Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection

Construction of a pneumolysin deficient mutant in streptococcus pneumoniae serotype 1 strain 519/43 and phenotypic characterisation

(2020) Vanessa S. Terra et al.   MICROBIAL PATHOGENESIS

Serotype-Independent Protection Against Invasive Pneumococcal Infections Conferred by Live Vaccine With lgt Deletion

(2019) A-Yeung Jang et al.   Frontiers in Immunology

Phase 1 trial of a 20-valent pneumococcal conjugate vaccine in healthy adults

(2019) Allison Thompson et al.   VACCINE

Next-Generation Whole-Cell Pneumococcal Vaccine

(2019) Morais et al.   Vaccines

Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4

(2018) Kosuke Nagai et al.   CELLULAR IMMUNOLOGY

A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice

(2018) Dandan Wang et al.   IMMUNOLOGICAL INVESTIGATIONS

Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice

(2018) Rui Tada et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular characterization of predominant Streptococcus pneumoniae serotypes causing invasive infections in Canada: the SAVE study, 2011–15

(2018) Alyssa R Golden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection

(2018) Tasson C. Rodrigues et al.   PLoS One

Immunogenicity and mechanisms of action of PnuBioVax, a multi-antigen serotype-independent prophylactic vaccine against infection with Streptococcus pneumoniae

(2018) Sue Hill et al.   VACCINE

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

(2018) M. Georgieva et al.   mBio

Effectiveness of the 13-valent pneumococcal conjugate vaccine against adult pneumonia in Italy: a case–control study in a 2-year prospective cohort

(2018) Rosa Prato et al.   BMJ Open

Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity

(2018) Danielle A. Wagner-Muñiz et al.   Frontiers in Immunology

Effectiveness and impact of the 10-valent pneumococcal conjugate vaccine, PHiD-CV: review of clinical trials and post-marketing experience

(2018) Tomas Mrkvan et al.   Expert Review of Vaccines

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants

(2018) David Greenberg et al.   VACCINE

Broad protective immune responses elicited by bacterium-like particle-based intranasal pneumococcal particle vaccine displaying PspA2 and PspA4 fragments

(2018) Jingcai Lu et al.   Human Vaccines & Immunotherapeutics

Impact of the 10-valent pneumococcal conjugate vaccine on antimicrobial prescriptions in young children: a whole population study

(2018) Elias Eythorsson et al.   BMC INFECTIOUS DISEASES

Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection

(2018) Kosuke Nagai et al.   VACCINE

Immunization with attenuated non-transformable pneumococcal pep27 and comD mutant provides serotype-independent protection against pneumococcal infection

(2018) Se-Jin Kim et al.   VACCINE

The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccine

(2018) Reshmi Mukerji et al.   VACCINE

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation

(2018) Franziska Voß et al.   Frontiers in Immunology

Development of pneumococcal vaccines over the last 10 years

(2017) Nicola Principi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

(2017) Michael E. Pichichero   Expert Review of Vaccines

Streptococcus pneumoniae serotype 19A: worldwide epidemiology

(2017) Raul Isturiz et al.   Expert Review of Vaccines

Impact of pneumococcal conjugate vaccines for children in high- and non–high-income countries

(2017) Robert Cohen et al.   Expert Review of Vaccines

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B

(2017) K. Aaron Geno et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Intranasal Immunization With an Attenuated pep27 Mutant Provides Protection From Influenza Virus and Secondary Pneumococcal Infections

(2017) Seung Han Seon et al.   JOURNAL OF INFECTIOUS DISEASES

Transcutaneous immunization with pneumococcal surface protein A in mice

(2017) Hiromi Nagano et al.   LARYNGOSCOPE

Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination

(2017) Rafał J. Mostowy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model

(2017) Maria Vetro et al.   Nanomedicine

Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

(2017) Aderonke Odutola et al.   VACCINE

Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial

(2017) Claire Entwisle et al.   VACCINE

Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism

(2017) Lucian Visan et al.   Human Vaccines & Immunotherapeutics

Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model

(2017) Agus Haryono et al.   Journal of Immunology Research

Effectiveness of pneumococcal vaccines in preventing pneumonia in adults, a systematic review and meta-analyses of observational studies

(2017) Myint Tin Tin Htar et al.   PLoS One

Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis

(2017) Evelyn Balsells et al.   PLoS One

A 32-Year Study of the Effect of Pneumococcal Vaccines on Invasive Streptococcus pneumoniae Disease

(2016) Ronald J. Stanek et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Prevention of Antibiotic-Nonsusceptible Invasive Pneumococcal Disease With the 13-Valent Pneumococcal Conjugate Vaccine

(2016) Sara Tomczyk et al.   CLINICAL INFECTIOUS DISEASES

Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA

(2016) B.J. Metcalf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses

(2016) JuliaE. Vela Ramirez et al.   Journal of Biomedical Nanotechnology

The effectiveness of pneumococcal polysaccharide vaccine 23 (PPV23) in the general population of 50 years of age and older: A systematic review and meta-analysis

