Article
Engineering, Biomedical
Eoin P. McKiernan, Cara Moloney, Tista Roy Chaudhuri, Shane Clerkin, Kevin Behan, Robert M. Straubinger, John Crean, Dermot F. Brougham
Summary: This study presents a successful grafting approach using a catechol-derived compound to bind polyethylene glycol (PEG) onto multicoe magnetic iron oxide nanoparticles (NFs), resulting in long-term colloidal stability in buffers and complex media. The study confirms the dominant role of internal magnetisation dynamics in providing high relaxivity and hyperthermic efficiency, and shows that these properties are unaffected by PEG molecular weight or corona formation in biological environments.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Shaghayegh Kohzadi, Najmeh Najmoddin, Hadi Baharifar, Mahdi Shabani
Summary: This study investigates the use of graphene oxide (GO) decorated with superparamagnetic iron oxide nanoparticles (SPION), polyethylene glycol functionalized SPION (GO/SPION@PEG), and chitosan functionalized SPION (GO/SPION@CS) to control the outbreak of diseases such as cancer and coronavirus. The results show that these nanocomposites have high magnetization, absorption rate, and cytotoxicity against cancer cells, as well as neutralizing properties against the SARS-CoV-2 virus.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Reeju Amatya, Seungmi Hwang, Taehoon Park, Kyoung Ah Min, Meong Cheol Shin
Summary: The study prepared PEG-starch-IONPs and investigated their physical properties through various techniques, revealing that PEGylation significantly increased drug accumulation in tumors, and PEG-starch-IONPs showed significant photothermal effects at the tumor site.
Article
Chemistry, Multidisciplinary
Fitriani Jati Rahmania, Yi-Shou Huang, Yitayal Admassu Workie, Toyoko Imae, Anna Kondo, Yukiko Miki, Ritsuko Imai, Takashi Nagai, Hiroshi Nakagawa, Noriyasu Kawai, Kaname Tsutsumiuchi
Summary: Combination therapy for cancer requires the development of promising carrier materials. In this study, nanocomposites including functional nanoparticles were synthesized and combined with iron oxide NP-embedded or carbon dot-coating iron oxide NP-embedded carbon nanohorn carriers. These nanocomposites showed potential for delivering anticancer drugs and the thermal and photothermal procedures increased drug release.
Article
Materials Science, Multidisciplinary
Najma Annuria Fithri, Yuao Wu, Gary Cowin, Fahima Akther, Huong D. N. Tran, Brian Tse, Nicholas Westra van Holthe, Shehzahdi S. Moonshi, Karlheinz Peter, Xiaowei Wang, Nghia P. Truong, Hang Thu Ta
Summary: In this study, activated platelet targeted gold-iron oxide nanoparticles were developed for the diagnosis and treatment of thrombosis related diseases. The nanoparticles enabled triple imaging modalities of magnetic resonance imaging, photoacoustic imaging, and fluorescence imaging, and also facilitated photothermal thrombolysis. The in vivo observation showed enhanced contrast and thrombus reduction in the targeted group compared to the non-targeted group.
APPLIED MATERIALS TODAY
(2023)
Article
Pharmacology & Pharmacy
Sri Amruthaa Sankaranarayanan, Aswathi Thomas, Neeraja Revi, Bhuvanesh Ramakrishna, Aravind Kumar Rengan
Summary: Personalized medicine is seen as an important milestone in addressing the genetic variations that affect an individual's response to drugs, and nanotheranostics are a potential solution to the challenges faced in personalized medicine development. Iron oxide nanoparticles have unique physicochemical properties that make them suitable for theranostic applications, and this review summarizes their recent advances in various applications such as MRI, magnetic biosensors, and drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chiseon Ryu, Hwangjae Lee, Hohyeon Kim, Seong Hwang, Yaser Hadadian, Ayeskanta Mohanty, In-Kyu Park, Beongki Cho, Jungwon Yoon, Jae Young Lee
Summary: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. In addition, the MNCs exhibited good colloidal stability under physiological conditions and maintained their heating efficiency during 48 h of incubation in cell culture medium.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Mohamed S. A. Darwish, Hohyeon Kim, Minh Phu Bui, Tuan-Anh Le, Hwangjae Lee, Chiseon Ryu, Jae Young Lee, Jungwon Yoon
Summary: This study prepared multifunctional magnetic nanoparticles with high performance for hyperthermia and imaging functionality, showing promising potential for both diagnostic and therapeutic processes.
Article
Polymer Science
Mona Ebadi, Ahmad Rifqi Md Zain, Tengku Hasnan Tengku Abdul Aziz, Hossein Mohammadi, Clarence Augustine T. H. Tee, Muhammad Rahimi Yusop
Summary: Coated iron oxide nanoparticles were synthesized for the delivery of sorafenib and their effects on cancer cells were investigated. The study demonstrated that the use of polyethylene glycol-coated iron oxide nanoparticles could enhance the effect of sorafenib on cancer cells.
Article
Physics, Applied
A. Coene, J. Leliaert
Summary: Nanomedicine research is exploring theranostics, a combination of therapy and diagnostics using magnetic nanoparticles, to provide flexible, personal, and precise care with improved patient outcomes. This article provides an overview of magnetic imaging techniques and theranostic applications based on magnetic nanoparticles, discusses their opportunities and challenges, and proposes three promising research directions. These include utilizing novel magnetic field sequences, developing smart theranostics with feedback mechanisms between particle applications and imaging procedures, and using data-driven models to enhance therapy and diagnostics. The importance of advancing magnetic nanoparticle imaging techniques and applications is emphasized to enable broader use in real clinical environments.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Jiacheng Yu, Changqian Cao, Fengjiao Fang, Yongxin Pan
Summary: Iron oxide nanoparticles, especially magnetoferritins, have shown potential for magnetic hyperthermia therapy due to their biocompatibility and high thermal conversion efficiency. In this study, a novel magnetoferritin particle with a larger magnetite/maghemite core size and higher saturation magnetization was synthesized using a recombinant ferritin from the hyperthermophilic archaeon Pyrococcus furiosus as a template at 90 degrees C. The enhanced magnetic properties of this magnetoferritin suggest its potential application in tumor magnetic hyperthermia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Roxana Cristina Popescu, Diana Iulia Savu, Miriam Bierbaum, Adriana Grbenicek, Frank Schneider, Hiltraud Hosser, Bogdan Stefan Vasile, Ecaterina Andronescu, Frederik Wenz, Frank A. Giordano, Carsten Herskind, Marlon R. Veldwijk
Summary: The study demonstrated that polyethylene glycol-encapsulated iron oxide nanoparticles showed potential for enhancing the intracellular delivery of a chemotherapeutic drug to improve the cytotoxic effects of ionizing radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Li-Hua Deng, Hai Jiang, Fu-Lin Lu, Han-Wei Wang, Yu Pu, Chang-Qiang Wu, Hong-Jie Tang, Ye Xu, Tian-Wu Chen, Jiang Zhu, Cheng-Yi Shen, Xiao-Ming Zhang
Summary: By using PEGylated SPIO nanoparticles as MRI contrast agents, different nanocrystal sizes and PEG coatings can be utilized to achieve T-1, T-2, or T-1-T-2 dual-mode imaging at different magnetic field intensities.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Saeideh Arsalani, Yaser Hadadian, Ernesto E. Mazon, Eder J. Guidelli, Emanuel Kava, Ana Paula Ramos, Alexandre Jose Gauldi, Theo Z. Pavan, Oswaldo Baffa, Antonio A. O. Carneiro
Summary: This study successfully synthesized bare magnetite NPs and PEG-MNPs with high stability and optimized physicochemical properties through an optimized synthesis method. In vitro biological assays on Escherichia coli strains demonstrated low cytotoxicity of these nanoparticles at high concentrations. Furthermore, the MNPs showed potential as theranostic agents in magnetomotive ultrasound imaging and magnetic hyperthermia.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ankita Chandra, Preeti Ravindra Bhoge, K. R. Chethan, Chethan D. D. Shanthamurthy, Raghavendra Kikkeri
Summary: In this study, highly fluorescent gold nanoclusters were engineered with sulfated oligo-iduronic acid ligands (I34), which showed strong binding to the HB-EGF receptor over FGF2, and regulated EGF receptor-mediated cancer cell homing in both 2D and 3D cell culture systems. These findings provide a new practical imaging tool for carbohydrate research.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yoo Sang Jeon, Bum Chul Park, Min Jun Ko, Jun Hwan Moon, Eunjin Jeong, Young Keun Kim
Summary: The study demonstrates a facile strategy and fabrication mechanism to synthesize nanotubes or nanocoils by selecting specific additives, providing a promising approach for preparing desired nanostructures. The addition of L-ascorbic acid allows for the regulation of nanostructure morphology, while vanadyl ascorbate plays a key role in surface conduction and structure assembly.
