Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Anatomy & Morphology
Sara Derhambakhsh, Javad Mohammadi, Mohammad Ali Shokrgozar, Hodjattallah Rabbani, Niloufar Sadeghi, Houra Nekounam, Sotoudeh Mohammadi, Ki-Bum Lee, Mehrdad Khakbiz
Summary: In vascular tissue engineering, the blockage of veins after entering the in vivo environment is a key obstacle. This is due to the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). The aim of this study was to convert the synthetic phenotype of VSMCs into the contractile phenotype to prevent abnormal growth. Electrical stimulation was applied to the cells, resulting in morphological alterations and changes in protein expression. The results showed that electrical stimulation can significantly affect the phenotype of VSMCs.
Review
Cell Biology
Alexander Nolze, Sebastian Matern, Claudia Grossmann
Summary: Calcineurin, a serine/threonine phosphatase, plays important roles in immune modulation, cardiac hypertrophy, and vascular function. It regulates various aspects of vascular smooth muscle cells, including proliferation, migration, differentiation, and function. Understanding the mechanisms of Calcineurin signaling provides insights into vascular development and pathogenesis.
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yu-Xia Zhang, Ri-Ning Tang, Li-Ting Wang, Bi-Cheng Liu
Summary: Chronic kidney disease (CKD) is a significant health issue globally, with vascular calcification (VC) playing a major role in the cardiovascular morbidity and high mortality of CKD. Intercellular crosstalk between ECs and SMCs is crucial in the development of VC associated with CKD.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Shira Landau, Abigail Newman, Shlomit Edri, Inbal Michael, Shahar Ben-Shaul, Yulia Shandalov, Tom Ben-Arye, Pritinder Kaur, Ming H. Zheng, Shulamit Levenberg
Summary: Lymphatic system plays a critical role in various biological processes, yet lymphangiogenesis is less studied compared to angiogenesis. By culturing human lymphatic endothelial cells on thick collagen sheets with supporting cells and blood endothelial cells, a functional lymphatic vessel network was successfully developed in a short period of time. The model provides a potential platform for investigating lymphangiogenesis and lymphatic disease mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Adrian Sowka, Pawel Dobrzyn
Summary: Adipose tissue serves as both an energy-storing tissue and an endocrine organ due to its secretion of adipose-specific factors called adipokines. Among these, adiponectin is a well-known adipokine with metabolic, anti-inflammatory, and antidiabetic properties. Perivascular adipose tissue (PVAT) acts on the vascular wall through adipokine secretion and adiponectin can affect the vascular wall through endothelial cells and vascular smooth muscle cells. Studies have suggested that adiponectin and its receptors may be potential therapeutic targets.
Article
Cell Biology
Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen
Summary: This study reveals the defective mechanosensation of vascular smooth muscle cells (VSMCs) during aging, leading to a decline in their ability to sense and adapt to mechanical perturbations. Aged VSMCs exhibit a relatively inert mechanobiological state with altered actin cytoskeletal integrity, resulting in impaired mechanosensitivity and dynamic mechanoresponse. This decline in mechanosensation is mediated by hyperactivity of Piezo1-dependent calcium signaling. Inhibition of Piezo1 can alleviate vascular aging and partially restore the loss in dynamic contractile properties in aged cells.
Article
Biochemistry & Molecular Biology
Ningning Sun, Beyongsam Chu, Dong-Hyun Choi, Leejin Lim, Heesang Song
Summary: Abnormal communication between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) promotes vascular diseases. ETS variant transcription factor 2 (ETV2) plays a role in pathological angiogenesis, but its role in the communication between ECs and VSMCs is unknown. CXCL5 induced by ETV2 in ECs promotes VSMC migration through MMP upregulation and the activation of Akt and p38/c-Jun.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alvaro Yogi, Marina Rukhlova, Claudie Charlebois, Ganghong Tian, Danica B. Stanimirovic, Maria J. Moreno
Summary: The study found that VSMCs differentiated from adipose-derived stem cells (ASCs) show potential for populating PET-based vascular scaffolds. By shortening the differentiation period and studying the role of downstream effectors of TGF-beta, the process was stabilized. The non-woven PET structure did not affect ASC differentiation, providing a novel alternative to address issues with long-term patency of vascular grafts.
