期刊
BIOMOLECULES
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/biom10030428
关键词
alpha-synuclein; NMR; secondary structure propensity; pre-structured motifs (PreSMos); intrinsically disordered protein
资金
- National Research Council of Science and Technology (NST) by the Korea government (MSIT) [CCL-19-17-KRIBB]
- Marie Sklodowska Curie Initial Training Network (MSC ITN) TRACT (TRAining in Cancer mechanisms and Treatment)
- Seoul National University (SNU)
- National Research Foundation of Korea [2019R1C1C1009685]
- National Research Foundation of Korea [2019R1C1C1009685] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Elucidating the structural details of proteins is highly valuable and important for the proper understanding of protein function. In the case of intrinsically disordered proteins (IDPs), however, obtaining the structural details is quite challenging, as the traditional structural biology tools have only limited use. Nuclear magnetic resonance (NMR) is a unique experimental tool that provides ensemble conformations of IDPs at atomic resolution, and when studying IDPs, a slightly different experimental strategy needs to be employed than the one used for globular proteins. We address this point by reviewing many NMR investigations carried out on the alpha-synuclein protein, the aggregation of which is strongly correlated with Parkinson's disease.
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