Review
Chemistry, Analytical
Yanawut Manmana, Takuya Kubo, Koji Otsuka
Summary: Point-of-care testing devices are essential for improving human life in both developing and developed countries. Specific biomolecules related to particular diseases are important targets for POC testing. Advances in new technologies have enabled researchers to develop POC devices in various platforms and designs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Qiangqiang Fu, Tao Qi, Ze Wu, Yongjian He, Shujuan Guan, Shihua Luo, Qi Zhang, Wenfeng Luo, Wei Xiao, Bo Situ, Lei Zheng
Summary: This study presents a portable and affordable smartphone-based Hb analyzer for quick anemia testing, especially suitable for high-risk patients in areas with limited medical resources.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Juxiang Liu, Ping Chen, Xulong Hu, Liping Huang, Zhi Geng, Hao Xu, Wenjun Hu, Lin Wang, Ping Wu, Gang L. Liu
Summary: The development of a nanoplasmonic enhanced isothermal amplification (NanoPEIA) method provides a fast and high-throughput detection platform for SARS-CoV-2. This method combines a nanoplasmonic sensor with isothermal amplification and can complete the entire detection process within a short time. It shows high sensitivity and specificity for detecting the N and orflab genes of SARS-CoV-2, making it suitable for POCT diagnosis in resource-poor and highly populated areas.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Mingliang Jiang, Raghuveer Lalitha Sridhar, Andrew B. Robbins, Alan D. Freed, Michael R. Moreno
Summary: Uniaxial testing is common for mechanical analysis of biological materials, but biaxial testing offers a more comprehensive understanding. Custom biaxial testing systems can overcome limitations of commercially available systems, providing a wider range of testing capabilities.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biochemical Research Methods
Alexandros A. Sklavounos, Carine R. Nemr, Shana O. Kelley, Aaron R. Wheeler
Summary: This study demonstrated a method for bacterial classification and antibiotic susceptibility testing using digital microfluidics, achieving automated and simultaneous results in under 18 hours through monitoring metabolic markers. The versatility and accuracy of this method were shown through successful identification of bacteria and validation of AST results.
Article
Chemistry, Analytical
Giorgio Gianini Morbioli, Nicholas C. Speller, Michael E. Cato, Amanda M. Stockton
Summary: The development of functional microfluidic devices requires iterative design, fabrication, and testing. While much focus has been on improving device design, attention to the testing phase is lacking. Traditional testing methods limit design modifications, but a new modular testing approach allows for faster testing and reduced design restrictions.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Yangfei Chen, Xuqi Chen, Mengna Li, Pengwei Fan, Bin Wang, Sheng Zhao, Weimin Yu, Shaohua Zhang, Yuchen Tang, Tingjuan Gao
Summary: This study introduces a custom-built microscopic CTC cytometer and a novel enrichment strategy based on a synthesized peptide ligand to address the challenges of instrumentation miniaturization and simplified sample preparation for CTC detection. The platform offers advantages such as high detection sensitivity, simplified sample preparation, and cost-effectiveness.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemical Research Methods
Aziz Taghbalout, Nathaniel Jillette, Albert W. Cheng
Summary: TALE.Sense is described as a versatile platform for sensing DNA sequences in live mammalian cells and generating customizable responses to discern cells with specified sequence targets. The platform demonstrates higher efficiency and dynamic range compared to zinc-finger based DNA sensors, and amplification loops and interchangeable transcriptional activation modules can further enhance its detection efficiency. The platform's versatility in detecting a range of target sites makes it suitable for identifying live cell variants with anticipated DNA sequences, and it can be integrated with other cellular or synthetic circuits to expand connections for inducible modules in synthetic biology.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Analytical
Xinghui Yu, Yongqiang Ma, Siyuan Liu, Chunchun Qi, Weiqi Zhang, Wen Xiang, Zhaoxian Li, Kai Yang, Shaoxian Duan, Xinrao Du, Jian Yu, Yan Xie, Zicheng Wang, Wentao Jiang, Li Zhang, Xiaodong Lin
Summary: Post-operative pathogenic infections in liver transplantation pose a serious threat to human health. Researchers have developed a chemiluminescence-based method for the rapid and sensitive detection of Staphylococcus aureus. By integrating specific capture and separation techniques, this portable device, integrated with a smartphone, enables specific detection of S. aureus with high antibacterial efficiency. The method is simple to use and cost-effective, demonstrating great potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Behnam Enghiad, Pu Xue, Nilmani Singh, Aashutosh Girish Boob, Chengyou Shi, Vassily Andrew Petrov, Roy Liu, Siddhartha Suryanarayana Peri, Stephan Thomas Lane, Emily Danielle Gaither, Huimin Zhao
Summary: Despite their broad utility, design and construction of plasmids remains laborious and time-consuming. Here the authors report a robust, versatile, and automated end-to-end platform that enables scarless construction of virtually any plasmid.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Yu Chen, Carlos A. Tristan, Lu Chen, Vukasin M. Jovanovic, Claire Malley, Pei-Hsuan Chu, Seungmi Ryu, Tao Deng, Pinar Ormanoglu, Dingyin Tao, Yuhong Fang, Jaroslav Slamecka, Hyenjong Hong, Christopher A. LeClair, Sam Michael, Christopher P. Austin, Anton Simeonov, Ilyas Singec
Summary: Through high-throughput screening, a small-molecule cocktail called CEPT was discovered to enhance the survival of human pluripotent stem cells (hPSCs) and their differentiated progeny by simultaneously blocking multiple stress mechanisms. This cocktail showed strong improvements in various key applications in stem-cell research, providing a rationale for the safe and efficient utilization of hPSCs.
