Review
Immunology
Xuelun Zou, Leiyun Wang, Linxiao Xiao, Sai Wang, Le Zhang
Summary: This article discusses the connection between gut microbiota and cerebrovascular diseases and investigates the involvement of gut microbes in the occurrence and development of CeVD. The study also evaluates the effectiveness of various therapies for CeVD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Shuxia Zhang, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiabo Sun
Summary: The gut-brain axis plays a crucial role in the prognosis and recovery of ischemic stroke, due to dysfunction of gut microbiota and changes in the gastrointestinal system and epithelial barrier integrity. The microbiota-derived metabolites have specific mechanisms that influence stroke outcomes. This review discusses the relationship between stroke and gut microbiota, the role of microbiota-derived metabolites, natural medicines targeting gut microbiota, and the potential therapeutic opportunities for stroke prevention, diagnosis, and treatment using gut microbiota and its metabolites.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Xiali Qin, Yu Gu, Tianyu Liu, Chen Wang, Weilong Zhong, Bangmao Wang, Hailong Cao
Summary: This review summarizes the current research progress on fungal dysbiosis in CRC, discusses the potential mechanisms of fungi in CRC development, and explores potential therapeutic strategies for CRC treatment. This contributes to a better understanding of the correlation between fungal community and CRC, with modulating fungal community being a promising target against CRC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Immunology
Ying Sun, Miaomiao Wen, Yue Liu, Yu Wang, Pengyu Jing, Zhongping Gu, Tao Jiang, Wenchen Wang
Summary: Lung cancer is a major cause of cancer-related deaths worldwide, and understanding its mechanisms and potential treatments is crucial. The microbiome, through its involvement in inflammatory responses, immune regulation, metabolic disorders, and genotoxicity, plays a significant role in the initiation and progression of lung cancer. This comprehensive review examines the distribution and biological functions of the human microflora, the relationship between the microbiome and clinical characteristics, and the microbiome's role in the clinical treatment of lung cancer. It provides a valuable foundation for our current understanding of lung cancer mechanisms and informs future treatment decisions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Lu Yang, Weihua Tan, Xinzhi Yang, Yong You, Jing Wang, Gebo Wen, Jing Zhong
Summary: Sorting nexins (SNXs) are a group of diverse cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play a crucial role in regulating intracellular protein trafficking. Dysfunctions of SNX proteins have been linked to various cancerous/neoplastic diseases, making them potential biomarkers and therapeutic targets for cancer diagnostics and treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Tejinder Pal Singh, Saurabh Kadyan, Harisha Devi, Gwoncheol Park, Ravinder Nagpal
Summary: The gut plays a significant role in regulating the physiology of various organs in the body, including the liver. The communication between the gut and liver is bidirectional, with gut-derived products being transported to the liver through the portal vein, triggering responses from the liver. Maintaining a healthy gut microbiome is crucial for the homeostasis of the gut-liver axis, while disturbances in this axis can lead to liver disorders. This article discusses the functional characteristics of a healthy gut-liver axis and explores the role of gut dysbiosis in liver diseases, as well as potential therapeutic approaches.
Review
Nutrition & Dietetics
Tao Zhang, Guangqi Gao, Hafiz Arbab Sakandar, Lai-Yu Kwok, Zhihong Sun
Summary: Pancreatic diseases such as pancreatitis, pancreatic cancer, and type 1 diabetes mellitus pose a significant challenge to human health. Recent studies have shown a strong connection between gut dysbiosis and pancreatic diseases. Researchers are now exploring the correlation between the gut microbiome and pancreatic diseases and developing novel therapeutic strategies.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Ting Zhang, Jin-ke Cheng, Yao-min Hu
Summary: Sarcopenia, a progressive loss of skeletal muscle mass and function with aging, has been shown to be closely related to gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential in ameliorating muscle loss.
AGEING RESEARCH REVIEWS
(2022)
Review
Nutrition & Dietetics
Rana F. Chehab, Tzu-Wen L. Cross, Michele R. Forman
Summary: Child undernutrition is a persistent and disproportionately prevalent public health challenge in low- and middle-income countries, with potential intergenerational consequences. The first 1000 days of life, from conception to a child's second birthday, are the most vulnerable period to undernutrition, and inadequate complementary feeding practices may lead to adverse health and growth outcomes in children. Recent studies suggest a potential link between disrupted gut microbiota, complementary feeding, and undernutrition, highlighting the importance of further research in this area for potential interventions.
ADVANCES IN NUTRITION
(2021)
Article
Microbiology
Illyane S. Lima, Ana C. Pego, Ana C. Martins, Ana R. Prada, Joao Tomas Barros, Gracelino Martins, Raffaella Gozzelino
Summary: Age-related dysbiosis can lead to sub-chronic inflammation, which primes the brain for neuroinflammation and neurodegenerative diseases. This study confirmed that the effects induced by age-related dysbiosis, rather than aging itself, increase the risk of Parkinson's disease (PD) onset. Germ-free (GF) mice were resistant to PD, but this resistance was reversed when they were colonized with stool from conventional old animals. Changes in gut microbiota composition can be targeted preventively by iron chelators to protect against neuroinflammation and the development of severe PD.
Review
Biochemistry & Molecular Biology
Jingyuan Gao, Xinzhu Yi, Zhang Wang
Summary: The study of the respiratory microbiome has entered a multi-omic era, where integrating different omic data types can provide comprehensive insights into the interaction between the lung microbiome and host immunity and inflammation in respiratory diseases. The application of multi-omics has advanced the field from associative assessment to causal understanding of the lung microbiome in the pathogenesis of respiratory diseases, although it still faces challenges in sample processing, data integration, and downstream validation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Alma Rosa Lezama Toledo, German Rivera Monroy, Felipe Esparza Salazar, Jea-Young Lee, Shalini Jain, Hariom Yadav, Cesario Venturina Borlongan
Summary: Human lifestyle and dietary behaviors contribute to the development of diseases, including neurodegenerative diseases. Changes in the gut microbiome have been associated with neurodegenerative diseases, and the inflammation associated with the gut microbiome plays a role in the development and prognosis of these diseases. The gut-brain axis represents an underexplored area for developing therapies for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yujing Zhang, Jihua Guo, Rong Jia
Summary: The maintenance of oral health has become a major global health challenge during the COVID-19 pandemic. Regulatory T cells (Treg) play essential roles in immune disorders associated with oral diseases, affecting the progression of periodontitis, apical periodontitis, oral precancerous lesions, and oral cancer. Understanding the distribution, function, and regulation of Treg cells may offer potential for immunotherapy in the treatment of oral diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jing Xu, Yuejin Yang
Summary: Cardiovascular diseases (CVDs) remain a major global health concern, with recent evidence suggesting that alterations in the gut microbiome may influence the pathogenesis and progression of CVDs. The underlying links are not fully understood, but advances in meta-omics approaches offer a promising new avenue for research and potential insights into cardiovascular diseases.
Review
Immunology
Wei Zhao, Rui-Xue Leng, Dong-Qing Ye
Summary: Receptor Interacting Serine/Threonine Kinase 2 (RIPK2) is a vital regulator in the inflammatory process and immune response. It plays a significant role in both innate and adaptive immunity, affecting inflammation, T cell proliferation, differentiation, and cellular homeostasis. Recent studies suggest the involvement of RIPK2 in various autoimmune diseases, making it a potential therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rajesh A. Rane, Shital Napahde, Pavan Kumar Bangalore, Niteshkumar U. Sahu, Nishant Shah, Yogesh A. Kulkarni, Kalyani Barve, Leena Lokare, Rajshekhar Karpoormath
CHEMICAL BIOLOGY & DRUG DESIGN
(2014)
Article
Pharmacology & Pharmacy
J. R. Patel, Kalyani H. Barve
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2012)
Review
Integrative & Complementary Medicine
Saloni Khogta, Jahanvi Patel, Kalyani Barve, Vaishali Londhe
JOURNAL OF HERBAL MEDICINE
(2020)
Review
Pharmacology & Pharmacy
Yamini Madav, Kalyani Barve, Bala Prabhakar
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Neurosciences
Paresh Patel, Kalyani Barve, Lokesh Kumar Bhatt
Summary: The study demonstrates the protective effect of Narirutin-rich fraction (NRF) against cerebral ischemia/reperfusion injury in rats. NRF pretreatment improves neurobehavioral alterations and histological findings and reduces oxidative damage.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Kripa Jain, Kalyani Barve, Lokesh Kumar Bhatt
Summary: This review summarizes the physiological roles and signal transduction of gasdermins and highlights their significance in pathological conditions such as autoimmune diseases, kidney diseases, and central nervous system diseases.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Kalyani Barve
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Chemistry, Medicinal
Kalyani Barve, Kushal Ruparel
Meeting Abstract
Pharmacology & Pharmacy
Kalyani Barve, Nima Bhonsale
INDIAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
N. M. Meghani, K. Barve, S. Wackchaure, M. B. Nandanwar, S. Latad, H. Mankani
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
(2012)