Article
Horticulture
Clarissa Marcelle Naidoo, Yougasphree Naidoo, Yaser Hassan Dewir, Moganavelli Singh, Aliscia Nicole Daniels, Hassan El-Ramady
Summary: This study investigated the antioxidant potential of leaf, stem, and latex extracts of Tabernaemontana ventricosa and evaluated their cytotoxic activity in HEK293, HeLa, and MCF-7 cell lines. The results showed that all parts of T. ventricosa exhibited strong antioxidant activity, which correlated with cytotoxicity.
Article
Multidisciplinary Sciences
Timothy M. Kegode, Joel L. Bargul, Hosea O. Mokaya, H. Michael G. Lattorff
Summary: This study aimed to investigate the chemical composition and bio-functional properties of Kenyan propolis. The results showed that the sampling region had a significant impact on the propolis's composition and functionality. The propolis contained abundant phytochemicals and exhibited antioxidant and antimicrobial activities. It was found that propolis collected from hotter climatic conditions had a higher phytochemical content and stronger antioxidant and antimicrobial activities.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Horticulture
Huseyin Irfan Balik
Summary: This study analyzed the chemical composition and antioxidant activity of Turkish hazelnuts, 18 Turkish standard hazelnut cultivars, and 2 hazelnut clones. Results showed variations in total phenolics, total flavonoids, antioxidant activity, and oil content among different cultivars. Some cultivars exhibited prominence in specific components.
INTERNATIONAL JOURNAL OF FRUIT SCIENCE
(2021)
Article
Forestry
Doroteja Vaitiekunaite, Greta Striganaviciute, Valeriia Mishcherikova, Vaida Sirgedaite-Seziene
Summary: Bacterial biostimulants are an eco-friendly alternative to chemical fertilizers. This study found that the inoculation of Paenibacillus sp. significantly affects the secondary metabolism of Populus trees during the later stages of the initial growth period.
Article
Biology
Pierre Lau, Pierre Lesne, Robert J. Grebenok, Juliana Rangel, Spencer T. Behmer
Summary: Poor nutrition and landscape changes are key factors causing the decline of wild and managed bee populations. However, the definition of 'poor nutrition' for bees is currently inadequate. Studying and characterizing the nutrient content of different pollen types is crucial for understanding pollen as a nutritional resource. Unfortunately, the use of different analytical approaches has complicated comparisons between studies and blurred our understanding of pollen nutrient content. This study proposes a unified approach for analyzing pollen nutrient content, which will help researchers better study and understand the nutritional ecology of bees and other pollen feeders.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nawaf Al-Maharik, Nidal Jaradat, Najlaa Bassalat, Mohammed Hawash, Hilal Zaid
Summary: The chemical constituents of the flavonoids fraction from Mandragora autumnalis ripe fruit were isolated and identified, and its effects on scavenging free radicals, inhibiting enzymes, cytotoxicity, antimicrobial activity, and antidiabetic activity were evaluated. The results showed that the flavonoids from Mandragora autumnalis have potential medicinal properties for the treatment of various ailments.
Article
Food Science & Technology
Sergio Rojo, Olga Escuredo, Maria Shantal Rodriguez-Flores, Maria Carmen Seijo
Summary: This study analyzed the botanical characteristics of 31 bee pollen samples from Galicia, Spain and found that the plant origin has an influence on the total phenol and flavonoid contents and antioxidant activity of bee pollen. Samples with higher presence of Castanea, Erica, Lythrum, and Campanula types showed higher levels of phenols, flavonoids, and antioxidant activities. On the other hand, Plantago and Taraxacum officinale types had lower content of these compounds and radical scavenging activity. Cluster analysis classified the bee pollen samples into three groups with significant differences in pollen types and nutritional properties. These findings highlight the botanical diversity and potential beneficial properties of bee pollen.
Article
Horticulture
Galia Gentscheva, Iliana Milkova-Tomova, Krastena Nikolova, Dragomira Buhalova, Velichka Andonova, Viliana Gugleva, Nadezhda Petkova, Ina Yotkovska, Nadezhda Ivanova
Summary: This study investigated bioactive compounds in Sambucus nigra L. blossoms and assessed the antioxidant potential of the extracts. The sample from the Rhodope region exhibited the highest antioxidant activity and total content of phenols and flavonols, suggesting that higher altitudes and lower temperatures in mountains may influence the accumulation of secondary metabolites in the blossoms, thereby enhancing their antioxidant potential.
Article
Food Science & Technology
Khaga Raj Sharma, Saroj Adhikari
Summary: This study aimed to investigate the biological activities, phenolic and flavonoid content, and chemical compounds in Artemisia vulgaris root and leaf at different altitudes in Nepal. The results showed that the biological activities of the extracts increased with higher altitudes, and the plants grown at high altitudes are rich sources of secondary metabolites that can combat infectious diseases and diabetes.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Horticulture
Rui M. A. Machado, Isabel Alves-Pereira, Rui Ferreira, Nazim S. Gruda
Summary: The study evaluated the effects of different substrates on spinach yield, phytochemical accumulation, and antioxidant activity. Results showed that coir pith and coir pith + fiber had similar leaf area and fresh yield to peat, but lower shoot dry weight accumulation and leaf chlorophyll in plants grown in coir. Total flavonoid content was higher in different types of coir, while total phenols and antioxidant activity were higher in coir pith.
Article
Biology
Arifa Khanam, Ashfaq Ahmad, Neelam Iftikhar, Qasim Ali, Tabinda Fatima, Farhan Khashim Alswailmi, Abdullah Ijaz Hussain, Sulaiman Mohammed Abdullah Alnasser, Jamshaid Akhtar
Summary: The polyphenols of Salvadora oleoides and Salvadora persica have significant antioxidant, anti-inflammatory, and analgesic activities, suggesting their potential therapeutic use as antioxidant, analgesic, and anti-inflammatory agents.
Article
Environmental Sciences
L. Arab, Y. Hoshika, H. Muller, L. Cotrozzi, C. Nali, M. Tonelli, P. Ache, E. Paoletti, S. Alfarraj, G. Albasher, R. Hedrich, H. Rennenberg
Summary: Chronic ozone exposure leads to carbohydrate deficiency in the roots of date palms, causing oxidative stress and making the roots particularly susceptible to this condition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Shaza M. Al-Massarani, Ali A. El-Gamal, Adnan J. Al-Rehaily, Ebtesam S. Al-Sheddi, Mai M. Al-Oqail, Nida N. Farshori, Alden S. Estep, Nurhayat Tabanca, James J. Becnel
Summary: Chromatographic purification of the alcoholic extract from the Saudi plant Nuxia oppositifolia resulted in the identification of five phenolic compounds, with two flavones and three phenylethanoid glycosides. The insecticidal and free radical scavenging activities of these compounds were evaluated, showing potential as secondary metabolites with lethal adulticidal effects against Ae. aegypti.
Article
Food Science & Technology
Simona Jacimovic, Jelena Popovic-Djordjevic, Beka Saric, Aleksandar Krstic, Violeta Mickovski-Stefanovic, Nebojsa D. Pantelic
Summary: This study evaluated the antioxidant activity and nutritional composition of commercially available dark chocolate samples with different cocoa contents. The results showed that chocolates with higher cocoa percentage exhibited stronger antioxidant activity. The total polyphenol and total flavonoid content of the samples depended on the cocoa content and the addition of dried fruit pieces. Additionally, the chocolates were found to be a good source of minerals such as magnesium, iron, manganese, and copper.
Article
Food Science & Technology
Mario Cavaco, Adriana Duarte, Marta Freitas, Clelia Afonso, Susana Bernardino, Leonel Pereira, Mendelson Martins, Teresa Mouga
Summary: Gelidium corneum, a well-known agarophyte, has high quality agar and interesting nutritional profile with seasonal variations. It is rich in protein and carbohydrates, low in lipids, and has good antioxidant capacity. It shows potential as a food or food supplement due to its attractive resource.
