Article
Multidisciplinary Sciences
Dhruv Patel, Vikram Kher, Bhushan Desai, Xiaomeng Lei, Steven Cen, Neha Nanda, Ali Gholamrezanezhad, Vinay Duddalwar, Bino Varghese, Assad A. Oberai
Summary: This study used machine learning algorithms to predict the need for intensive care and mechanical ventilation in COVID-19 patients and identified the most important features influencing the prediction. Blood panel profile data is crucial for predicting disease severity. RF predictors relying only on quantitative data showed good performance in prediction.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jitender Sharma, Roopali Rajput, Manika Bhatia, Pooja Arora, Vikas Sood
Summary: The COVID-19 pandemic has caused massive socio-economic losses and continues to threaten humans worldwide. Despite extensive research, the lack of unique identifying characteristics of the disease makes diagnosis and prognosis difficult. Understanding clinical manifestations, disease progression biomarkers, and risk factors is crucial for controlling and mitigating the spread of the virus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Asma Al Balushi, Jalila AlShekaili, Mahmood Al Kindi, Zainab Ansari, Murtadha Al-Khabori, Faryal Khamis, Zaiyana Ambusaidi, Afra Al Balushi, Aisha Al Huraizi, Sumaiya Al Sulaimi, Fatma Al Fahdi, Iman Al Balushi, Nenad Pandak, Tom Fletcher, Iman Nasr
Summary: Identifying immune cells and predictors of poor outcomes in COVID-19 is crucial. This study found that hospitalized patients had higher levels of inflammatory markers and certain immune cells were independent predictors of ICU admission or death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingstrom, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Stralin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Bjorkstrom, Jan-Inge Henter, Mattias Svensson
Summary: This study found that COVID-19 patients experience a redistribution of monocyte subsets towards intermediate monocytes and a general decrease in circulating dendritic cells. Severe disease is associated with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. The phenotypic alterations in mononuclear phagocytes are cell-lineage-specific and linked to the response against SARS-CoV-2 or COVID-19 severity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Paulina B. Szklanna, Haidar Altaie, Shane P. Comer, Sarah Cullivan, Sarah Kelliher, Luisa Weiss, John Curran, Emmet Dowling, Katherine M. A. O'Reilly, Aoife G. Cotter, Brian Marsh, Sean Gaine, Nick Power, Aine Lennon, Brian McCullagh, Fionnuala Ni Ainle, Barry Kevane, Patricia B. Maguire
Summary: This study evaluated whether parameters from a routine clinical hematology workup at the time of hospital admission could predict COVID-19 severity and the requirement for critical care, showing that these parameters are important predictors of disease severity with high sensitivity and specificity.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ada S. Cheung, Hui Yin Lim, Teddy Cook, Sav Zwickl, Ariel Ginger, Cherie Chiang, Jeffrey D. Zajac
Summary: This article provides a summary of the impact of gender-affirming hormone therapy on common laboratory tests and proposes an approach to interpretation. Case scenarios discussed include the effects of different hormone therapies on various test results, offering insights for clinical practice.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Alexander Kiani, Romina Roesch, Clemens M. Wendtner, Frank Kullmann, Thomas Kubin, Thomas Suedhoff, Marinela Augustin, Markus Schaich, Clemens Muller-Naendrup, Gerald Illerhaus, Frank Hartmann, Holger Hebart, Ruth Seggewiss-Bernhardt, Martin Bentz, Ernst Spaeth-Schwalbe, Peter Reimer, Ulrich Kaiser, Markus Kapp, Ullrich Graeven, Jens-Marcus Chemnitz, Joerg Baesecke, Helmut Lambertz, Ralph Naumann
Summary: Infection with SARS-CoV-2 leads to COVID-19, the course of which is highly variable and depends on numerous patient-specific risk factors. Patients with tumor diseases are considered to be more susceptible to severe COVID-19; however, they also represent a heterogeneous group of individuals with variable risk. Preinfection laboratory parameters may aid to identify patients at risk for severe COVID-19 at an early stage prior to infection with the virus.
Article
Infectious Diseases
Reem Al Dossary, Amani Alnimr, Reem Aljindan, Khaled R. Alkharsah, Ahmed K. Al-Qurayn, Obeid Eltreifi, Feras A. Alkuwaiti, Abdullah B. Almashouf, Ahmed M. Alsahlawi, Amal Alshammari, Dhoha Hudhaiah, Mohammed S. Alshahrani, Huda Bukhari
Summary: This study describes the clinical and epidemiological features of COVID-19 cases in the Eastern Province of Saudi Arabia and identified age, sex, and ethnicity as important predictors of COVID-19 severity. However, the viral load represented by the RT-PCR cycle threshold (Ct) values cannot be used as a predictor of illness severity.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Noha M. Elemam, Sarah Hammoudeh, Laila Salameh, Bassam Mahboub, Habiba Alsafar, Iman M. Talaat, Peter Habib, Mehmood Siddiqui, Khalid Omar Hassan, Omar Yousef Al-Assaf, Jalal Taneera, Nabil Sulaiman, Rifat Hamoudi, Azzam A. Maghazachi, Qutayba Hamid, Maha Saber-Ayad
Summary: This study developed a comprehensive predictive model for COVID-19 outcomes. By analyzing data from patients with different disease severities and control subjects, certain cytokines and biochemical markers were identified as predictors of severity. The model can provide accurate predictive value in basic biochemical and radiological investigations of COVID-19, and highlights critical pathways in the pathophysiology of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesco Cavallieri, Valentina Fioravanti, Francesco Bove, Eleonora Del Prete, Sara Meoni, Sara Grisanti, Marialuisa Zedde, Rosario Pascarella, Elena Moro, Franco Valzania
Summary: This review summarizes the clinical, biological, and neuroimaging features of COVID-19-related parkinsonism and discusses the possible pathophysiological mechanisms. The appearance of parkinsonism during or immediately after COVID-19 infection is a very rare event. Different mechanisms, including vascular damage and neuroinflammation, may play a role, and further long-term observational studies are needed to evaluate the association between COVID-19 infection and the development of Parkinson's Disease.
Article
Medicine, General & Internal
N. Broman, K. Rantasarkka, T. Feuth, M. Valtonen, M. Waris, U. Hohenthal, E. Rintala, A. Karlsson, H. Marttila, V. Peltola, T. Vuorinen, J. Oksi
Summary: IL-6 and CRP were found to be the strongest predictors of severity in hospitalized patients with COVID-19, showing significantly higher levels in patients eventually admitted to the ICU. No statistical differences were found in median levels of lymphocytes, D-dimer, or ferritin between the groups.
ANNALS OF MEDICINE
(2021)
Article
Engineering, Biomedical
Zhenyu Tang, Wei Zhao, Xingzhi Xie, Zheng Zhong, Feng Shi, Tianmin Ma, Jun Liu, Dinggang Shen
Summary: This study presents an automatic severity assessment for COVID-19 using chest CT images and laboratory indices, trained with a random forest model. The model shows promising results in three-fold cross-validation, indicating its effectiveness in assessing the severity of COVID-19.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Immunology
Maria Angeles Rodriguez-Hernandez, David Carneros, Maria Nunez-Nunez, Ramon Coca, Rosario Baena, Gema M. Lopez-Ruiz, Maria Elena Cano-Serrano, Alberto Martinez-Telleria, Ana Fuentes-Lopez, Juan Manuel Praena-Fernandez, Christoph Garbers, Jose Hernandez-Quero, Federico Garcia, Stefan Rose-John, Matilde Bustos
Summary: IL-6 signaling variables serve as useful tools for early identification and stratification of COVID-19 patients, with significant implications for treatment and clinical decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Khalid Alyafei, Rashid Ahmed, Farhan Fuad Abir, Muhammad E. H. Chowdhury, Khalid Kamal Naji
Summary: This article summarizes the efforts made in the domains from laboratory-based testing to monitoring asymptomatic COVID-19 patients using wearable devices, emphasizing the importance of screening asymptomatic patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biology
Adina M. Kamal, Florentina Dumitrescu, Adrian Mita, Denisa M. Sabiescu, Dragos O. Alexandru, Codruta E. Gheorghe, Monalisa M. Filip, Adriana Ionescu-Ciocalteu, Daniela T. Maria, Diana Kamal, Constantin K. Kamal
Summary: This study found that liver injury and elevated FIB-4 score were associated with the severity and poor clinical outcome of COVID-19 disease, and can also serve as important indicators for predicting COVID-19-related mortality.
