DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) Axis Senses Matrix Stiffness to Promote Vascular Calcification

Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalization of N-cadherin contacts

(2019) Songyi Xu et al.   Biology Open

DDR1 autophosphorylation is a result of aggregation into dense clusters

(2019) David S. Corcoran et al.   Scientific Reports

Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis

(2018) Marsel Lino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I

(2018) David A. Yeung et al.   JOURNAL OF MOLECULAR BIOLOGY

Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

(2018) Yelena Y. Bernadskaya et al.   Nature Communications

Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions

(2017) Delphine Sicard et al.   Journal of the Mechanical Behavior of Biomedical Materials

Intima heterogeneity in stress assessment of atherosclerotic plaques

(2017) Ali C. Akyildiz et al.   Interface Focus

Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction

(2017) Nuno M. Coelho et al.   Cell Reports

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

(2017) Victoria Juskaite et al.   eLife

Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling

(2016) Flora Gilde et al.   Acta Biomaterialia

Arterial Calcification in Diabetes MellitusHighlights

(2016) John N. Stabley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes MellitusHighlights

(2016) Kazuyuki Yahagi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway

(2016) Mohammed-Amine El Azreq et al.   Oncotarget

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice

(2015) Mu-En Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR−/−Mice by Restraining Noncanonical Wnt SignalsNovelty and Significance

(2015) Su-Li Cheng et al.   CIRCULATION RESEARCH

Mechanism of regulation of stem cell differentiation by matrix stiffness

(2015) Hongwei Lv et al.   Stem Cell Research & Therapy

Targeted Reduction of Vascular Msx1 and Msx2 Mitigates Arteriosclerotic Calcification and Aortic Stiffness in LDLR-Deficient Mice Fed Diabetogenic Diets

(2014) S.-L. Cheng et al.   DIABETES

Genetic Dissection of the Vav2-Rac1 Signaling Axis in Vascular Smooth Muscle Cells

(2014) S. Fabbiano et al.   MOLECULAR AND CELLULAR BIOLOGY

Vascular fibrosis in atherosclerosis

(2013) Tao-Hua Lan et al.   CARDIOVASCULAR PATHOLOGY

Regulation of adipose oestrogen output by mechanical stress

(2013) Sagar Ghosh et al.   Nature Communications

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

(2012) Kelvin KL Wong et al.   BMC Cardiovascular Disorders

Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification

(2012) Yong Sun et al.   CIRCULATION RESEARCH

Biochemical and mechanical environment cooperatively regulate skeletal muscle regeneration

(2012) Sarah Calve et al.   FASEB JOURNAL

Collagen I Induces Discoidin Domain Receptor (DDR) 1 Expression through DDR2 and a JAK2-ERK1/2-mediated Mechanism in Primary Human Lung Fibroblasts

(2011) Pedro A. Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1

(2011) Simone Lemeer et al.   Journal of Proteomics

Discoidin Domain Receptor-1 Deficiency Attenuates Atherosclerotic Calcification and Smooth Muscle Cell-Mediated Mineralization

(2009) Pamela J. Ahmad et al.   AMERICAN JOURNAL OF PATHOLOGY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells

(2008) Xianwu Li et al.   ATHEROSCLEROSIS

Matrix Elasticity, Cytoskeletal Tension, and TGF- : The Insoluble and Soluble Meet

(2008) R. G. Wells et al.   Science Signaling