Article
Multidisciplinary Sciences
Darae Kim, Jin-Oh Choi, Yang Hyun Cho, Kiick Sung, Jaewon Oh, Hyun Jai Cho, Sung-Ho Jung, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Jae-Joong Kim, Eun-Seok Jeon
Summary: The study showed that the need for preoperative renal replacement therapy does not indicate irreversible renal dysfunction in patients awaiting heart transplantation. However, postoperative renal replacement therapy was associated with progression to end-stage renal disease and mortality after heart transplantation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Takuya Iwamoto, Kohei Nishikawa
Summary: This study evaluated surrogate indicators for the development of viral infections after living kidney transplantation and found that the circulating count of IFN-gamma(+) CD8(+) T cells may serve as a promising biomarker for predicting opportunistic viral infections.
Article
Microbiology
Elsa Feredj, Etienne Audureau, Anna Boueilh, Vincent Fihman, Slim Fourati, Jean-Daniel Lelievre, Sebastien Gallien, Philippe Grimbert, Marie Matignon, Giovanna Melica
Summary: Respiratory tract infections (RTIs) are a major cause of death after kidney transplant. This study evaluated the impact of infectious disease consultation (IDC) before transplantation on RTIs and identified risk and protective factors associated with RTIs. The results showed that patients who received IDC had a lower incidence of RTIs, while RTIs were an independent risk factor for mortality. IDC was identified as an independent protective factor, and implementing systematic IDC may have a significant impact on reducing RTIs and related morbidity and mortality.
Review
Biochemistry & Molecular Biology
Milosz Miedziaszczyk, Katarzyna Lacka, Oskar Tomczak, Aleksander Bajon, Marta Primke, Ilona Idasiak-Piechocka
Summary: Chronic kidney disease-mineral and bone disorder is a complication of chronic kidney disease, and a significant percentage of kidney transplant patients experience persistent hyperparathyroidism. The treatment of persistent hyperparathyroidism in these patients is still controversial. This systematic review evaluates the effectiveness of different treatment options for persistent hyperparathyroidism in kidney transplant patients.
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Arzu Velioglu, Gokhan Guneri, Hakki Arikan, Ebru Asicioglu, Elif Tukenmez Tigen, Yiloren Tanidir, Ilker Tinay, Cumhur Yegen, Serhan Tuglular
Summary: The study aimed to determine the incidence of UTIs in renal transplant patients in the hospital, identify causative microbiological agents, risk factors, and effects on short-term graft survival. The results showed that age, longer indwelling urinary catheter stay time, and urologic complications were risk factors for UTI development in the first year of transplantation, and UTI had no negative impact on short-term graft survival. The study also highlighted the high incidence of UTI with MDROs in kidney transplant recipients, especially in male patients.
Article
Infectious Diseases
Alina Daciana Elec, Mihai Oltean, Patricia Goldis, Cristina Cismaru, Mihaela Lupse, Adriana Muntean, Florin Ioan Elec
Summary: This study reviewed 42 kidney transplant recipients with COVID-19, finding that antiretrovirals and RDV may increase the risk of renal impairment, but most patients can recover to baseline kidney function after discharge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ji-Young V. Kim, Sara Assadian, Zsuzsanna Hollander, Paloma Burns, Casey P. Shannon, Karen Lam, Mustafa Toma, Andrew Ignaszewski, Ross A. Davies, Diego Delgado, Haissam Haddad, Debra Isaac, Daniel Kim, Alice Mui, Miroslaw Rajda, Lori West, Michel White, Shelley Zieroth, Paul A. Keown, W. Robert McMaster, Raymond T. Ng, Bruce M. McManus, Megan K. Levings, Scott J. Tebbutt
Summary: This study demonstrates that gene expression associated with CD4+ Tconv and Treg can identify patients at risk of ACR. Complementing HEARTBiT with TGS improves the classification of ACR.
Article
Infectious Diseases
Dina Leth Moller, Soren Schwartz Sorensen, Neval Ete Wareham, Omid Rezahosseini, Andreas Dehlbeak Knudsen, Jenny Dahl Knudsen, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study investigates the pattern of bacterial and fungal bloodstream infections in pediatric liver and kidney transplant recipients, finding a high incidence of BSI with different pathogen compositions depending on the type of transplanted organ. Recommendations for antibiotic therapy should take into account the specific organ transplant and local resistance patterns.
