Article
Chemistry, Analytical
Cem Erkmen, Gozde Aydogdu Tig, Bengi Uslu
Summary: Selective and sensitive determination of Leptin was achieved using a hybrid sensor with dual recognition elements of aptamers and molecularly imprinted polymers (MIPs). The sensor exhibited a linear response in the concentration range of 1.0 fg/mL to 10.0 pg/mL with a limit of detection (LOD) of 0.31 fg/mL. Real samples, including human serum and plasma, were successfully analyzed with satisfactory recovery findings (106.2-109.0%).
Article
Chemistry, Analytical
Shanshan Li, Tingting Zhong, Qingxia Long, Cuiping Huang, Liying Chen, Dujuan Lu, Xin Li, Zhiqing Zhang, Guanghui Shen, Xiaoyan Hou
Summary: An electrochemical sensor utilizing molecularly imprinted polymer (MIP) on gold nanoparticles (AuNPs) electrode was developed for histamine (HIS) determination, showing enhanced performance and successful detection in alcoholic beverages. The results were in good agreement with high-performance liquid chromatography (HPLC) method, indicating the reliability and applicability of the proposed methodology for HIS detection in beer and wine samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Polymer Science
Letian Cheng, Zhilong Guo, Yuansheng Lin, Xiujuan Wei, Kongyin Zhao, Zhengchun Yang
Summary: In this study, sodium alginate was used as functional monomers to prepare BSA molecularly imprinted carboxylated multi-wall carbon nanotubes (CMWCNT)/CaAlg hydrogel films (MIPs) and non-imprinted hydrogel films (NIPs) using bovine serum albumin as template molecules and calcium chloride as a cross-linking agent. The MIP film exhibited a high adsorption capacity for BSA and specific recognition for BSA. The loaded MIP film on the electrode surface improved the electrochemical signal.
Article
Chemistry, Analytical
Huan Lu, Yan Huang, Hanyue Cui, Li Li, Yaping Ding
Summary: The study presents a molecularly imprinted electrochemical aptasensor that utilizes the specificity of molecularly imprinted technology and the affinity of aptamers for the selective recognition of amoxicillin.
Article
Chemistry, Analytical
Songqing Huang, Jianying Yang, Shuting Li, You Qin, Qian Mo, Limin Chen, Xinchun Li
Summary: This study describes a highly sensitive molecular imprinted-based electrochemical sensor for resveratrol, which can be directly detected in wines without the requirement of sample pretreatment. The carefully investigated preparation conditions resulted in a high-performance MIP-based sensor for electrochemical sensing of resveratrol.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yun Du, Chenglong Sun, Yuru Shen, Luyao Liu, Mingjian Chen, Qingji Xie, Hongbo Xiao
Summary: A novel electrode for sensitive analysis of As(III) was prepared, by cast-coating multiwalled carbon nanotubes on a glassy carbon electrode, enabling stable loading of gold nanoparticles and gold staining for efficient detection of As(III) through linear sweep anodic stripping voltammetry.
Article
Nanoscience & Nanotechnology
Jie Yang, Yucui Hou, Yi Ren, Chunhua Tang, HuanHuan Li, Jing Huang, Hanbing Jiang, Tongji Cai, Jia Zhao, Peng Yu
Summary: This study developed an electrochemical label-free progesterone aptasensor for detecting progesterone levels in environmental water samples. The sensor showed excellent repeatability and stability, with minimal interference from other molecules with similar structures to progesterone.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Masoumeh Sarabaegi, Mahmoud Roushani
Summary: The study introduces a method combining molecular imprinting and aptasensing for rapid and accurate detection of Pseudomonas aeruginosa, showing a wide linear dynamic concentration range and low detection limit. The sensor has advantages of low cost, high stability, low response time, and high sensitivity for measuring P. aeruginosa.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This work presents a molecularly imprinted (MIP) sensor for the determination of ethanethiol. The MIP/GCE sensor showed a linear range of 6.1-32.4 mg L-1 with good detection capability and reproducibility. The sensitivity of the sensor was enhanced by incorporating gold nano-particles. The sensor was successfully applied to determine ethanethiol in spiked wine samples.
