Article
Chemistry, Analytical
Tania Garcia-Maceira, Fe I. Garcia-Maceira, Jose A. Gonzalez-Reyes, Luis A. Torres-Sanchez, Ana Belen Aragon-Gomez, Maria Eugenia Garcia-Rubino, Elier Paz-Rojas
Summary: The study developed an antibody immobilization strategy to increase ELISA sensitivity by introducing tetrazine groups onto the surface, showing a significant improvement in detection sensitivity.
Article
Pharmacology & Pharmacy
Son Long Ho, Huan Yue, Sangyeol Lee, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Shuwen Liu, Abdullah Khamis Ali Al Saidi, Dejun Zhao, Ying Liu, Sung-Wook Nam, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee
Summary: Hydrophilic and biocompatible PAA-coated ultrasmall Gd2O3 nanoparticles were synthesized and conjugated with tumor-targeting ligands. The nanoparticles were successfully used for tumor imaging, showing higher contrasts at the tumor site and prolonged circulation in the blood.
Article
Environmental Sciences
Maofeng Liu, Gabriel Vecchi, Brian Soden, Wenchang Yang, Bosong Zhang
Summary: Climate change leading to atmospheric moistening exacerbates the spatial contrast in sea surface salinity, impacting ocean heat uptake. Salinification-driven surface salinity increase plays a key role in heat absorption by the ocean.
NATURE CLIMATE CHANGE
(2021)
Review
Pharmacology & Pharmacy
Zi-Xian Liao, Shan-hui Hsu, Shiue-Cheng Tang, Ivan Kempson, Pan-Chyr Yang, S. Ja Tseng
Summary: Targeting the tumor microenvironment is a promising strategy for cancer treatment to enhance specificity of delivery and transduction efficacy. This review highlights approaches involving modifying viral surface features, modulating the immune system, and targeting the physicochemical characteristics in tumor microenvironment to regulate therapeutic delivery.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Junhee Choi, Dong-In Kim, Jin-Young Kim, Salvador Pane, Bradley J. Nelson, Young-Tae Chang, Hongsoo Choi
Summary: This study investigated the enhancement of intracellular uptake of superparamagnetic iron oxide nanoparticles (SPIONs) through the use of rotating magnetic fields (RMFs). The physical parameters for favorable chain length for intracellular uptake were predicted and validated. The study also showed that enhanced intracellular uptake reduced magnetic hyperthermia time and strength, as well as particle concentration.
Article
Biochemistry & Molecular Biology
Huike Xing, Qi Zhan, Xueping Li, Sidi Li, Lijie Li, Jin Zhao, Xin Hou, Xubo Yuan
Summary: The development of ultra-long circulating nanodrug delivery systems has shown significant advantages in maintaining long-lasting tumor retention. This study proposes the concept of Sustained Irrigation effect (SI effect), which explains that the ultra-long circulating nanoparticles achieve prolonged tumor retention through sustained blood irrigation. An ON-OFF-ON fluorescence switch technology was developed to verify the SI effect. The findings reveal the key mechanism by which ultra-long circulating NDDSs enhance tumor accumulation and retention, providing experimental support for the development of ultra-long circulating delivery systems in clinical applications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Analytical
Meysam Rezaei, Payar Radfar, Marnie Winter, Lana McClements, Benjamin Thierry, Majid Ebrahimi Warkiani
Summary: As microfluidics-based technologies for single-cell analysis advance, a low-cost and reproducible method for rare single-cell analysis has become increasingly important. This method allows for rapid and efficient on-chip single-cell lysis and genetic material collection, enabling precise isolation of single cancer cells with high purity for subsequent RNA analysis. This highly controlled isolation method opens new avenues for studying subcellular functional mechanisms and identifying rare cells with potential functional or pathogenic consequences.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Kehui Zhu, Yingcan Xu, Rui Zhong, Wanjing Li, Hong Wang, Yee Shan Wong, Subramanian Venkatraman, Jiaxin Liu, Ye Cao
Summary: To address the drawbacks of liposome, a red blood cell-liposome combined drug delivery system (DDS) was developed to enhance tumor accumulation and extend blood circulation. The composite DDS improved liposomal tumor accumulation and blood circulation, showing potential for clinical application in antitumor therapy using autologous red blood cells.
