Article
Microbiology
Izumi Mashima, Yu-Chieh Liao, Chieh-Hua Lin, Futoshi Nakazawa, Elaine M. Haase, Yusuke Kiyoura, Frank A. Scannapieco
Summary: The genus Veillonella in the oral microbiome includes eight species with important metabolic pathways utilizing lactate as an energy source. Through a comparative pan-genome analysis, it was found that these species have conserved pathways using carbohydrates other than lactate as an energy source, helping to understand the metabolic network in oral microbiomes.
Article
Plant Sciences
Yvonne K. Jockel-Schneider, Sophia Gossner, Peggy Stoelzel, Imme Haubitz, Reinhold Carle, Nicole Petersen, Johannes Baulmann, Ulrich Schlagenhauf
Summary: This follow-up study showed that a nitrate-rich diet can improve the recovery of therapy-induced vascular impairments. The study suggests that increasing salivary nitrate/nitrite levels may be beneficial in restoring vascular function after treatment.
Review
Nutrition & Dietetics
Fatemeh Hosseini, Maryam Majdi, Sina Naghshi, Fatemeh Sheikhhossein, Kurosh Djafarian, Sakineh Shab-Bidar
Summary: A dose-response meta-analysis of observational studies found a positive association between dietary nitrate intake and risk of colorectal cancer, while nitrite from diet and nitrate from drinking water were not significantly associated with colorectal cancer risk.
CLINICAL NUTRITION
(2021)
Article
Microbiology
Shi-Min Zhang, Shir-Ly Huang
Summary: Short-chain fatty acids produced by gut commensal bacteria, including Veillonella and acetate and propionate, are associated with human health. Veillonella reprogrammed its lactate metabolism during the stationary phase, resulting in decreased propionate production. The study expands our understanding of the metabolism of commensal anaerobes in changing environments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Na Li, Hejing Wang, Huizhu Zhao, Mengyang Wang, Jin Cai, Yi Hao, Jia Yu, Yun Jiang, Xin Lu, Bianfang Liu
Summary: Veillonella ratti and Lactobacillus acidophilus regulate the gut environment and alleviate ulcerative colitis. Co-culturing experiments showed that they can promote lactic acid and SCFA production while reducing pH and glucose levels. In vivo experiments demonstrated that their combined intervention can mitigate ulcerative colitis, improve intestinal barrier integrity, suppress inflammation, and increase beneficial bacteria.
Article
Food Science & Technology
S. W. Park, T. J. Cho, M. S. Rhee
Summary: This study suggests that spore-forming bacteria (SFB) in reconstituted infant formula (RIF) may produce nitrite, which poses an underestimated microbial risk. Some SFB strains can rapidly produce substantial amounts of nitrite. This could lead to infants consuming more than seven times the acceptable daily intake of nitrite.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agricultural Engineering
Victor Pozzobon, Na Cui, Alissa Moreaud, Emilie Michiels, Wendie Levasseur
Summary: The addition of nitrite triggered growth rate inhibition in Chlorella vulgaris, while there was no impact on the pigment contents. Nitrate uptake rate increased with nitrate content, but nitrite uptake remained constant.
BIORESOURCE TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Jeffry Florian, Murali K. Matta, Ryan DePalma, Victoria Gershuny, Vikram Patel, Cheng-Hui Hsiao, Robbert Zusterzeel, Rodney Rouse, Kristin Prentice, Colleen Gosa Nalepinski, Insook Kim, Sojeong Yi, Liang Zhao, Miyoung Yoon, Susan Selaya, David Keire, Joyce Korvick, David G. Strauss
Summary: This study involving 18 healthy participants found that oral ranitidine did not significantly increase urinary excretion of NDMA compared to placebo under different dietary conditions.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Review
Biochemistry & Molecular Biology
Omar Zayed, Omar A. Hewedy, Ali Abdelmoteleb, Mohammed Ali, Mohamed S. Youssef, Ahmed F. Roumia, Danelle Seymour, Ze-Chun Yuan
Summary: Plants uptake and assimilate nitrogen from the soil, and nitrate and ammonium transporters play important roles in this process. Nitrogen is then incorporated into organic compounds through nitrogen metabolism pathways. Nitric oxide has been found to enhance plant survival under drought stress, and the interaction between nitrogen and salt stress has been studied. Excessive use of nitrate fertilizers can have negative impacts on health and the environment, highlighting the importance of alternative strategies. Genomics can identify new genes related to nitrogen fixation, which can be utilized to improve plant productivity.
Article
Biochemistry & Molecular Biology
Graziele C. Ferreira, Lucas C. Pinheiro, Gustavo H. Oliveira-Paula, Celio D. Angelis, Rafael L. Portella, Jose E. Tanus-Santos
Summary: The study demonstrated that pretreatment with Tempol affects the concentrations of NO metabolites in different tissues after oral nitrite administration, without increasing vascular nitrosation. Tempol enhanced nitrite concentrations in the stomach and plasma, as well as in the heart but decreased them in the liver.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Physical
Li Cai, Jinrui Guo, Ting Liu, Jing Tian, Zhaoli Wang, Yong Liu, Mohamed S. Hamdy, Xuping Sun
Summary: In this study, a novel Cu@Fe-Cu-CuFe2O4-x photocatalyst was prepared and used to selectively reduce NO3- to N-2 with a two-step reduction process. The first step achieved 91.0% NO3- reduction to NO2- and N-2, while the second step further enhanced the selectivity of NO2- reduction to N2 through the introduction of H2C2O4 and H2O2. The overall process achieved high NO3- removal efficiency and N-2 selectivity.
