Article
Geriatrics & Gerontology
Masamitsu Sugie, Kazumasa Harada, Marina Nara, Yoshihiro Kugimiya, Tetsuya Takahashi, Moe Kitagou, Hunkyung Kim, Shunei Kyo, Hideki Ito
Summary: This study aims to explore the prevalence and overlap of physical, cognitive, psychological, and social frailty among the elderly population, and identify factors that may help reduce frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Medicine, General & Internal
Huai-yu Wang, Xiaozhen Lv, Jian Du, Guilan Kong, Luxia Zhang
Summary: Frailty is prevalent among longevous population and associated with various adverse outcomes, such as limited physical performance, cognitive decline, and dependence. Frail males have a higher risk of mortality compared with frail females, and inactivity shows the strongest association with mortality risk in females.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Silvia Salvatori, Irene Marafini, Martina Franchin, Diletta Lavigna, Mattia Brigida, Chiara Venuto, Livia Biancone, Emma Calabrese, Diana Giannarelli, Giovanni Monteleone
Summary: It has been reported that frailty status can have a negative impact on the clinical progress of patients with inflammatory bowel diseases (IBDs). A recent study found that 20% of IBD patients are frail, and disease activity increases the risk of frailty. The study prospectively monitored a subgroup of frail patients, assessed the reversibility of frailty status, and analyzed factors associated with its reversibility. Results showed that frail phenotype is reversible in most IBD patients, with improvement in disease activity playing a significant role.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Tamaki Hirose, Yohei Sawaya, Masahiro Ishizaka, Naori Hashimoto, Akira Kubo, Tomohiko Urano
Summary: This study aimed to demonstrate the prevalence of pandemic-associated frailty in Japan, a country with an aging population, by comparing the frailty status before and during the COVID-19 outbreak. The results showed a steady increase in frailty among older adults during the pandemic.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Nadia M. Chu, Karen Bandeen-Roche, Qian-Li Xue, Michelle C. Carlson, A. Richey Sharrett, Alden L. Gross
Summary: Frailty (PFP) and its criteria are associated with cognitive function in older adults, with frailty showing excess effects on cognitive performance beyond criteria contributions. Different criteria have varying effects on cognitive change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Stacie G. Deiner, Edward R. Marcantonio, Shrunjal Trivedi, Sharon K. Inouye, Thomas G. Travison, Eva M. Schmitt, Tammy Hshieh, Tamara G. Fong, Long H. Ngo, Sarinnapha M. Vasunilashorn
Summary: Measuring frailty prior to surgery can help identify patients at risk for postoperative delirium. Both the frailty index and phenotype are associated with the development of delirium, but the index shows a stronger association.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Kaija Hiltunen, Riitta K. T. Saarela, Hannu Kautiainen, Hanna-Maria Roitto, Kaisu H. Pitkala, Paivi Mantyla
Summary: The study revealed that oral frailty is related to frailty phenotype, general health, nutrition, and the need for help with daily activities. As the severity of oral frailty increases, the prevalence of diseases and assistance required for daily activities also increases.
Article
Surgery
Randi J. Wong, Yara Mohamad, Yanin T. Srisengfa, Dorothea S. Kent, Srilakshmi Seetharaman, Rupal J. Shah, Jennifer C. Lai
Summary: This study found that low resilience is strongly associated with frail phenotype in patients with cirrhosis. Among the most resilient patients, only 10% were frail, while among the least resilient patients, 29% were frail. Therefore, effective interventions to mitigate frailty should include strategies to build resilience in patients with low baseline resilience.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Bader A. Alqahtani, Aqeel M. Alenazi
Summary: This study reveals a high prevalence of cognitive frailty among Saudi community-dwelling older individuals and identifies age, being single, and number of chronic conditions as associated factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Minna Koivukangas, E. Hietikko, T. Strandberg, S. Keinanen-Kiukaanniemi, R. Leskinen, R. Peters, R. Antikainen
Summary: The study found that frailty was less prevalent in the 1945 cohort compared to the 1935 cohort, especially significant among women. Low financial satisfaction was significantly associated with frailty, while low education level was associated with frailty in women and being unmarried or divorced in men.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Health Care Sciences & Services
Bader A. Alqahtani, Mohammed M. Alshehri, Ragab K. Elnaggar, Saad M. Alsaad, Ahmed A. Alsayer, Noura Almadani, Ahmed Alhowimel, Mohammed Alqahtani, Aqeel M. Alenazi
Summary: This study aimed to systematically search for data on the prevalence of frailty among community-dwelling elders in Middle Eastern countries and provide comprehensive evidence through meta-analysis. The findings indicated a higher prevalence of frailty in Middle Eastern nations. However, there is currently a lack of information on the incidence of frailty in these populations, which is essential for health, policymakers, and social care planning.
