighting the various functionalities gained by thiolation. These include enhanced bio- and mucoadhesive properties, improved cellular uptake, and permeation enhancement. Various applications such as drug delivery, targeted therapy, and diagnostics can benefit from thiolated nanoparticles.
Article
Nanoscience & Nanotechnology
Bao Le-Vinh, Christian Steinbring, Nguyet-Minh Nguyen Le, Barbara Matuszczak, Andreas Bernkop-Schnurch
Summary: Chitosan and its derivatives with high cell adhesion properties were designed and tested for their suitability as scaffold materials in tissue engineering. The attachment of a thiol group to chitosan significantly improved cell adhesion, with higher modification levels leading to better results. The resulting chitosan-based cryogels showed promise for 3D cell culture and tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Sobia Noreen, Andreas Bernkop-Schnuerch
Summary: Thiolation of poly- and oligosaccharides introduces various favorable properties for tissue engineering and wound healing, including stable 3D networks, enhanced cell adhesion and signaling, and controlled release of active ingredients.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Biomaterials
Yunli Duan, Zhigang Xu, Zhimin Liu
Summary: Molecularly imprinted solid-phase microextraction fibers with multi-site recognition were prepared and characterized for the enrichment of cross-class environmental endocrine disruptors (EEDs). These fibers showed higher extraction capacity and selectivity compared to non-imprinted and commercial fibers. The method achieved low detection limits and good recovery rates, indicating its potential for simultaneous and sensitive monitoring of multiple EEDs.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Amritha Manoharan, Jayalakshmi Jayan, T. M. Rangarajan, Kuntal Bose, Feba Benny, Reshma Susan Ipe, Sunil Kumar, Neelima Kukreti, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Hoon Kim, Bijo Mathew
Summary: Click chemistry is a fast and efficient method for combining desired chemical entities. It plays a crucial role in drug discovery and can be used in various areas such as peptide targeting and biomolecule quantification.
Article
Chemistry, Analytical
Xiaodong Yu, Jing Chai, Qian Zhuang, Xuying Duan, Chen Xiao, Shiyin He, Suming Tang, Guojie Zhao
Summary: In this study, it was found that repressors can be used as signal switches to develop biosensors. The researchers successfully controlled six DNA reactions using GalR and achieved three biosensing purposes using SDA and RE reactions.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Polymer Science
Luis-Felipe Sanchez, Jimmy Canepa, Suyeon Kim, Javier Nakamatsu
Summary: Chitin is a structural polysaccharide found in various organisms, with deacetylation producing chitosan, which has diverse applications in areas such as drug delivery and tissue engineering. The properties of chitosan are highly influenced by its N-acetylation degree and molecular weight. This study presents a method to produce chitosan with specific and predictable N-acetylation degree and molecular weight.
Review
Biochemistry & Molecular Biology
Dana Ortansa Dorohoi, Mihai Postolache, Cristina Delia Nechifor, Dan Gheorghe Dimitriu, Raluca Marinica Albu, Iuliana Stoica, Andreea Irina Barzic
Summary: Optical polymers have various advantages in devices like information storage, displays, optical communications, and filters due to their high transparency, flexibility, low cost, and film-forming ability. This review focuses on the optical birefringence of polymer materials, including the phenomenon of light double refraction, techniques to determine birefringence, and approaches to induce double refraction. The future of this field and potential advancements in materials for optical technologies are also briefly discussed.
Review
Polymer Science
Tyser Allami, Ahmed Alamiery, Mohamed H. Nassir, Amir H. Kadhum
Summary: The study focused on the effect of segmented structure on morphological annealing between polyurethane and thermoplastic polyurethane, as well as the further applications in biomedical and environmental fields. Additionally, research discussed the incorporation of inorganic nanofillers in polyurethane nanocomposites and the improvement of properties and thermal stability.
Article
Chemistry, Multidisciplinary
Yifan Zhang, Min Fang, Zhiyi Tan, Yu-ang Zhang, Chun-yu Huang, Lu Lu, Jinhuan Tian, Lihua Li, Changren Zhou
Summary: In this study, an injectable thiolated hyaluronate (HA-SH) hydrogel was designed as a stable drug-releasing platform for in situ tumor treatment. Biodegradable star-shaped polylactide (S-PLLA) was synthesized and fabricated into porous microspheres to encapsulate hydrophobic curcumin (Cur@S-PLLA), which was then blended with hydrophilic doxorubicin (Dox) and the HA-SH precursor to form composite in situ formable hydrogels [Cur@S-PLLA/(Dox)HA-SH]. The results showed that adding the microspheres improved the performance of the hydrogel, and the double drug system guaranteed a sustained release of drugs, achieving long-lasting tumor suppression and inhibiting the survival of cancer cells.
Article
Materials Science, Biomaterials
Hannah A. Pearce, Yu Seon Kim, Emma Watson, Kiana Bahrami, Mollie M. Smoak, Emily Y. Jiang, Michael Elder, Tate Shannon, Antonios G. Mikos
Summary: The field of biomaterials has made significant advancements in the past decade, with a growing focus on using microparticles as a platform for tissue engineering and drug delivery. Thiolated GMPs have been identified as a versatile and biocompatible platform for controlling cell ratios, growth factors, and drug release, showing great promise for modular applications in tissue engineering and drug delivery.
REGENERATIVE BIOMATERIALS
(2021)
Article
Computer Science, Information Systems
Hyun-Sik Choi, Thinh Ngo, Yushi Zhou
Summary: Skin and cancer cell treatments using high-intensity focused ultrasound (HIFU) technology have gained attention due to their lower side effects. This study analyzed the effect of gate oxide thickness on power efficiency in the CMOS process, showing that a relatively thin oxide thickness can achieve high power efficiency.
Article
Computer Science, Interdisciplinary Applications
Ling Liu, Belen Martin-Barragan, Francisco J. Prieto
Summary: Support Vector Machines (SVMs) have become popular in the field of machine learning, with various single-objective and multi-objective models proposed for multi-class classifications. The Projected Multi-objective SVM (PM) introduced in this paper works in a higher dimensional space, providing wider options for different misclassifications and reducing computational burdens. Experimental results show that PM outperforms other single-objective and multi-objective SVMs, promising quality approximations of the Pareto frontier with reduced computational burdens.
COMPUTERS & INDUSTRIAL ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Mohammad Atif Faiz Afzal, Andrea R. Browning, Alexander Goldberg, Mathew D. Halls, Jacob L. Gavartin, Tsuguo Morisato, Thomas F. Hughes, David J. Giesen, Joseph E. Goose
Summary: This paper outlines a MD simulation workflow based on GPU MD simulation and the refined OPLS3e force field to calculate glass transition temperatures of a large number of polymers. The protocol shows a consistent trend between predicted T-g values and empirical observation, aiding in the evaluation of polymers for various applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Christoph Federer, Victor Claus, Nathalie Hock, Julian David Friedl, Richard Wibel, Andreas Bernkop-Schnuerch
Summary: The effectiveness of enzyme triggered charge-converting nanoemulsions was improved by investigating surfactants with monophosphate esters bearing PEG of increasing chain length and different lipophilic tail structures. The study found that the lipophilic tail structure of the PEG surfactants played a significant role in the enzyme induced charge conversion, and there was an indirect correlation between the lipophilicity and the charge-reversing effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Zeynep Burcu Akkus-Dagdeviren, Andrea Fuerst, Julian David Friedl, Martina Tribus, Andreas Bernkop-Schnuerch
Summary: This study investigates the combined usage of Layer-by-Layer coating and alkaline phosphatase-responsive charge reversal strategies in colloidal drug delivery systems. The findings show that this combination improves cellular internalisation and decreases cytotoxic effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ahmad Saleh, Zeynep Burcu Akkus-Dagdeviren, Soheil Haddadzadegan, Richard Wibel, Andreas Bernkop-Schnuerch
Summary: The study developed peptide antibiotic-polyphosphatenanoparticles for targeted drug release on the intestinal epithelium. These nanoparticles showed protection against enzymatic degradation, superior mucus permeating properties, and the ability to release drug when triggered by intestinal alkaline phosphatase. The findings suggest that the PMB-PP NPs are promising delivery systems for protecting cationic peptide antibiotics, overcoming the mucus barrier, and providing direct drug release.
Article
Pharmacology & Pharmacy
Victor Claus, Helen Spleis, Christoph Federer, Katrin Zoeller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse, Andreas Bernkop-Schnuerch
Summary: In this study, the lipophilicity of insulin glargine was increased through hydrophobic ion pairing with sodium octadecyl sulfate, enabling its incorporation into self-emulsifying drug delivery systems (SEDDS). Two SEDDS formulations were developed and loaded with the insulin glargine-HIP complex. The results showed that the bioavailability of the complexed insulin glargine in the SEDDS formulations was significantly increased after oral administration in rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Bao Le-Vinh, Christian Steinbring, Nguyet-Minh Nguyen Le, Barbara Matuszczak, Andreas Bernkop-Schnurch
Summary: Chitosan and its derivatives with high cell adhesion properties were designed and tested for their suitability as scaffold materials in tissue engineering. The attachment of a thiol group to chitosan significantly improved cell adhesion, with higher modification levels leading to better results. The resulting chitosan-based cryogels showed promise for 3D cell culture and tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Sobia Noreen, Andreas Bernkop-Schnuerch
Summary: Thiolation of poly- and oligosaccharides introduces various favorable properties for tissue engineering and wound healing, including stable 3D networks, enhanced cell adhesion and signaling, and controlled release of active ingredients.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Gergely Kali, Bengi Ozkahraman, Flavia Laffleur, Patrick Knoll, Richard Wibel, Katrin Zoller, Andreas Bernkop-Schnurch
Summary: This study aimed to design and evaluate an anionic, thiolated cellulose derivative for its mucoadhesive and permeation-enhancing properties using enoxaparin as a model drug. The thiolated cellulose exhibited enhanced mucoadhesion on porcine intestinal mucosa and improved permeation in Caco-2 cell monolayer. In vivo studies in rats showed significantly higher oral bioavailability compared to the aqueous solution of the drug.