Article
Multidisciplinary Sciences
Yuanyuan Deng, Jiao Wang, Guijiao Xie, Guilin Zou, Shanshan Li, Jie Zhang, Wei Cai, Jixiong Xu
Summary: This study used 16S rRNA sequencing to analyze the gut microbiota of 65 newly diagnosed Graves' disease (GD) patients and 33 physical examination personnel. Significant differences were found between the two groups, and the gut microbiota composition of GD patients changed after treatment. The study suggested that the unique characteristics of gut microbiota in GD patients may be related to an imbalance in the immune system and gut microbiota.
Article
Plant Sciences
Mario Giordano, Charles A. Goodman, Fengying Huang, John A. Raven, Zuoxi Ruan
Summary: In most algae, NO3- assimilation is inhibited by NH4+, but in a marine non-diazotrophic cyanobacterium, NO3- assimilation is only sensitive to NH4+ when N does not limit growth. The genetic organization and expression of NAR genes in this cyanobacterium was studied, revealing that its nitrate reductase exhibits biphasic kinetics. NH4+ insensitivity may be associated with the binding of regulator NtcA to NAR gene promoters stimulated by high 2-oxoglutarate concentrations. NH4+ sensitivity in energy-limited cells is consistent with the lower energy cost of NH4+ utilization.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Environmental Sciences
Marzieh Nader, Behnam Hosseininezhad, Enayat Berizi, Seyed Mohammad Mazloomi, Saeid Hosseinzadeh, Morteza Zare, Zahra Derakhshan, Gea Oliveri Conti, Margherita Ferrante
Summary: This study investigated the levels of residual nitrite and nitrate in meat products in Iran and evaluated their health-related risks. The results showed that the levels of residual nitrite and nitrate in meat products were relatively low, indicating no significant carcinogenic risk for consumers in Iran.
ENVIRONMENTAL RESEARCH
(2022)
Article
Microbiology
Bente Nyvad, Nobuhiro Takahashi
JOURNAL OF ORAL MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Yuria Sato-Suzuki, Jumpei Washio, Dimas Prasetianto Wicaksono, Takuichi Sato, Satoshi Fukumoto, Nobuhiro Takahashi
SCIENTIFIC REPORTS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Hiroki Hihara, Ryo Tagaino, Jumpei Washio, Kittipong Laosuwan, Dimas Prasetianto Wicaksono, Kuniyuki Izumita, Rie Koide, Nobuhiro Takahashi, Keiichi Sasaki
Summary: The MSM-UNIT showed significantly higher biofilm removal rate compared to AIRFLOW. Little damage was observed in the area treated by the MSM-UNIT, and the surface roughness of the treated area showed no significant difference to the control. The MSM-UNIT can be safely and effectively used for removing biofilm on both simulated tooth surfaces and mucous membranes.
Article
Biochemistry & Molecular Biology
Shan Liu, Jumpei Washio, Satoko Sato, Yuki Abiko, Yuta Shinohara, Yuri Kobayashi, Haruki Otani, Shiori Sasaki, Xiaoyi Wang, Nobuhiro Takahashi
Summary: This study examined the effects of metformin on cell growth, metabolic activities, and nutrient consumption under different oxygen and nutrient conditions. The results showed that the efficacy of metformin was influenced by cell types, oxygen conditions, and nutrient availability. Additionally, metformin was found to induce metabolic switch and may have potential as a combinational therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuta Shinohara, Jumpei Washio, Yuri Kobayashi, Yuki Abiko, Keiichi Sasaki, Nobuhiro Takahashi
Summary: This study investigated the effects of oxygen concentration fluctuations on the glucose metabolism of oral squamous cell carcinoma and normal epithelial cells. It was found that rapid increases in oxygen levels significantly enhanced the metabolic activity of hypoxically cultured cancer cells, while normal cells did not respond to the changes in oxygen levels.
Article
Dentistry, Oral Surgery & Medicine
Xuelian Jiang, Yufei Wang, Xinwei Li, Zening Feng, Yuhao Zeng, Sili Han, Nobuhiro Takahashi, Linglin Zhang
Summary: This study aimed to develop a chewing gum containing a novel antimicrobial peptide GH12 and evaluate its biocompatibility, antimicrobial activity, and caries-preventive effects. The results showed that GH12 chewing gum inhibited the growth and biofilm formation of Streptococcus mutans, and had low cytotoxicity against human gingival epithelial cells. In the rat caries model, the Keyes scores of caries lesions in the GH12 chewing gum group were lower compared to the negative control group. These findings suggest that GH12 chewing gum has the potential to prevent dental caries as an adjuvant to regular oral hygiene.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fajar Kusuma Dwi Kurniawan, Retno Indrawati Roestamadji, Nobuhiro Takahashi, Udijanto Tedjosasongko, Ida Bagus Narmada, Meircurius Dwi Condro Surboyo, Indeswati Diyatri
Summary: This study investigated the oral microbiome profiles and IL-6, TNF-alpha levels of pregnant women using fixed orthodontic appliances. The results showed similar microbiome profiles between pregnant women with orthodontic appliances and the control group, but higher TNF-alpha levels in the orthodontic group. Therefore, oral hygiene and maintenance should be emphasized for pregnant women using orthodontic appliances.