Article
Multidisciplinary Sciences
Christopher S. Wilson, Emilee M. Hoopes, Alexander C. Falk, Daniel J. Moore
Summary: The immune system of healthy individuals is capable of regulating autoimmunity. However, in Type 1 Diabetes (T1D), natural IgM is unable to perform its normal immunoregulatory function. Treating diabetic mice with IgM from healthy donors or an IgM-enriched preparation called Pentaglobin can reverse the disease and boost protective immunity.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Jun Wang, Miriam Erlacher, Juncal Fernandez-Orth
Summary: Under inflammatory conditions, steady-state hematopoiesis switches to emergency myelopoiesis, leading to different forms of cell death and other changes in the hematopoietic system, ultimately causing loss of hematopoiesis function. In individuals with inherited bone marrow failure syndromes or immune-mediated aplastic anemia, chronic inflammatory signals may aggravate disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Nianji Yang, Matthew J. Moore, Praveesuda L. Michael, Miguel Santos, Yuen Ting Lam, Shisan Bao, Martin K. C. Ng, Jelena Rnjak-Kovacina, Richard P. Tan, Steven G. Wise
Summary: The study demonstrates that scaffold architecture can modulate immune responses to drive BM-MNC engraftment, with higher porosity scaffold enhancing the homing and engraftment of BM-MNCs. Histological analysis shows that HP scaffolds lead to thicker fibrous capsule formation and increased collagen deposition, with more native immune cells present compared to LP scaffolds. Different scaffold structures impact local inflammation and drive differential engraftment and remodeling behavior of infused BM-MNCs.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Oncology
Chiara Brignole, Fabio Pastorino, Patrizia Perri, Loredana Amoroso, Veronica Bensa, Enzo Calarco, Mirco Ponzoni, Maria Valeria Corrias
Summary: In children with metastatic neuroblastoma, the survival rate remains low despite aggressive treatments. Understanding the interaction between BM-infiltrating NB cells and the BM environment may help identify mechanisms for survival of metastatic cells, and new therapeutics targeting the microenvironment could improve outcomes. The unique nature of metastatic NB cells and the presence of multiple mechanisms favoring immune evasion underscore the need for synergistic immune therapy approaches.
Article
Geriatrics & Gerontology
Jingwen Tian, Hyo Kyun Chung, Ji Sun Moon, Ha Thi Nga, Ho Yeop Lee, Jung Tae Kim, Joon Young Chang, Seul Gi Kang, Dongryeol Ryu, Xiangguo Che, Je-Yong Choi, Masayuki Tsukasaki, Takayoshi Sasako, Sang-Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: Defects in muscle mitochondrial OxPhos promote bone marrow inflammation in mice, leading to decreased bone mass. Muscle mitochondrial dysfunction is linked to bone marrow inflammatory cytokine secretion via the CXCL12-CXCR4 signaling axis, which is critical for inducing low bone mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
David F. Moreno, Arturo Pereira, Natalia Tovar, Maria Teresa Cibeira, Laura Magnano, Maria Rozman, Monica Lopez-Guerra, Dolors Colomer, Beatriz Martin-Antonio, Raquel Jimenez-Segura, Ignacio Isola, Luis Gerardo Rodriguez-Lobato, Aina Oliver-Caldes, Mari Pau Mena, Laura Rosinol, Joan Blade, Carlos Fernandez de Larrea
Summary: This study analyzed 171 patients with asymptomatic IgM monoclonal gammopathies and found immunoparesis and bone marrow infiltration as biomarkers of progression. A risk model based on these two risk factors was developed, identifying an ultra-low risk group for progression.
Review
Pharmacology & Pharmacy
Kudzai Nyamondo, Helen Wheadon
Summary: This review explores the interactions between micro-environment and the hematopoietic system in adults, specifically focusing on the impact of bone marrow micro-environment on aging, age-related clonal hematopoiesis, and the development of myeloid malignancies. Additionally, the possible role of age-related clonal hematopoiesis and chronic inflammatory conditions in altering the dynamics of the bone marrow micro-environment is discussed.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexandra N. Rindone, Xiaonan Liu, Stephanie Farhat, Alexander Perdomo-Pantoja, Timothy F. Witham, Daniel L. Coutu, Mei Wan, Warren L. Grayson
Summary: Vascularization plays a critical role in cranial bone growth, maintenance, and healing. The study utilized a quantitative imaging platform to analyze the spatial relationship between blood vessels and skeletal progenitors in the murine calvarium, demonstrating specific vessel types are spatially correlated with skeletal progenitors during various cranial processes. Furthermore, the findings suggest a potential role for osteoclasts in maintaining the native cranial microvascular environment.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Hisashi Nomura, Naoko Wada, Hayato Takahashi, Yuko Kase, Jun Yamagami, Shohei Egami, Hisato Iriki, Miho Mukai, Aki Kamata, Hiromi Ito, Hideki Fujii, Tomoyuki Ishikura, Haruhiko Koseki, Takashi Watanabe, Taketo Yamada, Osamu Ohara, Shigeo Koyasu, Masayuki Amagai
Summary: The study reveals that Dsg3-specific B cells in mice do not undergo spontaneous pathogenic class switching in vivo and the induction of pemphigus phenotype is prevented under normal conditions.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Zhengxia Wang, Wei Liu, Huidi Hu, Jingxian Jiang, Chen Yang, Xijie Zhang, Qi Yuan, Xiaofan Yang, Mao Huang, Yanming Bao, Ningfei Ji, Mingshun Zhang
Summary: This study found that decreased expression of CD146 in pulmonary tissues is associated with increased inflammatory response in pulmonary cryptococcosis. Furthermore, CD146 deficiency worsens the infection by C. neoformans.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Martin Kohn, Christian Lanfermann, Robert Laudeley, Silke Glage, Claudia Rheinheimer, Andreas Klos
Summary: Recent research has shown that complement plays a crucial role in immune responses against intracellular pathogens like viruses. Experiments combining bone marrow transfer and challenge tests indicate that non-myeloid-derived, circulating/systemic C3 is the key player in protecting against Chlamydia psittaci-induced pneumonia in mice, particularly in developing pathogen-specific T- and B-cell responses. Myeloid-derived C3, on the other hand, has a minor, mainly fine-tuning role in this process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Joseph H. Oved, Andrew J. Paris, Kandace Gollomp, Ning Dai, Kathryn Rubey, Ping Wang, Lynn A. Spruce, Steven H. Seeholzer, Mortimer Poncz, G. Scott Worthen
Summary: Neutrophils play a critical role in sterile inflammation, engulfing and degrading extracellular DNA fragments to facilitate optimal organ repair.
Article
Biochemistry & Molecular Biology
Luana Tripodi, Davide Molinaro, Francesco Fortunato, Carolina Mella, Barbara Cassani, Yvan Torrente, Andrea Farini
Summary: This study demonstrates that ONX-0914, a selective inhibitor of the PSMB8 subunit of immunoproteasome, improves pathological traits associated with muscle wasting in a mouse model of Duchenne muscular dystrophy. It reduces inflammation, increases regulatory T cells, and buffers oxidative stress, ultimately leading to a decrease in fibrosis. This suggests that ONX-0914 could be a promising therapeutic approach for slowing down muscle mass loss in dystrophic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jiro Ikeda, Corey A. Scipione, Sharon J. Hyduk, Marwan G. Althagafi, Jawairia Atif, Sarah A. Dick, Maneesha Rajora, Erika Jang, Takuo Emoto, Junichi Murakami, Noriko Ikeda, Hisham M. Ibrahim, Chanele K. Polenz, Xiaotang Gao, Kelly Tai, Jenny Jongstra-Bilen, Ryota Nakashima, Slava Epelman, Clinton S. Robbins, Gang Zheng, Warren L. Lee, Sonya A. MacParland, Myron Cybulsky
Summary: This study revealed that radiation exposure inhibits LDL entry into the aortic intima at baseline and the earliest stages of atherosclerosis in a mouse model of bone marrow transplantation. Single-cell transcriptomic analysis showed a redirection of LDL uptake by endothelial cells to lysosomal degradation and reverse cholesterol transport pathways, reducing lipid accumulation within the intima and impacting lesion initiation and growth.
