Article
Infectious Diseases
Jinling Fang, Rifeng Chen, Donghua Liu
Summary: This study explores the association between Talaromyces marneffei and CD86 protein, revealing that the fungus has the ability to capture CD86 proteins from macrophages.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Fangyi Shu, Patcharin Thammasit, Kritsada Pruksaphon, Joshua D. D. Nosanchuk, Sirida Youngchim
Summary: This study investigates the expression of cytokine profiles in human THP-1 cells during T. marneffei infection. The results show that as the infection progresses, macrophages undergo slight M1 polarization before shifting to M2 polarization. This polarization transition is confirmed by the fungicidal ability and the expression of macrophage surface markers.
Article
Immunology
Kritsada Pruksaphon, Artid Amsri, Patcharin Thammasit, Joshua D. Nosanchuk, Sirida Youngchim
Summary: Pathogenic eukaryotes, such as fungi, release extracellular vesicles (EVs) that are composed of various bioactive components. These EVs contain virulence-associated molecules and play an important role in disease pathogenesis. Studies on Evans of Talaromyces marneffei show that they contain important virulence factors, stimulate macrophage activation, and enhance antimicrobial activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Mianluan Pan, Jianquan Zhang
Summary: This case report describes a case of Talaromyces marneffei infection after kidney transplantation. The patient presented with sore throat and odynophagia, and was successfully treated with antifungal therapy using voriconazole.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Biao Yang, Jingyu Wang, Hongye Jiang, Huixian Lin, Zihao Ou, Amir Ullah, Yuneng Hua, Juanjiang Chen, Xiaomin Lin, Xiumei Hu, Lei Zheng, Qian Wang
Summary: TM-derived EVs are a heterogeneous group of nanosized membrane vesicles that can be taken up by macrophages, leading to increased inflammatory response and upregulation of co-stimulatory molecules in macrophages. The proteins in EVs play a crucial role in regulating the function of RAW 264.7 macrophage cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Haiyan Ma, Jasper F. W. Chan, Yen Pei Tan, Lin Kui, Chi-Ching Tsang, Steven L. C. Pei, Yu-Lung Lau, Patrick C. Y. Woo, Pamela P. Lee
Summary: The study reveals that T. marneffei yeasts induce IL-1 beta production, with NLRP3 inflammasome playing a crucial role in host immune response. Dectin-1/Syk signaling pathway mediates IL-1 beta production, and NLRP3-ASC-caspase-1 inflammasome facilitates the processing of pro-IL-1 beta into IL-1 beta. Mice deficient in NLRP3 or caspase-1 show higher mortality and fungal load after T. marneffei infection, indicating the important role of NLRP3 inflammasome in host defense.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yueqi Li, Wudi Wei, Sanqi An, Junjun Jiang, Jinhao He, Hong Zhang, Gang Wang, Jing Han, Bingyu Liang, Li Ye, Hao Liang
Summary: This study investigated the ceRNA regulatory networks in TM-infected macrophages using NGS technology. The constructed ceRNA network showed associations between mRNA and pathways related to immunity, inflammation, and metabolism in TM-infected macrophages. Quantitative validation confirmed the consistent expression of randomly selected lncRNAs and mRNAs in the ceRNA network.
Article
Infectious Diseases
Di Yang, Lin-xia Shen, Ri-feng Chen, Yu Fu, Hong-yan Xu, Li-na Zhang, Dong-hua Liu
Summary: When cultured separately, T. marneffei does not express CD86, but does when co-cultured with macrophages. After infection by T. marneffei, CD86 expression on THP-1 cells decreases, leading to insufficient polarization of M1 macrophages. T. marneffei may absorb or uptake CD86 in supernatant produced by macrophages during contact, resulting in CD86 consumption in macrophages.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Jing Zhang, Hongfang Liu, Liyan Xi, Yun C. Chang, Kyung J. Kwon-Chung, Seyedmojtaba Seyedmousavi
Summary: OLOROFIM exhibits the highest antifungal activity against both mold and yeast phases of Talaromyces marneffei isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Kritsada Pruksaphon, Joshua D. Nosanchuk, Kavi Ratanabanangkoon, Sirida Youngchim
Summary: Talaromycosis is an opportunistic fungal disease caused by Talaromyces marneffei. The progression and outcome of the disease depend on the complex interaction between the pathogen and the host's immune response.
Review
Infectious Diseases
Suke Xing, Hui Zhang, Ye Qiu, Mianluan Pan, Wen Zeng, Jianquan Zhang
Summary: Patients with Talaromyces marneffei infection after transplant often present with disseminated infections, involving the respiratory and hematopoietic systems. It is recommended to use a combination of culture, biopsy, and next-generation sequencing for early diagnosis, and adjust the dosage of immunosuppressants timely. Antifungal therapy with amphotericin B followed by itraconazole is effective in treating Talaromyces marneffei infections in transplant recipients.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Pediatrics
Wei Hu, Xiao-Hong Yu, Wei-Qin Wei, Xuan Xiang
Summary: This article presents a case of a child with HIV and T.marneffei infection. The patient exhibited unique clinical manifestations including fever, abdominal pain, lymphadenopathy, hepatosplenomegaly, lower extremity ecchymosis, and bloody stool. The article emphasizes the importance of early laboratory and imaging diagnosis in improving the survival rate and quality of life for children.
