Review
Engineering, Biomedical
Yu Zhang, Pan He, Peng Zhang, Xuan Yi, Chunsheng Xiao, Xuesi Chen
Summary: Polypeptides are important biodegradable polymers widely used in drug delivery for cancer treatment. Conjugating anticancer drugs with polypeptides offers advantages in improving pharmacokinetics, enhancing targeting, and controlling drug release, contributing to enhanced therapeutic outcomes with reduced side effects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ye Wang, Wei Shen, Shuhan Liu, Ge Zhu, Xiandi Meng, Kuirong Mao, Jialiang Wang, Yong-Guang Yang, Chunsheng Xiao, Tianmeng Sun
Summary: The synthetic cationic anticancer polypeptide (ACPP) can induce immunogenic cancer cell death (ICD), enhance dendritic cell activation, increase natural killer cell levels, and effectively reprogram the tumor immunosuppressive microenvironment, with the anticancer immunity induced by ACPP being dose-dependent and capable of completely eliminating established tumors in 40% of cases.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Sandra Tejedor, Irene Dolz-Perez, Caitlin G. Decker, Amparo Hernandiz, Jose L. Diez, Raquel alvarez, Delia Castellano, Nahuel A. Garcia, Imelda Ontoria-Oviedo, Vicent J. Nebot, Hernan Gonzalez-King, Begona Igual, Pilar Sepulveda, Maria J. Vicent
Summary: This study demonstrates the use of polymer-conjugation to enhance cardioprotection with PUFAs in animal models of I/R-induced injury, showing potential for mitigating damage associated with coronary angioplasty. Enhanced solubility and stability of PUFA diDHA through PGA conjugation improved outcomes, providing evidence for the efficacy of this approach in protecting against I/R injury.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Chemical
Johanne Pirkin-Benameur, Denis Bouyer, Damien Quemener
Summary: Soft-matter materials research has made significant progress, introducing self-oscillating materials that utilize chemical oscillators to control pH-sensitive polymer chain movements, resulting in continuous pore-size oscillation. The functionalization of commercial membranes with polyethersulfone allows for pore size oscillation, as confirmed by water permeation analysis.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Biomedical
Chenyu Gong, Junjie Sun, Yan Xiao, Xue Qu, Meidong Lang
Summary: PLL-POIM-CA, a pH-responsive polypeptide, exhibits excellent antibacterial activities, especially in the treatment of multidrug-resistant bacterial infections, showing great potential for broad application prospects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Miao Pan, Chao Lu, Wancong Zhang, Huan Huang, Xingyu Shi, Shijie Tang, Daojun Liu
Summary: Anticancer peptides and polymers can interact with tumor cells to overcome multidrug resistance. In this study, PLO-b-PLF block copolypeptides were prepared and self-assembled into polymeric micelles. The cationic micelles interacted with cancer cells via electrostatic interactions and killed them via membrane lysis. To reduce cytotoxicity, anionic PLO(DCA)-b-PLF was designed to recover anticancer activity in the acidic tumor microenvironment. These PLO-based polypeptides have potential applications in drug-free tumor treatment.
Review
Oncology
Adnan Fojnica, Zehra Gromilic, Semir Vranic, Michael Murkovic
Summary: Peptides are abundant molecules with diverse functions and biological activities. Flaxseed oil, a natural substance, has been extensively studied for its biological effects. Cyclolinopeptides (CLPs), one of the components of flaxseed, have gained attention due to their cyclic nature and potential therapeutic applications. CLPs have shown anticancer effects and can inhibit cancer cell growth in various cancer types.
Article
Pharmacology & Pharmacy
Federica Rinaldi, Jacopo Forte, Giada Pontecorvi, Patrizia Nadia Hanieh, Alessandra Care, Maria Bellenghi, Valentina Tirelli, Maria Grazia Ammendolia, Gianfranco Mattia, Carlotta Marianecci, Rossella Puglisi, Maria Carafa
Summary: This study focused on the development of nanoemulsions and niosomes containing oleic acid for the treatment of melanoma, aiming to improve drug delivery efficiency and reduce toxicity. Results showed that these new nanostructures exhibited stability, pH-sensitivity, efficient cellular uptake, and no cell toxicity, indicating their potential as a powerful strategy for metastatic melanoma therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Assaf Zinger
Summary: In this paper, the author presents design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. The author also describes BNP fabrication methods and analyzes their advantages and challenges. Finally, future therapeutic applications of each BNP group are suggested and a new revolutionary concept for their use is proposed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Xianzhi Zhang, Ryan F. Landis, Puspam Keshri, Roberto Cao-Milan, David C. Luther, Sanjana Gopalakrishnan, Yuanchang Liu, Rui Huang, Gengtan Li, Morgane Malassine, Imad Uddin, Brayan Rondon, Vincent M. Rotello
Summary: Bioorthogonal catalysis is a promising strategy for imaging and therapeutic applications, with the use of a polymeric scaffold to encapsulate transition metal catalysts resulting in bioorthogonal polyzymes that enhance stability and demonstrate therapeutic potential by transforming a nontoxic prodrug into an anticancer drug.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Oncology
Mary O'Reilly, Anna Linehan, Aleksandar Krstic, Walter Kolch, Kieran Sheahan, Des C. Winter, Ray Mc Dermott
Summary: Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue globally. The incidence of EOCRC has been rising by 2% annually since 1994. Patients with EOCRC have distinct social, spiritual, fertility, and financial needs that need to be addressed. This review discusses the risk factors and management strategies for EOCRC.