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jody Tori O. Cabrera, Ayako Makino
Summary: Cell death and the clearance of apoptotic cells are regulated by signaling molecules. Abnormal clearance of apoptotic cells is associated with various health complications and diseases. During this process, phagocytic cells and/or apoptotic cells release signals to promote engulfment of apoptotic cells. In addition to macrophages and dendritic cells, other cell types such as endothelial cells and fibroblasts can also engulf apoptotic cells, although at a slower rate. This review focuses on the macrophage efferocytosis of vascular cells and its relation to cardiovascular disease, emphasizing the importance of efferocytosis-related molecules in maintaining vascular homeostasis.
PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Cell & Tissue Engineering
Nadia O. Abutaleb, George A. Truskey
Article
Cell & Tissue Engineering
Leigh Atchison, Nadia O. Abutaleb, Elizabeth Snyder-Mounts, Yantenew Gete, Alim Ladha, Thomas Ribar, Kan Cao, George A. Truskey
Article
Cell & Tissue Engineering
Megan E. Kondash, Anandita Ananthakumar, Alastair Khodabukus, Nenad Bursac, George A. Truskey
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Anandita Ananthakumar, Yiling Liu, Cristina E. Fernandez, George A. Truskey, Deepak Voora
Review
Engineering, Biomedical
Qiao Zhang, Elia Bosch-Rue, Roman A. Perez, George A. Truskey
Summary: Cardiovascular disease is the leading cause of death among older adults, with a focus on developing TEVS that closely resemble native vessels. Advancements in biofabrication techniques and novel biomaterials are driving this research forward.
APL BIOENGINEERING
(2021)
Article
Engineering, Biomedical
Onur Aydin, Austin P. Passaro, Ritu Raman, Samantha E. Spellicy, Robert P. Weinberg, Roger D. Kamm, Matthew Sample, George A. Truskey, Jeremiah Zartman, Roy D. Dar, Sebastian Palacios, Jason Wang, Jesse Tordoff, Nuria Montserrat, Rashid Bashir, M. Taher A. Saif, Ron Weiss
Summary: Remarkable progress in bioengineering has enabled the formulation of design principles for multicellular engineered living systems (M-CELS), integrating biological parts into functional modules within living machines. These design principles involve genetic circuit manipulation, self-assembly, cell communication, and artificial tissues/organs enabled through various technologies. The review introduces a blueprint for forward production of robust M-CELS and provides practical and theoretical frameworks for their design, control, and optimization. Potential applications range from biopharmaceuticals to environmental bioremediation.
APL BIOENGINEERING
(2022)
Letter
Cardiac & Cardiovascular Systems
Qiao Zhang, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, George A. Truskey
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biotechnology & Applied Microbiology
George A. Truskey
Summary: Computational biomechanics, when combined with advanced imaging techniques, can provide detailed patient-specific information for diagnosing and assessing treatments. However, challenges remain in terms of errors and missing information in patient data, computational requirements, and uncertainties in boundary conditions. This review discusses the use of deep learning to address these challenges and integrate large data sets and computational methods for real-time clinical information.
BIOENGINEERING-BASEL
(2023)
Meeting Abstract
Rheumatology
Lauren Covert, George Truskey, Jeffrey Dvergsten
ARTHRITIS & RHEUMATOLOGY
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Muath Bishawi, Michael Kaplan, Simbarashe Chidyagwai, Jhaymie Cappiello, Anne Cherry, David MacLeod, Ken Gall, Nathan Evans, Michael Kim, Rajib Shaha, John Whittle, Melanie Hollidge, George Truskey, Amanda Randles
Summary: In the early days of the COVID-19 pandemic, we developed a system for efficient and rapid ventilator splitting between patients with varying lung compliances and tidal volume requirements. By using computational modeling and simulation, we identified the optimal splitting method and airflow resistor, providing guidance for medical device design and patient treatment.
COMPUTATIONAL SCIENCE - ICCS 2022, PT III
(2022)
Meeting Abstract
Sport Sciences
Alexander Byron Sklivas, Dante Goss, Nenad Bursac, Alastair Khodahukus, Tim Koves, Deborah Muoio, Lauran Madden, George A. Truskey, William E. Kraus, Monica J. Hubal
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Multidisciplinary Sciences
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey
NATURE COMMUNICATIONS
(2020)
Article
Engineering, Biomedical
Caroline Rhim, William E. Kraus, George A. Truskey
AIMS BIOENGINEERING
(2020)