Article
Oncology
Anita Mamtani, Varadan Sevilimedu, Tiana Le, Monica Morrow, Andrea Barrio
Summary: The study found that even among patients initially ineligible for breast-conserving surgery, those who became eligible after neoadjuvant chemotherapy had low rates of local recurrence, suggesting that mastectomy may be safely avoided in these patients.
Article
Health Care Sciences & Services
Giulia Atzori, Marco Gipponi, Chiara Cornacchia, Raquel Diaz, Marco Sparavigna, Maurizio Gallo, Tommaso Ruelle, Federica Murelli, Simonetta Franchelli, Francesca Depaoli, Daniele Friedman, Piero Fregatti
Summary: This retrospective study evaluated the extent of a safe excision margin in patients with Stage I-II breast cancer undergoing breast-conserving surgery after neoadjuvant chemotherapy. The study found no significant difference in local recurrence-free survival among patients with different margin involvement. Patients with complete pathological response had a statistically significant advantage in disease-free survival and overall survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yu-Chun Song, Zhou Huang, Hui Fang, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Bo Chen, Yuan Tang, Shu-Nan Qi, Ning-Ning Lu, Ning Li, Ye-Xiong Li, Shu-Lian Wang
Summary: This study compares the recurrence and survival outcomes between breast-conserving surgery (BCS) and mastectomy after neoadjuvant chemotherapy (NACT). The results show that there is no significant difference in the 5-year locoregional recurrence rate, distant metastasis rate, and disease-free survival rate between the BCS and mastectomy groups. However, the BCS group has significantly higher 5-year breast cancer-specific survival rate and overall survival rate compared to the mastectomy group. Multivariate analysis also demonstrates that BCS significantly improves breast cancer-specific survival and overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nan Lin, Wangwu Liu, Mingwei Wang, Weikang Zhou, Shiyao Zheng, Jin Yang, Yongchao Fang, Weihang Wu, Weijin Yang, Yanyan Jiang, Yu Wang
Summary: This study investigated the effect of ultrasound-assisted carbon nanoparticle labeling in neoadjuvant chemotherapy for breast-conserving surgery in breast cancer. The results showed that it had a high accuracy rate in lymph node tracing and tumor resection extent determination.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Zhen-Yu Wu, Guk Bae Kim, Sangwook Lee, Seung Hyun Choi, Namkug Kim, BeomSeok Ko
Summary: The use of a three-dimensional printed breast surgical guide (BSG) based on prone and supine magnetic resonance imaging (MRI) allows for accurate estimation of the resection area in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy. This device provides precise quantitative MRI information about the tumor area, improving tumor localization accuracy and safe tumor removal.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhigeng Chen, Manxia Huang, Jianbo Lyu, Xin Qi, Fengtai He, Xiang Li
Summary: This study aimed to predict candidates for breast-conserving surgery (BCS) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) before and after neoadjuvant chemotherapy (NAC). The radiomics features from pre- and post-NAC DCE-MRI were significantly related to breast cancer shrinkage. The combined model with features from pre-post-NAC DCE-MRI showed better predictive performance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jie Luo, Feng Chen, Hong Cao, Wei Zhu, Jian Deng, Dan Li, Wei Li, Junjie Deng, Yangyan Zhong, Haigang Feng, Yilin Li, Xiongmeiyu Gong, Jutao Zeng, Jiaren Chen
Summary: Accurate preoperative localisation of tumours is crucial for successful breast-conserving surgery. We have developed a 3D-printed personalised breast surgery guide assisted with supine MRI and image 3D reconstruction technology, which allows precise mapping of tumour area onto the breast and injection of dye for more accurate intraoperative resection.
BIOENGINEERING-BASEL
(2023)
Article
Multidisciplinary Sciences
Han Shin Lee, Hee Jeong Kim, Il Yong Chung, Jisun Kim, Sae Byul Lee, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Hak Hee Kim, Joon Beom Seo, Jin Hee Ahn, Gyungyub Gong, Sangwook Lee, Namkug Kim, Beom Seok Ko
Summary: The study demonstrated the use of 3D printed-breast surgical guides for breast cancer patients undergoing neoadjuvant systemic therapy, which proved to be effective in identifying and marking the original tumor area during breast-conserving surgery.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Lifen Cao, Jonathan J. Hue, Mary Freyvogel, Pamela Li, Lisa Rock, Ashley Simpson, Jill Dietz, Robert Shenk, Megan E. Miller
Summary: The study found that male breast cancer patients are less likely to receive neoadjuvant chemotherapy compared to females, and are more inclined to undergo more aggressive surgery, but gender is not associated with neoadjuvant chemotherapy response and overall survival in breast cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Anna Weiss, Claire King, Samantha Grossmith, Leah Portnow, Sughra Raza, Faina Nakhlis, Laura Dominici, Thanh Barbie, Christina Minami, Suniti Nimbkar, Esther Rhei, Elizabeth A. Mittendorf, Tari A. King
Summary: This study found that approximately 19% of cLN in cN1 patients treated with NAC were non-SLNs. However, the pathology of cLN did not impact treatment recommendations, raising questions about the utility of routinely clipping biopsied lymph nodes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Cindy Cen, Jennifer Chun, Elianna Kaplowitz, Deborah Axelrod, Richard Shapiro, Amber Guth, Freya Schnabel
Summary: This study investigated the clinicopathologic characteristics, margin status, and re-excision rates for NAC+BCS patients with and without the use of MarginProbe. Patients with a larger residual tumor burden and ER-positive disease had a greater risk for inadequate margins at surgery. MarginProbe use was associated with a lower re-excision rate, supporting the use of BCS after NAC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Janine M. Simons, Julien G. Jacobs, Joost P. Roijers, Maarten A. Beek, Leandra J. M. Boonman-de Winter, Arjen M. Rijken, Paul D. Gobardhan, Jan H. Wijsman, Eric Tetteroo, Joan B. Heijns, C. Y. Yick, Ernest J. T. Luiten
Summary: The study found that there were no significant differences in long-term survival rates between patients undergoing breast-conserving surgery and mastectomy after neoadjuvant chemotherapy for breast cancer. Tumor biology and treatment response are significant prognostic indicators.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Matthew R. Woeste, Neal Bhutiani, Marilyn Donaldson, Kelly M. McMasters, Nicolas Ajkay
Summary: This study found that after implementing a no-ink-on-tumor margin policy, patients undergoing NAC had lower rates of re-excision and margin positivity, as well as higher satisfaction with breast cosmesis compared to those undergoing PBSC in the contemporary era.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhao Bi, Peng-Fei Qiu, Tao Yang, Peng Chen, Xian-Rang Song, Tong Zhao, Zhao-Peng Zhang, Yong-Sheng Wang
Summary: By studying the modified shrinkage classification modes, it can effectively guide breast-conserving surgery after neoadjuvant therapy. MRI 3D reconstruction can accurately predict the modified shrinkage modes and extent of residual tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tetsutaro Miyoshi, Satoshi Yamaguchi, Hiroshi Fujimoto, Shigeru Yoshioka, Masayuki Shiobara, Kazuo Wakatsuki, Kosuke Suda, Kotaro Miyazawa, Toshiaki Aida, Yoshihiro Watanabe, Masayuki Otsuka
Summary: The aim was to evaluate the feasibility of using RTPS and DIR for breast-conserving surgery in patients after neoadjuvant chemotherapy. Results showed that only 1 patient had carcinoma present in the surgical margins and subsequently developed breast tumor recurrence, with a mean excised breast volume of 6.8%.