期刊
BRAIN SCIENCES
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/brainsci10040226
关键词
orexin; prescription opioid use disorder; oxycodone; remifentanil; fentanyl
资金
- National Institute on Drug Abuse [AA006420, AA026999]
- National Institute on Alcohol Abuse and Alcoholism [AA006420, AA026999]
- Merck Investigator Studies Program [MISP59371]
Prescription opioids are potent analgesics that are used for clinical pain management. However, the nonmedical use of these medications has emerged as a major concern because of dramatic increases in abuse and overdose. Therefore, effective strategies to prevent prescription opioid use disorder are urgently needed. The orexin system has been implicated in the regulation of motivation, arousal, and stress, making this system a promising target for the treatment of substance use disorder. This review discusses recent preclinical studies that suggest that orexin receptor blockade could be beneficial for the treatment of prescription opioid use disorder.
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