期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm9041101
关键词
sedentariness; TV viewing; magnetic resonance imaging; brain; cognition; childhood; obesity
资金
- Spanish Ministry of Economy and Competitiveness [DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP, RTI2018-095284-J-100]
- European Regional Development Fund (ERDF), European Union's 2020 research and innovation program [667302]
- European Union [667302]
- Alicia Koplowitz Foundation
- UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence
- Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University
- European Regional Development Fund (ERDF) [SOMM17/6107/UGR, RD16/0022]
- SAMID III network, RETICS - PN I+D+I 2017-2021 (Spain)
- ISCIII-Sub-Directorate General for Research Assessment and Promotion
- EXERNET Research Network on Exercise and Health in Special Populations [DEP2005-00046/ACTI]
- Regional Government of Andalusia, Integrated Territorial Initiative 2014-2020 of the province of Cadiz [PI-0002-2017]
- Spanish Ministry of Science and Innovation [FJC2018-037925-I]
- Spanish Ministry of Education, Culture and Sport [FPU15/02645, FPU14/06837]
- Horizon 2020 Framework Programme [667302]
- CONICYT/BECAS Chile [72180543]
- Spanish Ministry of Science, Innovation and Universities [FJCI-2017-33396]
- Scientific Unit of Excellence on Excercise and Health (UCEES)
We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8-11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (beta ranging -0.314 to -0.489 and cluster size 106 to 323 voxels; p < 0.001), playing video games in three brain regions (beta ranging -0.391 to -0.359, and cluster size 96 to 461 voxels; p < 0.001) and total sedentary time in two brain regions (beta ranging -0.341 to -0.352, and cluster size 897 to 2455 voxels; p < 0.001). No brain regions showed a significant positive association (all p > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.
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