4.7 Letter

On the relationship between androgen-deprivation therapy for prostate cancer and risk of infection by SARS-CoV-2

期刊

ANNALS OF ONCOLOGY
卷 31, 期 10, 页码 1415-1416

出版社

ELSEVIER
DOI: 10.1016/j.annonc.2020.06.005

关键词

-

类别

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Oncology

Concomitant Drugs Prognostic Score in Patients With Metastatic Renal Cell Carcinoma Receiving Ipilimumab and Nivolumab in the Compassionate Use Program in Italy: Brief Communication

Sebastiano Buti, Umberto Basso, Diana Giannarelli, Ugo De Giorgi, Marco Maruzzo, Roberto Iacovelli, Luca Galli, Camillo Porta, Francesco Carrozza, Giuseppe Procopio, Giuseppe Fonarini, Giovanni Lo Re, Matteo Santoni, Roberto Sabbatini, Antonio Cusmai, Paolo Andrea Zucali, Carlo Aschele, Editta Baldini, Elena Zafarana, Adolfo Favaretto, Silvana Leo, Alketa Hamzaj, Rosanna Mirabelli, Franco Nole', Silvia Zai, Claudio Chini, Cristina Masini, Sonia Fatigoni, Andrea Rocchi, Emiliano Tamburini, Alessio Cortellini, Melissa Bersanelli

Summary: We developed a drug-based score to predict prognosis and treatment response in advanced cancer patients receiving immune checkpoint inhibitors (ICIs), and validated its value in a population of metastatic renal cell carcinoma patients treated with ipilimumab plus nivolumab. The model considers the use of certain drugs before immunotherapy initiation and demonstrated significant and clinically meaningful predictions for overall survival and progression-free survival. Further development will involve analyzing the gut microbiome and its link to drug exposure and immune sensitivity.

JOURNAL OF IMMUNOTHERAPY (2023)

Article Medicine, Research & Experimental

Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castration-resistant prostate cancer

Pier Vitale Nuzzo, Filippo Pederzoli, Calogero Saieva, Elisa Zanardi, Giuseppe Fotia, Andrea Malgeri, Sabrina Rossetti, Loana Valenca Bueno, Livia Maria Q. S. Andrade, Anna Patrikidou, Ricardo Pereira Mestre, Mikol Modesti, Sandro Pignata, Giuseppe Procopio, Giuseppe Fornarini, Ugo De Giorgi, Antonio Russo, Edoardo Francini

Summary: This study aimed to evaluate a prognostic model based on the time of metastatic disease presentation and disease burden for mCRPC patients receiving AA or Enza as first-line treatment. The analysis showed that patients with low disease burden had improved overall survival compared to those with high disease burden, regardless of the time of disease presentation.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Article Medicine, Research & Experimental

Gene's expression underpinning the divergent predictive value of [18F]F-fluorodeoxyglucose and prostate-specific membrane antigen positron emission tomography in primary prostate cancer: a bioinformatic and experimental study

Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato, Silvia Bruno, Anna Maria Orengo, Francesca Vitale, Sonia Carta, Silvia Chiola, Sabrina Chiesa, Alberto Miceli, Francesca D'Amico, Giuseppe Fornarini, Carlo Terrone, Michele Piana, Silvia Morbelli, Alessio Signori, Paola Barboro, Gianmario Sambuceti

Summary: This study investigated the independent and additive prognostic value of PSMA and FDG gene expression in risk-stratification of prostate cancer (PCa). Machine learning analysis identified a predictive functional network involving glucose metabolism-related genes. Cellular experiments showed that increased proliferation and migration of PCa cells were associated with enhanced FDG uptake and decreased PSMA retention, indicating the prognostic value of FDG PET imaging.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Review Urology & Nephrology

Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma

Matteo Rosellini, Andrea Marchetti, Veronica Mollica, Alessandro Rizzo, Matteo Santoni, Francesco Massari

Summary: The approval of immunotherapy agents has revolutionized the treatment of renal cell carcinoma, but biomarkers to predict immunotherapy response are urgently needed. Currently available prognostic models are based on clinical and laboratory factors, but new molecular features might improve disease prediction. Effective markers for guiding therapeutic strategies still need validation.