Article
Medical Laboratory Technology
Federica Braga, Sara Pasqualetti, Elena Aloisio, Mauro Panteghini
Summary: Laboratory results should be traceable to higher-order references and fulfill acceptable measurement uncertainty. Manufacturers need to define a calibration hierarchy to assign traceable values to system calibrators, while medical laboratories should verify traceability and estimate corresponding uncertainties. Internal quality control programs should monitor traceability and reliability of employed measuring systems to ensure clinical validity of test results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Letter
Medical Laboratory Technology
Dominika Szoke, Simone Caruso, Elena Aloisio, Sara Pasqualetti, Alberto Dolci, Mauro Panteghini
CLINICA CHIMICA ACTA
(2021)
Letter
Medical Laboratory Technology
Elena Aloisio, Felicia Stefania Falvella, Assunta Carnevale, Mauro Panteghini
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Letter
Gastroenterology & Hepatology
Sara Pasqualetti, Elena Aloisio, Mauro Panteghini
Review
Medical Laboratory Technology
Elena Aloisio, Federica Braga, Chiara Puricelli, Mauro Panteghini
Summary: KL-6 may have certain utility in evaluating the risk of IPF progression and predicting patient prognosis, but its detection power is limited. IPF patients with higher KL-6 concentrations may face a higher risk of developing acute exacerbation. However, there appears to be no clear association between KL-6 concentrations and patient mortality.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Letter
Emergency Medicine
Elena Aloisio, Sara Pasqualetti, Mauro Panteghini
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medical Laboratory Technology
Elena Aloisio, Giulia Colombo, Claudia Arrigo, Alberto Dolci, Mauro Panteghini
Summary: AST levels are often elevated in COVID-19 patients due to hepatocellular and muscle damage. While AST elevation may not independently predict worse outcomes, it could be related to tissue damage and its clinical significance remains unclear.
CLINICA CHIMICA ACTA
(2021)
Article
Medical Laboratory Technology
Simone Caruso, Elena Aloisio, Alberto Dolci, Mauro Panteghini
Summary: This study retrospectively evaluated lipase levels in 1,092 hospitalized COVID-19 patients and found that lipase elevation occurred in approximately 1/3 of the patients. However, lipase elevation was not associated with patient prognosis.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Elena Aloisio, Mauro Panteghini
LIVER INTERNATIONAL
(2021)
Letter
Medical Laboratory Technology
Alessia Capoferri, Elena Aloisio, Sara Pasqualetti, Mauro Panteghini
CLINICAL BIOCHEMISTRY
(2022)
Article
Immunology
Sarah Birindelli, Maciej S. Tarkowski, Marcello Gallucci, Marco Schiuma, Alice Covizzi, Przemyslaw Lewkowicz, Elena Aloisio, Felicia Stefania Falvella, Alberto Dolci, Agostino Riva, Massimo Galli, Mauro Panteghini
Summary: We developed a laboratory score based on blood cell parameters to predict survival in hospitalized COVID-19 patients. The score effectively differentiated between survivors and non-survivors, reflecting the severity of the disease and providing a valuable tool for clinical decision-making and allocation of medical resources.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medical Laboratory Technology
Giulia Colombo, Dominika Szoke, Elena Aloisio, Francesco Cavigioli, Alberto Dolci, Mauro Panteghini
CLINICAL CHEMISTRY
(2022)
Review
Medical Laboratory Technology
Mauro Panteghini, Alberto Dolci, Sarah Birindelli, Dominika Szoke, Elena Aloisio, Simone Caruso
Summary: Appropriateness in laboratory medicine can be improved through various interventions, including activating evidence-based preventative strategies, implementing computerized provider order entry, applying specific recommendations, removing outdated tests, restricting orders, conducting reflex testing, and setting minimum retesting intervals. Our experience confirms the important role of laboratory professionals in improving test appropriateness.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medical Laboratory Technology
Elena Aloisio, Giulia Colombo, Alberto Dolci, Mauro Panteghini
Summary: C-reactive protein (CRP) plays an important role in inflammatory conditions and infectious diseases. In COVID-19, elevated CRP levels in serum are frequently observed and are significantly associated with severe illness, intensive care requirements, and in-hospital death. However, there is a lack of consensus on how to interpret CRP levels in COVID-19, including the quality of assays used and the optimal cutoff values. It is crucial to ensure result harmonization and control measurement uncertainty in order to effectively utilize CRP thresholds and prevent misclassification of patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Giorgia Bianchi, Erika Frusciante, Giulia Colombo, Ilenia Infusino, Elena Aloisio, Mauro Panteghini
Summary: This study validated the feasibility of Alinity enzyme assays and found a positive proportional bias in ALP2 and ALP2F compared to ALP1 and RMP. The measurement uncertainty associated with ALP measurements did not meet the established analytical performance specifications. Additionally, the commutability of ConCC with clinical samples was not confirmed.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)