Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Article
Orthopedics
Andrea Schwab, Marinus A. Wesdorp, Jietao Xu, Florencia Abinzano, Claudia Loebel, Marc Falandt, Riccardo Levato, David Eglin, Roberto Narcisi, Martin J. Stoddart, Jos Malda, Jason A. Burdick, Matteo D'Este, Gerjo J. V. M. Van Osch
Summary: This study investigates the influence of various physicochemical properties of hydrogels on cell migration and related tissue formation using in vitro, ex vivo and in vivo models.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Materials Science, Biomaterials
Yue Zhu, Jialin Chen, Haoyang Liu, Wei Zhang
Summary: In this review, the authors systematically summarize the different types and physicochemical properties of photo-cross-linked hydrogels and explore the biological properties modulated through the incorporation of additives. The applications of photo-cross-linked hydrogels in cartilage and osteochondral repair are compiled and the current limitations and future perspectives of these hydrogels are also discussed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Cell & Tissue Engineering
Wenhui Zhang, Aoling Du, Shun Liu, Mingyue Lv, Shenghua Chen
Summary: dECM and hydrogels are widely used in regenerative medicine as biocompatible materials with unique biological activity. Hydrogels, with their high water content and ability to simulate human tissue environments, are considered ideal materials for tissue engineering.
REGENERATIVE THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Afarin Neishabouri, Alireza Soltani Khaboushan, Faezeh Daghigh, Abdol-Mohammad Kajbafzadeh, Masoumeh Majidi Zolbin
Summary: Reproduction of different tissues using scaffolds and materials is an important aspect of regenerative medicine. Decellularized extracellular matrix (dECM) has been used for the goal of regenerating whole organs. Recently, decellularization techniques have been widely utilized in producing suitable scaffolds for damaged organ regeneration. The advantages of decellularized ECM include preserved natural microenvironment features. Different decellularization methods have been developed for specific tissues to remove cells. Evaluation techniques have also been advanced to improve the efficacy of decellularization methods. Modification techniques enhance the characteristics of decellularized scaffolds for damaged tissue regeneration and other applications. However, challenges still exist in the field of decellularization methods and scaffold application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Charlot Philips, Lisanne Terrie, Lieven Thorrez
Summary: A review is presented on the progress and challenges in skeletal muscle decellularization, discussing different decellularization methods and applications of the scaffolds. Decellularized skeletal muscle has been primarily studied for regenerative purposes, focusing on tissue-specific morphological features and biochemical cues for muscle regeneration. However, this review expands the potential applications of decellularized skeletal muscle to demonstrate its versatility as a biomaterial.
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Markel Lafuente-Merchan, Sandra Ruiz-Alonso, Fatima Garcia-Villen, Idoia Gallego, Patricia Galvez-Martin, Laura Saenz-del-Burgo, Jose Luis Pedraz
Summary: This article reviews the advantages of using 3D bioprinting techniques for osteochondral regeneration, discusses the commonly used biomaterials, cell types, and active molecules, and considers the most recent promising results.
Article
Biochemistry & Molecular Biology
Viki Raz Lepsky, Sari Natan, Oren Tchaicheeyan, Avraham Kolel, Merav Zussman, Meital Zilberman, Ayelet Lesman
Summary: The study found that the addition of cells to fibrin gels slightly decreased drug release, with cellular activities affecting the release profile while forces generated by cells and matrix deformation had minimal impact on release profiles.
Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Murugan Prasathkumar, Subramaniam Sadhasivam
Summary: Biomaterials play a crucial role in regenerative medicine, enhancing tissue development, repair, angiogenesis, and wound healing. These bioactive compounds derived from natural resources like chitosan, hyaluronic acid, alginate, etc., exhibit significant effects in wound healing and antimicrobial activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Greta Ionela Barbulescu, Florina Maria Bojin, Valentin Laurentiu Ordodi, Iacob Daniel Goje, Andreea Severina Barbulescu, Virgil Paunescu
Summary: Cardiovascular diseases are the leading cause of global mortality. Decellularized cardiac extracellular matrix (dECM) has shown promise in tissue-regenerative medicine, but proper assessment of tissue composition and recellularization with organ-specific cells remain challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Weixing Chen, Yue Ming, Min Wang, Mingshu Huang, Hongyu Liu, Yisheng Huang, Zhijie Huang, Ling Qing, Qin Wang, Bo Jia
Summary: Regenerative medicine aims to transform clinical medicine through curative strategies, and the development of this field relies on multifunctional biomaterials. Hydrogels, which resemble the natural extracellular matrix and have good biocompatibility, are of interest in bioengineering and medical research. However, traditional hydrogels lack sufficient internal structure and cross-linking modes to achieve desired functions and stability. Introducing multifunctional nanomaterials into 3D hydrogel networks addresses these limitations and enables the display of various functionalities.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Review
Engineering, Biomedical
Kamil Elkhoury, Margaretha Morsink, Laura Sanchez-Gonzalez, Cyril Kahn, Ali Tamayol, Elmira Arab-Tehrany
Summary: Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
You-Rong Chen, Xin Yan, Fu-Zhen Yuan, Jing Ye, Bing-Bing Xu, Zhu-Xing Zhou, Zi-Mu Mao, Jian Guan, Yi-Fan Song, Ze-Wen Sun, Xin-Jie Wang, Ze-Yi Chen, Ding-Yu Wang, Bao-Shi Fan, Meng Yang, Shi-Tang Song, Dong Jiang, Jia-Kuo Yu
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Zhu-Xing Zhou, You-Rong Chen, Ji-Ying Zhang, Dong Jiang, Fu-Zhen Yuan, Zi-Mu Mao, Fei Yang, Wen-Bo Jiang, Xing Wang, Jia-Kuo Yu
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Orthopedics
Yi-Fan Song, Hai-Jun Wang, Xin Yan, Fu-zhen Yuan, Bing-Bing Xu, You -Rong Chen, Jing Ye, Bao-Shi Fan, Jia-Kuo Yu
Summary: Based on the literature review, the outcomes of MPFLR with or without TTO to treat recurrent or habitual patellar dislocation with an increased TT-TG distance appeared similar. The postoperative outcomes, congruence angles, and redislocation rates were comparable between the two surgical techniques.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
Zimu Mao, Jian Wang, Yongjian Wang, Dong Jiang, Xinjie Wang, Haijun Wang, Lin Lin, Yang Liu, Lin Zeng, Jiakuo Yu
Summary: The study compared the long-term clinical outcomes of single-bundle and double-bundle anterior cruciate ligament reconstruction in patients with isolated ACL rupture, showing that the double-bundle group had advantages in objective outcome measures and was superior in preventing cartilage degeneration. Age was identified as a preoperative risk factor for significant postoperative cartilage degeneration.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
Hai-Jun Wang, Yi-Fan Song, Xin Yan, Fei Wang, Jian Wang, Yong-Jian Wang, Lin Lin, Yang Liu, Song-Bo Han, Jia-Kuo Yu
Summary: The study aimed to analyze the anatomical landmarks of Schottle's point and establish a locating method for identification. The results demonstrated that Schottle's point was approximately 8 mm distal to the apex of the adductor tubercle and 8 mm from the posterior edge. The locating method without fluoroscopy showed high accuracy in MPFL reconstructions.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Meng Yang, Xin Yan, Fu-Zhen Yuan, Jing Ye, Ming-Ze Du, Zi-Mu Mao, Bing-Bing Xu, You-Rong Chen, Yi-Fan Song, Bao-Shi Fan, Jia-Kuo Yu