BMC INFECTIOUS DISEASES
(2021)
Review
Nutrition & Dietetics
Gerardo Sarno, Evelyn Frias-Toral, Florencia Ceriani, Martha Montalvan, Beatriz Quintero, Rosario Suarez, Eloisa Garcia Velasquez, Giovanna Muscogiuri, Antonio Iannelli, Vincenzo Pilone, Luigi Schiavo
Summary: Obesity is a global epidemic that increases the risk of chronic kidney disease (CKD). Bariatric surgery (BS) is the recommended treatment for morbid obesity, but its effectiveness and safety in end-stage renal disease (ESRD) or kidney transplant (KT) patients are still uncertain. This review aims to provide updated reports on the impact of BS on weight loss, complications, and graft and patient outcomes in ESRD patients with obesity. Although the authors suggest performing BS before KT, more multicenter trials are needed to confirm these recommendations.
Article
Surgery
Scott G. Westphal, Eric D. Langewisch, Amanda M. Robinson, Amber R. Wilk, Jianghu J. Dong, Troy J. Plumb, Ryan Mullane, Shaheed Merani, Arika L. Hoffman, Alexander Maskin, Clifford D. Miles
Summary: This study found that Kidney-alone transplant (KAT) candidates may face disadvantages due to the allocation priority given to multi-organ transplant (MOT) candidates. The analysis showed that next-sequential KAT candidates who missed out on receiving kidney offers were typically younger, more likely to be racial/ethnic minorities, and had higher sensitivities, leading to some candidates experiencing higher mortality rates and delays in transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Naamany Eviatar, Yahav Dafna, Mizrahi Nadav, Shochat Tzzipy, Mor Eytan, Green Hefziba
Summary: This study suggests that bloodstream infections after kidney transplantation can lead to long-term adverse outcomes, but early administration of appropriate antibiotics can mitigate this effect.
CLINICAL TRANSPLANTATION
(2022)
Article
Nutrition & Dietetics
Gordon Chun-Kau Chan, Jack Kit-Chung Ng, Kai-Ming Chow, Vickie Wai-Ki Kwong, Wing-Fai Pang, Phyllis Mei-Shan Cheng, Man-Ching Law, Chi-Bon Leung, Philip Kam-Tao Li, Cheuk-Chun Szeto
Summary: Frailty plays a significant role in predicting kidney transplant waitlisting and subsequent delisting, with interactions observed between frailty and body composition. Lean tissue wasting and malnutrition independently predicted delisting in frail and non-frail listed subjects, respectively. These findings highlight the importance of assessing frailty and body composition in pre-transplant evaluations.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Sarah Weinberger, Mandy Hubatsch, Tobias Klatte, Jorg Neymeyer, Frank Friedersdorff
Summary: Ureteral complications are common after renal transplantation and can lead to graft impairment and loss. This study evaluated the safety and efficacy of the self-expanding Allium ureteral stent in patients with ureteral complications. The success rate of the Allium stent was 60%, suggesting it may be an alternative to other treatment options.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Quantum Science & Technology
Patrick Huembeli, Alexandre Dauphin
Summary: Machine learning techniques enhanced by NISQ devices and VQC have shown good convergence for certain problems. However, there are still open questions regarding the convergence of the loss function and the trainability of these circuits. The Hessian matrix can provide valuable information for adjusting the learning rate during the training of variational circuits.
QUANTUM SCIENCE AND TECHNOLOGY
(2021)
Editorial Material
Surgery
Kyle R. Jackson, Dorry L. Segev
Summary: Donor/recipient incompatibility in kidney transplantation traditionally focused on ABO/HLA incompatibility. However, it is now recognized that factors such as age, weight, and HLA antigens can also impact recipient outcomes. A new paradigm of incompatibility has been proposed to consider all of these risk factors and improve donor/recipient compatibility through KPD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Transplantation
JiYoon B. Ahn, Sunjae Bae, Mark Schnitzler, Gregory P. Hess, Krista L. Lentine, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: The study found that early steroid withdrawal was associated with a decreased risk of posttransplant diabetes (PTD) in kidney transplant recipients. This association was more pronounced in recipients aged 55 and older.
TRANSPLANTATION DIRECT
(2022)
Article
Surgery
Sunjae Bae, Jennifer L. Alejo, Teresa P. Y. Chiang, William A. Werbel, Aaron A. R. Tobian, Linda W. Moore, Ashrith Guha, Howard J. Huang, Richard J. Knight, A. Osama Gaber, R. Mark Ghobrial, Mara A. McAdams-DeMarco, Dorry L. Segev
Summary: The study analyzed the impact of COVID-19 vaccination on the immune response of transplant patients, finding that mTOR inhibitors may have an effect on vaccine responses. However, the results indicated that the likelihood of antibody response was higher in patients using both MMF and mTORi, but this protective tendency disappeared after adjusting for MMF.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Nadia M. Chu, Sunjae Bae, Xiaomeng Chen, Jessica Ruck, Alden L. Gross, Marilyn Albert, Karin J. Neufeld, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Kidney transplant recipients with post-transplant delirium may experience worse executive function and increased risk of dementia. However, there may not be significant changes in overall cognitive function in the short term after kidney transplant.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Omid Shafaat, Yi Liu, Kyle R. Jackson, Jennifer D. Motter, Brian J. Boyarsky, Muhammad A. Latif, Frank Yuan, Adham Khalil, Elizabeth A. King, Atif Zaheer, Ronald M. Summers, Dorry L. Segev, Mara McAdams-DeMarco, Clifford R. Weiss
Summary: This study aimed to quantify the association between abdominal CT-based body composition measurements and post-liver transplant mortality. The results showed that pre-liver transplant sarcopenia was significantly associated with post-transplant mortality.
Article
Gastroenterology & Hepatology
Jane J. Long, Kieranjeet Nijhar, Reed T. Jenkins, Adham Yassine, Jennifer D. Motter, Kyle R. Jackson, Stephanie Jerman, Sepideh Besharati, Robert A. Anders, Ty B. Dunn, Christopher L. Marsh, Divya Rayapati, David D. Lee, Rolf N. Barth, Kenneth J. Woodside, Benjamin Philosophe
Summary: Digital imaging software (DIS) can standardize the definition and measurement of macrovesicular steatosis (MaS) and identify phenotypes associated with good clinical outcomes. It provides reproducible quantification of steatosis, which can increase the utilization of steatotic livers.
LIVER TRANSPLANTATION
(2023)
Letter
Surgery
Mary G. Bowring, Jessica M. Ruck, Mitchell G. Bryski, William Werbel, Aaron A. R. Tobian, Allan B. Massie, Dorry L. Segev, Christine M. Durand
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: This study analyzed a national cohort to assess the real-world effectiveness of statins in reducing all-cause mortality in kidney transplant recipients. The study found that statin use was significantly associated with lower mortality, and this protective effect might be greater when combined with mTOR inhibitors.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pediatrics
Sunjae J. Bae, George J. Schwartz, Susan R. Mendley, Bradley A. Warady, Susan L. Furth, Alvaro Munoz
Summary: This study analyzed eGFR trajectories in pediatric kidney transplant recipients before and after kidney replacement therapy (KRT), and found that risk factors associated with chronic kidney disease (CKD) progression had no significant impact on post-transplant eGFR decline, except for albuminuria and high blood pressure.
PEDIATRIC NEPHROLOGY
(2023)
Article
Immunology
Nitipong Permpalung, Teresa Po-Yu Chiang, Robin K. Avery, Darin Ostrander, Kausik Datta, Dorry L. Segev, Christine M. Durand, Sean X. Zhang, Allan B. Massie, Kieren A. Marr
Summary: A retrospective study was conducted to investigate COVID-19-associated pulmonary aspergillosis (CAPA), which is likely underdiagnosed and lacks sensitive diagnostic tools. A CAPA prediction model was built using multivariable logistic regression analysis, and the performance of the model was assessed using the area under the receiver operating characteristic curve (AUC). The model identified several factors, such as age, intubation time, dexamethasone treatment, and underlying diseases, that were significantly associated with CAPA, resulting in an AUC of 0.75. Screening at a cutoff of =0.085, the model showed a sensitivity of 82%, specificity of 51%, positive predictive value of 18.6%, and negative predictive value of 95.3%.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Nitipong Permpalung, Tao Liang, Shilpa Gopinath, Katrina Bazemore, Joby Mathew, Darin Ostrander, Christine M. Durand, Shmuel Shoham, Sean X. Zhang, Kieren A. Marr, Robin K. Avery, Pali D. Shah
Summary: This study found that respiratory viral infections are associated with chronic lung allograft dysfunction and mortality in lung transplant recipients. Secondary invasive fungal infections were also found to be prevalent in these patients and were associated with CLAD progression/death. Screening for fungal infections is crucial in this setting.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Niraj M. Desai, Sherry G. Leung, Jennifer D. Motter, Dorry L. Segev, Daniel Warren, Christine M. Durand
ANNALS OF INTERNAL MEDICINE
(2023)
Meeting Abstract
Immunology
Jennifer Motter, Kyle R. Jackson, Allan B. Massie, Jacqueline M. Garonzik-Wang, Dorry L. Segev