Article
Biochemistry & Molecular Biology
Olga Porembskaya, Vsevolod Zinserling, Vladimir Tomson, Yana Toropova, Eleonora A. Starikova, Vitaliy V. Maslei, Nika Bulavinova, Olga Kirik, Marina A. Syrtsova, Leonid Laberko, Maxim Galchenko, Vyacheslav Kravchuk, Sergey Saiganov, Alexander Brill
Summary: This study demonstrated that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the deep vein thrombosis (DVT) setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Mattes Becher, Thomas Heller, Sarah Schwarzenboeck, Jens-Christian Kroeger, Marc-Andre Weber, Felix G. Meinel
Summary: In this study, the prevalence of negative venous leg ultrasound in acute PE was investigated, with almost half of patients showing no signs of DVT. Negative venous ultrasound was more common in patients without DVT history, lower D-dimer levels, PE diagnosed with V/P-SPECT rather than CT, and more peripherally located PE.
Article
Medicine, General & Internal
Paul D. Stein, Fadi Matta, Mary J. Hughes
Summary: The study found that patients with deep venous thrombosis involving the inferior vena cava had higher in-hospital mortality than those with thrombosis at other locations. Mortality rates were similar between patients with pelvic vein deep venous thrombosis and proximal lower extremity deep venous thrombosis, with thrombolytic treatment showing reduced mortality. Pulmonary embolism occurred at a considerable rate regardless of the site of deep venous thrombosis.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ahmad Mahmoud, Katarina Glise Sandblad, Christina E. Lundberg, Gustaf Hellsen, Per Olof Hansson, Martin Adiels, Annika Rosengren
Summary: Overweight and obesity rates have increased, especially among the younger population. This study investigated the association between body mass index (BMI) in early pregnancy and the long-term risk of venous thromboembolism (VTE) in women. The results showed that higher BMI was associated with an increased risk of VTE. Even women with high normal BMI had a higher risk compared to lean women, while severe obesity was associated with a significantly elevated risk.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Zhen-Yi Jin, Chun-Min Li, Kai Zheng, Hong Qu, Wen-Tao Yang, Jia-Hao Wen, Wang-De Zhang, Hua-Liang Ren
Summary: This study found a high incidence of isolated distal deep venous thrombosis (IDDVT) concurrent with pulmonary embolism (PE) in gynecologic inpatients. Glucocorticoid therapy, hypertension, diabetes, and body mass index (BMI) were identified as independent risk factors for IDDVT patients with PE. A nomogram risk prediction model based on these factors was developed to facilitate early detection of concurrent PE.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Hematology
Amelie Gabet, Clemence Grave, Philippe Tuppin, Joseph Emmerich, Valerie Olie
Summary: The COVID-19 pandemic in 2020 had a significant impact on the epidemiology of VT and PE in France, leading to a decrease in the rate of patients hospitalized for PE and a threefold increase in related inpatient mortality rates. This emphasizes the importance of raising awareness about PE symptoms and the need for immediate medical care, especially for those infected with SARS-CoV-2.
THROMBOSIS RESEARCH
(2021)
Article
Nutrition & Dietetics
Shuai Yuan, Xue Li, Pierre-Emmanuel Morange, Maria Bruzelius, Susanna C. Larsson
Summary: This study used Mendelian randomization to investigate the causal associations between circulating fatty acids and risk of venous thromboembolism (VTE). The results showed that several fatty acids were negatively associated with VTE risk, while a few fatty acids were positively associated. The study provides guidance for prevention strategies targeting fatty acids.
Article
Cardiac & Cardiovascular Systems
Annie Brink, Johan Elf, Peter J. J. Svensson, Gunnar Engstrom, Olle Melander, Bengt Zoller
Summary: This study aimed to investigate whether there are sex-specific differences in risk factors for noncancer-related DVT and PE in middle-aged and older individuals. The results showed that anthropometric obesity measures were more strongly associated with DVT and PE in women than in men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Rheumatology
Viktor Molander, Hannah Bower, Thomas Frisell, Johan Askling
Summary: This study found a strong association between clinical RA disease activity and the risk of VTE, with RA patients having a significantly higher risk compared to non-RA individuals. Additionally, the risk of VTE in RA patients increased with higher disease activity levels, indicating that RA disease activity can be used as an additional tool for stratifying VTE risk in these patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Gastroenterology & Hepatology
Adam S. Faye, Kate E. Lee, John Dodson, Joshua Chodosh, David Hudesman, Feza Remzi, Jason D. Wright, Alexander M. Friedman, Aasma Shaukat, Timothy Wen
Summary: VTE-associated hospitalisations are increasing among patients with inflammatory bowel disease (IBD), and are associated with factors such as age, sex, type of IBD, race, and chronic corticosteroid use. Continued efforts for education and risk reduction are crucial.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Hematology
Nicolas Wenger, Tim Sebastian, Jurg H. Beer, Lucia Mazzolai, Drahomir Aujesky, Daniel Hayoz, Rolf P. Engelberger, Wolfgang Korte, Davide Voci, Nils Kucher, Stefano Barco, David Spirk
Summary: The study found differences in demographics, risk factors, and clinical outcomes between PE and DVT alone. Management of anticoagulation duration differs between the two manifestations of VTE in routine clinical practice, contrary to recommendations in the current consensus guidelines.
THROMBOSIS RESEARCH
(2022)
Review
Psychiatry
Xuan Di, Muyi Chen, Su Shen, Xiangli Cui
Summary: This study found that the use of antipsychotic drugs (APs) may increase the risk of venous thromboembolism (VTE), regardless of whether they are first-generation or second-generation APs. Low-potency FGAs have a greater impact on VTE risk compared to high-potency FGAs, and the risk of VTE is three times higher in young patients compared to the elderly.
PSYCHIATRY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Moriaki Inoko, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Takao Kato, Koh Ono, Takeshi Kimura
Summary: There is a lack of data on management strategies and clinical outcomes after recurrent venous thromboembolism (VTE). In this study, the population was divided into three groups and active cancer and sub-optimal intensity of anticoagulation therapy were identified as major factors contributing to recurrent VTE.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Anna Gluba-Brzozka, Janusz Lawinski, Magdalena Rysz-Gorzynska, Jacek Rysz
Summary: VTE, consisting of DVT and PE, is a major cause of cardiovascular disease. Current diagnosis and treatment guidance for VTE are limited, and there is a lack of understanding of the mechanisms and pathways responsible for the occurrence of observed alterations. The application of metabolomics profiling may play a significant role in early diagnosis and management, but more research is needed to fully understand VTE-related metabolic changes.
Article
Hematology
Omri Snir, Line Wilsgard, Nadezhda Latysheva, Casper J. E. Wahlund, Sigrid K. Braekkan, Kristian Hindberg, John-Bjarne Hansen
Summary: This study reveals an association between plasma levels of PDMVs and the risk of future VTE, suggesting a role of platelet activation in the pathogenesis of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
G. Curigliano, D. Lenihan, M. Fradley, S. Ganatra, A. Barac, A. Blaes, J. Herrmann, C. Porter, A. R. Lyon, P. Lancellotti, A. Patel, J. DeCara, J. Mitchell, E. Harrison, J. Moslehi, R. Witteles, M. G. Calabro, R. Orecchia, E. de Azambuja, J. L. Zamorano, R. Krone, Z. Iakobishvili, J. Carver, S. Armenian, B. Ky, D. Cardinale, C. M. Cipolla, S. Dent, K. Jordan
ANNALS OF ONCOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Thomas M. Maddox, Yang Song, Joseph Allen, Paul S. Chan, Adeela Khan, Jane J. Lee, Joshua Mitchell, William J. Oetgen, Angelo Ponirakis, Claire Segawa, John A. Spertus, Fran Thorpe, Salim S. Virani, Frederick A. Masoudi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Multidisciplinary Sciences
Joshua D. Mitchell, Brian F. Gage, Nicole Fergestrom, Eric Novak, Todd C. Villines
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Critical Care Medicine
Lisa K. Moores, Tobias Tritschler, Shari Brosnahan, Marc Carrier, Jacob F. Collen, Kevin Doerschug, Aaron B. Holley, David Jimenez, Gregoire Le Gal, Parth Rali, Philip Wells
Letter
Critical Care Medicine
Junad M. Chowdhury, Huaqing Zhao, Lisa K. Moores, Parth Rali
Editorial Material
Cardiac & Cardiovascular Systems
Joshua D. Mitchell
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Oncology
Brian A. Van Tine, Angela C. Hirbe, Peter Oppelt, Ashley E. Frith, Richa Rathore, Joshua D. Mitchell, Fei Wan, Shellie Berry, Michele Landeau, George A. Heberton, John Gorcsan, Peter R. Huntjens, Yoku Soyama, Justin M. Vader, Jose A. Alvarez-Cardona, Kathleen W. Zhang, Daniel J. Lenihan, Ronald J. Krone
Summary: This study reported the interim analysis of a phase II trial testing the upfront use of dexrazoxane with doxorubicin in soft-tissue sarcoma patients. The results showed that dexrazoxane did not reduce progression-free survival, and did not increase cardiotoxicity in patients receiving doxorubicin treatment. Involvement of cardio-oncologists is beneficial for monitoring and safe use of high-dose anthracyclines in soft-tissue sarcoma patients.