Article
Biophysics
Sakandar Rauf, Abdellatif Ait Lahcen, Abdulrahman Aljedaibi, Tutku Beduk, Jose Ilton de Oliveira Filho, Khaled N. Salama
Summary: The study introduces a new class of nanostructured gold modified LSG electrochemical sensing system, which is achieved through electrodeposition of gold chloride solution, showing significantly higher sensitivity and electrocatalytic activity compared to bare LSG and screen-printed gold electrodes. This system can be used for detecting biomarkers like Her-2 and easily detects different concentrations of biomarkers in undiluted human serum.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Ting Liu, Jianwei Huang, Zhipeng Lin, Chengsen Zhan, Dingrong Yi, Shouyu Wang
Summary: Optical spectroscopy is a widely used tool in analytical science, and a multipurpose optical fiber smartphone spectrometer (MOSS) has been designed to provide on-site biochemical sensing. The MOSS is compact but has excellent sensing performance, making it suitable for point-of-care testing.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Environmental
Zhe Sun, Min Qing, Yu Zhu Fan, Hang Yan, Nian Bing Li, Hong Qun Luo
Summary: In this study, an affordable and user-friendly colorimetric POCT sensing system based on sulfur quantum dots (S dots) is proposed for selectively monitoring four metal ions. The system utilizes paper-based analytical devices (PADs) to present four distinct visual signals and employs a scanner and smartphone App for quantitative analysis. Furthermore, the system demonstrates its potential for multiple logic operations and shows promise for on-site environmental testing and sophisticated molecular computation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Zhe Sun, Min Qing, Yu Zhu Fan, Hang Yan, Nian Bing Li, Hong Qun Luo
Summary: This study introduces a cost-effective and user-friendly colorimetric detection system based on sulfur quantum dots for selectively monitoring four metal ions. The system utilizes paper-based analytical devices to present distinct visual signals and converts them to HSV values for quantitative analysis through a smartphone App. By integrating multi-responsive blocks into the sulfur quantum dots, the platform demonstrates potential for on-site environmental testing and sophisticated molecular computation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Xin Chen, Henglu Zhang, Lanlan Li, Yang Xu, Weiping Lu, Yibing Lu
Summary: This study reveals that ENSMUST00000147869 can inhibit the proliferation and fibrosis of MMCs by regulating Hspa9 and inhibiting its interaction with HMGB1. This finding may provide a molecular marker for diagnosis and a therapeutic target for DN.
Article
Nanoscience & Nanotechnology
Shaopeng Li, Yuanfei Han, Haitao Zhou, Guangfa Huang, Jianwen Le, Xiaoyan Wang, Weijie Lu
Summary: The study established an isothermal compression model and successfully achieved precision forming of titanium matrix composites (TMCs) precision components with variable cross-sections. By optimizing the local microstructure and performance through controlling deformation degree in different section regions, the engineering strength and elongation were improved significantly.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Oncology
Elizabeth Zhang-Velten, You Zhang, Sepeadeh Radpour, Xuejun Gu, D. Nathan Kim, Prasanna Alluri, Chika Nwachukwu, Tsuicheng Chiu, Weiguo Lu, David Parsons, Jun Tan, Jennifer Gillespie, Stella Stevenson, Hak Choy, Robert Timmerman, Asal Rahimi
Summary: The article describes the institutional experience of using GammaPod for breast cancer radiation therapy from 2019 to 2021, including workflow, procedure step times, and techniques for improved efficiency.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Materials Science, Composites
Shaopeng Li, Yuanfei Han, Xiaoyan Wang, Guangfa Huang, Minhan Fang, Huigang Shi, Jianwen Le, Weijie Lu
Summary: This study creatively planted nano-TiB fibers in Ti-composite powder, forming a novel ultra-fine network structure. The high temperature was found to destroy and coarsen the nano-TiB fibers, highlighting the importance of controlling the sintering temperature for optimizing the TiB particle size and distribution.
COMPOSITES COMMUNICATIONS
(2022)
Article
Optics
Hepeng Zhao, Xinchao Zhao, Xuehong Zhang, Zhuangzhuang Cui, Yu Ou-Yang, Maobin Xie, Min Zheng, Xueyu Guan, Lijun Wu, Xinglei Zhou, Lihui Li, Yushuang Zhang, Yang Li, Ying Jiang, Wei Lu, Xiaoli Zhu, Chao Peng, Xiao Wang, Shaowei Wang, Xiujuan Zhuang
Summary: This study demonstrates the realization of a silicon-based vertical cavity surface-emitting laser by controlled preparation of high-gain erbium silicate materials and novel design of high optical feedback microcavity. The laser exhibits a small footprint, high efficiency, and low lasing threshold, making it a potential sub-micrometer coherent light source for optical communication.
