Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Sangeeta Ghuwalewala, Dishari Ghatak, Sumit Das, Stuti Roy, Pijush Das, Ramesh Butti, Mahadeo Gorain, Somsubhra Nath, Gopal C. Kundu, Susanta Roychoudhury
Summary: The study found an elevated expression of miR-146a in the CD44(high)CD24(low) population within OSCC cells and primary HNSCC tumors. Over-expression of miR-146a enhances stemness phenotype by stabilizing beta-catenin and resulting in loss of E-cadherin and CD24. CD24 is identified as a novel functional target of miR-146a, and mechanistic analysis reveals that higher CD24 levels inhibit AKT phosphorylation leading to beta-catenin degradation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaicheng Yang, Jianguang Zhao, Shenghui Liu, Shasha Man
Summary: TFAP2A overexpression is observed in many cases of OSCC, and the key signaling pathway associated is the RELA-TFAP2A-Wnt/β-catenin pathway. It was found that upregulation of RELA can promote the progression of OSCC, and TFAP2A activates the Wnt/β-catenin signaling pathway by targeting the promoter regions of β-catenin. The study suggests that the RELA-TFAP2A-Wnt/β-catenin pathway is a potential target for reducing the aggressiveness of OSCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Meng Wang, Zhigang Feng, Xiaoxi Li, Shulan Sun, Li Lu
Summary: LncRNA HCG22 is lowly expressed in OSCC cells and exerts anti-tumor properties by inhibiting the Akt, mTOR, and Wnt/beta-catenin pathways.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Stefan Stoiber, Faris F. Brkic, Tobias Maier, Julia Schnoell, Elisabeth Gurnhofer, Gregor Heiduschka, Lorenz Kadletz-Wanke, Lukas Kenner
Summary: This study evaluated the prognostic relevance of the Wnt/beta-CATENIN pathway in patients with HPV-positive HNSCC. High CTNNB1 expression was linked to better overall survival, and high beta-CATENIN expression was significantly associated with a better overall survival as well. Thus, beta-CATENIN expression may serve as a marker for better survival outcomes in patients with HPV-positive HNSCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shao-Cheng Liu, Chin-Sheng Huang, Chih-Ming Huang, Ming-Shou Hsieh, Mao-Suan Huang, Iat-Hang Fong, Chi-Tai Yeh, Chih-Cheng Lin
Summary: Isoorientin attenuates the stemness and epithelial-mesenchymal transition potential of OSCC cells by inhibiting the JAK/STAT3 and Wnt/β-catenin signaling pathways. It also enhances the cytotoxic effects of cisplatin against OSCC and inhibits the tumorigenicity and growth of OSCC in vivo through the disruption of Wnt/β-catenin/STAT3 signaling.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Suzhen Sun, Geng Su, Xijiao Zheng
Summary: SPINK5 functions as a prognostic biomarker in oral squamous cell carcinoma (OSCC), and its dysregulation is related to the loss of EHMT2. SPINK5 can inhibit the aggressiveness of OSCC cells by impairing the Wnt/beta-catenin pathway. Silencing EHMT2 blocks Wnt/beta-catenin signaling and tumor growth in OSCC, which can be reversed by SPINK5 knockdown. These findings suggest that SPINK5, mediated by the loss of EHMT2, can be a potential therapeutic target for OSCC.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Oncology
Pablo Ramos-Garcia, Miguel A. Gonzalez-Moles
Summary: This systematic review and meta-analysis evaluated the prognostic and clinicopathological significance of aberrant expression of beta-catenin in oral squamous cell carcinoma (OSCC). The study found that aberrant beta-catenin expression is significantly associated with poor overall survival, disease-free survival, lymph node involvement, higher clinical stage, larger tumor size, and moderately-poorly differentiated OSCC. The loss of beta-catenin in the cell membrane is the most impactful in terms of these associations.
Article
Biotechnology & Applied Microbiology
Chunyan Qiao, Tianyi Qiao, Shihui Yang, Lili Liu, Mengdan Zheng
Summary: The research revealed that upregulated SNHG17 in oral squamous cell carcinoma (OSCC) promoted cell growth by activating the Wnt/beta-catenin signaling pathway. ELF1 was identified as the transcription activator of CTNNB1 (beta-catenin mRNA) and played a crucial role in SNHG17-mediated OSCC cell growth. Additionally, SNHG17 and ELF1 acted as competing endogenous RNAs (ceRNAs) in OSCC by competitively binding to miR-384, regulating cell growth in the ceRNA network.
CANCER GENE THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruimin Zhao, Shiyang Wang, Lu Tan, Huajing Li, Junsong Liu, Shaoqiang Zhang
Summary: The study found that IGFL2-AS1 was highly expressed in tongue squamous cell carcinoma (TSCC) and had an impact on cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). IGFL2-AS1 acted as a competing endogenous RNA (ceRNA) by regulating the expression of miR-1224-5p and SATB homeobox 1 (SATB1), thereby regulating the Wnt/beta-catenin signaling pathway and TSCC progression.
Article
Cell Biology
Jiongyu Chen, Zhangzhu Zhou, Xueqiong Lin, Jiahui Liao, Yujie Zhang, Bingmeng Xie, Yiteng Huang, Lin Peng
Summary: This study investigates the relationship between cadmium (Cd) exposure and the development, progression, and therapeutic resistance of esophageal squamous cell carcinoma (ESCC). The results show that ESCC patients have higher levels of blood Cd compared to controls, and Cd exposure is associated with increased risk and rapid progression of ESCC. Long-term Cd exposure in ESCC cells leads to enhanced cell proliferation, invasion, and migration, as well as reduced efficacy of chemotherapy and irradiation. Cd also stimulates cancer cell stemness and activates the Wnt/β-catenin signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yunjiu Gou, Dacheng Jin, Shengliang He, Songchen Han, Qizhou Bai
Summary: RNF168 is found to be overexpressed in ESCC and associated with tumor stage and depth of invasion. Knockdown of RNF168 inhibits esophageal cancer cell proliferation, promotes apoptosis, interferes with cell movement, and ultimately suppresses tumor growth. RNF168 influences malignant behavior of esophageal cancer cells through regulating the Wnt/β-catenin signaling pathway.
Article
Medicine, Research & Experimental
Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu, Yi Zhong
Summary: This study identifies FAM83A as an oncogene of HNSCC with overexpression significantly associated with tumor size, lymph node status, and clinical tumor stages. FAM83A promotes HNSCC cell growth and metastasis by inducing EMT through activation of the Wnt/beta-catenin signaling pathway. Knockdown of FAM83A suppresses tumor growth and distant metastasis in xenograft animal models of HNSCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Plant Sciences
Cai-Wen Fan, Juan Tang, Jing-Chen Jiang, Mei-Mei Zhou, Mei-Shan Li, Heng-Shan Wang
Summary: This study demonstrated that PGG can inhibit proliferation, induce apoptosis and autophagy, and decrease metastatic capacity of NPC cells. Mechanistically, PGG exerts its effects through the p38 MAPK/mTOR and Wnt/beta-catenin pathways, providing evidence for PGG as a potential therapeutic option for NPC.