REGENERATIVE BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yunqiu Miao, Yuting Yang, Linmiao Guo, Mingshu Chen, Xin Zhou, Yuge Zhao, Di Nie, Yong Gan, Xinxin Zhang
Summary: This study presents the construction of nanocarriers that can mimic the biological and physical properties of red blood cells (RBCs) at different life stages. The nanocarriers demonstrated high immunocompatibility and superior antitumor efficacy compared to conventional chemotherapy drugs. The ability of the nanocarriers to deform and penetrate tumor tissues highlights their potential for future bionic design of nanomedicines.
Review
Engineering, Biomedical
Carolina F. Rodrigues, Natanael Fernandes, Duarte De Melo-Diogo, Ilidio J. Correia, Andre F. Moreira
Summary: Cancer nanomedicines have limited efficacy due to their quick elimination by the immune system. Increasing their blood circulation time and understanding the interaction between nanoparticles and biological components can improve their therapeutic outcomes, making them more effective in targeting tumors.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhan, Kaikai Yi, Xueping Li, Xiaoteng Cui, Eryan Yang, Ning Chen, Xubo Yuan, Jin Zhao, Xin Hou, Chunsheng Kang
Summary: This study demonstrated the importance of engineering exosomal lipids to enhance cancer cellular uptake, leading to improved tumor cell internalization and increased anti-tumor activity in vitro.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Shaojun Peng, Boshu Ouyang, Yongjie Xin, Wei Zhao, Shun Shen, Meixiao Zhan, Ligong Lu
Summary: Hypoxia-responsive nanogels have been developed for tumor drug delivery, showing superior drug release and tumor inhibition effects compared to other degradable nanogels. The synthesized (PMPC)-P-H nanogel exhibits ultra-long blood circulation, desirable immune compatibility, and high and long-lasting accumulation in tumor tissue, making it a promising nanocarrier for advanced tumor drug delivery.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, Research & Experimental
Yingping Zeng, Shufen Zhang, Sufen Li, Guangtao Song, Tingting Meng, Hong Yuan, Fuqiang Hu
Summary: Abnormal tumor blood vessels with high leakage can enhance tumor metastasis. Normalizing tumor blood vessels can reduce leakage and increase integrity. This study developed multifunctional nanoparticles combining chemotherapy and tumor blood vessel normalization for breast cancer treatment. The nanoparticles promoted expression of junction proteins in endothelial cells, protected endothelial cell layer integrity, and inhibited tumor cell migration and metastasis.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Cassandra E. Callmann, Matthew K. Vasher, Anindita Das, Caroline D. Kusmierz, Chad A. Mirkin
Summary: The biological properties of spherical nucleic acids (SNAs) are primarily determined by the oligonucleotide surface density, rather than the nanoparticle core identity. Furthermore, the payload-to-carrier mass ratio of SNAs is inversely proportional to the core size. Ultrasmall nanoparticle constructs (<10 nm diameter) exhibit unique properties, including increased payload-to-carrier ratios, reduced liver accumulation, renal clearance, and enhanced tumor infiltration.
Article
Nanoscience & Nanotechnology
Youngee Seo, Lida Ghazanfari, Alyssa Master, Hemant M. Vishwasrao, Xiaomeng Wan, Marina Sokolsky-Papkov, Alexander Kabanov
Summary: This study reports the development of a novel theranostic system called NanoFerrogels, which combines magnetic nanoparticles and polymeric micelles for cancer diagnosis and treatment. NanoFerrogels function as imaging agents for magnetic resonance imaging and as drug loading compartments. The experiments demonstrate the potential of NanoFerrogels as a remotely actuated theranostic platform for cancer therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kin Man Au, Roland Tisch, Andrew Z. Wang
Summary: Failure to establish immune tolerance can lead to autoimmune diseases. This study demonstrates a potential new strategy for treating autoimmune diseases by bioengineering programmed death-ligand 1 (PD-L1)- and cluster of differentiation 86 (CD86)-functionalized mouse Schwann cells (SCs) to modify disease progression and ameliorate symptoms without inducing systemic immunosuppression.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Xintao Zhang, Zheng Chai, Amanda Lee Dobbins, Michelle S. Itano, Charles Askew, Zhe Miao, Hongqian Niu, R. Jude Samulski, Chengwen Li
Summary: This study identifies a BBB shuttle peptide, PB5-3, that enhances the transduction of AAV9 in mouse brains. The peptide increases AAV9 transcytosis efficiency in a BBB cell model and slows the clearance of AAV9 from blood.
