Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Article
Rheumatology
Ian C. Scott, James Bailey, Chris White, Christian D. Mallen, Sara Muller
Summary: This study found that opioid prescribing is common in the management of inflammatory arthritis (IA) pain, despite limited evidence of efficacy and potential harms.
Article
Anesthesiology
Ria E. Hopkins, Gabrielle Campbell, Louisa Degenhardt, Suzanne Nielsen, Fiona Blyth, Milton Cohen, Natasa Gisev
Summary: Although multimodal management is recommended for chronic noncancer pain (CNCP), little is known about the long-term treatment utilization patterns among individuals using opioids. This study conducted in Australia found that many Australians using opioids for CNCP also used nonopioid pharmacological and nonpharmacological treatments. However, some treatment use was inconsistent with guidelines and the use of nonpharmacological treatments was associated with having private health insurance.
Article
Chemistry, Medicinal
Jing Sun, Shan Wang, Jun Wang, Xiuxiu Gao, Guanglei Wang
Summary: This study aimed to compare the effect of intravenous infusion of lidocaine with ultrasound-guided transverse abdominal plane (TAP) block on postoperative recovery and analgesia in patients undergoing bariatric surgery. The results showed that both lidocaine infusion and TAP block provided good postoperative recovery and analgesia, but lidocaine infusion had better analgesic effect at 12 hours and 24 hours postoperatively compared with TAP block.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Surgery
Rickesha Wilson, Sayf A. Said, Susan Rydzinski, Jesse Gutnick, Ali Aminian, Toms Augustin
Summary: This study evaluates the outcomes of maximal opioid reduction on top of an existing Enhanced Recovery after Surgery (ERAS) pathway in a bariatric surgery program. The results indicate that implementing an opioid-sparing protocol not only reduces opioid use in surgical patients, but also improves satisfaction with pain control.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Anesthesiology
Nafisseh S. Warner, Michelle Mielke, Brandon P. Verdoorn, David S. Knopman, William M. Hooten, Elizabeth B. Habermann, David O. Warner
Summary: This manuscript summarizes the evidence and critical knowledge gaps regarding the relationships between pain, opioid analgesics, and cognition in older adults. It provides a conceptual framework to guide future research in optimizing analgesic outcomes in older adults while minimizing deleterious effects on cognition.
Article
Surgery
Mark Dudash, Kashif Saeed, Shengxuan Wang, Alicia Johns, Ryan Colonie, Alexandra Falvo, Ryan Horsley, Jon Gabrielsen, Anthony T. Petrick, David M. Parker
Summary: This study found no benefit for postoperative pain or opioid requirements in patients undergoing robotic-assisted Roux-en-Y gastric bypass (RA-RYGB) compared to laparoscopic Roux-en-Y gastric bypass (L-RYGB), and the RA-RYGB group was more likely to report pain at the two-week follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Geriatrics & Gerontology
Laura A. Dowd, Amanda J. Cross, Felicity Veal, Choon Ean Ooi, J. Simon Bell
Summary: Effective interventions can improve analgesic use and appropriateness in long-term care facilities. Interventions involving prescribers, pharmacists, and nurses, with an educational component, are most effective. Combining education and decision support also shows promise. Medication review interventions can lead to changes in medication prescription.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Anesthesiology
Brian R. Schuler, Kenneth E. Lupi, Paul M. Szumita, Mary P. Kovacevic
Summary: This study evaluated the safety and impact of intravenous lidocaine for postoperative pain, finding that although most patients experienced adverse effects, the majority did not discontinue lidocaine use.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Pharmacology & Pharmacy
Daisuke Nishizawa, Makoto Nagashima, Shinya Kasai, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Ken-ichi Fukuda, Tatsuya Ichinohe, Masakazu Hayashida, Kazutaka Ikeda
Summary: Considerable individual differences are observed in the sensitivity to opioid analgesics. A study found that carriers of the G allele of the rs12496846 SNP in the C3orf20 gene region were significantly associated with higher postoperative analgesic requirements, and this SNP was also associated with the mRNA expression level of the C3orf20 gene.
Article
Surgery
Carl Johan Svensson, Christina E. Lundberg, Tatiana Zverkova Sandstrom, Paulin Andrell, Sven-Egron Thorn, Annika Rosengren, Axel Wolf
Summary: The study compared opioid consumption in patients with obesity who underwent RYGB surgery with population controls, and identified characteristics associated with opioid use.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Otorhinolaryngology
Zachary T. Elliott, Derek S. Mann, Michele Fiorella, Vanessa Christopher, Alyssa Givens, Ann Marie Martin, Tingting Zhan, Joseph Curry
Summary: The aim of this study was to identify potential predictive factors associated with increased or decreased opioid requirements after free tissue transfer (FTT) to the head and neck. The study found that preoperative opioid use was associated with higher postoperative opioid requirements. Multimodal pain management (MMPM) was not associated with a decreased opioid requirement.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Victor Mayoral Rojals, Angeles Canos Verdecho, Begona Soler Lopez
Summary: This study aims to assess the quality of treatment for chronic pain patients referred to specialized pain units. The findings show that 9.8% of patients were not receiving any analgesic treatment before referral, and 88.1% of patients experienced treatment modifications after referral. Women patients had higher levels of pain severity and changes in the diagnosis of the underlying condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Timur Yurttas, Mirjana Djurdjevic, Thomas W. Schnider, Miodrag Filipovic
Summary: This study aimed to investigate the efficacy of 1% lidocaine hydrochloride intravenous injection in obese patients undergoing bariatric surgery. The results showed that lidocaine did not improve postoperative pain scores, analgesia, or any secondary outcomes.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Surgery
Bestoun H. Ahmed, Anita P. Courcoulas, Amy L. Monroe, William F. Gourash, Jacques E. Chelly
Summary: Evidence supports using complementary techniques like auricular nerve field stimulation for pain control post-surgery. The NBD device showed a significant reduction in opioid use and pain levels following gastric bypass surgery, with good tolerability. Further placebo-controlled studies are needed to confirm these findings.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Surgery
Anita Paisant, Jeanne Burgmaier, Paul Calame, Melanie Loison, Sebastien Moliere, Cecile Brigand, Dihia Belabbas, Emilie Duchalais, Jean-Marc Regimbeau, Thierry Yzet, Arnaud Alves, Audrey Fohlen, Damien Bergeat, Estelle Vauclair, Julie Pellegrini, Emilia Ragot, Alexandre Lansier, Emeric Abet, Alexandre Nevot, Pascal Rousset, Mehdi Ouaissi, Marie Besson, Maxime Ronot, Massimo Giacca, Edouard Girard, Yann Tessier, Damien Massalou, Florent Poirier, Zaher Lakkis, Christophe Aube, Jean Francois Hamel, Guillaume Passot, Aurelien Venara
Summary: This study aimed to evaluate the association between the radiological score and the failure of conservative management in adhesive small bowel obstructions (aSBO). The results showed that a history of previous surgery was not a significant risk factor for conservative treatment failure, while a previous episode of aSBO was protective against treatment failure. Additionally, an Angers CT score of >= 5 was identified as an individual risk factor.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Flavie Thomas, Benjamin Menahem, Gil Lebreton, Karine Bouhier-Leporrier, Olivier Dejardin, Arnaud Alves
Summary: This study aimed to evaluate the incidence and risk factors for permanent stomas after sphincter-preserving surgery for rectal cancer, as well as compare long-term survival outcomes. Out of 257 patients, 16.7% developed permanent stomas after a median follow-up of 4.8 years, with severe post-operative complications and age being significant risk factors. Patients with permanent stomas had significantly lower overall survival and disease-free survival compared to those without stomas.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Alexandre Thobie, Anne-Marie Bouvier, Veronique Bouvier, Valerie Jooste, Lucille Queneherve, Jean-Baptiste Nousbaum, Arnaud Alves, Olivier Dejardin
Summary: The surgical volume of hospitals has a significant impact on the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). High-volume hospitals have better survival rates, while low-volume hospitals have higher post-operative mortality. The centralization of pancreatic surgery is a complex issue.
Article
Biochemistry & Molecular Biology
Marc Riffet, Benoit Dupont, Maxime Faisant, Damiano Cerasuolo, Benjamin Menahem, Arnaud Alves, Fatemeh Dubois, Guenaelle Levallet, Celine Bazille
Summary: The study aimed to analyze the impact of new histoprognostic factors on the survival of colon cancer patients and optimize their therapeutic management. The presence of isolated tumor deposits and an infiltrative type of tumor invasion significantly worsened overall survival and recurrence-free survival. High-grade budding was associated with a poor prognosis, but with no significant difference. In conclusion, these histoprognostic factors should be integrated into pathological reports of colon cancers to guide more aggressive treatments for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Coralie Lacroix, Marion Zamparini, Hugo Meunier, Anne-Lise Fiant, Yannick Le Roux, Adrien Lee Bion, Veronique Savey, Arnaud Alves, Benjamin Menahem
Summary: In a tertiary referral center, a study was conducted to identify preoperative risk factors for failure to discharge after bariatric surgery on or before postoperative day two. The study found that a history of psychiatric disorder, insulin-dependent diabetes, use of anticoagulant medication, distance to the referral center greater than 100 km, gallbladder lithiasis, and planned additional procedures were independent risk factors for delayed discharge.
WORLD JOURNAL OF SURGERY
(2023)
Review
Surgery
Mathilde Boullier, Audrey Fohlen, Stephanie Viennot, Arnaud Alves
Summary: Gastrointestinal bleeding of undetermined origin (GBUO) refers to gastrointestinal bleeding without an identified cause or location despite endoscopic assessment. The majority of cases of GBUO occur in the small intestine due to vascular, inflammatory, or tumoral causes. Video-capsule endoscopy (VCE) is recommended as the first-intention study in Europe, with CT-enteroscopy performed if intestinal obstruction is suspected. Enteroscopy is used for therapeutic or diagnostic purposes depending on the results of VCE or CT-enteroclysis, and intraoperative enteroscopy (IOE) is reserved for cases where preoperative enteroscopy fails or for recurrent GBUO after other studies and explorations.
JOURNAL OF VISCERAL SURGERY
(2023)
Review
Surgery
A. Mulliri, J. Gardy, O. Dejardin, V. Bouvier, M. Pocard, A. Alves
Summary: In France, there are social inequalities in health for patients with colorectal cancer (CRC). Underprivileged patients have a lower incidence of CRC but higher mortality rates. The reasons behind these social inequalities vary depending on the healthcare system. Factors such as reduced participation in screening campaigns and delayed diagnosis contribute to the disparities in survival rates. Disadvantaged patients also face challenges during treatment, including a higher risk of open surgery, severe complications, and delayed chemotherapy.
JOURNAL OF VISCERAL SURGERY
(2023)
Article
Anesthesiology
Florian Roquet, Anne Godier, Delphine Garrigue-Huet, Jean-Luc Hanouz, Fanny Vardon-Bounes, Vincent Legros, Romain Pirracchio, Sylvain Ausset, Jacques Duranteau, Bernard Vigue, Sophie Rym Hamada
Summary: This study examines coagulation factor administration strategies in French trauma centers, reporting the prevalence and timing of administration, quantity dispensed, and transfusion ratios. The main strategy for major bleeding combines the administration of fresh frozen plasma (FFP) and fibrinogen concentrate (FC), but compliance with the recommendations is low.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Article
Medicine, General & Internal
Thibaut Waeckel, Khelifa Ait Said, Benjamin Menahem, Anais Briant, Arnaud Doerfler, Arnaud Alves, Xavier Tillou
Summary: A 6-year follow-up study of 83 women who underwent bariatric surgery showed that the procedure had long-term effects in improving stress urinary incontinence (SUI) and overactive bladder disorders (OAB), leading to a positive impact on quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandre Thobie, Fabien Robin, Benjamin Menahem, Jean Lubrano, Karim Boudjema, Arnaud Alves, Olivier Dejardin, Laurent Sulpice
Summary: This retrospective study focused on the impact of post-pancreatectomy hemorrhage (PPH) on long-term survival after pancreatoduodenectomy (PD) for cancer. The results showed that PPH significantly increased mortality rate and severe postoperative complication rate, but after 6 months, PPH had no impact on mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Josephine Gardy, Sarah Wilson, Anne-Valerie Guizard, Veronique Bouvier, Laure Tron, Ludivine Launay, Arnaud Alves, Guy Launoy, Florence Molinie, Josephine Bryere, Olivier Dejardin
Summary: In this French population-based study, travel time was found to have an impact on cancer survival for different cancer types. Patients residing farther from the referral center had lower survival rates for some cancer sites. The effect of travel time varied depending on the tumor type, with different patterns observed.
Article
Surgery
Gautier Gelly, Hugo Meunier, Adrien Lee Bion, Marion Zamparini, Anne-Lise Fiant, Veronique Savey, Arnaud Alves, Benjamin Menahem
Summary: Revisional bariatric surgery (RBS) is a challenging procedure and this study analyzed data from 252 patients who underwent RBS after laparoscopic adjustable gastric banding (LAGB) or laparoscopic sleeve gastrectomy (LSG). The study found that RBS after LSG had a higher overall morbidity rate, while RBS after LAGB had more perioperative issues.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Alexandra Pellegrin, Charles Sabbagh, Stephane Berdah, Benjamin Menahem, Jean-Marc Regimbeau, Laura Beyer-Berjot, Arnaud Alves
Summary: This study reports on the quality of life of patients with sigmoid diverticulitis. The results show that long-term quality of life does not differ significantly between patients who received antibiotic therapy and those who received symptomatic treatment alone. However, for patients who experienced recurrent events, elective surgery appears to improve their quality of life. In conclusion, assessment of quality of life is important in diverticular disease and should guide operative indications.
JOURNAL OF VISCERAL SURGERY
(2023)
Article
Oncology
Audrey Fohlen, Remi Beaudouin, Arnaud Alves, Karine Bouhier-Leporrier, Christophe Pasik, Jean-Pierre Pelage
Summary: This study evaluated the tolerability and clinical, biological and radiological tumor response and survival rates in patients with unresectable neuroendocrine liver metastases treated by trans-catheter arterial embolization with conventional chemoembolization, using streptozocin, Lipiodol, and embolization microspheres. The results showed that this procedure using streptozocin is an effective and well-tolerated palliative option for patients with unresectable neuroendocrine liver metastases, with a high objective response rate and non-progressive disease rate. The overall survival rate at different time points was also encouraging.
Review
Health Care Sciences & Services
Roukaya Belhadjamor, Gilles Manceau, Benjamin Menahem, Charles Sabbagh, Arnaud Alves
Summary: The optimal resection of the left colonic angle in cancer treatment remains controversial. Recent advances in imaging techniques have allowed for better identification of the anatomical variations in this area.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
