Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Endocrinology & Metabolism
Isabel Heyde, Kimberly Begemann, Henrik Oster
Summary: The text discusses the role of adipose tissue in the circadian regulation of energy metabolism, with white and brown adipose tissue playing different roles in energy regulation through the release of endocrine factors and heat production. Adipose tissue rhythms are regulated by systemic signals and local clocks, impacting metabolic homeostasis. Disruption of circadian rhythms in adipose tissue can lead to obesity and related issues, highlighting the importance of stabilizing adipose tissue rhythms for combatting disrupted energy homeostasis and obesity.
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Physiology
Mingchen Xiong, Weijie Hu, Yufang Tan, Honghao Yu, Qi Zhang, Chongru Zhao, Yi Yi, Yichen Wang, Yiping Wu, Min Wu
Summary: The study revealed that E2F1 knockout increased mitochondria and UCP-1 expression in mouse adipose tissue by suppressing autophagy, promoting WAT browning. In vitro experiments showed that adipocytes lacking E2F1 exhibited upregulated UCP-1 and downregulated autophagy-related gene expression.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemical Research Methods
Li Zhang, Peng Ma, Zijing Wang, Tianshu Xu, Sin Man Lam, Guanghou Shui, Yuzhen Wang, Jiming Xie, Guifen Qiang
Summary: Using a multiomics approach, this study explored the mechanism of thermogenesis in BAT, revealing a high abundance of glycerophospholipids and sphingolipids in BAT. The study also identified specific lipid biomarkers and gene biomarkers that may serve as potential targets for antiobesity drugs by boosting BAT thermogenesis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Iker Gomez-Garcia, Jenifer Trepiana, Alfredo Fernandez-Quintela, Marta Giralt, Maria P. Portillo
Summary: This narrative review examines the sex differences in the effects of cold exposure, feeding pattern, and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. The findings suggest that females tend to activate thermogenesis earlier in response to cold exposure and exhibit greater sensitivity to overfeeding or energy restriction. Sexual development leads to increased BAT activity, especially in boys, while aging results in a decline in thermogenic capacity, particularly in men. Additionally, females are more susceptible to WAT browning. Further studies are needed to provide valuable information for personalized approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sergio Quesada-Vazquez, Anna Antolin, Marina Colom-Pellicer, Gerard Aragones, Laura Herrero, Josep Maria Del Bas, Antoni Caimari, Xavier Escote
Summary: A specific combination of metabolic cofactors showed promising results in treating obesity in a high-fat diet mouse model. The combination reduced obesity and adiposity, improved glucose and lipid metabolic parameters, increased lipid oxidation, and decreased adipocyte hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Liu, Jiatao Liu, Dewei Zeng, Huan Wang, Yun Wang, Jiali Xiong, Xingping Chen, Junyi Luo, Ting Chen, Qianyun Xi, Qingyan Jiang, Yongliang Zhang
Summary: This study demonstrated the significant role of miR-143 in obesity, with knockout of miR-143 leading to reduced body weight, improved energy metabolism and glucose tolerance. Knockout of miR-143 also affected the metabolism of adipose tissue, promoting the function of BAT and inhibiting lipogenesis in WAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhengyan Zhang, Di Yang, Junwei Xiang, Jingwen Zhou, Hua Cao, Qishi Che, Yan Bai, Jiao Guo, Zhengquan Su
Summary: Thermogenic organs in mammals play a crucial role in increasing heat production and energy regulation. Targeting specific signalling pathways to enhance energy expenditure via brown adipose tissue may be a potential strategy for treating obesity and related diseases. Studies have shown that various natural products can promote thermogenesis through different signalling pathways, offering potential for future research on weight-loss nutraceuticals or drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Oana C. Kulterer, Carsten T. Herz, Marlene Prager, Christoph Schmoeltzer, Felix B. Langer, Gerhard Prager, Rodrig Marculescu, Alexandra Kautzky-Willer, Marcus Hacker, Alexander R. Haug, Florian W. Kiefer
Summary: There is a higher prevalence of active brown adipose tissue (BAT) in lean individuals compared to obese individuals. However, the volume and activity of BAT are similar between lean and obese individuals with active BAT. In obese participants, there is a strong negative correlation between visceral fat and BAT volume, glucose uptake, and cold-induced thermogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhichao Wang, Qiong A. Wang, Yong Liu, Lei Jiang
Summary: Brown adipose tissue functions as an 'energy sink' in mammals, burning calories through substrates like lipids, glucose, and other metabolites to produce heat and support thermogenesis, contributing to overall metabolic homeostasis.
