期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 27, 页码 30189-30197出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07517
关键词
brimonidine; MOFs; polyurethane; ocular plugs; drug delivery
资金
- MINECO [MAT2016-80285-p]
- Spanish ALBA Synchrotron [2020014008]
- H2020 (MSCA-RISE-2016/NanoMed Project)
- Minas Gerais Research Foundation (FAPEMIG CNPJ) [21.949.888/0001-83]
- EPSRC [EP/N014960/1]
- ERC [771575]
- EPSRC [EP/N014960/1] Funding Source: UKRI
- European Research Council (ERC) [771575] Funding Source: European Research Council (ERC)
Novel MOF-based polymer nanocomposite films were successfully prepared using Zr-based UiO-67 as a metal-organic framework (MOF) and polyurethane (PU) as a polymeric matrix. Synchrotron X-ray powder diffraction (SXRPD) analysis confirms the improved stability of the UiO-67 embedded nanocrystals, and scanning electron microscopy images confirm their homogeneous distribution (average crystal size similar to 100-200 nm) within the 50 mu m thick film. Accessibility to the inner porous structure of the embedded MOFs was completely suppressed for N-2 at cryogenic temperatures. However, ethylene adsorption measurements at 25 degrees C confirm that at least 45% of the MOF crystals are fully accessible for gas-phase adsorption of nonpolar molecules. Although this partial blockage limits the adsorption performance of the embedded MOFs for ocular drugs (e.g., brimonidine tartrate) compared to the pure MOF, an almost 60-fold improvement in the adsorption capacity was observed for the PU matrix after incorporation of the UiO-67 nanocrystals. The UiO-67@PU nanocomposite exhibits a prolonged release of brimonidine (up to 14 days were quantified). Finally, the combined use of SXRPD, thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR) analyses confirmed the presence of the drug in the nanocomposite film, the stability of the MOF framework and the drug upon loading, and the presence of brimonidine in an amorphous phase once adsorbed. These results open the gate toward the application of these polymeric nanocomposite films for drug delivery in ocular therapeutics, either as a component of a contact lens, in the composition of lacrimal stoppers (e.g., punctal plugs), or in subtenon inserts.
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