(2016) Hannah Kraicer-Melamed et al.   VACCINE

Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen

(2016) Philippe Hermand et al.   Human Vaccines & Immunotherapeutics

Interim results of an ecological experiment — Conjugate vaccination against the pneumococcus and serotype replacement

(2016) William P Hausdorff et al.   Human Vaccines & Immunotherapeutics

Noninvasive Streptococcus pneumoniae Serotypes Recovered from Hospitalized Adult Patients in the United States in 2009 to 2012

(2015) Rodrigo E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis in US Children

(2015) Liset Olarte et al.   CLINICAL INFECTIOUS DISEASES

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles

(2015) Nitesh K. Kunda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Capsule Switching and Antimicrobial Resistance Acquired during Repeated Streptococcus pneumoniae Pneumonia Episodes

(2015) Bin Chang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance

(2015) Matthew R Moore et al.   LANCET INFECTIOUS DISEASES

Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

(2015) Y Fukuyama et al.   Mucosal Immunology

Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young children

(2015) Q Xu et al.   Mucosal Immunology

Mucosal Immunization with PsaA Protein, Using Chitosan as a Delivery System, Increases Protection Against Acute Otitis Media and Invasive Infection byStreptococcus pneumoniae

(2015) J.-H. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

(2015) W. Abdullah Brooks et al.   VACCINE

Safety, tolerability, and immunogenicity of 15-valent pneumococcal conjugate vaccine in healthy adults

(2015) Richard McFetridge et al.   VACCINE

Passive protection of mice againstStreptococcus pneumoniaechallenge by naturally occurring and vaccine-induced human anti-PhtD antibodies

(2015) Roger H Brookes et al.   Human Vaccines & Immunotherapeutics

Reactogenicity, safety and immunogenicity of a protein-based pneumococcal vaccine in Gambian children aged 2–4 years: A phase II randomized study

(2015) A Odutola et al.   Human Vaccines & Immunotherapeutics

Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

(2015) Yashuan Chao et al.   Frontiers in Cellular and Infection Microbiology

Identification of Proteins in Streptococcus pneumoniae by Reverse Vaccinology and Genetic Diversity of These Proteins in Clinical Isolates

(2014) Ana Paula Corrêa Argondizzo et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Contributions to Protection from Streptococcus pneumoniae Infection Using the Monovalent Recombinant Protein Vaccine Candidates PcpA, PhtD, and PlyD1 in an Infant Murine Model during Challenge

(2014) David Verhoeven et al.   Clinical and Vaccine Immunology

Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

(2014) Ravinder Kaur et al.   INFECTION AND IMMUNITY

Future Streptococcus pneumoniae vaccines

(2014) M. Alderson   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Influences of process and formulation parameters on powder flow properties and immunogenicity of spray dried polymer particles entrapping recombinant pneumococcal surface protein A

(2014) Chakkumkal Anish et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

What is behind the ear drum? The microbiology of otitis media and the nasopharyngeal flora in children in the era of pneumococcal vaccination

(2014) Nikki Mills et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Community-Acquired Pneumonia

(2014) Daniel M. Musher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study

(2014) Geert Leroux-Roels et al.   VACCINE

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model

(2014) David Verhoeven et al.   VACCINE

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles

(2013) Shannon L. Haughney et al.   Acta Biomaterialia

The history of pneumococcal conjugate vaccine development: dose selection

(2013) Jan T Poolman et al.   Expert Review of Vaccines

CD4 T Cell Memory and Antibody Responses Directed against the Pneumococcal Histidine Triad Proteins PhtD and PhtE following Nasopharyngeal Colonization and Immunization and Their Role in Protection against Pneumococcal Colonization in Mice

(2013) M. N. Khan et al.   INFECTION AND IMMUNITY

Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae

(2013) Il Gyu Kong et al.   INFECTION AND IMMUNITY

Pneumococcal vaccine and opsonic pneumococcal antibody

(2013) Joon Young Song et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability

(2013) Viviane M. Gonçalves et al.   VACCINE

Vaccine process technology

(2012) Jessica O. Josefsberg et al.   BIOTECHNOLOGY AND BIOENGINEERING

Serotype-independent pneumococcal vaccines

(2012) Eliane Namie Miyaji et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Issues and challenges in the development of pneumococcal protein vaccines

(2012) Amy Sarah Ginsburg et al.   Expert Review of Vaccines

PspK of Streptococcus pneumoniae Increases Adherence to Epithelial Cells and Enhances Nasopharyngeal Colonization

(2012) L. E. Keller et al.   INFECTION AND IMMUNITY

Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology

(2012) Jordan S. Orange et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

LytA, Major Autolysin ofStreptococcus pneumoniae, Requires Access to Nascent Peptidoglycan

(2012) Peter Mellroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pneumococcal Capsular Switching: A Historical Perspective

(2012) K. L. Wyres et al.   JOURNAL OF INFECTIOUS DISEASES

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates

(2012) Lorenzo Monasta et al.   PLoS One

Effect of Serotype on Focus and Mortality of Invasive Pneumococcal Disease: Coverage of Different Vaccines and Insight into Non-Vaccine Serotypes

(2012) Albert Jan van Hoek et al.   PLoS One

Effective protection against secondary pneumococcal pneumonia by oral vaccination with attenuated Salmonella delivering PspA antigen in mice

(2012) Sang-Uk Seo et al.   VACCINE

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

Nontypeable Pneumococci Can Be Divided into Multiple cps Types, Including One Type Expressing the Novel Gene pspK

(2012) I. H. Park et al.   mBio

Biochemical Characterization of the Histidine Triad Protein PhtD as a Cell Surface Zinc-Binding Protein of Pneumococcus

(2011) Elodie Loisel et al.   BIOCHEMISTRY

What is different about serotype 1 pneumococci?

(2011) Neil D Ritchie et al.   Future Microbiology

Bacterial Meningitis in the United States, 1998–2007

(2011) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

The future of pneumococcal disease prevention

(2011) Gail L. Rodgers et al.   VACCINE

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Selection of family 1 PspA molecules capable of inducing broad-ranging cross-reactivity by complement deposition and opsonophagocytosis by murine peritoneal cells

(2011) Cibelly Goulart et al.   VACCINE

Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice

(2011) Eun-Hye Kim et al.   VACCINE

Pneumococcal Polysaccharide Conjugate Vaccine (13-Valent, Adsorbed) [Prevenar 13®]†

(2011) Sean T. Duggan   PEDIATRIC DRUGS

Capsules ofStreptococcus pneumoniaeand Other Bacteria: Paradigms for Polysaccharide Biosynthesis and Regulation

(2010) Janet Yother   Annual Review of Microbiology

Immunization of Mice with Single PspA Fragments Induces Antibodies Capable of Mediating Complement Deposition on Different Pneumococcal Strains and Cross-Protection

(2010) A. T. Moreno et al.   Clinical and Vaccine Immunology

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization byStreptococcus pneumoniae

(2010) Jianghong Xu et al.   Clinical and Vaccine Immunology

Streptococcus pneumoniae: virulence factors and variation

(2010) A.M. Mitchell et al.   CLINICAL MICROBIOLOGY AND INFECTION

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

The Proline-Rich Region of Pneumococcal Surface Proteins A and C Contains Surface-Accessible Epitopes Common to All Pneumococci and Elicits Antibody-Mediated Protection against Sepsis

(2010) C. C. Daniels et al.   INFECTION AND IMMUNITY

Continued control of pneumococcal disease in the UK - the impact of vaccination

(2010) R. A. Gladstone et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

(2010) Maria Leonor S. Oliveira et al.   PLoS One

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

(2010) Ying-Jie Lu et al.   VACCINE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

(2010) Claudio Donati et al.   GENOME BIOLOGY

Efficacy of pneumococcal vaccination in adults: a meta-analysis

(2009) A. Huss et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Pneumococcal Conjugate Vaccine, Polysaccharide Vaccine, or Both for Adults? We’re Not There Yet

(2009) Katherine L. O’Brien   CLINICAL INFECTIOUS DISEASES

Pneumococcal conjugated vaccine: PHiD-CV

(2009) Ener Cagri Dinleyici et al.   Expert Review of Anti-Infective Therapy

10-valent pneumococcal nontypeableHaemophilus influenzaePD conjugate vaccine: Synflorix™

(2009) Roman Prymula et al.   Expert Review of Vaccines

Pneumolysin Localizes to the Cell Wall of Streptococcus pneumoniae

(2009) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

(2009) Tom van der Poll et al.   LANCET

Effect of Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis

(2009) Heather E. Hsu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

(2009) Zitta B. Harboe et al.   PLOS MEDICINE

Comparison of Pneumococcal Conjugate Polysaccharide and Free Polysaccharide Vaccines in Elderly Adults: Conjugate Vaccine Elicits Improved Antibacterial Immune Responses and Immunological Memory

(2008) Andrés de Roux et al.   CLINICAL INFECTIOUS DISEASES

Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway

(2008) J. Yuste et al.   INFECTION AND IMMUNITY

Chitosan formulations improve the immunogenicity of a GnRH-I peptide-based vaccine

(2008) Leonardo Sáenz et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A comparison of homologous recombination rates in bacteria and archaea

(2008) Michiel Vos et al.   ISME Journal

Pneumococcal whole-cell vaccine: optimization of cell growth of unencapsulated Streptococcus pneumoniae in bioreactor using animal-free medium

(2008) C. Liberman et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY