期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1864, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2020.194604
关键词
Chromatin; Transcription; SAGA; TFIID; TATA-binding protein; GCN5
资金
- Deutsche Forschungsgemeinschaft [SFB850, SFB992, TI688/1-1]
- Collaborative Center for X-linked Dystonia
- Netherlands Organization for Scientific Research [ALW820.02.013]
Transcription initiation is a major checkpoint in gene regulation for all living organisms, tightly linked to control of chromatin function. The SAGA coactivator, with its structural and functional similarities to the TFIID basal transcription factor, emphasizes the evolutionary relationship in controlling the activity of the TBP.
Transcription initiation constitutes a major checkpoint in gene regulation across all living organisms. Control of chromatin function is tightly linked to this checkpoint, which is best illustrated by the SAGA coactivator. This evolutionary conserved complex of 18-20 subunits was first discovered as a Gcn5p-containing histone acetyl-transferase, but it also integrates a histone H2B deubiquitinase. The SAGA subunits are organized in a modular fashion around its central core. Strikingly, this central module of SAGA shares a number of proteins with the central core of the basal transcription factor TFIID. In this review I will compare the SAGA and TFIID complexes with respect to their shared subunits, structural organization, enzymatic activities and chromatin binding. I will place a special emphasis on the ancestry of SAGA and TFIID subunits, which suggests that these complexes evolved to control the activity of TBP (TATA-binding protein) in directing the assembly of transcription initiation complexes.
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