Article
Biotechnology & Applied Microbiology
Yunxian Dong, Dongming Lv, Zirui Zhao, Zhongye Xu, Zhicheng Hu, Bing Tang
Summary: This study found that lycorine has the potential to be an anti-fibrotic drug for the intervention of hypertrophic scars. Lycorine selectively decreases the viability of fibroblasts and induces apoptosis. Additionally, lycorine inhibits the migration and contraction of fibroblasts and reduces the expression of collagen and alpha-SMA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Weijie Xia, Qianran Wang, Shaoyang Lin, Yuanyuan Wang, Junbo Zhang, Hailin Wang, Xia Yang, Yingru Hu, Huaping Liang, Yuangang Lu, Zhiming Zhu, Daoyan Liu
Summary: A high salt diet activates TRPC3, leading to mitochondrial calcium imbalance and promoting hypertrophic scar formation. The activation of TRPC3 triggers mitochondrial dysfunction and excessive ROS production, which promotes scar formation through ROS-mediated calcium channels and the Rho kinase/MLC pathway. This study reveals the underlying mechanism of high salt diet-induced hypertrophic scarring.
Article
Cell Biology
Qian Li, Xin Chen, Ling Chen, Hui Yan, Jun Li
Summary: The study demonstrated that LINC00173 promotes apoptosis of fibroblasts in hypertrophic scars, possibly through increasing beta-catenin expression. Overexpression of TSV1 and TSV2 also affects the apoptosis and proliferation of fibroblasts.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Jiarong Yu, Zhigang Mao, Zengding Zhou, Bo Yuan, Xiqiao Wang
Summary: The study found that there is a dysbiosis in the microbiome of hypertrophic scars, with Staphylococcus aureus as the dominant species, which is closely associated with chronic inflammation and scar formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qin Guo, Yujia Li, Yuan Chen, Jin Ji, Shizhong Zheng, Xuefen Xu, Biyun Zhang, Jianzhou Ye
Summary: Beta-Elemene, a compound extracted from the ginger family plant Wenyujin, has inhibitory effects on human hypertrophic scar fibroblasts (hHSFs) and induces apoptosis through the endoplasmic reticulum stress (ERS) pathway, possibly regulated by P53.
Article
Biochemistry & Molecular Biology
Joon Seok Lee, Gyeong Hwa Kim, Jong Ho Lee, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Keun Hur, Ho Yun Chung
Summary: In this study, miR-365a/b-3p was identified as a potential biomarker for hypertrophic scarring, suggesting its contribution to the formation of hypertrophic scars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lisha Li, Weiqiang Han, Yun Chen, Yuhua Chen
Summary: The study found that miR-3613-3p inhibits the formation of hypertrophic scars by targeting ARGLU1, thus suppressing cell proliferation and ECM protein expression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Maja Schlittler, Peter P. Pramstaller, Alessandra Rossini, Marzia De Bortoli
Summary: Hypertrophic cardiomyopathy is the most common inherited heart disease and a leading cause of sudden cardiac death in young people. Mutations in genes that encode structural proteins of the heart can cause hypertrophic cardiomyopathy, leading to myocardial fibrosis and impaired cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Bo Ri Kim, Soon Hyo Kwon, Jee Woo Kim, Woo-Jin Jeong, Wonjae Cha, Young Ho Jung, Jung-Im Na, Chang-Hun Huh, Jung-Won Shin
Summary: This study is the first clinical trial to demonstrate that early postoperative injection of PDRN can rapidly decrease postsurgical wound erythema, significantly reduce excessive scar formation, and improve scar outcomes. PDRN injection is an effective and safe treatment to prevent hypertrophic scars.
ADVANCES IN WOUND CARE
(2023)
Article
Chemistry, Medicinal
Yiman Chen, Huihui Deng, Liya Yang, Ling Guo, Min Feng
Summary: Hypertrophic scar is a common problem after skin burns or trauma, causing physical, psychological, and cosmetic issues for patients. Photodynamic therapy with 5-aminolevulinic acid (5-ALA) shows promise in treating hypertrophic scar. However, limitations in the clinical application of 5-ALA due to low permeability and rapid binding of protoporphyrin IX (PpIX) with iron ions have been observed. In this study, a mixture of 5-ALA and DFO (a special iron chelator) was used for hypertrophic scar treatment. The combination effectively blocked the biotransformation of PpIX, leading to increased accumulation of the photosensitizer and subsequent destruction of hypertrophic scar fibroblasts.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Dermatology
Alexandra Laberge, Mays Merjaneh, Syrine Arif, Sebastien Larochelle, Veronique J. Moulin
Summary: Hypertrophic scars are a common complication of burn injuries, characterized by excessive vascular density and pathological myofibroblasts. These myofibroblasts release microvesicles that promote blood vessel formation, with their production regulated by alpha-2-macroglobulin.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian P. Nischwitz, Julia Fink, Marlies Schellnegger, Hanna Luze, Vladimir Bubalo, Carolin Tetyczka, Eva Roblegg, Christian Holecek, Martin Zacharias, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Persistent inflammation during wound healing is identified as a precipitating factor in the development of hypertrophic scars. However, lack of standardized models and limited evidence for therapeutic approaches hinder research progress. This study aimed to investigate scar formation mechanisms and develop a method for generating standardized hypertrophic scars through prolonged inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Fu Han, Kejia Wang, Kuo Shen, Jing Wang, Shichao Han, Dahai Hu, Gaofeng Wu
Summary: This study investigated the therapeutic efficacy of bacterial extracellular vesicles (EVs) obtained from Lactobacillus druckerii in treating hypertrophic scars. The results showed that LDEVs inhibited the expression of Collagen I/III and α-SMA in fibroblasts derived from hypertrophic scars and reduced cell proliferation. In a mouse model, LDEVs suppressed hypertrophic scar formation and decreased α-SMA expression. Additionally, LDEVs promoted skin cell proliferation, new blood vessel formation, and wound healing. Proteomic analysis revealed that LDEVs inhibit hypertrophic scar fibrosis through multiple pathways. These findings suggest that Lactobacillus druckerii-derived EVs have potential applications in treating hypertrophic scars and other fibrosis diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zuhan Chen, Fang Xie, Tian Xia, Xiaoen Bian, Shichen Zhang, Jie Cai, Yanfeng Wang
Summary: Early application of quaternized chitin can effectively reduce scar hypertrophy, inhibit HS formation through regulating IL-6 expression, and may be a beneficial method in clinical wound management.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Kamila Raziyeva, Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Temirkhanova, Arman Saparov
Summary: Cardiac fibrosis is a common pathological consequence of myocardial diseases, resulting in heart dysfunction and failure. The mechanisms of cardiac fibrosis are still not fully understood, but there have been advances in developing new treatment strategies using cellular and animal models.