CIRCULATION RESEARCH
(2021)
Article
Allergy
Kelly Bruton, Paul Spill, Shabana Vohra, Owen Baribeau, Saba Manzoor, Siyon Gadkar, Malcolm Davidson, Tina D. Walker, Joshua F. E. Koenig, Yosef Ellenbogen, Alexandra Florescu, Jianping Wen, Derek K. Chu, Susan Waserman, Rodrigo Jimenez-Saiz, Slava Epelman, Clinton Robbins, Manel Jordana
Summary: The study found that blocking IL-4/IL-13 signaling can abort IgE production and skew the cytokine response away from a type 2 signature. T(H)2A cells identified by single-cell RNA sequencing expanded with peanut stimulation and maintained their pathogenic phenotype.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Tharini Sivasubramaniyam, Jiaqi Yang, Henry S. Cheng, Alexandra Zyla, Angela Li, Rickvinder Besla, Idit Dotan, Xavier S. Revelo, Sally Yu Shi, Helen Le, Stephanie A. Schroer, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Daniella Febbraro, Isabelle Ruel, Jacques Genest, Raymond H. Kim, Tak W. Mak, Daniel A. Winer, Clinton S. Robbins, Minna Woo
Summary: Research has shown that Dj1-deficient mice are protected against atherosclerosis, potentially through enhanced anti-inflammatory responses, suggesting that targeting Dj1 may provide a novel therapeutic avenue for treating atherosclerosis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Summary: The study found that aortic macrophage accumulation in abdominal aortic aneurysm (AAA) is primarily caused by adventitial recruitment of Lyve-1(-) macrophages, with a relative depletion of Lyve-1(+) macrophages. Selective targeting of macrophage subtypes may represent a potential novel therapeutic avenue for the medical treatment of AAA.
Article
Immunology
Pooja Mehta, Victoire Gouirand, Devi P. Boda, Jingxian Zhang, Sofia Gearty, Bahar Zirak, Margaret M. Lowe, Sean Clancy, Ian Boothby, Kelly M. Mahuron, Adam Fries, Matthew F. Krummel, Parminder Mankoo, Hsin-Wen Chang, Jared Liu, Joshua M. Moreau, Tiffany C. Scharschmidt, Adil Daud, Esther Kim, Isaac M. Neuhaus, Hobart W. Harris, Wilson Liao, Michael D. Rosenblum
Summary: The study identifies LAYN (layilin) as preferentially expressed on a subset of activated Tregs in human skin, with a role in facilitating Treg adhesion and limiting their suppressive capacity. This mechanism may influence Treg motility and immune regulation in nonlymphoid tissues, potentially guiding therapeutic strategies for immune modulation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Joshua M. Moreau, Miqdad O. Dhariwala, Victoire Gouirand, Devi P. Boda, Ian C. Boothby, Margaret M. Lowe, Jarish N. Cohen, Courtney E. Macon, John M. Leech, Lokesh A. Kalekar, Tiffany C. Scharschmidt, Michael D. Rosenblum
Summary: Skin T-regs play a crucial role in regulating inflammation and protecting skin immunity, influencing epithelial cell biology through integrin and TGF-beta pathways. After skin injury, they activate TGF-beta and promote inflammation responses to protect the host from infection.
SCIENCE IMMUNOLOGY
(2021)
Article
Cell Biology
Eva Kaufmann, Nargis Khan, Kim A. Tran, Antigona Ulndreaj, Erwan Pernet, Ghislaine Fontes, Andreanne Lupien, Patrice Desmeules, Fiona McIntosh, Amina Abow, Simone J. C. F. M. Moorlag, Priya Debisarun, Karen Mossman, Arinjay Banerjee, Danielle Karo-Atar, Mina Sadeghi, Samira Mubareka, Donald C. Vinh, Irah L. King, Clinton S. Robbins, Marcel A. Behr, Mihai G. Netea, Philippe Joubert, Maziar Divangahi
Summary: A study found that while BCG vaccine can provide protection against influenza virus, it is ineffective against SARS-CoV-2. This may be due to the unique pulmonary vasculature damage caused by SARS-CoV-2, which facilitates the virus to spread to other organs, including the central site for BCG-induced trained immunity. In addition, individuals vaccinated with BCG show a strong immune response to influenza virus but minimal response to SARS-CoV-2.
Article
Immunology
Sarah A. Dick, Anthony Wong, Homaira Hamidzada, Sara Nejat, Robert Nechanitzky, Shabana Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, Abdul Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, Sarah Q. Crome, Burkhard Becher, Myron Cybulsky, Filio Billia, Shaf Keshavjee, Seema Mital, Clint S. RobbillS, Tak W. Mak, Slava Epelman
Summary: This study reveals the existence of three macrophage subpopulations in mice based on common life cycle properties and core gene signatures. These subpopulations are present in multiple tissues and TLF+ macrophages show the highest transcriptional conservation.