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Chemistry, Multidisciplinary
C. Tilden Hagan, Cameron Bloomquist, Samuel Warner, Nicole M. Knape, Isaiah Kim, Hayley Foley, Kyle T. Wagner, Sue Mecham, Joseph DeSimone, Andrew Z. Wang
Summary: This study utilized advances in 3D printing and drug delivery science to design a novel drug-loaded arrowhead array device (AAD) for localized chemotherapy at the surgical site, aiming to reduce local recurrence of cancer. The results demonstrated that the AAD significantly decreased local recurrence and improved survival in mouse cancer models, and showed potential for personalized treatment in the clinical setting.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Li Wang, Yubai Zhou, Xuedan Wu, Xinrui Ma, Bing Li, Ransheng Ding, Michael A. Stashko, Zhanhong Wu, Xiaodong Wang, Zibo Li
Summary: MerTK is abnormally expressed in various cancers, but the sensitivity of tumors to MerTK suppression may vary. In this study, a radiolabeled agent [F-18]-MerTK-6 was developed and showed prominent uptake in tumors in initial evaluation, suggesting it as a promising PET agent for MerTK imaging.
Article
Multidisciplinary Sciences
Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad Pecot, Gianpietro Dotti, Hongwei Du
Summary: Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. CAR-T cells targeting B7-H3 and expressing the chemokine receptor CCR2b show improved accumulation in the brain and enhanced anti-tumor activity. This strategy could improve the efficacy of adoptive T-cell therapies in patients with solid tumors presenting with brain metastases.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Devika M. Varma, Cole J. Batty, Rebeca T. Stiepel, Elizabeth G. Graham-Gurysh, John A. Roque, Erik S. Pena, M. Shamim Hasan Zahid, Kunyu Qiu, Aaron Anselmo, David B. Hill, Ted M. Ross, Eric M. Bachelder, Kristy M. Ainslie
Summary: This study investigates the use of nasal gel formulation for influenza vaccination and demonstrates that nasal gel can generate rapid serum and mucosal humoral immune responses.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Esteban A. Oyarzabal, Li-Ming Hsu, Manasmita Das, Tzu-Hao Harry Chao, Jingheng Zhou, Sheng Song, Weiting Zhang, Kathleen G. Smith, Natale R. Sciolino, Irina Y. Evsyukova, Hong Yuan, Sung-Ho Lee, Guohong Cui, Patricia Jensen, Yen-Yu Ian Shih
Summary: This study reveals the selective neuromodulatory effect of norepinephrine-releasing neurons in the locus coeruleus on the default mode network of the brain. The activation of these neurons alters neuronal activity coupling and cerebral blood volume within the frontal DMN, strengthens functional connectivity within the frontal DMN, and is mediated by reduced modulatory inputs from retrosplenial and hippocampal regions.
Article
Oncology
Miranda B. Carper, Saumya Goel, Anna M. Zhang, Jeffrey S. Damrauer, Stephanie Cohen, Matthew P. Zimmerman, Gabrielle M. Gentile, Kshitij Parag-Sharma, Ryan M. Murphy, Kotaro Sato, Kwangok P. Nickle, Randall J. Kimple, Wendell G. Yarbrough, Antonio L. Amelio
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with increasing incidence rates worldwide. This study identified the overexpression and constitutive activation of CRTC2 in HNSCC, which is associated with poor prognosis. By regulating subcellular localization of CRTC2, the study found that inhibiting nuclear CRTC2 can reduce cellular proliferation, migration, and invasion.
