Article
Microbiology
Ying-Shu Liao, Bo-Han Chen, Ru-Hsiou Teng, You-Wun Wang, Jui-Hsien Chang, Shiu-Yun Liang, Chi-Sen Tsao, Yu-Ping Hong, Hui-Yung Sung, Chien-Shun Chiou
Summary: Research in Taiwan has shown that C. coli and C. jejuni are highly resistant to most therapeutic antimicrobials. Whole-genome sequencing was used to analyze genetic diversity among isolates and genetic resistance determinants associated with antimicrobial resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat
Summary: This preclinical murine intervention study provides initial evidence for the promising treatment option of oral urolithin-A application in acute C. jejuni infection, paving the way for future clinical studies in human campylobacteriosis.
Review
Microbiology
Walid Ghazi Al Hakeem, Shahna Fathima, Revathi Shanmugasundaram, Ramesh K. Selvaraj
Summary: C. jejuni is the leading cause of human foodborne illness associated with poultry, beef, and pork consumption. Horizontal transmission from the environment is considered to be the primary source of C. jejuni in commercial poultry farms. C. jejuni expresses virulence factors regulated by a two-component system that mediates its ability to survive in the host.
Article
Infectious Diseases
Rozan O. Al-Khresieh, Hala Al-Daghistani, Saeid M. Abu-Romman, Lubna F. Abu-Niaaj
Summary: This study investigates the link between human campylobacteriosis and the consumption of potentially contaminated food, finding that chicken meat is the main source of infection. The colonization rate of Campylobacter jejuni in chickens is influenced by the slaughterhouse environment, and antibiotic resistance is widespread among Campylobacter strains.
Article
Gastroenterology & Hepatology
Bilal Djeghout, Samuel J. Bloomfield, Steven Rudder, Ngozi Elumogo, Alison E. Mather, John Wain, Nicol Janecko
Summary: This study investigated the genomic diversity of Campylobacter jejuni within individual stool specimens from four campylobacteriosis patients. The findings show that the C. jejuni population recovered from an individual patient's stool are genetically diverse even within the same sequence type, indicating that patients were likely infected with a heterogeneous C. jejuni population. The diversity of the C. jejuni population found within individual stool specimens can inform future methodological approaches to attribution and outbreak investigations.
Article
Microbiology
Andrea Laconi, Ilenia Drigo, Nicola Palmieri, Lisa Carraro, Elena Tonon, Raffaela Franch, Luca Bano, Alessandra Piccirillo
Summary: The study revealed that Campylobacter isolates from chicken livers possessed a higher number of virulence-associated genes, which might contribute to the development of pathological lesions in these isolates within the host.
VETERINARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bodo Linz, Irshad Sharafutdinov, Nicole Tegtmeyer, Steffen Backert
Summary: Infection with Campylobacter jejuni causes campylobacteriosis, a common gastrointestinal infection. The disease is characterized by diarrhea lasting up to two weeks. C. jejuni possesses various peptidases and proteases that play critical roles in its cellular processes and pathogenesis. These enzymes are involved in protein quality control, protein transport, nutrient acquisition, biofilm formation, and virulence. Understanding the evolution of these proteases and their potential as targets for anti-bacterial therapies is also discussed.
Review
Gastroenterology & Hepatology
Yara El Dessouky, Salma W. Elsayed, Nehal Adel Abdelsalam, Nehal A. Saif, Avelino Alvarez-Ordonez, Mohamed Elhadidy
Summary: Campylobacteriosis is a global public health threat. High-throughput sequencing technologies can improve subtyping and resistance gene detection. The review aims to provide a comprehensive understanding of the epidemiology, clinical presentation, antibiotic resistance, and transmission dynamics of Campylobacter, with a focus on Campylobacter jejuni.
Article
Microbiology
Andrea Laconi, Roberta Tolosi, Ilenia Drigo, Luca Bano, Alessandra Piccirillo
Summary: This study assessed the ability of C. jejuni and C. coli strains isolated from diseased poultry to form biofilm. The results showed that C. jejuni strains were classified as no, weak, and moderate biofilm producers, while all C. coli strains were weak producers. Genes involved in chemotaxis, adhesion, and invasion were present in all C. jejuni strains. Further investigations are needed to better understand the genetic determinants involved in extra-intestinal Campylobacter biofilm formation.
VETERINARY MICROBIOLOGY
(2023)
Article
Microbiology
Luca Robinson, Janie Liaw, Zahra Omole, Dong Xia, Arnoud H. M. van Vliet, Nicolae Corcionivoschi, Abderrahman Hachani, Ozan Gundogdu
Summary: The Type VI Secretion System (T6SS) plays crucial roles in bacterial antagonism, subversion of host cells, and niche colonisation. A unique and conserved T6SS cluster associated with Campylobacter jejuni Integrated Element 3 (CJIE3) was identified as Campylobacter jejuni Pathogenicity Island-1 (CJPI-1), which contains canonical VgrG homologues and a Type II toxin-antitoxin module.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Biochemistry & Molecular Biology
Irshad Sharafutdinov, Nicole Tegtmeyer, Mathias Musken, Steffen Backert
Summary: The study found that the Campylobacter bacteria can disrupt cellular junctions and allow non-invasive microbiota to transmigrate through the paracellular route. This discovery has important implications for understanding Campylobacter-associated diseases such as inflammatory bowel disease.
Article
Gastroenterology & Hepatology
Angelina Kraski, Soraya Mousavi, Markus M. Heimesaat, Stefan Bereswill, Ralf Einspanier, Thomas Alter, Greta Goelz, Soroush Sharbati
Summary: This study explored the regulatory role of miR-125a-5p in the infection process of C. jejuni in the human colon mucosa. It was found that miR-125a-5p can regulate the expression of the sialyltransferase ST3GAL1, thus affecting the host cell response to the infection. Additionally, the miRNA-dependent modulation of mucin-type O-glycosylation may be part of the mucosal immune response.
Article
Biochemistry & Molecular Biology
Stefan Bereswill, Soraya Mousavi, Dennis Weschka, Agnes Buczkowski, Sebastian Schmidt, Markus M. Heimesaat
Summary: The increasing prevalence of food-borne Campylobacter jejuni infections is a serious health issue. Antibiotic therapy is not recommended, so novel treatment options are needed. This study focused on the use of an iron-chelating compound, desferoxamine (DESF), to alleviate the disease in a mouse model of acute campylobacteriosis. The results showed that oral application of DESF improved the clinical outcome of infected mice by reducing colonic cell damage, decreasing neutrophil accumulation, and inhibiting cytokine secretion.
Article
Microbiology
Xiaoqi Zang, Hongyue Lv, Haiyan Tang, Xinan Jiao, Jinlin Huang
Summary: This study analyzed 1609 Campylobacter jejuni isolates from various ecological origins in China. The results showed that disease associated capsular genotypes and LOS classes over-represented in human isolates were also dominant in animals, especially cattle. High-risk lineages CC-22, CC-464, and CC-21, found in human isolates with GBS worldwide, were also present in food animal isolates with disease associated capsular types, indicating a potential clonal spread across different regions and hosts.
FRONTIERS IN MICROBIOLOGY
(2021)