期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 26, 页码 28952-28964出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c04080
关键词
hydrogel; BNN6; nitric oxide; gas therapy; wound healing
资金
- Natural Science Foundation of China [31870943]
- Science and Technology Project of Guangdong Province [2018A050506040, 2018A050506019, 2018A050506021]
- Science and Technology Program of Guangzhou [201907010032, 201907010037]
- Pearl River S&T Nova Program of Guangzhou [201710010155, 201806010072]
Bacteria-infected wounds are attracting increasing attention, as antibiotic misuse and multidrug-resistant bacteria complicate their treatment. Herein, we reported a photothermal activity-based drug consisting of beta-cyclodextrin (beta CD)-functionalized graphene oxide (GO) near-infrared light-responsive nanovehicles combined with the nitric oxide donor BNN6, in a methacrylate-modified gelatin (GelMA)/hyaluronic acid graft dopamine (HA-DA) hydrogel. The synergistic effects of photothermal and gas therapies are expected to improve antibacterial efficiency and reduce drug resistance. The results revealed that GelMA/HA-DA/GO-beta CD-BNN6 was an ideal antibacterial material that improved collagen deposition and angiogenesis and promoted wound healing in a mouse model of full-thickness skin repair, compared to the commercially available Aquacel Ag dressing. We developed a multifunctional nanocomposite hydrogel that exhibited antibacterial and angiogenic properties, adhesiveness, and mechanical properties that enhance the regeneration of bacteria-infected wounds.
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