Article
Biochemical Research Methods
Manshu Li, Xinrui Ma, Christopher J. Molnar, Shuli Wang, Zhanhong Wu, Vladimir V. Popik, Zibo Li
Summary: An efficient modular strategy for rapid assembly of PET agents has been developed, which allows for a combinatorial approach to cross-linking of positron emitter-bearing prosthetic groups with various ligands. The strategy utilizes a sequential and selective double-click reaction, specifically the strain-promoted azide alkyne cyclization (SPAAC) coupling, to produce a stable intermediate that can be modified with azide-tagged biomolecules. Several PET agents have been successfully constructed using this strategy, and the modularity of the approach has been demonstrated in the preparation of PSMA PET agents, where the hydrophilicity can be easily modified to improve tumor to background contrast.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Organic
Wei Chen, Xuedan Wu, Joshua B. McManus, Gerald T. Bida, Kang-Po Li, Zhanhong Wu, David A. Nicewicz, Zibo Li
Summary: This study reports an innovative labeling method that incorporates the short-lived positron emitter carbon-11 into bioactive molecules using photoredox catalysis. The method is easy to operate and allows for scalable synthesis of the labeled compounds.
Article
Chemistry, Multidisciplinary
P. Hiranmartsuwan, X. Ma, J. Nootem, R. Daengngern, A. Kamkaew, P. Pinyou, W. Wattanathana, V. Promarak, Z. Li, K. Chansaenpak
Summary: Three new aggregation-induced emission (AIE) molecules were synthesized by incorporating tetraphenylethylene (TPE) unit to triazaborolopyridinium (TBP). These compounds exhibited broad absorption and emission spectra in various solvents, with TPE-linked TBP and the compound with a phenylene bridge showing high fluorescence quantum yields and solvent-sensitive behaviors, while the derivative with a thiophene bridge exhibited lower fluorescence quantum yield and less solvent dependence. The presence of a thiophene moiety resulted in a redshift in the absorption and emission spectra.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yu Cong, Ji Hyun Lee, Donna L. Perry, Kurt Cooper, Hui Wang, Saurabh Dixit, David X. Liu, Irwin M. Feuerstein, Jeffrey Solomon, Christopher Bartos, Jurgen Seidel, Dima A. Hammoud, Ricky Adams, Scott M. Anthony, Janie Liang, Nicolette Schuko, Rong Li, Yanan Liu, Zhongde Wang, E. Bart Tarbet, Amanda M. W. Hischak, Randy Hart, Nejra Isic, Tracey Burdette, David Drawbaugh, Louis M. Huzella, Russell Byrum, Danny Ragland, Marisa C. St Claire, Jiro Wada, Jonathan R. Kurtz, Lisa E. Hensley, Connie S. Schmaljohn, Michael R. Holbrook, Reed F. Johnson
Summary: This study compared disease progression of SARS-CoV-2 in three different models of golden hamsters and found that aged wild-type hamsters developed more severe pneumonia than young wild-type hamsters or hACE2 hamsters. The study also demonstrated that hACE2 hamsters presented with minimal to mild hemorrhagic pneumonia but succumbed to SARS-CoV-2-related meningoen-cephalitis, indicating the potential impact of the virus on the central nervous system.
ANTIVIRAL RESEARCH
(2023)
Article
Cell Biology
Nazira El-Hage, Matthew J. Haney, Yuling Zhao, Myosotys Rodriguez, Zhanhong Wu, Mori Liu, Carson J. Swain, Hong Yuan, Elena V. Batrakova
Summary: We have developed a novel EV-based drug delivery system for the treatment of Batten disease (BD) by transporting the lysosomal enzyme TPP1. The EVs were loaded with TPP1 through transfection of parent cells and showed successful delivery to the brain in a mouse model of BD. The TPP1-loaded EVs exhibited therapeutic effects by eliminating lipofuscin aggregates, reducing inflammation, and improving neuronal survival, possibly through activation of the autophagy pathway. Continued research into effective therapies for BD is crucial for improving patient outcomes.