From Tank to Treatment: Modeling Melanoma in Zebrafish

Oxidative phosphorylation promotes primary melanoma invasion

(2020) Amel Salhi et al.   AMERICAN JOURNAL OF PATHOLOGY

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

(2020) Cristina Santoriello et al.   NATURE CELL BIOLOGY

Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish

(2019) Fiona Henderson et al.   CANCER RESEARCH

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

(2019) Chuan Yan et al.   CELL

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model

(2019) Francesca Precazzini et al.   DEVELOPMENTAL BIOLOGY

Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma

(2019) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211

(2019) Tamar Golan et al.   Science Signaling

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment

(2019) Elena Gómez-Abenza et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

(2019) Jana Travnickova et al.   CANCER RESEARCH

The Case for Modeling Human Infection in Zebrafish

(2019) Margarida C. Gomes et al.   TRENDS IN MICROBIOLOGY

Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

(2019) Alec K Gramann et al.   eLife

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion

(2018) Alicia M. McConnell et al.   DEVELOPMENTAL BIOLOGY

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma

(2018) Alexander M.M. Eggermont et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

(2018) Maomao Zhang et al.   Cancer Discovery

Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

(2018) Vadim Grigura et al.   Biology Open

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model

(2018) Giulia Fornabaio et al.   Scientific Reports

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

(2018) Julien Ablain et al.   SCIENCE

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

(2017) Chiara Gabellini et al.   INTERNATIONAL JOURNAL OF CANCER

Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma

(2017) Arvind M. Venkatesan et al.   JOURNAL OF CLINICAL INVESTIGATION

Microenvironment-derived factors driving metastatic plasticity in melanoma

(2017) Isabella S. Kim et al.   Nature Communications

The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth

(2017) Kimberley Hanson et al.   Oncotarget

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

(2017) Catherine M. Scahill et al.   PLoS Genetics

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

(2017) Christie Ciarlo et al.   eLife

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

(2016) Anna C. Thomas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

(2016) Mai Abdel Mouti et al.   Oncotarget

Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism

(2016) Chengjian Zhao et al.   Scientific Reports

RSK1 Activation Promotes Invasion in Nodular Melanoma

(2015) Amel Salhi et al.   AMERICAN JOURNAL OF PATHOLOGY

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells

(2015) Sharanya Iyengar et al.   DEVELOPMENTAL CELL

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

(2015) Seher Balaban et al.   Biomed Research International

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Temperature-sensitive splicing ofmitfaby an intron mutation in zebrafish

(2014) Zhiqiang Zeng et al.   Pigment Cell & Melanoma Research

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

(2013) James A. Lister et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clonal BRAF Mutations in Melanocytic Nevi and Initiating Role of BRAF in Melanocytic Neoplasia

(2013) Iwei Yeh et al.   JNCI-Journal of the National Cancer Institute

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

(2013) GuangJun Zhang et al.   PLoS Genetics

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

(2013) Jennifer Yen et al.   GENOME BIOLOGY

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly penetrant melanoma in a zebrafish model is independent of ErbB3b signaling

(2012) Cristina Santoriello et al.   Pigment Cell & Melanoma Research

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Integrative analysis of the melanoma transcriptome

(2010) M. F. Berger et al.   GENOME RESEARCH

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

(2010) Cristina Santoriello et al.   PLoS One

Global Repression of Cancer Gene Expression in a Zebrafish Model of Melanoma Is Linked to Epigenetic Regulation

(2010) Viviana Anelli et al.   Zebrafish

Fish immunology

(2009) Graham J. Lieschke et al.   CURRENT BIOLOGY

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model

(2009) C. Michailidou et al.   Disease Models & Mechanisms

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

(2008) W. M. Lin et al.   CANCER RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

KIT Gene Mutations and Copy Number in Melanoma Subtypes

(2008) C. Beadling et al.   CLINICAL CANCER RESEARCH

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE