Review
Immunology
Zena Wehbe, Maya Wehbe, Rabah Iratni, Gianfranco Pintus, Hassan Zaraket, Hadi M. Yassine, Ali H. Eid
Summary: The slow roll-out and insufficient supply of COVID-19 vaccines remain a challenge, while therapeutic options are also important in addition to vaccines. Repurposed drugs like ivermectin are being sought as potential treatments for COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Hoda Awad, Basmala Hassan, Sara Dweek, Yasmeen Aboelata, Mutasem Rawas-Qalaji, Iman Saad Ahmed
Summary: The literature review suggests that ivermectin has certain value in the treatment of mild COVID-19 cases and is more effective as a prophylactic agent. Recent trials have also explored the use of novel nasal formulations of ivermectin.
Review
Chemistry, Medicinal
Jacopo Cusinato, Ylenia Cau, Anna Maria Calvani, Mattia Mori
Summary: Drug repurposing has played a crucial role in accelerating clinical trials and shortening regulatory review times in response to the COVID-19 pandemic, with remdesivir being the first specific antiviral drug approved for treatment. Other drugs like corticosteroids and LMWH are also being used, while ongoing research aims to deliver optimized therapeutic tools for future epidemics.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)
Review
Gastroenterology & Hepatology
Tarik Asselah, David Durantel, Eric Pasmant, George Lau, Raymond F. Schinazi
Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.
JOURNAL OF HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pedro N. Batalha, Luana S. M. Forezi, Carolina G. S. Lima, Fernanda P. Pauli, Fernanda C. S. Boechat, Maria Cecilia B. V. de Souza, Anna C. Cunha, Vitor F. Ferreira, Fernando de C. da Silva
Summary: The article discusses the chemical aspects of drugs studied as candidates for COVID-19 therapy, providing a comprehensive overview for the chemical community.
BIOORGANIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Lucia Prieto Santamaria, Marina Diaz Uzquiano, Esther Ugarte Carro, Nieves Ortiz-Roldan, Yuliana Perez Gallardo, Alejandro Rodriguez-Gonzalez
Summary: This review presents a data-driven drug repositioning process that associates COVID-19-related genes and symptoms with drugs, resulting in a list of 13 potential candidates against COVID-19. The therapeutic potential of these drugs is supported by published studies and clinical trials.
DRUG DISCOVERY TODAY
(2022)
Review
Infectious Diseases
Saverio Paltrinieri, Alessia Giordano, Angelica Stranieri, Stefania Lauzi
Summary: Feline infectious peritonitis (FIP) and COVID-19, caused by coronaviruses, share some similar pathogenic and immunopathogenic events. Preventive measures recommended for preventing SARS-CoV-2 spread have also shown success in eradicating FIP in feline households. Additionally, the therapeutic compound GS-441524, effective against FIP, is the active form of Remdesivir used as a therapeutic option for COVID-19.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Multidisciplinary Sciences
Puneet Rawat, Divya Sharma, Ambuj Srivastava, Vani Janakiraman, M. Michael Gromiha
Summary: Researchers compared experimentally verified SARS-CoV-2 neutralizing antibodies with commercial therapeutic monoclonal antibodies and identified three potential therapeutic antibodies targeting CTLA4 and IL17A for combating severe SARS-CoV-2 infection. These candidate antibodies have dual activities of viral neutralization and immunosuppression, and could also be utilized in diagnostic test kits for SARS-CoV-2 infection. The in silico workflow to screen and analyze antibodies for repurposing is believed to have broad applications.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Farshad M. Shirazi, Roya Mirzaei, Samaneh Nakhaee, Amir Nejatian, Shokouh Ghafari, Omid Mehrpour
Summary: The global COVID-19 pandemic has led to changes in behavior and the evaluation of potential therapies, including ivermectin. While ivermectin appears to be safe with minimum side effects, there are still serious questions about its effectiveness in treating patients with COVID-19.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Carmen Mirabelli, Jesse W. Wotring, Charles J. Zhang, Sean M. McCarty, Reid Fursmidt, Carla D. Pretto, Yuanyuan Qiao, Yuping Zhang, Tristan Frum, Namrata S. Kadambi, Anya T. Amin, Teresa R. O'Meara, Jason R. Spence, Jessie Huang, Konstantinos D. Alysandratos, Darrell N. Kotton, Samuel K. Handelman, Christiane E. Wobus, Kevin J. Weatherwax, George A. Mashour, Matthew J. O'Meara, Arul M. Chinnaiyan, Jonathan Z. Sexton
Summary: Drug repurposing is an effective method for rapidly identifying drugs against SARS-CoV-2. Research has found that lactoferrin can inhibit virus infection in multiple cell models, showing potential for treating COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Dan-Yang Liu, Jia-Chen Liu, Shuang Liang, Xiang-He Meng, Jonathan Greenbaum, Hong-Mei Xiao, Li-Jun Tan, Hong-Wen Deng
Summary: A pharmacologic and transcriptomic approach was used to screen drug candidates novel for COVID-19 treatment, resulting in the identification of individual drug candidates and synergistic drug combinations. Most repurposing drugs significantly impacted B cells. The findings may accelerate the discovery of an effective therapeutic treatment plan for COVID-19 patients.
