Article
Pharmacology & Pharmacy
Huijie Wu, Shuyi Chen, Chenyang Liu, Jiajia Li, Xiangxiang Wei, Mengping Jia, Jieyu Guo, Jiayu Jin, Dan Meng, Xiuling Zhi
Summary: This study found that the expression of SPTBN1 was significantly lower in primary breast cancer tumors than in normal tissues, and lower levels of SPTBN1 were associated with significantly shorter progression-free survival. Loss of SPTBN1 promoted EMT, the viability of MDA-MB-231 and BT549 in vitro, and the growth of MDA-MB-231 tumor xenografts in vivo by upregulating miR-21 level.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Antonio Lahera, Pilar Lopez-Nieva, Hernan Alarcon, Jose L. Marin-Rubio, Maria A. Cobos-Fernandez, Pablo Fernandez-Navarro, Agustin F. Fernandez, Laura Vela-Martin, Isabel Sastre, Sara Ruiz-Garcia, Pilar Llamas, Jose L. Lopez-Lorenzo, Javier Cornago, Javier Santos, Jose Fernandez-Piqueras, Maria Villa-Morales
Summary: Despite frequent alterations in the JAK/STAT pathway in T-ALL/LBL, there is currently no approved therapy for patients with constitutive JAK/STAT signaling. This study identifies SOCS3 hypermethylation as a recurrent event in T-ALL/LBL and demonstrates its potential as a therapeutic target by counteracting the constitutive activation of the JAK/STAT pathway through different molecular mechanisms.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
A. H. Gao, Y. R. Hu, W. P. Zhu
Summary: IFN-gamma inhibits ovarian cancer progression by enhancing SOCS1 to suppress STAT3 and STAT5 protein phosphorylation, thus preventing cell proliferation, migration, invasion, and promoting apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Pathology
Liang Chen, Yunlong Wang, Banglin Zhang
Summary: AJAP1 is down-regulated in prostate cancer and its abnormal expression can affect the functions of prostate cancer cells, including epithelial mesenchymal transition, migration, invasion, and stem cell formation. The methylation level of AJAP1 promoter may have an impact on AJAP1 expression. In addition, inhibition of the JAK2/STAT3 pathway can reduce EMT, cell migration, and stem cell sphere formation in prostate cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pharmacology & Pharmacy
Hong-Tai Tzeng, I-Tsu Chyuan, Jenn-Haung Lai
Summary: The JAK/STAT signaling pathway plays a crucial role in immune regulation, affecting cell proliferation, survival, inflammation, and immune tolerance. Aberrant activation of this pathway can lead to autoimmune diseases and cancer progression, while targeting JAK/STAT has shown efficacy in suppressing inflammation. The success of small-molecule JAK inhibitors in treating rheumatologic diseases highlights their therapeutic potential in other conditions.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Shu-ming Chen, Ali Raza Jahejo, Fazul Nabi, Shakeel Ahmed, Jin-feng Zhao, Jin Yu, Chen-liang Zhang, Guan-bao Ning, Ding Zhang, Sayed Haidar Abbas Raza, Wen-xia Tian
Summary: This study investigated the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway-related genes in thiram-induced tibial dyschondroplasia (TD) in broiler chickens. The findings suggest that differential expression of STAT3 and SOCS3 may play a crucial role in regulating abnormal proliferation, differentiation, or apoptosis of chondrocytes in the early stages of TD. Various molecular and histological analyses showed significant changes in gene expression and protein localization of STAT3 and SOCS3 in thiram-induced TD chickens, indicating their involvement in the pathogenesis of TD.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Oncology
Yih-Giun Cherng, Yi Cheng Chu, Vijesh Kumar Yadav, Ting-Yi Huang, Ming-Shou Hsieh, Kwai-Fong Lee, Wei-Hwa Lee, Chi-Tai Yeh, Jiann Ruey Ong
Summary: Hepatitis virus is a major risk factor for liver cancer. The study demonstrated that momelotinib effectively suppressed the expression of the IFNGR-JAK-STAT-PARP1 pathway, resulting in the downregulation of cancer stem cell genes and enhancing the anti-tumor efficacy of sorafenib, maximizing therapeutic potential for patients with HCC.
