Article
Immunology
Meiping Chen, Shiyi He, Phoebe Miles, Chunlin Li, Yijun Ge, Xuechan Yu, Linfeng Wang, Weina Huang, Xue Kong, Shanni Ma, Yiting Li, Qingwen Jiang, Wen Zhang, Chao Cao
Summary: Perturbation of the nasal microbiome is associated with the phenotypes and severity of chronic airways disease, including asthma and allergic rhinitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Allergy
Nicholas J. Campion, Sergio Villazala-Merino, Ryan S. Thwaites, Victoria Stanek, Helen Killick, Eleftheria Pertsinidou, Mohammed Zghaebi, Josef Toth, Renate Froschl, Thomas Perkmann, Katharina Gangl, Sven Schneider, Robin Ristl, Ian C. Scott, Emma Suzanne Cohen, Magnus Molin, Margit Focke-Tejkl, Guenther Regelsberger, Trevor T. Hansel, Rudolf Valenta, Verena Niederberger-Leppin, Julia Eckl-Dorna
Summary: This study aimed to characterize the immunologic and clinical nasal responses to birch pollen allergen challenge, with a special focus on the late allergic response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Meiping Chen, Yijun Ge, Wanmi Lin, Haiping Ying, Wen Zhang, Xuechan Yu, Chunlin Li, Chao Cao
Summary: Patients with asthma comorbid AR have a lower quality of life compared to isolated asthma patients, and they also have higher levels of systemic cytokines in plasma. However, there is no significant difference in cytokine levels in the nasal lavage fluid among the three groups. This study helps to better understand the airway inflammation in asthma patients with or without AR.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Annabelle M. Watts, Nicholas P. West, Peter K. Smith, Allan W. Cripps, Amanda J. Cox
Summary: Distinct gene expression profiles were observed between AR sufferers and controls in both blood and nasal mucosa samples. The study also found a close interaction between local and systemic immunity, with specific genes identified potentially serving as biomarkers for evaluating treatment effectiveness or targets for drug discovery in AR.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Microbiology
Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Kim
Summary: Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and Staphylococcus epidermidis reduces allergic inflammation by suppressing IL-33 production, which is a key mechanism of reduction of IL-33 and Th2 inflammation.
Article
Biochemistry & Molecular Biology
Bo-Jeong Pyun, Kyuhyung Jo, Joo Young Lee, Ami Lee, Myung-A Jung, Youn-Hwan Hwang, Dong Ho Jung, Kon-Young Ji, Susanna Choi, Yun Hee Kim, Taesoo Kim
Summary: Caesalpinia sappan Linn. heartwood water extract (CSLW) has anti-inflammatory and antioxidant properties and can alleviate symptoms of allergic rhinitis (AR) by controlling the allergic inflammatory reaction of the nasal epithelium.
Article
Allergy
Min Wang, Wenyu She, Jun Yang, Xiangdong Wang, Yuan Zhang, Xu Zhang, Luo Zhang
Summary: Gene expression in patients with allergic rhinitis, suspected allergic rhinitis, and nonallergic rhinitis showed similarity with most genes related to Th2 inflammation. CST1, TFF3, and ITLN1 may have the potential to differentiate allergic rhinitis from nonallergic rhinitis. Understanding the mechanisms underlying different types of rhinitis may aid in diagnosis and treatment.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatsuro Nakamura, Yuri Tachibana, Takahisa Murata
Summary: The study revealed that 8-iso-prostaglandin E-2 (PGE(2)) may serve as a ligand for TP-mediated nasal obstruction in mice.
Article
Multidisciplinary Sciences
Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, Doo Hee Han
Summary: This study investigated the effect of DEP exposure on allergic rhinitis using a mouse model sensitized to house dust mite. The results showed that mice co-exposed to HDM and DEP exhibited increased allergic symptom scores compared to mice exposed to HDM alone. This suggests that DEP may exacerbate allergic rhinitis by increasing levels of interleukin-17A in the nasal mucosa.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Hai-Yun Li, Zhao-Ming Tang, Zhe Wang, Jian-Min Lv, Xiao-Ling Liu, Yu-Lin Liang, Bin Cheng, Ning Gao, Shang-Rong Ji, Yi Wu
Summary: This study identifies CRP as a crucial factor in acetaminophen-induced liver injury, limiting the destructive activation of complement and suppressing inflammation. CRP treatment shows a longer therapeutic time window and effectively alleviates liver injury compared to traditional treatment methods.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Otorhinolaryngology
Haotao Zeng, Jiangqi Liu, Lihua Mo, Minyao Li, Aifa Tang, Xianhai Zeng, Miao Zhao, Pingchang Yang
Summary: In this study, nasal secretions of allergic rhinitis patients were analyzed, and 15 differentially expressed proteins (DEPs) were identified. These DEPs were significantly correlated with the total nasal symptom scores of patients with allergic rhinitis.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Oncology
Fangwei Zhou, Peiqiang Liu, Hao Lv, Ziang Gao, Wenchuan Chang, Yu Xu
Summary: The expression levels of miR-31 were significantly decreased in the nasal mucosa of patients with allergic rhinitis (AR). Upregulation of miR-31 attenuated allergic symptoms and inflammatory cytokine production, suggesting it could serve as a novel therapeutic target for AR.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Yuan Wang, Xuan Li, Shuntong Gu, Junhong Fu
Summary: This study found differences in the composition and function of the conjunctival and nasal microbiome in patients with allergic rhinoconjunctivitis (ARC) or allergic rhinitis (AR), suggesting a relationship between allergic conditions and the local microbiome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Shubhayu Saha, Ambarish Vaidyanathan, Fiona Lo, Claudia Brown, Jeremy J. Hess
Summary: The study found that the seasonal distribution of pollen types and their impact on health varied across different MSAs. All pollen types were associated with an increased relative risk of allergic rhinitis visits, while only tree and weed pollen were associated with an increased risk of medication fills. Controlling for air pollution and ILI did not significantly impact the effect estimates.