Article
Chemistry, Multidisciplinary
Gunhyu Bae, Myeong Soo Kim, Ramar Thangam, Thomas Myeongseok Koo, Woo Young Jang, Jinho Yoon, Seong-Beom Han, Letao Yang, Seong Yeol Kim, Nayeon Kang, Sunhong Min, Hyunsik Hong, Hong En Fu, Min Jun Ko, Dong-Hwee Kim, Woong Kyo Jeong, Dong-Hyun Kim, Tae-Hyung Kim, Jeong-Woo Choi, Ki-Bum Lee, Ramasamy Paulmurugan, Yangzhi Zhu, Han-Jun Kim, Junmin Lee, Jong Seung Kim, Ali Khademhosseini, Young Keun Kim, Heemin Kang
Summary: The study focuses on tuning the diameter and interdistance of RGD-bearing AuNPs on Fe3O4 nanotemplates to regulate stem cell differentiation and adhesion functions.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuri Kim, Thomas Myeongseok Koo, Ramar Thangam, Myeong Soo Kim, Woo Young Jang, Nayeon Kang, Sunhong Min, Seong Yeol Kim, Letao Yang, Hyunsik Hong, Hee Joon Jung, Eui Kwan Koh, Kapil D. Patel, Sungkyu Lee, Hong En Fu, Yoo Sang Jeon, Bum Chul Park, Soo Young Kim, Steve Park, Junmin Lee, Luo Gu, Dong-Hyun Kim, Tae-Hyung Kim, Ki-Bum Lee, Woong Kyo Jeong, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang
Summary: The study demonstrates the modulation of integrin recognition and macrophage adhesion by tuning the submolecular ligand size and spacing at the nanoscale level.
ADVANCED MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jun Hwan Moon, Seunghyun Kim, Taesoon Kim, Yoo Sang Jeon, Yanghee Kim, Jae-Pyoung Ahn, Young Keun Kim
Summary: Nanoscale ruthenium and ruthenium alloys with low resistivity values are potential candidates for interconnect and barrier materials in integrated circuits. Electrodeposition can produce ruthenium nanowires with excellent resistivity and microstructure.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Physical
Taehyun Kim, Quynh Anh T. Nguyen, Gyu Won Kim, Min Hyeok Lee, Seok In Yoon, Sonny H. Rhim, Young Keun Kim
Summary: Spin-orbit torque (SOT) based magnetization switching is a current area of interest, and we propose a W-Si alloy as a potential spin current-generating layer in nonvolatile embedded memory and logic devices. Experimental results confirm the required properties of the proposed W-Si/CoFeB heterostructures.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jeong Ook Soh, Bum Chul Park, Hyeon Su Park, Myeong Soo Kim, Hong En Fu, Young Keun Kim, Ju Hun Lee
Summary: A new nucleic acid amplification method called nanoparticle-based surface localized amplification (nSLAM) is combined with electrochemical detection (ECD) to develop a nucleic acid biosensor platform that overcomes limitations in other methods and exhibits high sensitivity for emerging pathogens like the coronavirus.
Article
Environmental Sciences
Yun-Sik Lee, Bum Chul Park, Dae Beom Lee, Hyun-Gi Min, Min-Suk Kim, Sung-Chul Kim, Sung Ok Won, June Wee, Eunji Chae, Cheolho Sim, Youngeun Kim, Jeong-Gyu Kim, Young Keun Kim, Kijong Cho
Summary: We developed a method to enhance the efficiency of arsenic (As) capture and improve ecosystem health by reorganizing the structure of iron oxyhydroxide. The reorganized iron oxyhydroxide immobilized As species through a synergistic mechanism, leading to the rehabilitation of As-contaminated soils. This study provides a foundation for crystallization-based material engineering and advances our understanding of soil-nanoparticle-contaminant interactions.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Jungbae Yoon, Jun Hwan Moon, Jugyeong Chung, Yu Jin Kim, Kihwan Kim, Hee Seong Kang, Yoo Sang Jeon, Eunsoo Oh, Sun Hwa Lee, Kihoon Han, Dongmin Lee, Chul-Ho Lee, Young Keun Kim, Donghun Lee
Summary: A barcode magnetic nanowire is a multi-layered magnetic structure with more than one segment type. It has attracted significant attention in bioengineering due to selective functionalization and novel interactions between layers. However, analyzing the magnetic properties of individual nanowires remains challenging. This study investigates the characterization of a single magnetic nanowire based on magnetic images obtained via wide-field quantum microscopy, allowing for extraction of critical magnetic properties.