Summary: The research demonstrates that miR-210-3p promotes chondrogenic differentiation and inhibits adipogenic differentiation of BMMSCs through the HIF-3 alpha signaling pathway, providing a promising new therapeutic target for cartilage regeneration.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Biotechnology & Applied Microbiology
Zimu Mao, Baoshi Fan, Xinjie Wang, Ximeng Huang, Jian Guan, Zewen Sun, Bingbing Xu, Meng Yang, Zeyi Chen, Dong Jiang, Jiakuo Yu
Summary: The use of tissue engineering scaffold, especially biomaterials, has shown significant effectiveness in tendon-bone healing and can be enhanced by biological interventions. Current research is mainly focused on animal models, calling for further clinical trials to explore the full potential of these approaches in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
Junjie Xu, Kang Han, Thay Q. Lee, Caiqi Xu, Wei Su, Jiebo Chen, Jiakuo Yu, Shikui Dong, Jinzhong Zhao
Summary: ACL reconstruction alone does not restore intact knee kinematics in knees with concurrent ACL tears and severe ALS injury. Both ACL-ALSR and ACLR+LET procedures restore knee stability at certain flexion degrees, with ACL-ALSR resulting in less restriction in internal rotation.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Review
Cell & Tissue Engineering
Bao-Shi Fan, Yang Liu, Ji-Ying Zhang, You-Rong Chen, Meng Yang, Jia-Kuo Yu
Summary: The study summarized the 5C basic principles for establishing modern standardized stem cell banks and discussed the applications of stem cells in managing sports injuries. Proposing these principles will benefit in standardizing stem cell research and establishing modern stem cell banks, while the establishment of stem cell banks can help the scientific community cope with the difficulty of obtaining stem cell samples.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Polymer Science
Jian Guan, Fu-zhen Yuan, Zi-mu Mao, Hai-lin Zhu, Lin Lin, Harry Huimin Chen, Jia-kuo Yu
Summary: The 3D-printed PEGDA-GelMA-CSMA scaffolds not only possess adequate mechanical strength, but also maintain a suitable 3D microenvironment for differentiation, proliferation, and extracellular matrix production of bone marrow mesenchymal stem cells (BMSCs).
Article
Pharmacology & Pharmacy
Fu-Zhen Yuan, Hu-Fei Wang, Jian Guan, Jiang-Nan Fu, Meng Yang, Ji-Ying Zhang, You-Rong Chen, Xing Wang, Jia-Kuo Yu
Summary: This study successfully fabricated PLGA microspheres loaded with KGN and CMC-OCS hydrogel, forming CMC-OCS/MPs scaffold. The MPs showed significant collapse after ultrasound treatment and sustained release of KGN. Compared to scaffolds with only CMC-OCS, CMC-OCS@MPs scaffolds exhibited improved mechanical properties and drug release capabilities.
Review
Orthopedics
Ding-yu Wang, Cassandra A. Lee, Yan-zhang Li, Bo Zhang, Nan Li, Dong Jiang, Jia-kuo Yu
Summary: The systematic review found that severe cartilage damage is associated with decreased survivorship of meniscal allograft transplant (MAT). Factors such as sex, surgical side, concomitant ACL reconstruction showed no relationship with survivorship, while BMI, tobacco use, and arthroscopic versus open procedure had no influence on survivorship. There were conflicting and limited evidence for some determinants, warranting further study, particularly on older age.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Xin Yan, Bo Yang, Yourong Chen, Yifan Song, Jing Ye, Yufan Pan, Bini Zhou, Yuqing Wang, Fengbiao Mao, Yuanchen Dong, Dongsheng Liu, Jiakuo Yu
Summary: The DNA supramolecular hydrogel has been shown to provide excellent protection for MSCs against shear forces, promoting quality cartilage formation, reducing osteophyte formation, and normalizing subchondral bone under high friction conditions of OA. This material has potential as a promising cell delivery system for various MSCs therapies.
ADVANCED MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Meng Yang, Rong-Hui Deng, Fu-Zhen Yuan, Ji-Ying Zhang, Zi-Ning Zhang, You-Rong Chen, Jia-Kuo Yu
Summary: This study investigates the use of cell adhesion peptide-modified polyethylene glycol (PEG) hydrogels as scaffolds for cartilage repair. The results show that cysteine-arginine-glycine-aspartic acid (CRGD) can enhance the interaction between peripheral blood mesenchymal stem cells (PBMSCs) and PEG hydrogels, promoting chondrogenic differentiation and tissue regeneration.
