Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey 2007-2016

(2019) Michael Chen-Xu et al.   Arthritis & Rheumatology

TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid

(2019) Junxia Zhang et al.   BIOCHIMIE

Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes

(2019) Bingqing Zhang et al.   Molecular Medicine Reports

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Modulating Macrophage Polarization through CCR2 Inhibition and Multivalent Engagement

(2018) Michael B. Deci et al.   MOLECULAR PHARMACEUTICS

Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease

(2018) Myoungsoo Lee et al.   Immune Network

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

(2018) Irena Kaplanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

(2017) Matthew D. McGeough et al.   JOURNAL OF CLINICAL INVESTIGATION

The shift of macrophages toward M1 phenotype promotes aortic valvular calcification

(2017) Geng Li et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

TNF-α and cancer cachexia: Molecular insights and clinical implications

(2017) Hetal J. Patel et al.   LIFE SCIENCES

Uric acid induces the expression of TNF-α via the ROS-MAPK-NF-κB signaling pathway in rat vascular smooth muscle cells

(2017) Lirong Tang et al.   Molecular Medicine Reports

An overview of pharmacodynamic modelling, ligand-binding approach and its application in clinical practice

(2017) Mohammed Saji Salahudeen et al.   SAUDI PHARMACEUTICAL JOURNAL

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

(2017) Allah Nawaz et al.   Nature Communications

Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population

(2017) Jie Wu et al.   Scientific Reports

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose

(2016) Israel Torres-Castro et al.   IMMUNOLOGY LETTERS

Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition

(2016) Tae Yang Yu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets

(2016) Humaira Rasheed et al.   PLoS One

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

(2016) Michael Zhang et al.   PLoS One

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

(2016) Roselind S. Lam et al.   PLoS One

Mechanism of high affinity inhibition of the human urate transporter URAT1

(2016) Philip K. Tan et al.   Scientific Reports

Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia

(2015) Shinobu Sugihara et al.   CIRCULATION JOURNAL

Effect of TLR4/MyD88 Signaling Pathway on Expression of IL-1βand TNF-αin Synovial Fibroblasts from Temporomandibular Joint Exposed to Lipopolysaccharide

(2015) Xuefen Lin et al.   MEDIATORS OF INFLAMMATION

CD11c+ monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23

(2015) I C Arnold et al.   Mucosal Immunology

Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies

(2015) Zhengtao Liu et al.   Scientific Reports

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

(2015) Wenjie Lu et al.   Scientific Reports

Definition of hyperuricemia and gouty conditions

(2014) Thomas Bardin et al.   CURRENT OPINION IN RHEUMATOLOGY

Decreased Expression of the Fractalkine Receptor CX3CR1 on Circulating Monocytes as New Feature of Sepsis-Induced Immunosuppression

(2014) Alexandre Pachot et al.   JOURNAL OF IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

(2013) Lu Jia et al.   PLoS One

Peripheral Monocyte Expression of the Chemokine Receptors CCR2, CCR5 and CXCR3 is Altered at Parturition in Healthy Women and in Women with Systemic Lupus Erythematosus

(2013) S. Björkander et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

TLR Agonists Stimulate Nlrp3-Dependent IL-1  Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

(2012) Y. He et al.   JOURNAL OF IMMUNOLOGY

Increased Reactive Oxygen Species and Tumor Necrosis Factor-Alpha Production by Monocytes are Associated with Elevated Levels of Uric Acid in Pre-Eclamptic Women

(2011) Maria T. S. Peraçoli et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development

(2011) Akifumi Kushiyama et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus Study

(2011) Tanica Lyngdoh et al.   PLoS One

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE