期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 36, 页码 40673-40683出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c11739
关键词
NIR-induced chemodynamic therapy; photothermal; subcellular; lipid peroxide; lysosome pathway death
资金
- National Natural Science Foundation of China (NSFC) [81971734, U1605225, 31800794]
- Program for Innovative Research Team in Science and Technology in Fujian Province University
The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS-NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo.
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