Article
Chemistry, Multidisciplinary
Rodrigo S. Heyder, Fatemah S. Sunbul, Rashed M. Almuqbil, Cory B. Fines, Sandro R. P. da Rocha
Summary: Gemcitabine was chemically modified and polymerized into a biodegradable polymeric structure with high drug loading and controlled release profiles, engineered into nanoparticles for potential drug delivery applications in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Applied
Emilie Portier, Fabrice Azemar, Belkacem Tarek Benkhaled, Jean-Francois Bardeau, Fabienne Fay, Karine Rehel, Vincent Lapinte, Isabelle Linossier
Summary: The study aimed to design an amphiphilic fouling release coating containing POx as additives to replace coatings containing biocides, and evaluate its impact on PDMS coatings. Experimental results showed that POx-silicone coating had similar antibacterial fouling efficiency to PEG-silicone coating.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Multidisciplinary
Adrian Najer, Alexis Belessiotis-Richards, Hyemin Kim, Catherine Saunders, Federico Fenaroli, Christopher Adrianus, Junyi Che, Renee L. Tonkin, Hakon Hogset, Samuel Lorcher, Matthew Penna, Stuart G. Higgins, Wolfgang Meier, Irene Yarovsky, Molly M. Stevens
Summary: This study systematically investigates the structural, dynamic, and antifouling properties of polymersomes made of PMOXA-b-PDMS-b-PMOXA. The results suggest that maximizing the length of PMOXA while maintaining sufficient membrane stability can improve the antifouling performance of polymersomes. In vitro and in vivo experiments support these findings and indicate that blends of copolymers with varied lengths outperform single copolymer presentation.
Article
Chemistry, Multidisciplinary
Joshua P. Morrow, Zihnil A. I. Mazrad, Ashley I. Bush, Kristian Kempe
Summary: This study reports the synthesis and characterization of water-soluble Fer-1 poly(2-oxazoline)-drug conjugates (PDCs) for anti-ferroptosis therapy. The conjugates showed improved anti-ferroptosis activity compared to reversible linked Fer-1. This work introduces the first active Fer-1 PDCs and a highly tuneable poly(2-oxazoline)-based PDC platform for anti-ferroptosis applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Semira Bener, Ewa Pavlova, Hynek Benes, Ondrej Sedlacek
Summary: Intelligent redox-responsive polymers have great potential in biomedical applications. This study successfully synthesized thioether-containing PAOx through a simple post-polymerization modification and demonstrated its oxidation-responsive behavior by self-assembling into micelles.
Article
Polymer Science
Xuejun Pan, Muhammad Waqas Ishaq, Muhammad Waqas Ali, Jinxian Yang, Lianwei Li, Yougen Chen
Summary: In this study, a library of comb-like polymers with varied grafting densities was prepared and their conformational properties in solution were investigated. PEtOx-N-3 was synthesized as the grafting side chain and grafted onto PPA backbone to obtain comb-like PPA(Nb)-g-PEtOx(47)-sigma(g) samples with different grafting densities. The molecular parameters of these comb-like polymers were extracted using a Quadruple-detection size-exclusion chromatography system. The study revealed a transition in polymer shape from starlike to comb-like, and further to branched comb-like structure as the backbone length increases.
Article
Polymer Science
Jan Svoboda, Niccolo Lusiani, Radoslava Sivkova, Ognen Pop-Georgievski, Ondrej Sedlacek
Summary: This study compares the antifouling properties of water-soluble poly(2-oxazoline) (PAOx) and poly(2-oxazine) (PAOzi) brushes grafted to gold surfaces. The results show that all polymer-modified surfaces have better antifouling properties than bare gold surfaces and analogous PEG coatings. The study suggests that the resistance to protein fouling comes from both surface hydrophilicity and the molecular structural flexibility of the polymer brushes.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Shaffiq Zainal Osman Shah, Anna Trengove, Andrea J. O'Connor, John F. Quinn, Kristian Kempe
Summary: Interpenetrating polymer networks (IPNs) composed of independent crosslinked networks can enhance material properties for various applications. The study reports the first simultaneous IPN using cationic ring-opening polymerization (CROP) and reversible addition-fragmentation chain-transfer (RAFT) polymerization. The results demonstrate the compatibility and tunability of IPNs with different crosslinkers.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Polymer Science
David Pizzi, Ayaat M. Mahmoud, Tobias Klein, Joshua P. Morrow, James Humphries, Zachary H. Houston, Nicholas L. Fletcher, Craig A. Bell, Kristofer J. Thurecht, Kristian Kempe
Summary: PEtOx bottlebrushes, a type of biocompatible polymer, show great potential as therapeutic carriers due to their low fouling nature and good biocompatibility. Increasing the backbone or side-chain length of PEtOx bottlebrushes leads to decreased cellular association in vitro and longer blood circulation times in vivo. This insight may be beneficial for designing next-generation PEtOx bottlebrushes with customized profiles for specific applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Annelore Podevyn, Sandra Van Vlierberghe, Peter Dubruel, Richard Hoogenboom
Summary: The combination of natural and synthetic polymers to form hybrid hydrogels offers the potential of fabricating new materials with dual polymer properties. This study synthesized two alkene-functionalized poly(2-alkyl/aryl-2-oxazoline) (PAOx) copolymers and one gelatin derivative, thiolated gelatin (gel-SH), as precursors for hybrid hydrogels through a photo-induced radical thiol-ene crosslinking process. The results showed that hydrogels with an excess amount of PAOx precursor exhibited increased mechanical stability. The thermo-responsive properties of a specific hydrogel film were also investigated, showing promise for developing hybrid poly(2-oxazoline)-gelatin hydrogels with predictable properties.
Article
Polymer Science
Lucca Trachsel, Matteo Romio, Marcy Zenobi-Wong, Edmondo M. Benetti
Summary: Cyclic macromolecules exhibit enhanced mechanical strength and greater hydration in hydrogels, compared to their linear counterparts, due to the higher effective intramolecular repulsion between polymer segments and the topology effects.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Catia G. Alves, Rita Lima-Sousa, Bruna L. Melo, Paula Ferreira, Andre F. Moreira, Ilidio J. Correia, Duarte de Melo-Diogo
Summary: The authors developed a novel nanoparticle that can be triggered by laser light for anticancer therapy. In vitro assays showed that the nanoparticle effectively reduced the viability of cancer models when exposed to laser light, while no cytotoxicity was observed without laser light. This on-demand effect may help reduce side effects, and the nanoparticle also exhibited good stability for future translation.
Article
Chemistry, Physical
Janice Caroline Hardt, Michelly Cristina Galdioli Pella, Ana Caroline Reis Meira, Andressa Giombelli Rosenberger, Josiane Caetano, Douglas Cardoso Dragunski
Summary: This study evaluated the potential application of silver sulfadiazine loaded PBAT/PCL microfibers as wound dressings, which exhibited antimicrobial activity and controlled release. The results showed that the fiber diameter and crystallinity were concentration-dependent on the silver sulfadiazine, and the release profile was biphasic with both fast and sustained release.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Joachim F. R. Van Guyse, Debaditya Bera, Richard Hoogenboom
Summary: The synthesis of a polymer with a specific responsive temperature range was achieved in this study, allowing for fine-tuning of its adaptive behavior through molecular recognition. By complexing with cyclodextrins, a temperature-sensitive phase transition process was successfully implemented with high reversibility and precision.
Article
Biochemistry & Molecular Biology
Jacob D. Ramsey, Ian E. Stewart, Emily A. Madden, Chaemin Lim, Duhyeong Hwang, Mark T. Heise, Anthony J. Hickey, Alexander Kabanov
Summary: The novel coronavirus has caused a global pandemic with no approved treatment. Poly(2-oxazoline) block copolymers have been found to stabilize drug nanocrystal suspensions and are suitable for aerosol delivery while maintaining antiviral efficacy.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Organic
Margeaux A. Miller, Rachael A. Day, Daniel A. Estabrook, Ellen M. Sletten
Article
Chemistry, Multidisciplinary
Irene Lim, Antoine Vian, Heidi L. van de Wouw, Rachael A. Day, Carlos Gomez, Yucen Liu, Arnold L. Rheingold, Otger Campas, Ellen M. Sletten
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Daniel A. Estabrook, Rachael A. Day, Ellen M. Sletten
Summary: This study presents a method to create redox-responsive PFC nanoemulsions using cleavable poly(2-oxazoline) diblock copolymer surfactants, allowing for cargo release within cells. A noncovalent fluorous tagging strategy successfully solubilizes GFP plasmids inside the PFC nanoemulsions, enabling protein expression selectively with stimuli-responsive surfactants. This work offers a novel approach to non-viral gene delivery and demonstrates a general method for nanoemulsions that respond to endogenous stimuli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Rachael A. Day, Ellen M. Sletten
Summary: The study discusses three methods to directly probe endosomal/lysosomal rupture, including calcein dye dilution, lysosome size quantification, and visualization of membrane integrity with a genetically engineered cell line. These methods can help understand the limiting factors in the therapeutic use of nanomaterials.
Review
Chemistry, Physical
Rachael A. Day, Ellen M. Sletten
Summary: Photodynamic therapy (PDT) utilizes photosensitizer and light to generate reactive oxygen species for treating diseases, with tumors often being hypoxic. Delivering photosensitizer and oxygen efficiently is crucial, and using perfluorocarbons can help co-deliver oxygen to enhance treatment efficacy.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Chemistry, Organic
Liubo Li, Anton El Khoury, Brennan O'Neil Clement, Carolyn Wu, Patrick G. Harran
Summary: In this study, polyhydroxylated chains reminiscent of lactonized deoxoKdn type sugars were synthesized through sequential organocatalytic additions. Functionalized chain precursors to portimine were assembled via further homologation and acylation reactions. This work provides advanced intermediates useful for exploring the biosynthesis and de novosynthesis of portimine.
Article
Chemistry, Multidisciplinary
Daniel A. Estabrook, John O. Chapman, Shuo-Ting Yen, Helen H. Lin, Ethan T. Ng, Linglan Zhu, Heidi L. van de Wouw, Otger Campas, Ellen M. Sletten
Summary: This study introduces a new endogenous stimulus, biomacromolecule crowding, by leveraging changes in thermoresponsive properties of polymers upon high concentrations of crowding agents. Thermoresponsive materials are shown to respond to macromolecule concentration at physiological temperatures, opening up new possibilities for application.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Daniel A. Estabrook, Amanda F. Ennis, Rachael A. Day, Ellen M. Sletten
Article
Chemistry, Multidisciplinary
Rachael A. Day, Daniel A. Estabrook, Jessica K. Logan, Ellen M. Sletten
CHEMICAL COMMUNICATIONS
(2017)