CLINICAL CANCER RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Srilakshmi Vallabhaneni, Kathleen W. Zhang, Jose A. Alvarez-Cardona, Joshua D. Mitchell, Henning Steen, Pamela K. Woodard, Daniel J. Lenihan
Summary: Cardiovascular magnetic resonance (CMR) plays a crucial role in cardio-oncology by identifying early signs of potential chemotherapy-related cardiac dysfunction and guiding appropriate treatment. Multiparametric analysis with myocardial strain and tissue characterization is essential for addressing important clinical questions in this field.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Review
Oncology
Joshua D. Mitchell, Daniel A. Cehic, Marita Morgia, Carmen Bergrom, Joanne Toohey, Patricia A. Guerrero, Maros Ferencik, Robin Kikuchi, Joseph R. Carver, Vlad G. Zaha, Jose A. Alvarez-Cardona, Sebastian Szmit, Andres J. Daniele, Juan Lopez-Mattei, Lili Zhang, Jorg Herrmann, Anju Nohria, Daniel J. Lenihan, Susan F. Dent
Summary: Radiation therapy is a key component of cancer treatment, but can have long-term cardiovascular effects such as atherosclerosis and valvular dysfunction. The International Cardio-Oncology Society provides recommendations on cardiovascular management and follow-up, emphasizing early detection of atherosclerotic vascular disease for preventive therapy.
JACC: CARDIOONCOLOGY
(2021)
Review
Oncology
Carmen Bergom, Julie A. Bradley, Andrea K. Ng, Pamela Samson, Clifford Robinson, Juan Lopez-Mattei, Joshua D. Mitchell
Summary: Radiation therapy is crucial in cancer treatment, but radiation-induced cardiac dysfunction remains a concern. Utilizing advanced technology like cardiac imaging and cardiovascular risk assessment can help reduce cardiac risks and guide post-radiotherapy care. Further personalizing radiotherapy based on enhanced dosimetry and comprehensive cardiac toxicity data can minimize cardiac dysfunction.
JACC: CARDIOONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Aamir Javaid, Joshua D. Mitchell, Todd C. Villines
Summary: The study revealed that coronary artery calcium (CAC) is prevalent in low-risk young adults, and individuals with any CAC have higher risks of cardiovascular events and myocardial infarction. Severe CAC is associated with increased risks for all outcomes including death. CAC may be useful for clinical decision-making in select young adults.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Douglas Kyrouac, Walter Schiffer, Brandon Lennep, Nicole Fergestrom, Kathleen W. Zhang, John Gorcsan, Daniel J. Lenihan, Joshua D. Mitchell
Summary: The accuracy of apical-sparing strain pattern on transthoracic echocardiography (TTE) for predicting cardiac amyloidosis (CA) varies depending on the patient cohort. Apical sparing increased the likelihood of diagnosing CA with modest sensitivity and specificity. GLS/EF ratio may be a more reliable screening tool for CA, indicating a need for improved practice and disease awareness.
Article
Cardiac & Cardiovascular Systems
Natasha K. Wolfe, Joshua D. Mitchell, David L. Brown
Summary: This study aimed to investigate the association of GDMT adherence with long-term mortality in patients with CAD and HFrEF. The results showed that GDMT was independently associated with a significant reduction in mortality, regardless of revascularization with CABG. Strategies to improve GDMT adherence are needed to maximize survival in this population.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2021)
Review
Medicine, General & Internal
Kathleen W. Zhang, Srilakshmi Vallabhaneni, Jose A. Alvarez-Cardona, Ronald J. Krone, Joshua D. Mitchell, Daniel J. Lenihan
Summary: Cardiac amyloidosis is increasingly recognized as an underdiagnosed cause of heart failure, leading to potential diagnostic delays. Early diagnosis is crucial for improving clinical outcomes, highlighting the importance of primary care providers' awareness to enhance timely diagnosis and early treatment.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Oncology
Kathleen W. Zhang, Jennifer Miao, Joshua D. Mitchell, Jose Alvarez-Cardona, Kelsey Tomasek, Yan Ru Su, Mary Gordon, R. Frank Cornell, Daniel J. Lenihan
JACC: CARDIOONCOLOGY
(2020)