Article
Radiology, Nuclear Medicine & Medical Imaging
Doo Young Lee, Jaeseung Shin, Sungwon Kim, Song-Ee Baek, Suji Lee, Nak-Hoon Son, Mi-Suk Park
Summary: The study evaluated the performance of a CT-based radiomics model in identifying malignant IPMNs and compared it with the 2017 ICGs. The CT radiomics model exhibited better diagnostic performance than the ICGs, potentially allowing a more quantitative assessment of IPMNs.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Mihyeon Park, Jisun Lee, Yook Kim, Kyung Sik Yi, Bum Sang Cho, Chi-Hoon Choi, Kil Sun Park
Summary: This article describes two cases in which patients were initially diagnosed with SCNs, but were misdiagnosed as IPMN due to radiologic imaging showing apparent connection between the pancreatic duct and cystic lesion, leading to unnecessary surgery. Particular attention should be paid to the interpretation of clinicoradiologic findings of pancreatic cystic lesions, especially in the decision of surgical intervention. Additionally, awareness of the atypical radiologic features of SCN may expand the knowledge base of radiologists.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Young Kon Kim, Seon Kyoung Kim, Honsoul Kim, Soohyun Ahn
Summary: The high-risk features for malignant IPMN showed comparable diagnostic accuracy between CT and MRI, with MRI being superior in detecting mural nodules. However, both modalities had similar performance in distinguishing malignant from benign IPMNs.
EUROPEAN RADIOLOGY
(2021)
Article
Surgery
Wei Liu, Bing Peng
Summary: This study compared the curative efficacy and outcomes of laparoscopic duodenum-preserving total pancreatic head resection (LDPPHRt) and laparoscopic pancreaticoduodenectomy (LPD) for pancreatic-head intraductal papillary mucinous neoplasm (IPMN). The results showed that the perioperative outcomes were similar between the two procedures, but LDPPHRt had better quality of life after surgery.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Yoshinori Takeda, Hiroshi Imamura, Jiro Yoshimoto, Yuki Fukumura, Ryuji Yoshioka, Yoshihiro Mise, Seiji Kawasaki, Akio Saiura
Summary: The study highlights the clinical entity of T1a invasive intraductal papillary mucinous carcinoma specifically observed in patients with intraductal papillary mucinous carcinoma, associated with excellent postoperative survival outcomes. The survival advantage of invasive intraductal papillary mucinous carcinoma over pancreatic ductal adenocarcinoma is attributed to intrinsic indolent biological behavior, especially in patients without lymphatic invasion or lymph node metastasis.
Article
Gastroenterology & Hepatology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Summary: This study investigated the long-term effects of dilation of the main pancreatic duct (MPD) on intraductal papillary mucinous neoplasms (IPMNs) and found that MPD dilation was associated with higher incidence and prevalence of pancreatic carcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Devarshi R. Ardeshna, Shiva Rangwani, Troy Cao, Timothy M. Pawlik, Peter P. Stanich, Somashekar G. Krishna
Summary: Hereditary pancreatic cancer accounts for about 10% of pancreatic cancer diagnoses. Early detection of pre-cancerous pancreatic cysts, such as intraductal papillary mucinous cystic neoplasms (IPMNs), has become an important focus to reduce pancreatic cancer incidence and mortality. This review explores the prevalence of IPMNs in patients with hereditary pancreatic cancer and their relatives, and discusses the need for surveillance changes in high-risk individuals.
Article
Gastroenterology & Hepatology
Stefano Crippa, Alessandro Fogliati, Roberto Valente, Omid Sadr-Azodi, Urban Arnelo, Gabriele Capurso, Asif Halimi, Stefano Partelli, Zeeshan Ateeb, Paolo Giorgio Arcidiacono, J. Matthias Lohr, Massimo Falconi, Marco Del Chiaro
Summary: The study evaluated the diagnostic accuracy of International and European guidelines for intraductal papillary mucinous neoplasms, finding that the guidelines have relatively low diagnostic accuracy, with European guidelines being more aggressive. Endoscopic ultrasound can improve accuracy in patients with moderate-risk features.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Oncology
Beata Jablonska, Pawel Szmigiel, Slawomir Mrowiec
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are a type of pancreatic tumor, accounting for a small percentage of pancreatic neoplasms. They are categorized into different types with varying management strategies based on tumor characteristics and patient factors. There are several guidelines available for diagnosing and managing IPMNs.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seo-Youn Choi, Ji Hye Min, Jung Hoon Kim, Hyun Jeong Park, Yeun-Yoon Kim, Yeo Eun Han, Sung Hwan Bae, Jeong Hyun Lee, Yoon-Hyeong Choi, Ji Eun Moon
Summary: This study evaluated the interobserver agreement and diagnostic performance of MRI assessment in predicting the malignant potential of pancreatic IPMN according to radiologists' experience. The results showed substantial agreement among radiologists for high-risk stigmata and better agreement among more-experienced reviewers. The diagnostic performance of MRI assessment for predicting malignant IPMN was good.
Article
Oncology
Manuel Gentiluomo, Chiara Corradi, Paolo Giorgio Arcidiacono, Stefano Crippa, Massimo Falconi, Giulio Belfiori, Riccardo Farinella, Laura Apadula, Gaetano Lauri, Niccolo Bina, Cosmeri Rizzato, Federico Canzian, Luca Morelli, Gabriele Capurso, Daniele Campa
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with limited treatment options and late diagnosis. Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of PDAC, and identifying high-risk IPMN patients can help improve survival rates. This study investigated both genetic and non-genetic risk factors in a cohort of IPMN patients and found potential associations with smoking status and obesity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Francesca Aleotti, Stefano Crippa, Giulio Belfiori, Domenico Tamburrino, Stefano Partelli, Enrico Longo, Diego Palumbo, Nicolo Pecorelli, Marco Schiavo Lena, Gabriele Capurso, Paolo Giorgio Arcidiacono, Massimo Falconi
Summary: This study evaluated surgical indications and complications in patients with low-grade intraductal papillary mucinous neoplasms. The results showed a decrease in the rate of patients undergoing surgery for low-grade intraductal papillary mucinous neoplasms and a high incidence of postoperative complications.
Article
Medicine, General & Internal
Vladimir Djordjevic, Nikica Grubor, Jelena Djokic Kovac, Marjan Micev, Natasa Milic, Djordje Knezevic, Pavle Gregoric, Zeljko Lausevic, Mirko Kerkez, Srbislav Knezevic, Dejan Radenkovic
Summary: The successful management of pancreatic cystic neoplasm (PCN), especially intraductal papillary mucinous neoplasm (IPMN), relies on a careful combination of clinical, radiological, and histopathological findings. This study compared preoperative evaluation with pathological reports in IPMN and evaluated the diagnostic performance of European evidence-based guidelines on pancreatic cystic neoplasms (EEBGPCN) and Fukuoka Consensus guidelines (FCG). While EEBGPCN and FCG showed comparable diagnostic performance, there were limitations in the false-positive rate for surgical resection, emphasizing the need for a multidisciplinary approach in selecting patients for surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Tingting Lin, Xin Chen, Jingjing Liu, Yingying Cao, Wenjing Cui, Zhongqiu Wang, Cheng Wang, Xiao Chen
Summary: Imaging-based pancreatic atrophy is significantly associated with malignant IPMNs or invasive carcinoma, serving as an independent factor. In MPD-involved IPMNs, pancreatic atrophy performs better in identifying invasive carcinoma compared to mural nodules.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Minoru Tada, Hideo Koh, Keisuke Tateishi, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Teppei Morikawa, Kei Saito, Tomotaka Saito, Tatsuya Sato, Kaoru Takagi, Naminatsu Takahara, Ryota Takahashi, Atsushi Tanaka, Mariko Tanaka, Tetsuo Ushiku, Kiyoshi Hasegawa, Kazuhiko Koike
Summary: This study found that patients with IPMN and blood type A or B were more likely to develop pancreatic carcinoma compared to those with blood type O. ABO blood group may serve as a biomarker for pancreatic cancer risk among patients with IPMNs.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Surgery
Emanuele Damiano Luca Urso, Filippo Crimi, Giorgio Rivella, Francesco Celotto, Pietro Zucchetta, Laura Albertoni, Salvatore Pucciarelli, Quoc Riccardo Bao
Summary: This study reports a rare case of duodenal lesion in a 41-year-old female patient, which was evaluated for malignant potential and treatment planning using clinical staging and (18)FDG PET/MRI. Robotic transduodenal excision was performed based on the findings. The study suggests that accurate staging with (18)FDG PET/MRI can be very useful in the management of duodenal lesions with uncertain malignant potential.