Review
Pharmacology & Pharmacy
Linwei Lu, Qianzhu Xu, Jun Wang, Sunyi Wu, Zimiao Luo, Weiyue Lu
Summary: Drug nanocrystals can enhance the solubility and bioavailability of poorly water-soluble drugs, and active tumor-targeted drug delivery systems can improve the efficacy and safety of chemotherapy.
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
Article
Chemistry, Physical
Huaduo Wu, Yuanfei Han, Jianwen Le, Nan Zong, Shaopeng Li, Yifei Luo, Guangfa Huang, Jianwei Mao, Weijie Lu
Summary: A new titanium matrix composite with distinctive architecture consisting of isolated fiber-like structural region within continuously Ti region was designed and fabricated. The role of TiB contents on microstructural evolution and mechanical response was investigated. The designed composite with appropriate TiB content showed a better combination of strength and ductility.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Shuzhen Peng, Yun Chang, Xingli Zeng, Rong Lai, Mujing Yang, Dandan Wang, Xiaoshun Zhou, Yong Shao
Summary: We successfully programmed polyadenine DNA into a parallel duplex assembly using a polyvalent-binding assembler called nitidine (NIT) at neutral pH. The molecule planarity of natural isoquinoline alkaloids (NIAs) was found to be a determining factor in this assembly process. We also developed a gold nanoparticles-based colorimetric method to screen NIT out of NIAs for constructing the polyadenine assembly. Our work will inspire further interest in developing switches and sensors based on polyadenine by concentrating NIT within the parallel assembly.
ANALYTICA CHIMICA ACTA
(2023)
Article
Neurosciences
Xiaoming Zhao, Yuehui Liao, Zhiwei Tang, Yicheng Xu, Xin Tao, Dandan Wang, Guoyu Wang, Hongsheng Lu
Summary: Recently, personality trait recognition has become an interesting and active topic in psychology, affective neuroscience, and artificial intelligence. This paper proposes a new method of multimodal personality trait recognition that integrates audio-visual modalities based on a hybrid deep learning framework. Experimental results demonstrate the effectiveness of this method.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Optics
Liangliang Zhang, Dandan Wang, Feng Liu, Hao Wu, Guohui Pan, Huajun Wu, Zhendong Hao, Hong Zhang, Jiahua Zhang
Summary: A novel strategy of minimizing bond angle distortion is realized to suppress thermal quenching in NIR phosphors, resulting in enhanced thermal stability. The findings provide new insights and possibilities for the exploration of thermally stable NIR phosphors.
LASER & PHOTONICS REVIEWS
(2023)
Review
Oncology
Meng Dong, Jianrong Wu, Renhua Wu, Dandan Wang, Ruifeng Liu, Hongtao Luo, Yuhang Wang, Junru Chen, Yuhong Ou, Qiuning Zhang, Xiaohu Wang
Summary: This study conducted a meta-analysis to evaluate the efficacy and safety of proton beam therapy (PBT) for rhabdomyosarcoma (RMS). The results showed that PBT had good local control, progression-free survival, and overall survival rates for RMS patients, with minimal side effects.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Yuhang Wang, Ruifeng Liu, Qiuning Zhang, Meng Dong, Dandan Wang, Junru Chen, Yuhong Ou, Hongtao Luo, Kehu Yang, Xiaohu Wang
Summary: High-grade gliomas remain difficult to treat despite standard therapy. Charged particle beams, especially carbon ion beams, have the potential to improve treatment outcomes. This systematic review assessed the safety, efficacy, and dosimetry of carbon-ion or proton radiotherapy for high-grade gliomas. The analysis of eleven eligible articles showed that charged particle radiotherapy was effective with manageable side effects. Carbon ion boost appeared to be superior to proton boost, but dose-escalation using proton boost was associated with severe brain necrosis. Further randomized control trials are needed, along with systemic therapeutic options.
RADIATION ONCOLOGY
(2023)
Article
Zoology
Dandan Wang, Xiaolong Hu, Minling Li, Jie Liu, Ming Tang, Wuhua Liu, Jianwen Zhan, Yongtao Xu, Weiwei Zhang
Summary: This study investigated the winter diet composition and interspecific relationships of South China sika deer, Reeve's muntjac, and Chinese hare in Taohongling. The results showed that the three species had overlapping diets, but Chinese hare had the widest food choice. The diet niche overlap index indicated a more similar niche and potential competition between sika deer and Reeve's muntjac.
Article
Energy & Fuels
Fei Zhao, Yalou Li, Xiaoxin Zhou, Dandan Wang, Yawei Wei, Fang Li
Summary: Coal-fired power plants can effectively reduce carbon emissions through ammonia-coal co-firing technology. We propose a low-carbon power supply and multi-timescale energy storage system, which includes batteries, fuel cells and the coal-fired power plant equipped with the ammonia-coal co-combustion module. This system can handle short and long term fluctuations in renewable energy and we use optimization models and simulations to analyze its economic and environmental performances.