Article
Chemistry, Physical
Merymene Boukadida, Amira Anene, Najeh Jaoued-Grayaa, Yves Chevalier, Souhaira Hbaieb
Summary: The choice of functional monomer in molecularly imprinted polymers (MIPs) is crucial for designing selective recognition sites for adsorption. Studies using H-1 NMR spectroscopy revealed that the weakly acidic acrylamide (AA) showed stronger hydrogen-bonding interactions with histamine (HA) compared to methacrylic acid (MAA). Adsorption isotherms and modeling of MIPs demonstrated a higher selective binding of HA to AA-based MIPs.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Fatih Turk, Abdullah Atilgan, Nimet Yildirim-Tirgil
Summary: Molecularly imprinted polymer (MIP) and DNA aptamers with the ability to detect targets with high sensitivity and specificity by simulating the structure and function of antibodies and biological receptors have been combined to create hybrid alternatives with enhanced attributes and desirable properties. A new method has been developed to produce aptamer/MIP hybrids for protein biomarkers that is simple and reproducible. Multi-walled carbon nanotubes (MWCNTs) were used to develop sensitive sensor/biosensors due to their outstanding chemical/mechanical stability. The MWCNTs/Aptamer/MIP system was characterized using various techniques and showed satisfactory results in terms of sensitivity, selectivity, stability, and practical analysis when tested with thrombin as a model peptide.
ANALYTICAL LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Yuyang Zhao, Jinrui Zhang, Gang Qiao, Dongshuai Hou, Biqin Dong, Hongyan Ma
Summary: This study investigates the synergistic effect of carboxylated carbon nanotubes and poly(vinyl alcohol) on the mechanical properties of cement paste. The results demonstrate that their combination significantly increases the flexural strength of the cement paste and the strength enhancement mechanism is revealed from the perspectives of cement matrix enhancement and interface enhancement.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Tabkrich Khumsap, Suwussa Bamrungsap, Vu Thi Thu, Loc Thai Nguyen
Summary: A novel electrochemical sensor based on epitope-imprinted polydopamine was developed for sensitive and selective detection of ovalbumin. The sensor showed excellent sensitivity, a wide linear range, and good selectivity against other proteins, making it suitable for detecting allergic proteins in the food supply chain.
BIOELECTROCHEMISTRY
(2021)
Article
Food Science & Technology
Yanbo Wang, Linfang Li, Huan Li, Yafei Peng, Linglin Fu
Summary: A sandwich biosensor using magnetic particles and carbon dots was proposed for the detection of TM in seafood products, with a detection limit of 30.76 ng mL(-1). The method demonstrated excellent specificity and accuracy in detecting TM in commercial samples, showing great potential for applications.
Article
Electrochemistry
Khanittha Ponsanti, Nipaporn Ngernyuang, Benchamaporn Tangnorawich, Kesara Na-Bangchang, Kanyarat Boonprasert, Adis Tasanarong, Teerachat Saeheng, Akkaracha Hanwattanakul, Chiravoot Pechyen
Summary: This study presents an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles for detecting total hemoglobin and glycated hemoglobin in blood samples. The sensor shows a linear response and reliability, making it a promising approach for sensitive point-of-care testing of HbA1c in diabetes patients.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Correction
Biochemical Research Methods
Ashraf M. Mahmoud, Saad A. Alkahtani, Mohamed M. El-Wekil
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Ashraf M. Mahmoud, Saad A. Alkahtani, Mohamed M. El-Wekil
Summary: A gold nanoparticle-modified copper-based metal organic framework was developed for the electrochemical determination of cysteine. The fabricated electrode showed excellent sensitivity, low detection limit, and accurate quantification of cysteine in real samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Correction
Electrochemistry
Ashraf M. Mahmoud, Mater H. Mahnashi, Samer S. Abu-Alrub, Saad A. Alkahtani, Mohamed M. El-Wekil
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Saad A. Alkahtani, Ashraf M. Mahmoud, Mohamed M. El-Wekil
Summary: Copper-based metal organic frameworks modified with gold nanoparticles were fabricated and successfully applied for electrochemical sensing of D-penicillamine. The nanocomposite showed good detection performance.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Ashraf M. Mahmoud, Mater H. Mahnashi, Adel M. Al Fatease, Mahmoud A. H. Mostafa, Mohamed M. El-Wekil, Ramadan Ali
Summary: A bimodal strategy for the detection of toxic flavonoid rutin was proposed, using nitrogen and sulfur co-doped carbon dots for fluorometric and electrochemical determination, with high sensitivity and selectivity.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Ashraf M. Mahmoud, Mohamed M. El-Wekil, Ramadan Ali, Hany A. Batakoushy, Reem Y. Shahin
Summary: In this study, Cu, N@CQDs were synthesized as a peroxidase-like catalyst for the oxidative coupling of amoxicillin with 4-aminoantipyrine, resulting in a pink quinoneimine chromogen. The colorimetric and fluorometric assays of amoxicillin using Cu, N@CQDs showed reliable results.
Article
Chemistry, Multidisciplinary
Bandar A. Alyami, Ali O. Alqarni, Yahya S. Alqahtani, Mater H. Mahnashi, Qamar Javed, Mubashir Hassan, Tehreem Tahir, Anser Ali, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Summary: This study provides the first report on the mechanism of tyrosinase inhibition by fluoroquinolones, which is critical for melanin-dependent responses, including toxicity.