Review
Endocrinology & Metabolism
Alev Eroglu Altinova
Summary: The browning of white adipose tissue (WAT), which refers to the emergence of beige adipocytes, can be influenced by various factors such as cold, beta (3)-adrenergic stimulation, and excess adiposity. Recent studies suggest that therapies targeting the browning of WAT can be effective in reducing obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Zachary LaRussa, Hsuan-Chih N. Kuo, Kathryn West, Zhijun Shen, Kevin Wisniewski, Patrick Tso, Karen T. T. Coschigano, Chunmin C. C. Lo
Summary: Dietary lipids induce apolipoprotein A4 (APOA4) production and brown adipose tissue (BAT) thermogenesis, which can be further enhanced by exogenous APOA4. However, chronic high-fat diet (HFD) feeding attenuates the production of APOA4 and BAT thermogenesis. This study shows that overexpression of APOA4 in the small intestine and maintenance of elevated plasma APOA4 level lead to increased BAT thermogenesis and protection against HFD-induced obesity in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Haijun Dong, Man Qin, Peng Wang, Shufan Li, Xing Wang
Summary: This review summarizes the regulatory effects of exercise on adipose tissue metabolism and the possible mechanisms, with special focus on activating the sympathetic nervous system and promoting the secretion of exerkines. These findings have implications for the prevention and treatment of obesity and related metabolic diseases through exercise.
Article
Cardiac & Cardiovascular Systems
Kelsey M. Pinckard, Vikram K. Shettigar, Katherine R. Wright, Eaman Abay, Lisa A. Baer, Pablo Vidal, Revati S. Dewal, Devleena Das, Silvia Duarte-Sanmiguel, Diego Hernandez-Saavedra, Peter J. Arts, Adam C. Lehnig, Valerie Bussberg, Niven R. Narain, Michael A. Kiebish, Fanchao Yi, Lauren M. Sparks, Bret H. Goodpaster, Steven R. Smith, Richard E. Pratley, E. Douglas Lewandowski, Subha Raman, Loren E. Wold, Daniel Gallego-Perez, Paul M. Coen, Mark T. Ziolo, Kristin Stanford
Summary: The study demonstrates that brown adipose tissue (BAT) improves cardiac function through the release of the lipokine 12,13-diHOME. Sustained overexpression of 12,13-diHOME can mitigate the detrimental effects of a high-fat diet on the heart, while incubation of cardiomyocytes with 12,13-diHOME enhances mitochondrial respiration.
Article
Nutrition & Dietetics
Pablo Vidal, Lisa A. Baer, Elisa Felix-Soriano, Felix T. Yang, Daniel A. Branch, Kedryn K. Baskin, Kristin Stanford
Summary: The prevalence of metabolic diseases is increasing, with diet being a major contributing factor. Exercise is effective in combating metabolic diseases. This study found that a high-fat diet impairs metabolic function, while a high-phosphate diet does not significantly affect glucose metabolism. Exercise can reverse the detrimental effects of a high-fat diet and restore metabolic function.
Article
Medicine, Research & Experimental
Carmem Peres Valgas Da Silva, Vikram K. Shettigar, Lisa A. Baer, Eaman Abay, Kelsey M. Pinckard, Jorge Vinales, Sarah L. Sturgill, Pablo Vidal, Mark T. Ziolo, Kristin I. Stanford
Summary: This study demonstrates that aerobic exercise can significantly improve survival after myocardial infarction (MI), independent of its effects on cardiac function. However, exercise does not have an impact on obesity and glucose intolerance induced by a high-fat diet (HFD). This highlights the importance of considering environmental interventions, including diet, in the cardiac rehabilitation of obese patients.
Review
Cardiac & Cardiovascular Systems
Matthew J. J. Mears, Harrison L. L. Hookfin, Priya Bandaru, Pablo Vidal, Kristin I. I. Stanford, Loren E. E. Wold
Summary: The use of electronic cigarettes by young adolescents has dramatically increased in recent years, with manufacturers adapting to make them more appealing to this demographic. However, research is beginning to show that e-cigarette use can have negative effects on cardiac function, vascular integrity, and cardiometabolic health. It is important to have a comprehensive understanding of these effects in order to inform policymakers of the dangers associated with e-cigarette use.
CIRCULATION RESEARCH
(2023)
Article
Engineering, Biomedical
Devleena Das, William R. Lawrence, Ludmila Diaz-Starokozheva, Ana I. Salazar-Puerta, Neil Ott, Erin R. Goebel, Abhishek Damughatla, Pablo Vidal, Summer Gallentine, Jordan T. Moore, Douglas Kayuha, Natalia C. Mendonca, Jared B. Albert, Robert Houser, Jed Johnson, Heather Powell, Natalia Higuita-Castro, Kristin I. Stanford, Daniel Gallego-Perez
Summary: This study presents a novel approach to enhance autologous adipose engraftment techniques by co-injecting pulverized electrospun poly(lactic-co-glycolic acid) (PLGA) fibers with adipose tissue. The results demonstrate that this method has no detrimental effect on adipocyte viability and significantly improves reperfusion, vascularity, and graft volume retention.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