Article
Pharmacology & Pharmacy
Lingli Ding, Song Gu, Bingyu Zhou, Min Wang, Yage Zhang, Siluo Wu, Hong Zou, Guoping Zhao, Zhao Gao, Liangliang Xu
Summary: Fractures have a negative impact on an individual's quality of life, but Ginsenoside Compound K (CK) found in Ginseng has shown potential for promoting bone regeneration and angiogenesis. This study found that CK can promote osteogenic differentiation of rat bone marrow mesenchymal stem cells and increase tube formation capacity in human umbilical vein endothelial cells. In a rat open femoral fracture model, CK was found to improve fracture repair and increase the formation of H type vessel in the fracture callus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xuan He, Zhiqi Han, Weidong Jiang, Fangfang Huang, Chao Ren, Qian Wei, Nuo Zhou
Article
Cell & Tissue Engineering
Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao, Yangyang Yu, Yan Liu, Huijuan Shen, Zhenchen Zhao, Xuanping Huang, Nuo Zhou
Summary: MiR-205 is identified as a significant regulator in the MDO process, with inhibition of this miRNA shown to accelerate MDO-related mineralization. These findings offer new insights into the mechanistic basis for this procedure, highlighting potential targets for therapeutic clinical intervention.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Hejia Guo, Weidong Jiang, Suhua Huang, Xuanping Huang, Cuiping Li
Summary: A study identified 12 differentially expressed proteins in serum exosomes of oral squamous cell carcinoma (OSCC), with C-reactive protein, von Willebrand factor, and leucine-rich alpha-2-glycoprotein showing high sensitivity and specificity as new biomarkers for diagnosing OSCC. Combined biomarkers outperformed individual proteins in diagnosis. Furthermore, tumor-derived exosomes were found to promote migration of oral cancer cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Weidong Jiang, Peiqi Zhu, Fangfang Huang, Zhenchen Zhao, Tao Zhang, Xiaoning An, Fengchun Liao, Lina Guo, Yan Liu, Nuo Zhou, Xuanping Huang
Summary: Distraction osteogenesis (DO) is a method used to treat large bone defects in oral and maxillofacial surgery. This study found that the m(6)A modification level increases significantly during DO and is also elevated during EPC angiogenesis under hypoxic conditions, along with an increase in METTL3 levels. Inhibiting METTL3 in EPCs suppresses various angiogenic activities, while overexpression of METTL3 enhances these activities, suggesting that METTL3 accelerates bone regeneration during DO by promoting EPC angiogenesis through the PI3K/AKT pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Tao Zhang, Weidong Jiang, Fengchun Liao, Peiqi Zhu, Lina Guo, Zhenchen Zhao, Yan Liu, Xuanping Huang, Nuo Zhou
Summary: This study aimed to investigate whether exosomes derived from distraction osteogenesis (DO) and bone fracture (BF) serum could stimulate osteogenic differentiation and identify the relevant genes involved. The results showed that exosomes accelerated osteogenesis in DO, possibly through co-expression of MSTRG.532277.1 and FBXL14, providing new therapeutic targets for bone regeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Cell & Tissue Engineering
Zhiqi Han, Xuan He, Yuan Feng, Weidong Jiang, Nuo Zhou, Xuanping Huang
Summary: This study reveals a novel mechanism of Hsp20-mediated regulation of canine EPCs via Akt activation in a hypoxic microenvironment.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Orthopedics
Fengchun Liao, Ziqi Liao, Tao Zhang, Weidong Jiang, Peiqi Zhu, Zhenchen Zhao, Henglei Shi, Dan Zhao, Nuo Zhou, Xuanping Huang
Summary: This study reveals that suppressing THBS1 in ECFC-Exos may enhance angiogenesis and bone healing, providing a promising strategy to shorten the duration of DO procedures.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Cell Biology
Yuan Feng, Zhiqi Han, Weidong Jiang, Huijuan Shen, Yangyang Yu, Nuo Zhou, Xuanping Huang
Summary: This study revealed a novel mechanism of ATF4-mediated regulation of BMSC under hypoxia. Hypoxia promoted migration, osteoblast differentiation, and ATF4 expression in BMSC, while knockdown of ATF4 inhibited these effects. This research is of great significance for understanding the role of BMSC in MDO.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Pathology
Cuiping Li, Hejia Guo, Juan Xiong, Binghua Feng, Peiqi Zhu, Weidong Jiang, Panpan Jiang, Xiaoping Su, Xuanping Huang
Summary: This study found that MAGI2-AS3 and CCDC144NL-AS1 were overexpressed in patients with OSCC and correlated with clinicopathologic factors. These two lncRNAs may promote cell proliferation, invasion, and migration in OSCC cells by regulating the PI3K-AKT-mTOR pathway, providing new therapeutic strategies for OSCC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Integrative & Complementary Medicine
Peiqi Zhu, Weidong Jiang, Shixi He, Tao Zhang, Fengchun Liao, Di Liu, Xiaoning An, Xuanping Huang, Nuo Zhou
Summary: The optimal concentration of 6.25mg/L PNS was determined to promote cell proliferation, tube formation, and migration. PNS can enhance EPC angiogenesis through the activation of the Wnt/β-catenin signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