ENVIRONMENTAL HEALTH
(2021)
Editorial Material
Allergy
Athanasios Damialis, Stefanie Gilles, Claudia Traidl-Hoffmann
Article
Dermatology
Miriam Zidane, Hans-Wilfried Jungkunz, Birgit Kahle, Anya Miller, Falk Ochsendorf, Cord Sunderkoetter, Claudia Traidl-Hoffmann, Gerda Wurpts, Alexander Nast
Summary: This guideline aims to provide criteria and procedures for the differential diagnosis of acute or chronic, unilateral or bilateral redness of the lower leg, and offers algorithms and diagnostic pathways. Finding the correct diagnosis is crucial for selecting appropriate treatment and reducing unnecessary use of antibiotics. The guideline also summarizes the characteristics of over 40 other relevant diagnoses to facilitate further differential diagnoses.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Gastroenterology & Hepatology
Christoph Roemmele, Maria Kahn, Stephan Zellmer, Anna Muzalyova, Gertrud Hammel, Christina Bartenschlager, Albert Beyer, Jonas Rosendahl, Tilo Schlittenbauer, Johannes Zenk, Bilal Al-Nawas, Roland Frankenberger, Juergen Hoffmann, Christoph Arens, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann, Alanna Ebigbo
Summary: This study investigated the risk factors for SARS-CoV-2 infection among healthcare workers (HCWs) in medical disciplines with aerosol-generating procedures (AGP). The results showed that regions with higher incidence rates, hospital settings, and HCWs in gastrointestinal endoscopy (GIE) had a significantly increased risk of infection.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Environmental Sciences
Surendra Ranpal, Miriam Sieverts, Verena Woerl, Georgia Kahlenberg, Stefanie Gilles, Maria Landgraf, Kira Koepke, Franziska Kolek, Daria Luschkova, Tobias Heckmann, Claudia Traidl-Hoffmann, Carmen Buttner, Athanasios Damialis, Susanne Jochner-Oette
Summary: Intraspecific genetic variation may limit the influence of environmental factors on plant traits. This study investigated the pollen production of 28 birch individuals and found temporal and clonal variations in pollen production. Synchronized high or low pollen production is not strictly dependent on genotypes or site-specific factors. The study suggests the advantage of appropriate clone selection based on application and long-term monitoring.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Allergy
Zeinab Fneish, Jennifer Becker, Felix Mulenge, Bibiana Costa, Luise Krajewski, Veronica Duran, Annett Ziegler, Vivien Sommer, Claudia Traidl-Hoffmann, Stefanie Gilles, Ulrich Kalinke
Editorial Material
Allergy
Claudia Traidl-Hoffmann
Article
Dermatology
Luise Rauer, Matthias Reiger, Madhumita Bhattacharyya, Patrick M. M. Brunner, James G. G. Krueger, Emma Guttman-Yassky, Claudia Traidl-Hoffmann, Avidan U. U. Neumann
Summary: This study investigated the skin microbiome of 48 adult patients with moderate-to-severe atopic dermatitis (AD) and found that the diversity of the skin microbiome is associated with patients' demographic and clinical cofactors, as well as disease severity. Specifically, the relative abundance of Staphylococcus aureus and the evenness of the microbiome were associated with AD severity. These findings are important for the development of personalized treatments for AD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Ingrida Sauliene, Arunas Valiulis, Ilona Keriene, Laura Sukiene, Dovile Dovydaityte, Nina Prokopciuk, Vaidotas Valskys, Roberta Valskiene, Athanasios Damialis
Summary: The number of children suffering from respiratory allergies and asthma has been increasing globally, making it crucial to understand the presence of inhalant biological particles in school facilities, where children spend a significant amount of their time. While there have been numerous studies on outdoor bioaerosol exposure, there are still uncertainties regarding the diversity and deposition of airborne pollen and fungi indoors, especially in schools. This study aimed to examine the indoor environment of public schools and assess the biodiversity and abundance of bioaerosols, such as fungi and pollen, in order to determine potential health risks for children.
Review
Allergy
Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Kian Fan Chung, Bernard Clot, Martine Collaud Coen, Gennaro D. Amato, Athanasios Damialis, Javier Dominguez-Ortega, Carmen Galan, Stefanie Gilles, Stephen Holgate, Mohamed Jeebhay, Stelios Kazadzis, Nikolaos G. Papadopoulos, Santiago Quirce, Joaquin Sastre, Fiona Tummon, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Pablo Alonso-Coello, Carlos Canelo-Aybar, Yahveth Cantero-Fortiz, David Rigau, Josefina Salazar, Francisca Verdugo-Paiva, Marek Jutel, Cezmi A. Akdis, Ioana Agache
Summary: This study aimed to investigate the impact of pollen exposure on asthma exacerbations and found that outdoor pollen exposure may have an effect on asthma exacerbation, particularly in children under 18 years of age. Further research is needed to evaluate the effects of pollen on asthma exacerbation, considering factors such as pollen sensitization, hay fever, air pollution, green spaces, and pre-existing medications, in order to improve preventive measures.
Article
Biophysics
Surendra Ranpal, Susanne von Bargen, Stefanie Gilles, Daria Luschkova, Maria Landgraf, Claudia Traidl-Hoffmann, Carmen Buettner, Athanasios Damialis, Susanne Jochner-Oette
Summary: High-altitude environments are susceptible to climate change, making it important to study plant traits in these regions to understand future impacts. The research on pollen production at different altitudes in mountains is currently limited. In this study, birch pollen production was investigated along an altitudinal gradient in the European Alps. It was found that mean pollen production varied between 0.4 and 8.3 million grains per catkin. No significant relationships were observed between reproductive metrics and altitude. However, the minimum temperature of the previous summer was significantly correlated to pollen, flower, and catkin production.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Review
Allergy
Nikolaos G. Papadopoulos, Cezmi Akdis, Mubeccel Akdis, Athanasios Damialis, Giuseppina Esposito, Ioana Fergadiotou, Christian Goroncy, Pierre Guitton, Maia Gotua, Kleanthis Erotokritou, Tuomas Jartti, Clare Murray, Athanasios Nenes, Sotirios Nikoletseas, Susetta Finotto, Spyros N. Pandis, Valeria Ramiconi, Angela Simpson, Aki Soudunsaari, Anna Starbrost, Maria Staiano, Antonio Varriale, Paraskevi Xepapadaki, Torsten Zuberbier, Isabella Annesi-Maesano
Summary: While the number and types of indoor air pollutants is increasing, little is known about the impact of their synergistic interactions on human health. Different populations have varying susceptibility to pollutants, and low socioeconomic backgrounds further contribute to susceptibility. The SynAir-G project aims to understand and quantify the interactions between different pollutants in order to improve targeting and standards, specifically in the school setting. It will develop a comprehensive monitoring system, advance environmentally friendly interventions, and disseminate knowledge to stakeholders.
Article
Gastroenterology & Hepatology
Christoph Roemmele, Maria Kahn, Stephan Zellmer, Anna Muzalyova, Gertrud Hammel, Christina Bartenschlager, Albert Beyer, Jonas Rosendahl, Tilo Schlittenbauer, Johannes Zenk, Bilal Al-Nawas, Roland Frankenberger, Juergen Hoffmann, Christoph Arens, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann, Alanna Ebigbo
Summary: Healthcare workers (HCWs) have a high risk of SARS-CoV-2 infection, especially during aerosol-generating procedures (AGP). This study found that regions with higher incidence rates, hospital settings, and HCWs in gastrointestinal endoscopy (GIE) had a significantly increased risk of infection.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Meeting Abstract
Immunology
Z. Fneish, J. Becker, F. Mulenge, B. Costa, L. Krajewski, V. Duran, A. Ziegler, C. Traidl-Hoffmann, S. Gilles, U. Kalinke
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Environmental Studies
Stephan Jung, Ye Yuan, Maria Stange Del Carpio, Thomas Pawlik, Stephan Hartmann, Nicole Estrella, Jose Oteros, Claudia Traidl-Hoffmann, Athanasios Damialis, Jeroen Buters, Annette Menzel
Summary: This study found a significant correlation between grassland percentage and pollen concentration, especially within 10 km of the pollen traps. The grassland percentage and pollen concentration varied greatly between pollen stations.