Article
Nanoscience & Nanotechnology
Jeong Kyu Lee, Jiyoung Lee, Seok In Yoon, Min Hyeok Lee, Jin Seo Lee, Yunho Jang, Dae-Yun Kim, Sug-Bong Choe, Jongsun Park, Young Keun Kim
Summary: This study proposes an optical verification method for spin-orbit torque (SOT) physically unclonable functions (PUFs). The SOT devices are resistant to degradation and thermal changes, and can generate secret keys with high reproducibility. A simple optical method based on the magneto-optical Kerr effect is introduced to verify the authenticity of the proposed SOT PUF device. Furthermore, the feasibility of using a W/CoFeB/MgO/Ta structure as a PUF is assessed, with the 24-bit device showing a reliability of 97.8 +/- 1.03%.
ADVANCED ELECTRONIC MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jun Hwan Moon, Eunjin Jeong, Seunghyun Kim, Taesoon Kim, Eunsoo Oh, Keun Lee, Hauk Han, Young Keun Kim
Summary: Integrated circuits (ICs) face challenges in delivering anticipated performance improvements while increasing the cost and complexity with each generation. The demand for advanced interconnect metallization rises with continuous IC scaling, leading to the exploration of new materials for routing nanoscale interconnects. This review discusses the challenges in interconnect structures as physical dimensions shrink and explores problem-solving options based on material properties, introducing new materials for barriers and conductors. The comprehensive discussion aims to bridge the gap between academia and industry in implementing materials for advanced interconnect technology.
Article
Pharmacology & Pharmacy
Andre-Rene Blaudszun, Woo Jun Kim, Wooram Um, Hong Yeol Yoon, Man Kyu Shim, Kwangmeyung Kim
Summary: This study proposes a combinational photodynamic and cancer immunotherapy using adoptive transfer of photosensitizer-loaded cytotoxic T cells. The loaded T cells efficiently produce reactive oxygen species under visible light irradiation and significantly inhibit tumor growth in a murine lymphoma model.
Article
Chemistry, Multidisciplinary
Geunwoo Kim, Soogil Lee, Sanghwa Lee, Byonggwon Song, Byung-Kyu Lee, Duhyun Lee, Jin Seo Lee, Min Hyeok Lee, Young Keun Kim, Byong-Guk Park
Summary: This study investigates the effects of annealing on the tunnel magnetoresistance ratio in CoFeB/MgO/CoFeB-based magnetic tunnel junctions with different capping layers and correlates them with microstructural changes. The findings indicate that the proper selection of a capping layer can increase the annealing temperature of MTJs, making it compatible with the complementary metal-oxide-semiconductor backend process.
Article
Nanoscience & Nanotechnology
Min Hyeok Lee, Seok-Jong Kim, Seok In Yoon, Jeong Kyu Lee, Han Seok Ko, Gyusang Kim, Seokhie Hong, Kyung-Jin Lee, Young Keun Kim
Summary: This study examines the role of the field-like torque (FLT) in spin-orbit torque (SOT) devices and its impact on the switching process. By manipulating the ratio of FLT to damping-like torque (DLT), the study demonstrates the potential of this material structure as a true random number generator (TRNG).
Article
Chemistry, Multidisciplinary
Yong-Su Jo, Hye-Min Park, Gwang-Hwa Jin, Bhabani Sankar Swain, Seok-Hong Min, Young Keun Kim, Seung-Min Yang
Summary: This paper presents a coating-assisted vapor-phase synthesis method to inhibit the agglomeration of nanoparticles in MLCC electrodes. The experimental results show that using potassium chloride as the coating agent at 950 degrees C can significantly reduce the agglomeration ratio.
Article
Chemistry, Physical
Bum Chul Park, Jiung Cho, Jiliang Zhang, Mawuse Amedzo-Adore, Dae Beom Lee, Sung-Chul Kim, Jong Seong Bae, Young Rang Uhm, Sang-Ok Kim, Jehyoung Koo, Yong-Mook Kang, Young Keun Kim
Summary: The growing interest in rechargeable batteries has led to a surge in demand and price for raw materials. Researchers have found that earth-abundant iron oxyhydroxide (FeOOH) could be a potential anode material for sodium-ion rechargeable batteries (SIBs). However, the irreversible conversion reaction of FeOOH has limited its application. In this study, researchers manipulated the bio-inspired Fe redox from FeOOH-acetate hybrid nanoplatelets (FAHPs) to make the conversion reaction with sodium ions highly reversible. By exploiting the interplaying redox of inorganic and organic materials in hybrid structures, this study established a novel method to enable highly reversible conversion reactions and enhance electrochemical capacity for both sodium and lithium ions.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)