Review
Pharmacology & Pharmacy
Lianxiang Luo, Qin Qiu, Fangfang Huang, Kaifeng Liu, Yongqi Lan, Xiaoling Li, Yuge Huang, Liao Cui, Hui Luo
Summary: This article summarizes the current status of drug repurposing in COVID-19, which includes virtual computer screening, network pharmacology, and bioactivity-based drug repurposing, as a potentially beneficial treatment option for COVID-19.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Biochemistry & Molecular Biology
Kawthar Mohamed, Niloufar Yazdanpanah, Amene Saghazadeh, Nima Rezaei
Summary: This systematic review provides an overview of studies using computational methods for drug repurposing in COVID-19, highlighting existing drugs with the potential to impact SARS-CoV2 through various mechanisms and the need for further clinical research to determine their efficacy in treating COVID-19.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemical Research Methods
Hilal Tayara, Ibrahim Abdelbaky, Kil To Chong
Summary: The global increase in deaths due to the COVID-19 pandemic caused by SARS-CoV-2 has prompted researchers to urgently seek potential treatments using computational methods and artificial intelligence techniques. This review discusses promising studies utilizing Omics-based data and AI algorithms as well as other computational tools to combat the pandemic.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Chemistry, Multidisciplinary
Rosa Aghdam, Mahnaz Habibi, Golnaz Taheri
Summary: COVID-19, caused by SARS-CoV-2, lacks specific treatments. This study proposes a computational drug repurposing approach using existing drugs for COVID-19 treatment, identifying potential candidate drugs for therapy.
JOURNAL OF CHEMINFORMATICS
(2021)
Article
Chemistry, Medicinal
Chun-Feng Chang, Wen-Hsing Lin, Yi-Yu Ke, Yih-Shyan Lin, Wen-Chieh Wang, Chun-Hwa Chen, Po-Chu Kuo, John T. A. Hsu, Biing-Jiun Uang, Hsing-Pang Hsieh
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Yi-Yu Ke, Chun-Ping Chang, Wen-Hsing Lin, Chia-Hua Tsai, I-Chen Chiu, Wan-Ping Wang, Pei-Chen Wang, Pei-Yi Chen, Wen-Hsin Lin, Chun-Feng Chang, Po-Chu Kuo, Jen-Shin Song, Chuan Shih, Hsing-Pang Hsieh, Ya-Hui Chi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Tsung-Sheng Wu, Wen-Hsing Lin, Hui-Jen Tsai, Ching-Cheng Hsueh, Tsu Hsu, Pei-Chen Wang, Hui-You Lin, Yi-Hui Peng, Cheng-Tai Lu, Lung-Chun Lee, Chih-Hsiang Tu, Fang-Chun Kung, Hui-Yi Shiao, Teng-Kuang Yeh, Jen-Shin Song, Jia-Yu Chang, Yu-Chieh Su, Li-Tzong Chen, Chiung-Tong Chen, Weir -Torn Jiaang, Su-Ying Wu
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Shu-Yu Lin, Yung Chang Hsu, Yi-Hui Peng, Yi-Yu Ke, Wen-Hsing Lin, Hsu-Yi Sun, Hui-Yi Shiao, Fu-Ming Kuo, Pei-Yi Chen, Tzu-Wen Lien, Chun-Hwa Chen, Chang-Ying Chu, Sing-Yi Wang, Kai-Chia Yeh, Ching-Ping Chen, Tsu-An Hsu, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Hsing-Pang Hsieh
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shu-Yu Lin, Chun-Feng Chang, Mohane Selvaraj Coumar, Pei-Yi Chen, Fu-Ming Kuo, Chun-Hwa Chen, Mu-Chun Li, Wen-Hsing Lin, Po-Chu Kuo, Sing-Yi Wang, An-Siou Li, Chin-Yu Lin, Chen-Ming Yang, Teng-Kuang Yeh, Jen-Shin Song, John T. A. Hsu, Hsing-Pang Hsieh