APPLIED SCIENCES-BASEL
(2022)
Correction
Chemistry, Applied
Ashraf M. Mahmoud, Mater H. Mahnashi, Adel Al Fatease, Mahmoud A. H. Mostafa, Mohamed M. El-Wekil, Ramadan Ali
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Spectroscopy
Rasha M. K. Mohamed, Sabrein H. Mohamed, Aml M. Asran, Ibrahim H. Alsohaimi, Hassan M. A. Hassan, Hossieny Ibrahim, Mohamed M. El-Wekil
Summary: Novel biomass-derived carbon dots co-doped with nitrogen and sulfur were synthesized from milk powder and methionine precursors. The carbon dots were used for ratiometric fluorescence sensing of Cu (II) and risedronate sodium. The sensing platform showed high sensitivity and selectivity, detecting Cu (II) and risedronate sodium in a wide concentration range with low LODs. The system was successfully applied to determine Cu (II) and risedronate sodium in different sample matrices with good accuracy and precision.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Medicinal
Mohamed A. A. Orabi, Omaish Salman Alqahtani, Bandar A. Alyami, Ahmed Abdullah Al Awadh, El-Shaymaa Abdel-Sattar, Katsuyoshi Matsunami, Dalia I. Hamdan, Mohamed E. Abouelela
Summary: This research investigates the activity of Carissa macrocarpa leaf extract fractions against lung adenocarcinoma cell line and Leishmania major, revealing potential anti-lung cancer and anti-Leishmaniasis effects. The analysis of compounds within the extract fractions provides insights into the mechanism of action.
Article
Chemistry, Analytical
Ashraf M. Mahmoud, Mater H. Mahnashi, F. M. Alshareef, Mohamed M. El-Wekil
Summary: A reliable dual-mode electrochemical and fluorometric sensor was developed for ultrasensitive and selective detection of rutin. The sensor utilized vanadium disulfide quantum dots functionalized with hydropropyl-beta-cyclodextrin. The sensor exhibited low detection limits, simplicity, cost-effectiveness and ease of operation, making it promising for rutin detection in various matrices.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Ashraf M. Mahmoud, Bandar A. Alyami, Mater H. Mahnashi, F. M. Alshareef, Yahia S. AlQahtani, Mohamed M. El-Wekil
Summary: A novel electrochemical sensor composed of chitosan, polyethylene glycol, porous magnesium metasilicate, and silver nanoparticles was proposed for sensitive and selective detection of glutathione (GSH). The sensor exhibited excellent sensitivity, anti-fouling performance, good selectivity, and sufficient stability. More importantly, it was successfully applied for the estimation of GSH in dietary supplements and human plasma serum samples with acceptable recoveries and RSDs values.
MICROCHEMICAL JOURNAL
(2023)
Correction
Chemistry, Analytical
Mater H. Mahnashi, Ashraf M. Mahmoud, Khalid Alhazzani, A. Z. Alanazi, Ali Mohammed Alaseem, Mohammad M. Algahtani, Mohamed M. El-Wekil
Article
Chemistry, Analytical
Rasha M. K. Mohamed, Sabrein H. Mohamed, Aml M. Asran, Ibrahim H. Alsohaimi, Hassan M. A. Hassan, Hossieny Ibrahim, Mohamed M. El-Wekil
Summary: A novel electrochemical sensing platform based on gold nanoparticles anchored conductive carbon black modified graphite nanopowder flakes paste electrode was developed for the detection of Favipiravir (FVP). The sensor exhibited excellent sensitivity, stability, and anti-interference capability, allowing simultaneous detection of FVP and co-administered drug paracetamol (PCT). The detection limits for FVP and PCT were 7.5 nM and 4.3 nM, respectively. The sensor was successfully applied for simultaneous detection of FVP and PCT in spiked human plasma and pharmaceutical preparations, as well as in the presence of ascorbic acid in a real sample.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
A. Z. Alanazi, Khalid Alhazzani, Ali M. Alaseem, Abdullah R. Alanzi, Saeed Abdullah Al Awadh, Fahaad S. Alenazi, Ahmad J. Obaidullah, Mohamed M. El-Wekil
Summary: In this study, a molecularly imprinted polymer (MIP) sensor was successfully developed for the specific detection of aminoglycoside kanamycin (KANA). The fabricated sensor exhibited high sensitivity and selectivity, good stability and reproducibility, and cost-effectiveness. It was capable of detecting KANA in the range of 0.55-550 nM with a limit of detection (LOD) of 161 pM (S/N = 3). The sensor was also successfully applied for the detection of KANA in milk and honey samples with good accuracy and precision (RSD % ≤ 3.3%), demonstrating its reliability.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