Article
Pharmacology & Pharmacy
Richard Wibel, Florina Veider, Barbara Hoyer, Joseph Chamieh, Andreas Bernkop-Schnuerch
Summary: Organic solvents have a substantial impact on the solubility and precipitation rate of drugs in self-emulsifying drug delivery systems. This impact is particularly significant for moderately lipophilic drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Victor Claus, Matthias Sandmeier, Nathalie Hock, Helen Spleis, Sera Lindner, Monika Kalb, Andreas Bernkop-Schnuerch
Summary: In this study, the lipophilicity of model proteins was increased by combining various surfactants with insulin, bovine serum albumin, and horseradish peroxidase. The key factors responsible for complex formation were identified. The formed complexes were stable in simulated gastrointestinal fluids and could be incorporated into self-emulsifying drug delivery systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zeynep Burcu Akkus-Dagdeviren, Sema Arisoy, Julian David Friedl, Andrea Fuerst, Ahmad Saleh, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop enzyme-activated charge-reversal lipid nanoparticles (LNPs) as novel gene delivery systems. The researchers successfully anchored a transfection promoter on the surfaces of LNPs to achieve high encapsulation and efficient gene delivery. The experiment results showed that the enzyme-triggered charge reversal of LNPs resulted in significantly increased transfection efficiency in human alveolar epithelial cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Nathalie Hock, Dennis To, Eva Sanchez Armengol, Simona Summonte, Anna Seybold, Christoph Federer, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop biodegradable polyphosphate nanoparticles as long-acting drug delivery systems by utilizing ubiquitarian alkaline phosphatase. The nanoparticles were prepared and characterized, showing good stability and release characteristics. The results also demonstrated their biocompatibility and lack of toxicity. These findings open up new opportunities in parenteral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Florina Veider, Eva Sanchez Armengol, Andreas Bernkop-Schnuerch
Summary: The past two decades have seen significant progress in the development of surface charge-reversible nanoparticles for drug delivery and diagnosis. These nanoparticles can change their surface charge from negative to positive at the target site, thereby improving drug delivery and diagnostic agent sensitivity. They have also shown potential in overcoming biofilms and delivering antibiotics directly to cell membranes of microorganisms. This review highlights the latest design and emerging applications of charge-reversible nanoparticles in drug delivery and diagnosis.
Article
Engineering, Biomedical
Arne Matteo Joergensen, Christian Steinbring, Daniel Stengel, Dennis To, Pascal Schmid, Andreas Bernkop-Schnuerch
Summary: This study developed self-emulsifying drug delivery systems containing dry reverse micelles (SEDDS-dRMsPMB) loaded with the model peptide drug polymyxin B (PMB) using anionic (AOT), cationic (DODAB), amphoteric (SL), or non-ionic (P85) surfactants. These systems showed high payload, efficient cellular uptake, and maintained antimicrobial activity, suggesting a potential game-changing strategy for oral peptide drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Dennis To, Gergely Kali, Soheil Haddadzadegan, Arne Matteo Joergensen, Katharina Nigl, Fabrizio Ricci, Andreas Bernkop-Schnuerch
Summary: Nanoemulsions with enhanced gastro-intestinal retention time can be achieved by incorporating thiolated surfactants into their surface. Two generations of thiolated surfactants were synthesized and characterized, and their incorporation into nanoemulsions improved the mucoadhesiveness. S-protected thiol derivatives showed the highest mucoadhesive properties among all tested surfactants.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Katrin Zoeller, Anna Karlegger, Martyna Truszkowska, Daniel Stengel, Andreas Bernkop-Schnuerch
Summary: This study investigates the cellular uptake of hydrophobic complexes via nanocarriers using hydrophobic ion pairs (HIPs) formed between two fluorescent components. The results show that HIPs increase the lipophilicity of the model drugs and incorporating HIPs into nanoemulsions (NE) further enhances cellular uptake. HIPs serve as a powerful tool to visualize the cellular distribution of hydrophobic complexes and study their cellular uptake.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
