期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 526, 期 4, 页码 913-919出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.04.004
关键词
Turbot; myo-inositol; Low salinity; Cortisol; Osmoregulation
资金
- Earmarked Fund for Modern Agro-Industry Technology Research System [CARS-47-G01]
- AoShan Talents Cultivation Program - Pilot National Laboratory for Marine Science and Technology (Qingdao) [2017ASTCP-OS04]
- National Natural Science Foundation of China [41706168]
- Agricultural Fine Breed Project of Shandong [2019LZGC031]
- Key Research and Development Plan of Nation [2018YFD0900102]
- Central Public-interest Scientific Institution Basal Research Fund, YSFRI, CAFS [20603022019019]
- Central Public-interest Scientific Institution Basal Research Fund, CAFS [2020TD25]
Myo-inositol is a major intracellular osmolyte that can be accumulated to protect cells from a variety of stresses, including fluctuations in the osmolality of the environment, and cortisol is thought to be an osmotic hormone in teleost fish. In this study, dietary myo-inositol resulted in increased Na+-K+-ATPase activity and gene expression of partial ion channel genes and prolonged survival time of turbot (Scophthalmus maximus) under low salinity. The cortisol regulated by dietary myo-inositol also was correlated with these outcomes. The optimal concentrations of cortisol stimulated gill Na+-K+-ATPase activity and increased the expression of ion channel genes to enhance low salinity tolerance, as indicated by longer survival time under low salinity. When cortisol level was suppressed, myo-inositol failed to increase the survival time of turbot under low salinity, and strong correlations between cortisol concentration and Na+-K+-ATPase activity, expression of partial ion channel genes, and survival time of turbot were detected. These results showed that myo-inositol enhanced the low salinity tolerance of turbot by modulating cortisol synthesis. (C) 2020 Elsevier Inc. All rights reserved.
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