Article
Geriatrics & Gerontology
Osamu Katayama, Sangyoon Lee, Seongryu Bae, Keitaro Makino, Yohei Shinkai, Ippei Chiba, Kenji Harada, Hiroyuki Shimada
Summary: This study investigated the lifestyle activity patterns of urban community-dwelling Japanese older adults, focusing on physical frailty and cognitive impairment. Using latent class analysis, four classes of activity patterns were identified, and it was found that physical frailty and cognitive impairment were independently associated with certain types of lower engagement in activities.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Review
Geriatrics & Gerontology
C. -p. Chung, W. -j. Lee, L. -n. Peng, H. Shimada, T. -f. Tsai, C. -p. Lin, H. Arai, Liang-Kung Chen
Summary: In this unprecedented era of longevity, healthy aging is a public health priority. Identifying those at risk and implementing effective interventions, such as targeting the PCDS phenotype, can significantly improve cognitive function in older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Jia Qian Chia, Kristabella Low, Justin Chew, Jun Pei Lim, Liuh Ling Goh, Gervais Wansaicheong, Wee Shiong Lim
Summary: After studying 230 older adults, it was found that FPQ performed better in early detection of frailty, while FRAIL showed better concurrent validity for inflammation and body composition.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Xue-zhai Zeng, Ling-bing Meng, Ying-ying Li, Na Jia, Jing Shi, Chi Zhang, Xing Hu, Jia-bin Hu, Jian-yi Li, Di-shan Wu, Hui Li, Xin Qi, Hua Wang, Qiu-xia Zhang, Juan Li, De-ping Liu
Summary: The aim of this study was to investigate the prevalence and factors associated with frailty and pre-frailty in older adults in China. The results showed that frailty and pre-frailty are very common among older adults in China and differ significantly between different regions, genders, and rural/urban areas. Appropriate public health prevention strategies should be developed based on identified risk factors in order to reduce the burden of frailty among older adults in China.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Shohei Okamoto, Erika Kobayashi
Summary: This study found a significant association between social isolation and cognitive functioning, particularly among individuals aged 75 or older. However, after addressing endogeneity, this association was not confirmed. Further research is needed to reveal the causal relationship and detailed mechanisms of the health effects of social relationships.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Shohei Okamoto, Erika Kobayashi, Hiroshi Murayama, Jersey Liang, Taro Fukaya, Shoji Shinkai
Summary: This empirical study found that differences in cognitive functioning and decline between men and women can be attributed to various individual attributes, such as education and occupation. Men seem to engage in activities that enhance cognitive functioning more than women, supporting the cognitive reserve hypothesis.
Article
Psychology, Biological
Takanao Tanaka, Shohei Okamoto
Summary: This study found that during the initial months of the pandemic, Japan experienced a decrease in suicide rates possibly due to factors like government subsidies, reduced working hours, and school closure. However, during the second wave, there was an increase in suicide rates, particularly among females and children/adolescents.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Public, Environmental & Occupational Health
Takanao Tanaka, Shohei Okamoto, David Canning
Summary: Cross-national studies have found limited evidence of benefits in the linkage between health-care spending and population health. This study suggests that variation in health spending is not associated with decreased mortality rates and has a weak association with increased health-care resources and service utilization. In contrast, gross domestic product per capita is significantly associated with increased health resources, higher service utilization, and lower mortality rates.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ching-Ju Chiu, Yun-An Chen, Erika Kobayashi, Hiroshi Murayama, Shohei Okamoto, Jersey Liang, Yuh-Huey Jou, Chia-Ming Chang
Summary: This study compared the development of physical disability in populations of Taiwan and Japan, finding that Japan had a higher prevalence of ADL disability but lower rates of IADL and mobility disabilities compared to Taiwan. The onset of different types of disabilities varied in age between the two countries, with older adults in Japan not reporting ADL limitations until 77 years old.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Multidisciplinary Sciences
Shohei Okamoto
Summary: This study found that income was the strongest predictor of adolescent health outcomes, with higher parental education levels also impacting child health-related behaviors. Future research on health disparities among children/adolescents should carefully consider choosing an SES indicator.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Phap Tran Ngoc Hoang, Aya Kadota, Yuichiro Yano, Akiko Harada, Takehito Hayakawa, Shohei Okamoto, Naoko Miyagawa, Keiko Kondo, Nagako Okukda, Yoshiuni Kita, Akira Okayama, Yukihiro Fujita, Hiroshi Maegawa, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima
Summary: In middle-aged Japanese adults, diabetes and prediabetes are associated with a higher risk of disability and mortality.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Shohei Okamoto, Kazuki Kamimura, Kohei Komamura
Summary: This study examines the determinants of vaccine hesitancy, reasons for hesitation, and the potential effectiveness of vaccine passports in mitigating vaccine hesitancy. The research findings indicate that concerns about vaccine safety and side effects are major reasons for vaccine hesitancy, and younger age, lower socioeconomic status, and weaker COVID-19 fear are associated with vaccine hesitancy. The implementation of vaccine passports and the easing of public health restrictions are found to increase vaccine acceptance rates.
Article
Geriatrics & Gerontology
Shohei Okamoto, Erika Kobayashi, Kohei Komamura
Summary: This study examines the effects of retirement on health and other outcomes using data from the Japan Household Panel Survey. The results show that retirement has positive effects on psychological well-being, exercise habits, and time spent on unpaid work. However, the psychological benefits of retirement diminish over time, while positive effects on healthy habits and unpaid activities persist.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Shohei Okamoto
Summary: This study analyzed the changes in mobility across different travel destinations in Japan to assess social distancing behavior. The results suggest that government interventions may help control human mobility outside the home, but their effectiveness may decline over time if repeated and enforced for extended periods.
JOURNAL OF TRANSPORT & HEALTH
(2022)
Article
Geriatrics & Gerontology
Erika Kobayashi, Ken Harada, Shohei Okamoto, Jersey Liang
Summary: This study examined the association between living alone and well-being among older adults in Japan, taking into account social context factors such as urbanization and time period. The results showed that older adults who lived alone continuously or started living alone between survey waves had higher levels of depressive symptoms compared to those who lived with someone continuously. This effect was more pronounced in rural areas and among men. Additionally, the impact of living alone on depressive symptoms decreased in the year 2015 compared to 1990, possibly due to increased depressiveness in older adults who lived with others.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Economics
Shohei Okamoto, Haruka Sakamoto, Kazuki Kamimura, Kohei Komamura, Erika Kobayashi, Jersey Liang
Summary: This study estimates the economic benefits of healthy aging by analyzing the economic losses caused by functional limitations among middle-aged and older people. The research found that functional limitations are associated with a higher retirement probability and increased total health spending among individuals aged 60 and above. The estimated financial costs generated by functional limitations, including foregone wages and medical/long-term care expenses, were approximately USD 72.7 billion. Health interventions can lead to economic benefits by preventing exits from the labor market and reducing medical and long-term care costs.
HEALTH ECONOMICS REVIEW
(2023)
Article
Public, Environmental & Occupational Health
Junko Sano, Yuzuki Hirazawa, Kohei Komamura, Shohei Okamoto
Summary: As people live longer, they face various risks associated with aging, such as economic uncertainty and health issues. To ensure a better quality of life for older people, creating an environment where they can thrive even with declining intrinsic capacity is crucial. This review provides an overview of Japan's systems and initiatives in supporting the well-being of older adults and highlights the remaining challenges they face.
ARCHIVES OF PUBLIC HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Shohei Okamoto, Kohei Komamura
Summary: This review provides an overview of Japan's public long-term care system and offers insights to other countries facing challenges related to population ageing. Although Japan's approach may not be universally applicable, the challenges faced by older people are common, including financing, labor shortages, and support for those with dementia.
ARCHIVES OF PUBLIC HEALTH
(2022)
Article
Gerontology
Erika Kobayashi, Ikuko Sugawara, Taro Fukaya, Shohei Okamoto, Jersey Liang
Summary: This study found that retirement age has an impact on individuals' participation in social activities, with fully retired individuals more likely to increase these activities when they retire in their early seventies. Therefore, encouraging social engagement before retirement and removing barriers to starting new activities in old age are crucial.
Article
Geriatrics & Gerontology
Wen Hao, Yi-fan Shan, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Satoe Okabayashi, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi
Summary: The study found that dual decline in gait speed and cognition is associated with a higher risk of late-life dementia, particularly in older Japanese men. These findings highlight the importance of early screening for dual decline.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Lijun Zhao, Kexin Hu, Weiting Liu, Haonan Qi, Guodong Li, Jun Chen, Limin Han
Summary: This study found that Anemonin (ANE) can delay cellular senescence through the PARP1-NAD+-SIRT1 signaling pathway, suggesting it as a potential effective anti-aging strategy.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Mohammad Soleimani Farsani, Mohammad Fathi, Zahra Hemati Farsani, Zinab Gourgin Karaji
Summary: Swimming training has a significant effect on the expression of Neural cell adhesion molecule (NCAM), Semaphorin 3A (SEMA3A), and Profilin-1 (PFN1) proteins in the gastrocnemius muscle of Alzheimer-like phenotype rats.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Hailin Zhang, Kai Kang, Shuaijie Chen, Qiong Su, Weijie Zhang, Lishan Zeng, Xiaoyan Lin, Feng Peng, Jinxiu Lin, Dajun Chai
Summary: This study found that longitudinal changes in cardiac function in patients with AMI were independently associated with high baseline serum LDH levels. Baseline LDH levels may be an important parameter for predicting future cardiac dysfunction after AMI, especially in the elderly.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Alberto Pilotto, Marina Barbagelata, Wanda Morganti, Emanuele Seminerio, Guido Iaccarino, Armando Genazzani, Carlo Trompetto, Gennarina Arabia, Maddalena Illario, Erica Volta, Carlo Custodero, Alberto Cella
Summary: The prevention and treatment of frailty condition among multimorbid older adults is becoming a healthcare priority. A multidimensional approach using information and communication technology (ICT) offers a way to implement and monitor personalized interventions. The MULTIPLAT_AGE project aims to provide multidimensional interventions for older adults using a shared online platform, including transitional care, automatic home-care, appropriate drug prescription, tele-rehabilitation, and remote cognitive stimulation.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Weida Lyu, Tomoki Tanaka, Bo-Kyung Son, Yasuyo Yoshizawa, Masahiro Akishita, Katsuya Iijima
Summary: The study found that the Eleven-Check questionnaire could be used to screen frailty and sarcopenia status in community-dwelling older adults. The high-risk group had a higher risk of frailty and sarcopenia.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Editorial Material
Geriatrics & Gerontology
Liang-Kung Chen
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Robbert J. J. Gobbens, Sandra Kuiper, Henriette Dijkshoornf, Marcel A. L. M. van Assen
Summary: This study examined the associations between chronic diseases and multidimensional frailty comprising physical, psychological, and social frailty. The results showed that chronic diseases, especially urinary incontinence and severe back disorder, were associated with frailty. The study recommends assigning different weights to individual chronic diseases in measuring multimorbidity and its effects on multidimensional frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Naoko Sakuma, Hiroyuki Suzuki, Susumu Ogawa, Toru Takebayashi, Yoshinori Fujiwara
Summary: The study found a positive bidirectional association between hand dexterity and maximum gait speed with executive function performance, while handgrip strength and usual gait speed showed no associations. This suggests that hand dexterity and motor speed have an important impact on cognitive function and are mutually dependent on each other.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Sunghwan Ji, Ji Yeon Baek, Eunju Lee, Il-Young Jang, Hee-Won Jung
Summary: By validating the KWGS guideline in older Korean adults, this study found that different phenotypes of sarcopenia were associated with increased frailty and higher risks of institutionalization and mortality. Functional sarcopenia demonstrated comparable prognosis with sarcopenia (not severe) and was linked to greater frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Review
Geriatrics & Gerontology
Masatoshi Nakamura, Kosuke Takeuchi, Taizan Fukaya, Gakuto Nakao, Andreas Konrad, Takamasa Mizuno
Summary: Static stretching can decrease the passive stiffness of the muscle-tendon unit (MTU) and/or muscles in older adults. The effects of static stretching on stiffness are comparable between older and young adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Ji Liu, Qiaoyi Chen
Summary: This study examines the relationship between depressive symptoms, sleep duration, and cognitive performance among older adults. The results suggest that early depressive symptoms are associated with increased depressive symptoms, shortened sleep duration, and worsened cognition. Sleep duration and depression progression mediate the relationship between early depressive symptoms and cognitive performance.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Yong-Hao Pua, Berend Terluin, Laura Tay, Ross Allan Clark, Julian Thumboo, Ee-Ling Tay, Shi-Min Mah, Yee-Sien Ng
Summary: This study introduces and demonstrates the utility of an item response theory (IRT) method in estimating frailty index (FI) interpretation thresholds in community-dwelling adults, providing a new tool and reference for defining frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Mengxiao Hu, Haiyang Yu, Yike Zhang, Bowen Xiang, Qing Wang
Summary: This study found bidirectional associations among the accumulation of chronic conditions, disability, and depressive symptoms, especially between disability and depression. Women were more sensitive to the accumulation of chronic conditions through disability.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Juan Carlos Pineiro-Fernandez, Ramon Rabunal-Rey, Ana Maseda, Eva Romay-Lema, Roi Suarez-Gil, Sonia Pertega-Diaz
Summary: This study describes the distribution and temporal trends of the centenarian population and their hospital admissions in Spain over the past two decades. It found a significant increase in the centenarian population and hospital admissions, with regional and sex-based differences. Women represented a larger proportion of centenarians and hospital admissions. Understanding these trends and differences is crucial for implementing interventions that ensure adequate healthcare for centenarians.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)