期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 35, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202000933
关键词
cyclic cell penetrating peptide; graphene oxide; multidrug resistance; nuclear targeting; synergistic therapy
类别
资金
- Focus Area Nanoscale of Freie Universitat Berlin
- National Natural Science Foundation of China [NSFC 51703244, 51973233]
- Natural Science Foundation of Jiangsu Province [BK20170730]
- Deutsche Forschungsgemeinschaft [SFB 765, SPP 1623]
- Fundamental Research Funds for the Central Universities [2632020ZD13]
- Iran Science Elites Federation
- China Scholarship Council (CSC)
Multidrug resistance resulting from a variety of defensive pathways in cancer has become a global concern with a considerable impact on the mortality associated with the failure of traditional chemotherapy. Therefore, further research and new therapies are required to overcome this challenge. In this work, a cyclic R10 peptide (cR(10)) is conjugated to polyglycerol-covered nanographene oxide to engineer a nanoplatform for the surmounting of multidrug resistance. The nuclear translocation of the nanoplatform, facilitated by cR(10)peptide, and subsequently, a laser-triggered release of the loaded doxorubicin result in efficient anticancer activity confirmed by both in vitro and in vivo experiments. The synthesized nanoplatform with a combination of different features, including active nucleus-targeting, high-loading capacity, controlled release of cargo, and photothermal property, provides a new strategy for circumventing multidrug resistant cancers.
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