期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 39, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202002043
关键词
drug delivery; ferritin; mesoporous silica nanoparticle; targeting
类别
资金
- National Natural Science Foundation of China [41621004, 41704072]
- China Postdoctoral Science Foundation [2017M610979]
- Zink Student Research Support Fund
Mesoporous silica nanoparticles (MSNs) functionalized with redox-sensitive or pH-sensitive nanovalves for doxorubicin delivery and release by using recombinant human H chain ferritin (HFn) as a cap have been designed and fabricated. In both cases, transmission electron microscope observatory, dynamic light scattering change, Fourier transform infrared spectra examination, thermogravimetric analysis show that HFn can be chemically bonded to MSNs while retaining its ability to target transferrin receptor 1 (TfR1). Cargo loading and release studies demonstrate that HFn is an efficient capping agent, blocking the pores of MSN preventing cargo molecules from diffusing out, and is responsive to redox stimuli or pH changes. More importantly, HFn can not only cap the MSNs, but also enables targeted cargo delivery to malignant cells by binding to the TfR1 that has been overexpressed in various tumors, which can be reflected by the cell viability and fluorescence microscope analysis results comparing with cyclodextrin as the capping agent and TfR1 blocking assay. The in vivo study reveals the excellent efficacy of doxorubicin loaded and HFn capped MSNs on suppression of tumor growth. The new developed drug delivery system features mutually benefit and mutually support, providing strategy for achieving specific-site therapeutics delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据