NATURE REVIEWS UROLOGY (2023)

Article Oncology

Clinico-Pathological Features Influencing the Prognostic Role of Body Mass Index in Patients With Advanced Renal Cell Carcinoma Treated by Immuno-Oncology Combinations (ARON-1)

Matteo Santoni, Francesco Massari, Zin W. Myint, Roberto Iacovelli, Martin Pichler, Umberto Basso, Jindrich Kopecky, Jakub Kucharz, Sebastiano Buti, Alessia Salfi, Thomas Buettner, Ugo De Giorgi, Ravindran Kanesvaran, Ondrej Fiala, Enrique Grande, Paolo Andrea Zucali, Giuseppe Fornarini, Maria T. Bourlon, Sarah Scagliarini, Javier Molina-Cerrillo, Gaetano Aurilio, Marc R. Matrana, Renate Pichler, Carlo Cattrini, Tomas Buechler, Emmanuel Seront, Fabio Calabro, Alvaro Pinto, Rossana Berardi, Anca Zgura, Giulia Mammone, Jawaher Ansari, Francesco Atzori, Rita Chiari, Roubini Zakopoulou, Orazio Caffo, Giuseppe Procopio, Maria Bassanelli, Ilaria Zampiva, Carlo Messina, Zsofia Kueronya, Alessandra Mosca, Dipen Bhuva, Nuno Vau, Lorena Incorvaia, Sara Elena Rebuzzi, Giandomenico Roviello, Ignacio Ortego Zabalza, Alessandro Rizzo, Veronica Mollica, Ilaria Catalini, Fernando Sabino M. Monteiro, Rodolfo Montironi, Nicola Battelli, Mimma Rizzo, Camillo Porta

Summary: Obesity is associated with improved response to immunotherapy in metastatic renal cell carcinoma, but its prognostic significance and association vary across subgroups.

CLINICAL GENITOURINARY CANCER (2023)

Article Cell Biology

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type

Costantino Ricci, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Giorgia Di Filippo, Eugenia Franchini, Francesco Massari, Veronica Mollica, Valentina Tateo, Federico Mineo Bianchi, Maurizio Colecchia, Andres Martin Acosta, Michelangelo Fiorentino

Summary: The study aimed to assess the staining pattern of FoxA2 in different patterns of yolk sac tumour postpubertal-type (YSTpt) and other germ cell tumours of the testis (GCTT), comparing it with glypican-3 (GPC3) and α-fetoprotein (AFP). The results showed that FoxA2 is a highly sensitive and specific biomarker for YSTpt, especially in rare and difficult-to-diagnose histological patterns, and it is superior to GPC3 and AFP. However, mature glands of teratoma postpubertal-type (Tpt) could be a potential diagnostic pitfall.

HISTOPATHOLOGY (2023)

Review Biochemistry & Molecular Biology

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?

Federica Borea, Marika A. Franczak, Maria Garcia, Matteo Perrino, Nadia Cordua, Ryszard T. Smolenski, Godefridus J. Peters, Rafal Dziadziuszko, Armando Santoro, Paolo A. Zucali, Elisa Giovannetti

Summary: Malignant Pleural Mesothelioma (MPM) is a rare neoplasm that is usually diagnosed at an advanced stage and requires systemic treatment due to its ineligibility for radical surgery. Chemotherapy has been the standard treatment for 20 years until immune checkpoint inhibitors were introduced. However, the prognosis remains poor, and targeted therapies for MPM have mostly failed in clinical trials. This review aims to explore the potential reasons for treatment failures and determine the need for further research in this area.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Oncology

Apalutamide-induced lichenoid reaction in a patient with non-metastatic castrate-resistant prostate cancer

Malvina Cremante, Silvia Puglisi, Annalice Gandini, Antonio Guadagno, Fabio Catalano, Alessandra Damassi, Veronica Murianni, Miguel Angel Llaja Obispo, Giuseppe Luigi Banna, Sebastiano Buti, Sara Elena Rebuzzi, Pasquale Rescigno, Giuseppe Fornarini

Summary: Apalutamide, an oral selective androgen receptor inhibitor, is approved by FDA for the treatment of high-risk non-metastatic castration-resistant prostate cancer (M0 CRPC) and metastatic castration-sensitive prostate cancer (mHSPC). This case report describes a rare skin adverse event, lichenoid reaction, induced by Apalutamide. A multidisciplinary approach confirmed the correlation between lichenoid reaction and the drug.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2023)

Article Oncology

Characterization of Tumor and Immune Tumor Microenvironment of Primary Tumors and Metastatic Sites in Advanced Renal Cell Carcinoma Patients Based on Response to Nivolumab Immunotherapy: Preliminary Results from the Meet-URO 18 Study

Sara Elena Rebuzzi, Matteo Brunelli, Francesca Galuppini, Valerio Gaetano Vellone, Alessio Signori, Fabio Catalano, Alessandra Damassi, Gabriele Gaggero, Pasquale Rescigno, Marco Maruzzo, Sara Merler, Francesca Vignani, Alessia Cavo, Umberto Basso, Michele Milella, Olimpia Panepinto, Manlio Mencoboni, Marta Sbaraglia, Angelo Paolo Dei Tos, Veronica Murianni, Malvina Cremante, Miguel Angel Llaja Obispo, Michele Maffezzoli, Giuseppe Luigi Banna, Sebastiano Buti, Giuseppe Fornarini

Summary: This study identified differential immunohistochemical patterns in the tumors of patients who responded and did not respond to nivolumab, an immunotherapy. Tumors in responders showed poor presence of CD4+ immune cells, high expression of CD56 on tumor cells, and high expression of phosphorylated mTOR protein. Further investigation with genomic analysis is planned to examine the prognostic role of the tumor microenvironment.

CANCERS (2023)

Article Biochemistry & Molecular Biology

The DASciS Software for BSI Calculation as a Valuable Prognostic Tool in mCRPC Treated with 223RaCl2: A Multicenter Italian Study

Maria Silvia De Feo, Viviana Frantellizzi, Matteo Bauckneht, Alessio Farcomeni, Luca Filippi, Elisa Lodi Rizzini, Valentina Lavelli, Maria Lina Stazza, Tania Di Raimondo, Giuseppe Fornarini, Sara Elena Rebuzzi, Mammini Filippo, Paolo Mammucci, Andrea Marongiu, Fabio Monari, Giuseppe Rubini, Angela Spanu, Giuseppe De Vincentis

Summary: This multicenter study aimed to assess the impact of baseline bone scan index (BSI) on overall survival (OS) in mCRPC patients treated with (RaCl2)-Ra-223. The results showed that baseline BSI significantly predicts OS in mCRPC treated with (RaCl2)-Ra-223.

BIOMEDICINES (2023)

Review Chemistry, Medicinal

Agnostic Approvals in Oncology: Getting the Right Drug to the Right Patient with the Right Genomics

Valentina Tateo, Paola Valeria Marchese, Veronica Mollica, Francesco Massari, Razelle Kurzrock, Jacob J. Adashek

Summary: With the rise of precision medicine, the field of oncology has undergone significant changes due to the discovery of druggable genes or immune targets through next-generation sequencing. Biomarker-based treatments are emerging, and there are currently six tissue-agnostic therapies approved by the FDA.

PHARMACEUTICALS (2023)

Article Oncology

The role of the caregiver in older patients with advanced prostate cancer: results from the ADHERE Prospective Study of the Meet-URO network

Emilio Francesco Giunta, Silvia De Padova, Shobana Anpalakhan, Ugo De Giorgi, Marco Maruzzo, Sara Elena Rebuzzi, Marika Cinausero, Lucia Fratino, Helga Lipari, Teresa Gamba, Davide Bimbatti, Arianna Dri, Paola Ermacora, Francesca Vignani, Umberto Basso, Sebastiano Buti, Annalice Gandini, Malvina Cremante, Giuseppe Fornarini, Pasquale Rescigno, Giuseppe Luigi Banna

Summary: This study aimed to assess the characteristics of caregivers and the impact of their presence or absence on the clinical outcomes of older mCRPC patients treated with ABI or ENZ. The research found a detrimental effect of caregivers in managing older mCRPC patients, especially those identified as frail by the geriatric G8 screening score. Further research is needed to identify and address patients' vulnerability areas, which could have a detrimental effect on prognosis.

