Article
Neurosciences
Ziying Zhu, Xiaona Zhang, Haojie Hao, Heran Xu, Jun Shu, Qian Hou, Min Wang
Summary: Exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) play a key role in promoting wound repair and skin regeneration by recruiting and stimulating fibroblasts to secrete nerve growth factors (NGFs) for skin nerve repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Ziying Zhu, Yujun Zhang, Zhihua Huang, Haojie Hao, Muyang Yan
Summary: We found that small extracellular vesicles (sEVs) produced from umbilical cord mesenchymal stem cells (MSC-sEVs) cultured under hypoxia can promote repair and regeneration of peripheral nerve injury (PNI). These findings suggest that MSC-sEVs may be a promising therapeutic drug candidate for PNI treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yanjun Guan, Zhiqi Ren, Boyao Yang, Wenjing Xu, Wenjun Wu, Xiangling Li, Tieyuan Zhang, Dongdong Li, Shengfeng Chen, Jun Bai, Xiangyu Song, Zhibo Jia, Xing Xiong, Songlin He, Chaochao Li, Fanqi Meng, Tong Wu, Jian Zhang, Xiuzhi Liu, Haoye Meng, Jiang Peng, Yu Wang
Summary: Autologous nerve grafting is the gold standard treatment for peripheral nerve defects, but its limited availability and donor area destruction restrict its widespread use. Tissue-engineered neural regeneration materials have been developed, and in this study, a modified poly-caprolactone/silk fibroin material with extracellular matrix (ECM) derived from human umbilical cord mesenchymal stem cells (hUMSCs) was successfully fabricated. The biomimetic material showed excellent biological properties, supporting Schwann cell anchorage, axon regeneration, and angiogenesis processes. Additionally, the dual-bionic material bridged peripheral nerve defects in rats similarly to autologous nerve transplantation. This study provides a new concept for designing neural regeneration materials with potential clinical applications.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding
Summary: This study found that Exo(-)FBS-cultured HUCMSCs have similar characteristics to FBS-cultured HUCMSCs and showed better therapeutic effects in a mouse osteoarthritis model. These findings provide a basis for future clinical trials using Exo(-)FBS-cultured stem cells for the treatment of osteoarthritis.
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Review
Cell & Tissue Engineering
Oldouz Shareghi-oskoue, Leili Aghebati-Maleki, Mehdi Yousefi
Summary: Premature ovarian failure (POF) is a problem for women before the age of 40, characterized by symptoms such as amenorrhea and low estrogen levels. The current treatment approach involves stem cell therapy, particularly HUCMSC transplantation, which has shown to effectively improve ovarian function and treat infertility.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Elsa Gonzalez-Cubero, Maria Luisa Gonzalez-Fernandez, Maria Rodriguez-Diaz, Marta Palomo-Irigoyen, Ashwin Woodhoo, Vega Villar-Suarez
Summary: The study investigated the therapeutic benefits of adipose tissue derived-mesenchymal stem cells (ASCs) and ASC-conditioned medium (CM) in promoting myelination and axonal regeneration. Results showed that both ASCs and CM could potentially aid in nerve regeneration, especially in reversing the effects of TNF-induced nerve damage on myelination-related genes and proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Muhammad Saad Shaikh, Zara Shahzad, Esraa Abdulgader Tash, Omer Sefvan Janjua, Muhammad Ikram Khan, Muhammad Sohail Zafar
Summary: Periodontal disease can cause irreparable damage to tooth-supporting tissues, but traditional treatments cannot restore lost tissue. Periodontal regeneration using stem cells, including human umbilical cord mesenchymal stem cells, shows promising results with advantages such as easy collection, low immunorejection, and affordability.
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jingyue Zhang, Shiheng Zhang, Yueming Yang, Ling Liu
Summary: The study found that umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) can effectively treat adriamycin-induced cardiomyopathy by restoring myocardial function and alleviating inflammatory response.