Review
Obstetrics & Gynecology
Irfan Yunianto, Margaret Currie, Kenny Chitcholtan, Peter Sykes
Summary: This review aims to explore the potential of using the JAK inhibitor ruxolitinib for therapeutic targeting of the JAK/STAT signaling pathway in patients with epithelial ovarian cancer. Preclinical studies have shown that ruxolitinib can effectively reduce ovarian cancer cell viability and metastasis, as well as enhance the anti-tumor activity of chemotherapy drugs. Although early clinical trials have not fully supported its efficacy in solid tumors, there is evidence supporting the use of ruxolitinib in combination with chemotherapy and other targeted drugs in the ovarian cancer setting.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Oncology
Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Habbanakuppe D. Preetham, S. Chandra Nayaka, Vijai K. Gupta, Salundi Basappa, Gautam Sethi, Kanchugarakoppal S. Rangappa
Summary: Signal transducer and activator of transcription 3 (STAT3) is a crucial transcription factor involved in various human malignancies. Its activation promotes tumor progression, while inhibiting STAT3 signaling can effectively suppress tumor growth. This review provides a comprehensive overview of the mechanisms of STAT3 signal transduction, its negative regulators, the role of STAT3 in oncogenesis, and the inhibition of STAT3 signaling by natural compounds with potential anti-tumor activity.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Sara La Manna, Marilisa Leone, Flavia Anna Mercurio, Daniele Florio, Daniela Marasco
Summary: Researchers have designed several peptidomimetics to mimic the function of SOCS3 protein, with one chimeric peptide showing anti-inflammatory and antioxidant properties. The length and position of the cyclic analogues were found to play a crucial role in their structure and function.
Article
Agriculture, Dairy & Animal Science
Annah Lee, Gabriela Cardoso Dal Pont, Michele Battaglia, Ryan J. Arsenault, Michael H. Kogut
Summary: This study examines the effect of chestnut tannins (ChT) on broiler chicken immunity pathways, finding that ChT may influence host immunity through an IL-6 mediated response beneficial for early defense against pathogens. Additionally, the inclusion of ChT alters the role of the JAK-STAT pathway in the regulation of the immune system.
Article
Oncology
Siting Li, Yuexin Hu, Ouxuan Liu, Xiao Li, Bei Lin
Summary: The study found that MCP-4 is highly expressed in ovarian cancer tissues and is associated with patient prognosis. MCP-4 overexpression promotes cell migration and invasion in ovarian cancer, inhibits apoptosis, and activates the p38 MAPK signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Tao Li, Hong Ge, Qingyan Yang, Junmei Wang, Qian Yin, Hongbin Wang, Gaolei Hou
Summary: This study demonstrates that miR-19b-3p facilitates glioma progression by activating the JAK-STAT signaling pathway through targeting SOCS3, highlighting a novel therapeutic target for glioma treatment.
METABOLIC BRAIN DISEASE
(2023)
Review
Pathology
Ahmed Hjazi, Rasha Fadhel Obaid, Sally Saad Ali, Bekhzod Abdullaev, Hashem O. Alsaab, Huldani Huldani, Rosario Mireya Romero-Parra, Yasser Fakri Mustafa, Beneen M. Hussien, Sarah Jaafar Saadoon
Summary: Long non-coding RNAs (lncRNAs) transcribed from the human genome have emerged as important regulators in cellular activities, particularly in controlling gene expression. They have been found to regulate various factors related to tumorigenesis through the JAK-STAT signaling pathway, either by directly targeting or indirectly modulating its components. Moreover, lncRNAs can also act as downstream effectors of the pathway. The relationship between JAK-STAT signaling and lncRNAs varies among different types of cancers, and lncRNAs play a dual role in tumorigenesis or tumor suppression. This review focuses on the reciprocal regulation and functions of lncRNAs and the JAK-STAT pathway, providing insights into potential targets for clinical therapeutics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)