SCIENCE IMMUNOLOGY
(2022)
Article
Biology
Idit Dotan, Jiaqi Yang, Jiro Ikeda, Ziv Roth, Evan Pollock-Tahiri, Harsh Desai, Tharini Sivasubramaniyam, Sonia Rehal, Josh Rapps, Yu Zhe Li, Helen Le, Gedaliah Farber, Edouard Alchami, Changting Xiao, Saraf Karim, Marcela Gronda, Michael F. Saikali, Amit Tirosh, Kay-Uwe Wagner, Jacques Genest, Aaron D. Schimmer, Vikas Gupta, Mark D. Minden, Carolyn L. Cummins, Gary F. Lewis, Clinton Robbins, Jenny Jongstra-Bilen, Myron Cybulsky, Minna Woo
Summary: Deficiency of macrophage Jak2 accelerates atherosclerosis primarily due to defects in cholesterol efflux from macrophages.
COMMUNICATIONS BIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S. Robbins, Hiroya Kawai, Ken-ichi Hirata
Article
Immunology
Takuo Emoto, Jessie Lu, Tharini Sivasubramaniyam, Hassaan Maan, Aniqa B. Khan, Amina A. Abow, Stephanie A. Schroer, Sharon J. Hyduk, Marwan G. Althagafi, Trevor D. McKee, Fred Fu, Shiva Shabro, Antigona Ulndreaj, Felix Chiu, Elvira Paneda, Shaun Pacheco, Tao Wang, Angela Li, Jean X. Jiang, Peter Libby, Mansoor Husain, Bo Wang, Barry B. Rubin, Myron I. Cybulsky, Clinton S. Robbins
Summary: Macrophage colony stimulating factor-1 (CSF-1) plays a critical role in maintaining myeloid lineage cells. This study reveals that CSF-1 is involved in bone development and monocyte survival, differentiation, and migration. It also shows that CSF-1 is provided by sinusoidal endothelial cells and perivascular mesenchymal stromal cells to support monocytes.
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Madison Moss, Mariela Pauli, Joshua M. Moreau, Jarish N. Cohen, Michael D. Rosenblum, Margaret M. Lowe
Summary: The human skin xenograft model is an important option for translational research in skin immunology. This paper provides an optimized technique for transplanting human skin onto mice and discusses necessary considerations for downstream experimental aims. Adherence to these methods allows for maintenance of xenografts for over 6 weeks post-surgery, facilitating experimental characterization of human skin and preclinical testing of compounds in vivo.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biology
Parastoo Boroumand, David C. Prescott, Tapas Mukherjee, Philip J. Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y. Zhu, Zhi Liu, Clinton Robbins, Dana J. Philpott, Stephen E. Girardin, Amira Klip
Summary: During obesity and high fat-diet feeding, there is an increase in pro-inflammatory macrophages in adipose tissue as well as invasive Ly6C(high) monocytes produced by the bone marrow. This study explores the relationship between bone marrow adipocytes and Ly6C(high) monocytes, and finds that the whitening of bone marrow adipocytes precedes the rise of adipose tissue macrophages during high fat-diet feeding in mice. Ex vivo treatment of bone marrow cells with conditioned media from bone marrow adipocytes or white adipocytes also favors the presence of Ly6C(high) monocytes. Furthermore, there is a metabolic reprogramming and mitochondrial fission in monocytes before the shift towards Ly6C(high) phenotype.
Article
Biochemistry & Molecular Biology
Jeff E. Glasgow, James R. Byrnes, Susannah D. Barbee, Joshua M. Moreau, Michael D. Rosenblum, James A. Wells
Summary: Layilin is a transmembrane receptor that bridges extracellular ligands with the cytoskeleton through its interaction with talin. Recent studies have shown that Layilin is upregulated in T cells in multiple disease states, indicating its importance in adaptive immune response. However, little is known about its precise role in mediating extracellular interactions and its modulation in disease states. This study identified Layilin's interaction with certain glycosylated collagens through its dependence on calcium ions, and generated species cross-reactive antibodies to block this interaction using a differential phage display strategy.
CELL CHEMICAL BIOLOGY
(2022)