Article
Polymer Science
Isaac Benavides, Timothy J. Deming
Summary: We have prepared a new water-soluble, nonionic homopolypeptide poly(L-homoserine) and poly(L-homoserine) block copolymers with controllable segment lengths. The conformational preferences of poly(L-homoserine) in both the solid state and in solution have been determined. Poly(L-homoserine) is soluble in water and adopts a disordered conformation, making it a promising candidate for applications in biology as a nonionic, water-soluble homopolypeptide. Towards this goal, a poly(L-homoserine) containing a block copolypeptide has been prepared and found to self-assemble into micro- and nanoscale vesicles in water.
Article
Polymer Science
Isaac Benavides, Timothy J. Deming
Summary: We have successfully prepared a new water-soluble, nonionic homopolypeptide poly(L-homoserine), as well as poly(L- homoserine) block copolymers with controllable segment lengths. The conformational preferences of poly(L-homoserine) were determined in both the solid state and in solution. The poly(L-homoserine) showed promising potential for applications in biology due to its solubility in water and disordered conformation. To further explore its potential, a block copolypeptide containing poly(L-homoserine) was prepared and found to self-assemble into micro- and nanoscale vesicles in water.
Article
Materials Science, Multidisciplinary
Mahmoud Baranei, Ramezan Ali Taheri, Mahtab Tirgar, Ardeshir Saeidi, Fatemeh Oroojalian, Lokman Uzun, Azadeh Asefnejad, Frederik R. Wurm, Vahabodin Goodarzi
Summary: This study introduced a new, stable plasma, pH-sensitive niosomal formulation of green tea extract (GTE) with excellent bioavailability and cytotoxic effect against cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Polymer Science
Robert D. Murphy, Ronnie V. Garcia, Andreas Heise, Andreas J. Heise
Summary: Peptide hydrogels are critical building blocks for various scientific applications due to their high water capacity, tunable mechanical properties, and modular synthetic design. They are particularly interesting in the biomedical field due to their biomimetic structure and biocompatibility, making them suitable for 3D printing matrices. This review discusses two strategies for preparing peptide hydrogels using solid-phase peptide synthesis and N-carboxyanhydride ring opening polymerization, and explores their applicability in 3D printing and potential research directions.
PROGRESS IN POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiaoya Ding, Gao Li, Peng Zhang, E. Jin, Chunsheng Xiao, Xuesi Chen
Summary: An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yuezhou Huang, Chenyang Hu, Yanchuan Zhou, Ranlong Duan, Zhiqiang Sun, Pengqi Wan, Chunsheng Xiao, Xuan Pang, Xuesi Chen
Summary: A new polymerization route based on reversible CO2 insertion and chemoselective ring opening copolymerization has been developed, allowing for the preparation of multi-block polyesters and potential wider applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Jinlong Chen, Yilin Dong, Chunsheng Xiao, Youhua Tao, Xianhong Wang
Summary: The research team successfully synthesized a novel class of poly(epsilon-lysine) mimics through ring-opening polymerization, avoiding tedious deprotection procedures, and exhibited high antimicrobial activities and excellent biocompatibility.
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Lin An, Peng Zhang, Wei Shen, Xuan Yi, Weitian Yin, Rihua Jiang, Chunsheng Xiao
Summary: A sulfur dioxide (SO2) polymer prodrug was designed for the treatment of melanoma, showing potential for inhibiting melanoma progression by releasing SO2 and DOX internally to achieve a synergistic anti-tumor effect. This study highlights a new avenue for combating melanoma through the combination of SO2-based gas therapy and chemotherapeutics.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ye Wang, Wei Shen, Shuhan Liu, Ge Zhu, Xiandi Meng, Kuirong Mao, Jialiang Wang, Yong-Guang Yang, Chunsheng Xiao, Tianmeng Sun
Summary: The synthetic cationic anticancer polypeptide (ACPP) can induce immunogenic cancer cell death (ICD), enhance dendritic cell activation, increase natural killer cell levels, and effectively reprogram the tumor immunosuppressive microenvironment, with the anticancer immunity induced by ACPP being dose-dependent and capable of completely eliminating established tumors in 40% of cases.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Quanwei Sun, Xiaohui Hou, Jinming Yang, Mengmeng Zhang, Ye Yang, Yang Liu, Wei Shen, Dengke Yin
Summary: Photosensitive nanosized metal-organic frameworks have been developed as nanophotosensitizers for photodynamic therapy, but their effectiveness is limited by fast blood clearance and poor tumor retention. Researchers fabricated a CQ-loaded photosensitive nanoMOF coated with heparin to sensitize PDT, increasing the tumor accumulation of nanoPSs and eliminating self-protective autophagy in cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Mengmeng Zhang, Wei Shen, Qianqian Jiang, Quanwei Sun, Yang Liu, Ye Yang, Dengke Yin
Summary: Photodynamic therapy (PDT) is a non-invasive and safe treatment, but the tumor microenvironment limits its efficacy. Curcumol, a compound with immune activation effects, faces challenges in in vivo application due to its solubility and volatility. This study successfully delivered curcumol to tumor cells using a metal-organic framework system and demonstrated its therapeutic and immunostimulatory effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Quanwei Sun, Jinming Yang, Wei Shen, Huiyu Lu, Xiaohui Hou, Yang Liu, Yujing Xu, Qinghua Wu, Zihua Xuan, Ye Yang, Dengke Yin
Summary: This study developed a multifunctional metal-organic framework to enhance the efficacy of photodynamic therapy and stimulate antitumor immune responses.
Article
Environmental Sciences
Li Xu, Wei Shen, Yang Liu, Mingyan Zhang, Ye Yang, Dengke Yin
Summary: Long-term exposure to fenpropathrin may induce oxidative stress and disrupt the intestinal barrier, leading to increased intestinal absorption of gliquidone.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nanoscience & Nanotechnology
Wencui Shang, Quanwei Sun, Chenxu Zhang, Hanmeng Liu, Ye Yang, Yang Liu, Wenheng Gao, Wei Shen, Dengke Yin
Summary: In this study, a hyaluronic acid derivative that can scavenge ROS was developed as a nanocarrier for sinomenine delivery, aiming to remodel the oxidative/inflammatory microenvironment in rheumatoid arthritis (RA) and provide new possibilities for the development of therapeutic polymers and combined therapeutic strategies.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Xuan Yi, Pengqi Wan, Wei Shen, Xiaonong Zhang, Peng Zhang, Chunsheng Xiao
Summary: This study reports the design and synthesis of antitumor lipo-polylysine polymers as synthetic mimics of biosynthetic lipopeptide surfactants for cancer therapy. The optimal polymer exhibits broad-spectrum anticancer activity against multiple cancer cells, including drug-resistant ones, while showing low toxicity to normal cells. Mechanistically, the optimal polymer interacts with the cancer cell membrane and induces necrosis by perforating the cell membrane, which is different from the mechanism of traditional anticancer drugs. In vivo studies demonstrate that the optimal polymer efficiently inhibits tumor growth without causing obvious side effects. Overall, the lipopeptide-mimicking lipo-polylysine provides a new, cost-effective, and biocompatible anticancer strategy with high efficacy.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Ruonan Su, Haixia Wang, Chunsheng Xiao, Yu Tao, Mingqiang Li, Zhuanggui Chen
Summary: Delayed neutrophil apoptosis has been associated with acute lung injury. Venetoclax, a Bcl-2 inhibitor, has shown potential in improving clinical outcomes of acute lung injury but faces delivery challenges due to its water insolubility. Utilizing an amphiphilic polymer-based nanoparticle, Nf-venetoclax was able to increase neutrophil apoptosis in vivo, demonstrating effective therapy for acute lung injury.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Yu Zhang, Hongyu Zhang, Pan He, Xuan Yi, Xinming Liu, Chunsheng Xiao
Summary: A novel GSH-responsive SO2 polymeric prodrug was designed and synthesized to release both Irinotecan and SO2 in tumor cells, exerting an enhanced anti-proliferative effect against HepG2 cells when combined. The drug-loaded nanoparticles showed a stronger antitumor effect than free antineoplastics in HepG2 cells, indicating the promising potential of this polymeric prodrug in chemotherapeutic drug delivery.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)