SUPPORTIVE CARE IN CANCER (2023)

Article Oncology

Global Real-World Outcomes of Patients Receiving Immuno-Oncology Combinations for Advanced Renal Cell Carcinoma: The ARON-1 Study

Matteo Santoni, Francesco Massari, Zin W. Myint, Roberto Iacovelli, Martin Pichler, Umberto Basso, Jindrich Kopecky, Jakub Kucharz, Sebastiano Buti, Mimma Rizzo, Luca Galli, Thomas Buettner, Ugo De Giorgi, Ravindran Kanesvaran, Ondrej Fiala, Enrique Grande, Paolo Andrea Zucali, Giuseppe Fornarini, Maria T. Bourlon, Sarah Scagliarini, Javier Molina-Cerrillo, Gaetano Aurilio, Marc R. Matrana, Renate Pichler, Carlo Cattrini, Tomas Buechler, Emmanuel Seront, Fabio Calabro, Alvaro Pinto, Rossana Berardi, Anca Zgura, Giulia Mammone, Jawaher Ansari, Francesco Atzori, Rita Chiari, Aristotelis Bamias, Orazio Caffo, Giuseppe Procopio, Maria Bassanelli, Sara Merler, Carlo Messina, Zsofia Kueronya, Alessandra Mosca, Dipen Bhuva, Nuno Vau, Lorena Incorvaia, Sara Elena Rebuzzi, Giandomenico Roviello, Ignacio Ortego Zabalza, Alessandro Rizzo, Veronica Mollica, Giulia Sorgentoni, Fernando Sabino M. Monteiro, Rodolfo Montironi, Nicola Battelli, Camillo Porta

Summary: The ARON-1 study collected real-world data on the use of immuno-combination therapies as first-line treatment for mRCC patients globally. The study showed that immuno-combination therapies are effective in the real-world context of mRCC, with longer survival observed in patients treated with IO + TKI combinations compared to IO + IO combinations in the intermediate/poor risk population.

TARGETED ONCOLOGY (2023)

Review Pathology

Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT

Costantino Ricci, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Alessia Grillini, Eugenia Franchini, Marco Grillini, Riccardo Schiavina, Francesco Massari, Veronica Mollica, Valentina Tateo, Federico Mineo Bianchi, Lorenzo Bianchi, Matteo Droghetti, Thais Maloberti, Giovanni Tallini, Maurizio Colecchia, Andres Martin Acosta, Joao Lobo, Kiril Trpkov, Michelangelo Fiorentino, Dario de Biase

Summary: The 2022 WHO classification introduced new kidney entities with specific mutational backgrounds. Molecular techniques such as next-generation sequencing (NGS) are commonly used for evaluation. Our study focused on low-grade oncocytic tumors (LOT) of the kidney and found a strong association with mutations in the mTOR pathway.

VIRCHOWS ARCHIV (2023)

Editorial Material Medicine, General & Internal

Cardiac Metastasis from Prostate Cancer: A Case Study Underlying the Crucial Role of the PSMA PET/CT

Annalice Gandini, Matteo Bauckneht, Luca Sofia, Laura Tomasello, Giuseppe Fornarini, Elisa Zanardi

Summary: Prostate cancer remains a major global health issue, and the introduction of PSMA PET/CT has greatly enhanced its diagnostic capabilities. This case study highlights the sensitivity of PSMA PET/CT in detecting metastatic prostate cancer, including a rare intra-atrial metastasis. It emphasizes the importance of next-generation imaging techniques in advancing our understanding of prostate cancer metastasis.

DIAGNOSTICS (2023)

暂无数据