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu, Marc G. Jeschke
Summary: This study compared the cell characteristics of burned skin-derived mesenchymal stromal/stem cells with umbilical cord mesenchymal stromal/stem cells, revealing differences in mesenchymal differentiation capacity and cytokine secretion. However, other aspects like population doubling time, colony formation, cell proliferation, and immune markers showed no significant differences, indicating potential for cell therapy and skin regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Emergency Medicine
Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Summary: This study investigated the role of exosomes derived from Schwann cell-like cells (SCLCs) in peripheral nerve regeneration. SCLCs-exo significantly enhanced motor function recovery, attenuated muscle atrophy, and facilitated axonal regrowth, myelin formation, and angiogenesis. Furthermore, SCLCs-exo efficiently promoted proliferation and migration of Schwann cells and upregulated the expression of neurotrophic factors, myelin regulators, and myelin proteins.
Article
Veterinary Sciences
Eva Punzon, Maria Garcia-Castillo, Miguel A. Rico, Laura Padilla, Almudena Pradera
Summary: This study aimed to evaluate the safety of intra-articular administration of equine umbilical cord mesenchymal stem cells (EUC-MSC) in young healthy dogs under field conditions. The safety profile of allogenic canine adipose derived mesenchymal stem cells (CAD-MSC) and placebo was also compared. The results show that the intra-articular administration of equine umbilical cord mesenchymal stem cells in dogs is safe.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Cell Biology
Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou
Summary: Osteoarthritis is a common and disabling disease, and surgical treatment is the main approach. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells that promote cartilage regeneration through the secretion of various trophic factors. The combination of hUC-MSCs with other substances also shows a significant synergistic effect on osteoarthritis treatment. Some scholars have suggested transplanting stem cells into damaged cartilage to slow down the progression of osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Kendrick To, Bridget Zhang, Karl Romain, Christopher Mak, Wasim Khan
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2019)
Review
Biotechnology & Applied Microbiology
Kendrick To, Karl Romain, Christopher Mak, Achi Kamaraj, Frances Henson, Wasim Khan
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Rheumatology
Kendrick To, Christopher Mak, Chen Zhang, Yuhui Zhou, Stephanie Filbay, Wasim Khan
Summary: The meta-analysis conducted on the association between alcohol consumption and OA found a negative correlation, especially with weekly or more frequent alcohol intake. However, this association was less significant after adjusting for confounding factors, possibly due to selection bias and lack of appropriate adjustment for confounding variables.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Cell Biology
Nikhil Agarwal, Christopher Mak, Christine Bojanic, Kendrick To, Wasim Khan
Summary: Cell-based therapies derived from adipose tissue, specifically AMSC therapy and SVF therapy, have been shown to be safe and effective treatments for knee OA in old adults, reducing pain and improving knee function over time.
Article
Cell Biology
Christopher C. H. Mak, Kendrick To, Karim Fekir, Roger A. Brooks, Wasim S. Khan
Summary: The aim of this study was to determine the optimal in vitro chondrocyte co-culture condition that promotes infrapatellar fat pad-derived (IFPD) ASC chondrogenic gene expression. The results showed that co-culture increased chondrogenic gene expression, and the expression level decreased with increasing ASC-to-chondrocyte seeding ratios. These findings provide important insights into the mechanisms of clinical ASC therapies.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Nutrition & Dietetics
Henry Yue Hong Meng, Christopher Chi Hang Mak, Wing Yan Mak, Tao Zuo, Ho Ko, Francis Ka Leung Chan
Summary: This review examines the association between probiotics and neurocognitive function in age-related dementia. The results show that probiotics have limited evidence of improving neurocognitive function in humans, but promising results in animal studies. The analysis suggests that the neurocognitive effect of probiotics is associated with an altered gut microbiome profile and modulation of certain pathways.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Justin Ho, Christopher Chi Hang Mak, Vivek Sharma, Kendrick To, Wasim Khan
Summary: This systematic review examined Mendelian randomization (MR) studies on risk factors and causal effects of osteoarthritis (OA) and conducted a meta-analysis. The findings indicate that body mass index (BMI) has a positive causal effect on OA, while serum calcium and low-density lipoprotein (LDL) levels have negative causal effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)