Article
Biochemistry & Molecular Biology
Katarina Simic, Nina Todorovic, Snezana Trifunovic, Zoran Miladinovic, Aleksandra Gavrilovic, Silvana Jovanovic, Natasa Avramovic, Dejan Godevac, Ljubodrag Vujisic, Vele Tesevic, Ljubica Tasic, Boris Mandic
Summary: Schizophrenia is a common mental disorder that significantly impairs patients' functioning and leads to premature death. There are gaps in the understanding and diagnosis of this disease, but personalized and precise approaches are needed for patients through customized medical treatment and reliable monitoring of treatment response. Metabolomic investigations of serum samples of Serbian patients with schizophrenia led to the identification of 26 metabolites/biomarkers for this disorder. These findings provide a good starting point for the establishment of a universal set of biomarkers for schizophrenia, including metabolites that are common among different ethnic and geographic origins.
Article
Engineering, Chemical
Olja Sovljanski, Anja Saveljic, Milica Acimovic, Vanja Seregelj, Lato Pezo, Ana Tomic, Gordana Cetkovic, Vele Tesevic
Summary: The genus Ocimum, particularly Ocimum basilicum, has a long history of traditional medicinal use in Serbia. This study evaluated the antioxidant and antimicrobial potentials of essential oil and hydrolate of two different varieties of Ocimum basilicum from Serbia. The results showed that the essential oils of Ocimum basilicum are rich in bioactive compounds, especially linalool, and have significant biological activities.
Article
Biochemistry & Molecular Biology
Stefan Ivanovic, Katarina Simic, Stefan Lekic, Milka Jadranin, Ljubodrag Vujisic, Dejan Godevac
Summary: This study used Allium ursinum and poisonous adulterants Convallaria majalis and Arum maculaturn as a model to detect adulterants in edible plants. Metabolomic analysis was conducted using H-1 NMR spectroscopy, and biomarkers of adulteration were identified using 2D NMR and LC-MS techniques. Isovitexin, vicenin II, azetidine-2-carboxylic acid, and trigonelline were found to indicate adulteration in A. ursinum samples. The study suggests that the plant metabolomics approach can be used to identify biomarkers of adulteration in edible plants.
Article
Nutrition & Dietetics
Margarita Dodevska, Jelena Kukic Markovic, Ivana Sofrenic, Vele Tesevic, Milica Jankovic, Brizita Djordjevic, Nevena Dj. Ivanovic
Summary: This study examined the similarities and differences in the nutritional composition of nuts and seeds, highlighting seeds as a better source of nutrients compared to nuts. Combining nuts and seeds as part of a healthy dietary pattern would be beneficial.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Milena M. Petrovic, Cornelia Roschger, Kevin Lang, Andreas Zierer, Milan Mladenovic, Snezana Trifunovic, Boris Mandic, Milan D. Joksovic
Summary: Novel quinoline-4-carboxylic acid-chalcone hybrids were synthesized and showed inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) and cytotoxic activity against A375 cells.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Multidisciplinary
Marina M. Maletic, Ana M. Kalijadis, Vladimir Lazovic, SneZana Trifunovic, Biljana M. Babic, Alesandra Dapcevic, Janez Kovac, Marija M. Vukcevic
Summary: N-doped TiO2/carbon composites with different nitrogen content were prepared and characterized. It was found that N doping improved the adsorption capacity but decreased the photocatalytic efficiency. However, TiO2/CN0.05 composite obtained under specific conditions showed high efficiency in removing pollutants.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Valerija Madzgalj, Aleksandar Petrovic, Uros Cakar, Vesna Maras, Ivana Sofrenic, Vele Tesevic
Summary: This study aimed to demonstrate the aromatic profile of wines produced from two native grape cultivars Krstac (K) and Zizak (Z). The use of enzymatic preparations and different skin contact times resulted in increased content of aromatic compounds, particularly 2-phenylethyl and isoamyl alcohols. The wines from both varieties showed higher content of certain acids and esters, which contribute to the fruity aroma and pleasant taste of the wine. Sensory evaluation showed high grades for wines with longer skin contact time.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Marina G. Dimitrijevi, Goran A. Bogdanovi, Snezana Trifunovic, Milan D. Joksovi
Summary: An efficient pTSA-mediated cyclization cascade reaction has been developed for the synthesis of pyrrolo [3,4-c]quinoline-1,3-dione derivatives from Pfitzinger's ester and benzoyl hydrazines. This method avoids the additional step of converting quinoline-3,4-dicarboxylic acids to an anhydride and allows direct reaction of the ester derivative with hydrazine nucleophiles.