Article
Oncology
Giulia Cerretti, Diego Cecchin, Luca Denaro, Mario Caccese, Marta Padovan, Vittorina Zagonel, Giuseppe Lombardi
Summary: This study reports a case of a 42-year-old patient with BRAF(V600E) mutant and SOX2 amplification glioblastoma who showed a radiologic and metabolic complete response to personalized treatment with dabrafenib, trametinib, and silybin. Personalized treatment with BRAF and MEK inhibitors showed promising activity in patients with BRAF(V600E) mutant glioblastoma, and silybin may play an important role in reducing drug resistance, especially in patients with SOX2 amplification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas W. Georgi, Dietrich Stoevesandt, Lars Kurch, Joerg M. Bartelt, Dirk Hasenclever, Helmut Dittmann, Jiri Ferda, Peter Francis, Christiane Franzius, Christian Furth, Daniel Graefe, Alexander Gussew, Martin Huellner, Leon J. Menezes, Mona Mustafa, Lars Stegger, Lale Umutlu, Klaus Zoephel, Pietro Zucchetta, Dieter Koerholz, Osama Sabri, Christine Mauz-Koerholz, Regine Kluge
Summary: 18F-FDG PET/MRI may be the preferred diagnostic method for Hodgkin lymphoma patients due to its combination of metabolic information from PET and excellent soft-tissue contrast from MRI, while avoiding radiation exposure from CT. However, longer examination times are a major issue, especially for children requiring anesthesia. Therefore, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Letter
Oncology
Gregorio Barila, Filippo Crimi, Massimiliano Arangio Febbo, Laura Pavan, Susanna Vedovato, Giulio Cabrelle, Chiara Zanon, Cristina Campi, Diego Cecchin, Pietro Zucchetta, Carmelo Lacognata, Gianpietro Semenzato, Renato Zambello
LEUKEMIA & LYMPHOMA
(2023)
Article
Medicine, General & Internal
Lucia Moletta, Alberto Friziero, Simone Serafini, Valeria Grillo, Elisa Sefora Pierobon, Giovanni Capovilla, Michele Valmasoni, Cosimo Sperti
Summary: Pancreatic metastases from other neoplasms are rare, and the role of surgery for this condition is unclear. This study investigated the role of resection in patients with pancreatic secondary lesions. Radical resection of metastases to the pancreas is feasible and safe, and may provide a survival benefit for selected patients, especially those with metastases from renal cell carcinoma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Chiara Giraudo, Elisa Carraro, Elena Cavallaro, Monica Zuliani, Liliya Spampinato Gotsyak, Davide Massano, Antonella Modugno, Lara Mussolin, Alessandra Biffi, Diego Cecchin, Marta Pillon, Pietro Zucchetta
Summary: Hodgkin's lymphoma (HL) has a good prognosis in children, adolescents, and young adults, but the development of adverse effects such as Bone Ischemic Lesions (BILs) is a concern. This study evaluated the role of [F-18]FDG-PET-MR in detecting BILs in pediatric HL patients. BILs were detected through PET-MR imaging as medullary lesions with a tortuous border. Among 53 HL patients, 18.9% developed BILs, with mostly multifocal lesions. PET-MR is a sensitive technique for detecting asymptomatic BILs, which can be monitored through clinical follow-up.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Antoine Verger, Igor Yakushev, Nathalie L. Albert, Bart van Berckel, Matthias Brendel, Diego Cecchin, Pablo Aguiar Fernandez, Francesco Fraioli, Eric Guedj, Silvia Morbelli, Nelleke Tolboom, Tatjana Traub-Weidinger, Donatienne Van Weehaeghe, Henryk Barthel
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Clinical Neurology
Bonato Giulia, Mozzetta Stefano, Busse Cinzia, Cecchin Diego, Cagnin Annachiara
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Elena Monai, Erica Silvestri, Marta Bisio, Annachiara Cagnin, Marco Aiello, Diego Cecchin, Alessandra Bertoldo, Maurizio Corbetta
Summary: This study analyzed the case of a patient with a focal brain lesion using a multi-modal approach and found that the lesion caused disconnection and functional impairments beyond the borders of the anatomical damage, extending to remote areas and being associated with metabolic and electrical abnormalities.
FRONTIERS IN NEUROLOGY
(2023)
Review
Pediatrics
Davide Meneghesso, Nicola Bertazza Partigiani, Rachele Spagnol, Alessandra Rosalba Brazzale, Alessandro Morlacco, Enrico Vidal
Summary: This study conducted a systematic review with meta-analysis to analyze the predictive value of nadir creatinine on long-term renal function in infants with posterior urethral valves (PUVs). The results showed that nadir creatinine is the best prognostic factor for long-term renal function in PUV patients, and a value above the cutoff of 1 mg/dL should be considered a significant predictor for the risk of chronic kidney disease (CKD) and end-stage kidney disease (ESKD).
FRONTIERS IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Cristina Campi, Chiara Briani, Alessandro Salvalaggio, Chiara Giraudo, Alberto Cipriani, Alessandro Zorzi, Pietro Zucchetta, Roberto Vettor, Diego Cecchin
Summary: The study introduced a new semi-quantification method for diagnosing ATTR cardiac amyloidosis when SPET/CT is not available, and it showed that the heart-to-thigh ratio (RHT) can accurately distinguish between healthy controls and subjects likely affected by CA especially in the male population.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Medicine, General & Internal
Lino Polese, Emilia Giugliano, Michele Valmasoni
Summary: This paper examines the importance of patient positioning in endoscopic procedures, discussing how gravity can affect various factors during the surgery and emphasizing the need for endoscopists to consider the patient's anatomy and endoscope position.
JOURNAL OF CLINICAL MEDICINE
(2023)
