期刊
SCIENCE ADVANCES
卷 6, 期 15, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aaz6980
关键词
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资金
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education [NRF-2017R1D1A1B03034177]
- Yonsei University College of Medicine [6-2019-0078]
As extracellular vesicles that play an active role in intercellular communication by transferring cellular materials to recipient cells, exosomes offer great potential as a natural therapeutic drug delivery vehicle. The inflammatory responses in various disease models can be attenuated through introduction of super-repressor I kappa B (srI kappa B), which is the dominant active form of I kappa B alpha and can inhibit translocation of nuclear factor kappa B into the nucleus. An optogenetically engineered exosome system (EXPLOR) that we previously developed was implemented for loading a large amount of srI kappa B into exosomes. We showed that intraperitoneal injection of purified srI kappa B-loaded exosomes (Exo-srI kappa Bs) attenuates mortality and systemic inflammation in septic mouse models. In a biodistribution study, Exo-srI kappa Bs were observed mainly in the neutrophils, and in monocytes to a lesser extent, in the spleens and livers of mice. Moreover, we found that Exo-srlicB alleviates inflammatory responses in monocytic THP-1 cells and human umbilical vein endothelial cells.
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