Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis

Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

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A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

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Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection

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PubChem 2019 update: improved access to chemical data

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The Ebola outbreak, 2013–2016: old lessons for new epidemics

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Toremifene interacts with and destabilizes the Ebola virus glycoprotein

(2016) Yuguang Zhao et al.   NATURE

Cationic amphiphilic drugs enhance entry of lentiviral particles pseudotyped with rabies virus glycoprotein into non-neuronal cells

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Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1

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Ebolavirus Glycoprotein Directs Fusion through NPC1 + Endolysosomes

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Antiviral drug discovery: broad-spectrum drugs from nature

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Combating emerging viral threats

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Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection

(2015) Shanshan He et al.   Science Translational Medicine

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

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Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process

(2015) Cristiano Salata et al.   Pathogens and Disease

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

(2015) Peter B. Madrid et al.   ACS Infectious Diseases

Ebola Virus and Severe Acute Respiratory Syndrome Coronavirus Display Late Cell Entry Kinetics: Evidence that Transport to NPC1+Endolysosomes Is a Rate-Defining Step

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The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

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Lassa Fever in Post-Conflict Sierra Leone

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Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle

(2013) Yuan-Lung Cheng et al.   CLINICAL SCIENCE

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for ‘Orphan’ Molecules

(2013) Michael Reutlinger et al.   Molecular Informatics

Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection

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FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

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Impact of Intra- and Interspecies Variation of Occludin on Its Function as Coreceptor for Authentic Hepatitis C Virus Particles

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Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

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Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

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A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle

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Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

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Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection

(2009) P. Gastaminza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amiodarone Alters Late Endosomes and Inhibits SARS Coronavirus Infection at a Post-Endosomal Level

(2008) Konrad Stadler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

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A 96-well flow cytometric screening assay for detecting in vitro phospholipidosis-induction in the drug discovery phase

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