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Hui-Yi Shiao, Ching-Chuan Kuo, Tsu Hsu, Cheng-Tai Lu, Pei-Chen Wang, Tsung-Sheng Wu, Yi-Hui Peng, Hui-You Lin, Ching-Ping Chen, Ya-Ling Weng, Fang-Chun Kung, Mine-Hsine Wu, Yu-Chieh Su, Kuo-Wei Huang, Ling-Hui Chou, Ching-Cheng Hsueh, Kuei-Jung Yen, Po-Chu Kuo, Chen-Lung Huang, Li-Tzong Chen, Chuan Shih, Hui-Jen Tsai, Weir-Torn Jiaang
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Cheng-Wei Yang, Tzu-Ting Peng, Hsing-Yu Hsu, Yue-Zhi Lee, Szu-Huei Wu, Wen-Hsing Lin, Yi-Yu Ke, Tsu-An Hsu, Teng-Kuang Yeh, Wen-Zheng Huang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
BIOMEDICAL JOURNAL
(2020)
Article
Chemistry, Medicinal
Ya-Hui Chi, Teng-Kuang Yeh, Yi-Yu Ke, Wen-Hsing Lin, Chia-Hua Tsai, Wan-Ping Wang, Yen-Ting Chen, Yu-Chieh Su, Pei-Chen Wang, Yan-Fu Chen, Zhong-Wei Wu, Jen-Yu Yeh, Ming-Chun Hung, Mine-Hsine Wu, Jing-Ya Wang, Ching-Ping Chen, Jen-Shin Song, Chuan Shih, Chiung-Tong Chen, Chun-Ping Chang
Summary: The study describes the design and synthesis of pyrimidine-based derivatives that can inhibit Aurora A kinase activity and reduce levels of MYC-family oncoproteins. Compound 25, resulting from pharmacokinetic optimization, demonstrated oral bioavailability and effectively reduced cMYC protein levels, showing potential for treatment of MYC-amplified cancers.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Mu-Chun Li, Wen-Hsing Lin, Pei-Chen Wang, Yu-Chieh Su, Pei-Yi Chen, Chu-Min Fan, Ching-Ping Chen, Chen-Lung Huang, Chun-Hsien Chiu, Ling Chang, Chiung-Tong Chen, Teng-Kuang Yeh, Hsing-Pang Hsieh
Summary: The rare oncogenic NTRK gene fusions result in uncontrolled TRK signaling, leading to various solid tumors in adults and children. Compound 39, designed and synthesized based on the architecture of the multi-targeted clinical candidate BPR1K871, showed high selectivity for TRKA, potent cellular activity, good oral bioavailability, and in vivo efficacy in a xenograft model, making it a promising next-generation, selective, orally-administered type II TRK inhibitor.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Kun-Hung Lee, Wan-Ching Yen, Wen-Hsing Lin, Pei-Chen Wang, You-Liang Lai, Yu-Chieh Su, Chun-Yu Chang, Cai-Syuan Wu, Yu-Chen Huang, Chen-Ming Yang, Ling-Hui Chou, Teng-Kuang Yeh, Chiung-Tong Chen, Chuan Shih, Hsing-Pang Hsieh
Summary: The study describes the discovery of orally active and selective CSF1R inhibitors, demonstrating their potent anti-tumor effects through in vivo experiments. By utilizing molecular docking and structural studies, the researchers were able to enhance the potency of the inhibitors and alter the tumor microenvironment to increase the M1/M2 ratio.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Meeting Abstract
Oncology
Ya-Hui Chi, Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Mine-Hsine Wu, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiung-Tong Chen, Chuan Shih
Meeting Abstract
Oncology
Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Dai-Hui Jhuo, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Po-Chu Kuo, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiun-Tong Chen, Chuan Shih, Ya-Hui Chi
Meeting Abstract
Oncology
Ya-Hui Chi, Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Hsing-Pang Hsieh
Meeting Abstract
Chemistry, Multidisciplinary
Hsing-Pang Hsieh, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Wen-Hsing Lin, John T. -A. Hsu, Chiung-Tong Chen, Teng-Kuang Yeh
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)