Article
Environmental Sciences
Jason T. Magnuson, Kara E. Huff Hartz, Corie A. Fulton, Michael J. Lydy, Daniel Schlenk
Summary: The neurotoxic effects of bifenthrin on rainbow trout mainly involve disrupting neuroendocrine function, affecting cell signaling pathways, and inducing apoptosis. Research findings suggest that low concentrations of bifenthrin can have significant impacts on endangered fish species.
Article
Environmental Sciences
Wonhyoung Park, Sunwoo Park, Whasun Lim, Gwonhwa Song
Summary: Research results indicate that bifenthrin inhibits cell proliferation and viability, induces cell cycle arrest and apoptosis in both porcine trophectoderm and uterine luminal epithelial cells. Bifenthrin also damages mitochondria, induces reactive oxygen species production, leading to endoplasmic reticulum stress and calcium dysregulation in the cells. Finally, bifenthrin alters MAPK/PI3K signaling pathway and expression of pregnancy-related genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Krista M. Dalton, Timothy L. Lochmann, Konstantinos Floros, Marissa L. Calbert, Richard Kurupi, Giovanna T. Stein, Joseph McClanaghan, Ellen Murchie, Regina K. Egan, Patricia Greninger, Mikhail Dozmorov, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Lisa Shock, Jennifer Koblinski, John Glod, Sosipatros A. Boikos, Cyril H. Benes, Anthony C. Faber
Summary: MYCN-amplified neuroblastoma is sensitive to the combination of the lactate transporter MCT1 inhibitor AZD3965 and the mitochondrial complex I inhibitor phenformin. Low expression of MCT4, combined with high expression of MCT2 and MCT1 chaperone CD147 in MYCN-amplified neuroblastoma, confers sensitivity to this combination therapy, leading to disruption of glycolysis and oxidative phosphorylation, ATP production, endoplasmic reticulum stress, and ultimately, cell death.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Critical Care Medicine
Yibing Wei, Jiyoun Kim, Harri Ernits, Daniel Remick
Summary: Neutrophils play a critical role in eradicating pathogenic organisms, especially bacteria, but their prolonged activation in septic patients can exacerbate tissue and organ damage. The different activation states and chemotaxis of neutrophils in septic patients are discussed, along with the dysregulation of neutrophil functions during sepsis. Delayed neutrophil apoptosis may contribute to organ injury or improve pathogen clearance, showing the dual nature of neutrophil responses in sepsis.
Article
Biochemistry & Molecular Biology
Naeun Yoon, Hyunbeom Lee, Geonhee Lee, Eun Hye Kim, Seong Hwan Kim, Jeong-O Lee, Yunseon Song, Jinyoung Park, So-Dam Kim, Yeojin Kim, Byung Hwa Jung
Summary: The study revealed that zinc induces apoptosis in Raji cells by altering protein phosphorylation and metabolite levels, with arachidonic acid identified as a key inducer of apoptosis. Choline metabolism was found to play a crucial role in zinc-induced Raji cell apoptosis.
Article
Environmental Sciences
Gaolong Zhong, Fang Wan, Shaofeng Wu, Xuanxuan Jiang, Zhaoxin Tang, Xiaoyong Zhang, Riming Huang, Lianmei Hu
Summary: The study demonstrated that co-exposure to arsenic and antimony can result in oxidative damage and mitochondrial injury in the liver, leading to abnormal liver energy metabolism and lipid metabolism disorder. Mitophagy and apoptosis play important roles in the mechanisms of arsenic/antimony cytotoxicity to mouse livers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Dan Song, Chao Xu, Askild L. Holck, Rong Liu
Summary: ACR exposure has been shown to cause neurotoxicity, reproductive toxicity, and carcinogenicity, but the exact mechanism of its toxicity remains unknown. In this study, it was demonstrated that ACR inhibited autophagic flux, increased ROS content, and led to apoptosis and inflammatory responses. Metabolomic analysis revealed significant differences in metabolic profiles between ACR treated and control cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Entomology
Marcelo M. Rabelo, Izailda B. Santos, Silvana Paula-Moraes
Summary: This study investigated the resistance and fitness stability of Spodoptera exigua to chlorantraniliprole and pyrethroid insecticides. The results showed that resistance to bifenthrin was stable, while resistance to chlorantraniliprole was unstable. This study provides important guidance for managing resistant pests and recommending insecticide rotation strategies.
Article
Environmental Sciences
Na Qiao, Yanyang Yang, Jianzhao Liao, Hui Zhang, Fan Yang, Feiyang Ma, Qingyue Han, Wenlan Yu, Ying Li, Lianmei Hu, Jiaqiang Pan, Riaz Hussain, Zhaoxin Tang
Summary: The study found that high copper diet in pigs led to renal dysfunction, as indicated by elevated serum creatinine levels and renal tubular epithelial cell swelling. Transcriptomics and metabolomics analysis revealed significant changes in genes and metabolites in the kidneys of pigs in the high copper diet group, suggesting disruption in glycerophospholipids and glycosphingolipids metabolism pathways. Furthermore, copper exposure induced mitochondrial apoptosis and inhibited autophagy, highlighting the importance of these mechanisms in copper-induced renal damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Abdulrahman L. Al-Malki, Ashraf Bakkar, Etimad A. Huwait, Elie K. Barbour, Kalid O. Abulnaja, Taha A. Kumosani, Said S. Moselhy
Summary: This study evaluated the anti-proliferative and pro-apoptotic effects of strigol/albumin/chitosan nanoparticles (S/A/CNP) on HepG2 cell line, finding that it can modulate energetic and epigenetic metabolites, making it a potential therapeutic agent for hepatocellular carcinoma.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Feng Zhou, Lu Lu Zhong, Yang Tan, Li Liu, Gang Pei
Summary: In this study, the reproductive toxicity of Triptolide (TP) and its mechanism were investigated using a metabolomic approach. The results showed that TP induced histopathological changes in the ovaries of rats, leading to follicular apoptosis and damage to the ovarian microstructure. Metabolomics analysis revealed significant differences in small molecule metabolites in the ovaries and serum of TP-treated rats compared to the control group.
Article
Pharmacology & Pharmacy
Nguyen Phuoc Long, Jung-Hwa Oh, Se-Myo Park, Nguyen Thi Hai Yen, Nguyen Ky Phat, Yong-Soon Cho, Hyung Min Kim, Seokjoo Yoon, Jae-Gook Shin, Dong Hyun Kim
Summary: This study used untargeted metabolomics and transcriptomics to investigate the molecular processes occurring in the liver and kidney of rats after treatment with colistin methanesulfonate (CMS). The results showed dose- and treatment duration-dependent metabolic alterations in the kidney, while only minor changes were observed in the liver. Gene expression profiles indicated that high-dose treatment was associated with disrupted metabolism, oxidative stress, and inflammatory responses in the kidney.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyuan Meng, Jiajia Cui, Li Liu, Chunmei Yang, Xin Bao, Jianjun Wang, Xiaojun Chen
Summary: This study investigated the effects of CAP on zebrafish, demonstrating low bioaccumulation, promotion of liver growth, induction of oxidative stress and apoptosis, disruption of metabolic phenotype, and strong correlation between liver function changes and metabolic phenotype changes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Joanna Skiba, Aleksandra Kowalczyk, Damian Trzybinski, Krzysztof Wozniak, Valerije Vrcek, Magdalena Gapinska, Konrad Kowalski
Summary: This paper reports a Yb(OTf)(3)-mediated etherification reaction to obtain R,R and S,R isomers of ferrocenyl glycol nucleic acid (Fc-GNA) nucleosides from their stereo-defined (S,R) precursor. The mechanism of the reaction is explained by density functional theory calculations, and the obtained compounds show reversible oxidation of the ferrocenyl portion. Anticancer activity studies reveal that the (S,R) nucleoside exhibits the highest activity against cancer cells HeLa and Ishikawa, inducing apoptosis in HeLa cells at a concentration of IC50=66.0 μM after 72 hours of treatment.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yanli Wang, Xiaowan Huang, Xiao Zhang, Jingchen Wang, Keyan Li, Guotao Liu, Kexin Lu, Xiang Zhang, Chengping Xie, Teresa Zheng, Yung-Yi Cheng, Qiang Wang
Summary: Allobetulin is a compound similar in structure to betulinic acid, and it has a low toxicity but induces apoptosis in cancer cells. However, it shows weak antiproliferative effects in several tumor cell lines. In this study, a new series of allobetulon/allobetulin-nucleoside conjugates were designed and synthesized to enhance its potency. Compound 10d exhibited superior antiproliferative activity in comparison to cisplatin and oxaliplatin against multiple human cancer cell lines, and it achieved this through the regulation of protein expression levels.