Article
Chemistry, Analytical
Mengting Chen, Zexuan Liu, Yinyin Guan, Yuxuan Chen, Weipeng Liu, Yingju Liu
Summary: The rational design and synthesis of high-performance nanozymes have been achieved in this study, which can mimic the activity of oxidase and enable sensitive detection of substances. The nanozyme consists of Co nanoparticles and N-doped carbon nanotubes with a hollow core-shell structure, and it can catalyze the colorless substance TMB. A colorimetric-fluorescence dual-mode immunosensor has been developed for the detection of OTA, which shows high sensitivity and accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Hongshuai Zhu, Bingfeng Wang, Yingju Liu
Summary: The development of multifunctional biomimetic nanozymes with high catalytic activity and sensitive response is rapidly advancing. In this work, a facile template-assisted strategy for synthesizing Fe(OH)(3) nanocages was proposed, and it was demonstrated to have excellent catalytic activity. Based on Fe(OH)(3)-induced biomimetic nanozyme catalyzed reactions, a self-tuning dual-mode fluorescence and colorimetric immunoassay was successfully constructed for ochratoxin A (OTA) detection.
Article
Chemistry, Applied
Hongyuan Shang, Xiaofei Zhang, Meili Ding, Aiping Zhang, Cheng Wang
Summary: This article describes a universal colorimetric-photothermal-smartphone triple-mode sensing platform for the detection of food-grade glutathione (GSH) at point-of-care. The platform utilizes commercially available filter paper, a thermometer, and a smartphone to achieve high sensitivity and accuracy in GSH detection. The platform shows potential for easily determining GSH in commercial samples using simple testing strips.
Article
Nanoscience & Nanotechnology
Shi-Wen Lv, Ning Zhao, Jing-Min Liu, Fei-Er Yang, Chun-Yang Li, Shuo Wang
Summary: The novel metalorganic framework-derived NiCo2O4 with enhanced catalytic activity serves as an effective sensing platform for detecting various compounds with low detection limit and broad linear range. The enzyme-like properties of NiCo2O4 contribute to the sensitive chromogenic sensing performance for detecting Cu2+, Fe3+, and other compounds.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Hongshuai Zhu, Chuanhe Liu, Xinxin Liu, Zhu Quan, Weipeng Liu, Yingju Liu
Summary: A multi-colorimetric immunosensor based on the mimetic enzyme etching of gold nanobipyramids was established to detect ochratoxin A. The method showed high sensitivity and specificity, indicating its potential for OTA detection in real samples.
Article
Multidisciplinary Sciences
Xin Yuan, Xiaoling Wu, Jun Xiong, Binhang Yan, Ruichen Gao, Shuli Liu, Minhua Zong, Jun Ge, Wenyong Lou
Summary: Enzymes often exhibit low stability and activity in complicated environments, hindering their industrial and environmental applications. In this study, a metal-organic frameworks-based artificial enzyme system was developed to achieve high hydrolytic activity under mild conditions. The researchers discovered that the hydrolysis catalyzed by MOFs followed two distinct mechanisms, and the MOFs demonstrated high stability and broad substrate specificity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Wang Chen, Xingping Zhang, Qian Zhang, Guohao Zhang, Shixiang Wu, Hualin Yang, Yu Zhou
Summary: A dual-readout immunoassay based on Ce4+ oxidizing TMB and Ce3+ inducing AIE of AuNCs was developed for the detection of OTA in corn samples. The LODs were as low as 0.62 ng/mL for fluorescent assay and 0.81 ng/mL for colorimetric assay, with the recoveries of OTA ranging from 94.4% to 107.7% in the fluorescent mode and 93.7% to 106.9% in the colorimetric mode.
ANALYTICA CHIMICA ACTA
(2022)
Article
Spectroscopy
Huanhuan Chen, Chaoqun Sun, Na Huang, Jiahui Wen, Yu Xiao, Dan Yang, Yijuan Long, Li Liu, Huzhi Zheng
Summary: In this study, we have discovered a new oxidase mimic, Ru(bpy)32+, which possesses high photo-induced oxidase-like activity and can catalyze the color reaction of TMB with dissolved oxygen. It has a high catalytic constant and has been successfully applied in a colorimetric biothiol assay.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biophysics
Yaokun Xia, Tingting Chen, Li Zhang, Xiaoling Zhang, Wanhua Shi, Guanyu Chen, Wenqian Chen, Jianming Lan, Chunyan Li, Weiming Sun, Jinghua Chen
Summary: Exosomal microRNAs are important biomarkers for cancer diagnosis and monitoring, but detecting them remains a challenge. This study introduces a method using MAA with visible-light-induced oxidase mimic activity for miR-21 detection, offering a potential tool for cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Shun Wang, Mengke Wang, Yuchuan Liu, Xianyu Meng, Yu Ye, Xiaowei Song, Zhiqiang Liang
Summary: A novel conjugated microporous polymer was developed as a mimic of a photosensitized oxidase, capable of detecting glutathione with high accuracy and promising practical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Kuda Feke, Melisew Tadele Alula
Summary: In this study, a colorimetric method for determination of chromium (VI) in water based on the oxidase-like activity of solvothermal synthesized copper oxide is reported. The method showed excellent selectivity and feasibility for analysis of chromium (VI) in tap water samples and environmental samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Shiyu Hu, Zhe Han, Guohao Yan, Xinghui Hou, Shasha Yi, Zongtao Zhang, Ying Zhou, Liying Zhang
Summary: In this study, a light-activated oxidase mimic was prepared using NiO nanosheets modified with carbon quantum dots (CQDs). The NiO@CQDs showed high selectivity and stability, and could be used for colorimetric detection of Cu2+.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Tao Zhang, Wenhui He, Xiaodan Song, Dongzhi Wu, Yaokun Xia, Yan Liu, Linzhao Wu, Weiming Sun, Fengfei Lin, Jinghua Chen
Summary: An organic artificial enzyme with visible-light-stimulated oxidase-like activity was synthesized for colorimetric sensing of acid phosphatase (ACP) detection. The reaction system can be controlled using light switch, providing a facile, photo-switchable and low-cost strategy for ACP detection.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Xiaoqian Tang, Jiasi Zuo, Cheng Yang, Jun Jiang, Qi Zhang, Jianfeng Ping, Peiwu Li
Summary: Biotoxins, including mycotoxins, marine toxins, and bacterial food toxins, pose significant threats in various fields such as food, feed, seafood, and medicine due to their potential harmful effects on humans. The increased consumption of fast food and prepared food without considering associated toxins is a critical issue. Therefore, the development of effective methods for monitoring biotoxins is crucial. In recent years, biosensors have been widely used for biotoxin detection due to their simplicity, quick detection procedure, low cost, and other advantages. This study provides a comprehensive overview of the application of biosensors in biotoxin detection, focusing on optical, electrochemical, piezoelectric, and photothermal applications. Additionally, the integration of different detection platforms as multimodal combination biosensors is discussed to meet the demand for highly accurate technologies. Major challenges faced by biosensors are examined, and novel insights for improving food safety technology are provided.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tianxiao Mei, Sheng Zhang, Jie Sun, Yihui Hu
Summary: This study presents a rapid, sensitive, and selective colorimetric assay for sulfite based on the intrinsic oxidase-like activity of 2D cobalt oxyhydroxide nanosheets, which can be used for detecting sulfite in food samples. The presence of sulfite effectively inhibits the reaction system and causes color and absorbance changes, facilitating sulfite detection.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)