Article
Integrative & Complementary Medicine
Stefan Ivanovic, Dejan Godevac, Petar Ristivojevic, Gordana Zdunic, Danilo Stojanovic, Katarina Savikin
Summary: This study investigated the HPTLC profile of different chokeberry samples and identified the main markers responsible for classification using multivariate analysis. The results demonstrated that the HPTLC-based metabolomics approach is a reliable technique for detecting chokeberry adulteration.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Plant Sciences
Ivana Sofrenic, Boban Andelkovic, Dejan Godevac, Stefan Ivanovic, Katarina Simic, Jovana Ljujic, Vele Tesevic, Slobodan Milosavljevic
Summary: Chemotaxonomy in Euphorbia species growing wild in Serbia was studied using H-1 NMR-based metabolomics. Challenges, such as individual genetic and environmental variations, were overcome by applying a holistic approach based on multivariate data analysis. The optimized metabolomics approach revealed chemotaxonomic biomarkers and unique metabolites for each species, confirming the potential of metabolomics in Euphorbia chemotaxonomy.
Article
Integrative & Complementary Medicine
Juliana Scanavacca, Wanessa de Campos Bortolucci, Ezilda Jacomassi, Irineia Paulina Baretta, Maria Graciela Iecher Faria, Carla Maria Mariano Fernandez, Vele Tesevic, Jasmina Glamoclija, Marina Sokovic, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study evaluated the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil. The essential oil showed broad antibacterial and antifungal activity, making it a potential alternative for microbial control.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Biochemistry & Molecular Biology
Milka Jadranin, Natasa Avramovic, Zoran Miladinovic, Aleksandra Gavrilovic, Ljubica Tasic, Vele Tesevic, Boris Mandic
Summary: This study explored and compared the lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C). The results revealed alterations in lipid metabolism in BD patients, highlighting the role of lipid pathways in BD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Valerija Madzgalj, Aleksandar Petrovic, Uros Cakar, Vesna Maras, Ivana Sofrenic, Vele Tesevic
Summary: This study aimed to show the aromatic profile of wines produced from two autochthonous grape cultivars Krstac and Zizak. Skin contact and the use of enzymatic preparations increased the content of aromatic compounds, particularly 2-phenylethyl and isoamyl alcohols. Furthermore, the wines showed increased content of esters responsible for fruity aroma and pleasant taste compared to the control.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jovana Stankovic Jeremic, Dejan Godevac, Stefan Ivanovic, Katarina Simic, Antoaneta Trendafilova, Milica Acimovic, Slobodan Milosavljevic
Summary: The study used HPTLC-based metabolomics to compare metabolite changes during Artemisia annua development, showing that this method is reliable for investigating metabolic changes during plant development.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jovica Brankovic, Vesna M. Milovanovic, Dusica Simijonovic, Sladana Novakovic, Zorica D. Petrovic, Snezana S. Trifunovic, Goran A. Bogdanovic, Vladimir P. Petrovic
Summary: In this study, a series of pyrazolone-type compounds were synthesized and evaluated for their potential as antiviral agents against SARS-CoV-2. The results showed that these compounds exhibited favorable binding affinity towards several proteins of the virus, as well as promising drug-like properties and pharmacokinetic parameters. This research provides valuable insights for further in vitro investigations.