Article
Biology
Wudi Wei, Gang Wang, Hong Zhang, Xiuli Bao, Sanqi An, Qiang Luo, Jinhao He, Lixiang Chen, Chuanyi Ning, Jingzhen Lai, Zongxiang Yuan, Rongfeng Chen, Junjun Jiang, Li Ye, Hao Liang
Summary: The study reveals the role of cellular alternative splicing in Talaromyces marneffei immune escape. A truncated protein called NCOR2-013 is upregulated after T. marneffei infection and it inhibits the transcriptional activation of pro-inflammatory cytokines. TUT1 is identified as the AS regulator that promotes T. marneffei immune evasion. These findings provide insights into the molecular mechanisms of T. marneffei immune escape and potential targets for talaromycosis therapy.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ye Qiu, Jie Huang, Yu Li, Wen Zeng, Mianluan Pan, Jiemei Cen, Hui Zhang, Xuejiao Sun, Dongming Qu, Jianquan Zhang
Summary: Most patients with TM and NTM co-infections had a missed diagnosis of one of the TM or NTM pathogens. The levels of AIGAs, WBC, N, ESR, and CRP in TM and NTM co-infections were remarkably higher than in mono-infection. High-titer AIGAs may be a potential risk factor and susceptibility factor for co-infection of TM and NTM in HIV-negative hosts.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Huimin Yan, Yunjun Mo, Shilin Liu, Xiaojuan Luo, Lianlian Liu, Lintao Zhou, Xiuming Zhang, Yunsheng Chen, Ke Cao
Summary: This study reports a case of a pediatric patient infected with Talaromyces marneffei (TM), which led to the development of hemophagocytic lymphohistiocytosis (HLH) due to genetic mutations. The study highlights the importance of early identification of the causative agent and investigation of potential immunodeficiency in triggering HLH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Jing Zhang, Yunqing Zhang, Jinglin Qin, Sha Lu, Wenying Cai, Jiahao Li, Huaiqiu Huang, Sulian Yang, Liyan Xi
Summary: Combining 2940-nm Er:YAG laser treatment with 5% amorolfine lacquer showed better improvement in mild and moderate onychomycosis of toenails and higher mycological clearance rate compared to amorolfine monotherapy. However, both groups saw little improvement in severe onychomycosis at either 12 or 24 weeks.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Microbiology
Xing Xiao, Yu Li, Yu Lan, Jing Zhang, Ya He, Wenying Cai, Zhiwen Chen, Liyan Xi, Junmin Zhang
Summary: The study identified that the pksA gene is essential for melanin synthesis in F. monophora, and its knockout resulted in attenuated melanogenesis, growth rate, sporulation ability, and virulence. The Delta pksA mutant was found to be more sensitive to oxidative stress, extreme pH, and antifungal drugs compared to the wild-type strain.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Microbiology
Jing Zhang, Hongfang Liu, Liyan Xi, Yun C. Chang, Kyung J. Kwon-Chung, Seyedmojtaba Seyedmousavi
Summary: OLOROFIM exhibits the highest antifungal activity against both mold and yeast phases of Talaromyces marneffei isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Dermatology
Liya He, Xin Mei, Sha Lu, Jianchi Ma, Yongxuan Hu, Dongdong Mo, Xinsheng Chen, Ruiqiang Fan, Liyan Xi, Ting Xie
Summary: The study investigated the characteristics of T. marneffei infection in non-HIV individuals in mainland China. It found that T. marneffei infections in non-HIV individuals are increasing, with atypical symptoms leading to misdiagnosis as other diseases. Accurate diagnosis and timely antifungal agent treatment are crucial for effective management of the disease.
Article
Infectious Diseases
Bingming Zhu, Yanqing Hu, Xianyi Zhou, Kangxing Liu, Wangrong Wen, Yongxuan Hu
Summary: This study retrospectively analyzed the drug sensitivity of Neisseria gonorrhoeae in two teaching hospitals in South China, revealing a gradual increase in resistance to ceftriaxone and azithromycin from 2016 to 2020. Antimicrobial resistance monitoring through culture and drug sensitivity testing is considered crucial in the region due to high-level resistance observed.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Dermatology
X-Q Chen, D-Y Zheng, Y-Y Xiao, B-L Dong, C-W Cao, L. Ma, Z-S Tong, M. Zhu, Z-H Liu, L-Y Xi, M. Fu, Y. Jin, B. Yin, F-Q Li, X-F Li, P. Abliz, H-F Liu, Y. Zhang, N. Yu, W-W Wu, X-C Xiong, J-S Zeng, H-Q Huang, Y-P Jiang, G-Z Chen, W-H Pan, H. Sang, Y. Wang, Y. Guo, D-M Shi, J-X Yang, W. Chen, Z. Wan, R-Y Li, A-P Wang, Y-P Ran, J. Yu
Summary: This study in China found that tinea capitis mostly affected children aged 2-8 years, with a higher prevalence in boys. The pathogen spectrum varied significantly across regions and age groups, suggesting the need for tailored diagnostic and treatment strategies for different populations.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Xianzhong Zhu, Bowen Zheng, Wenying Cai, Jing Zhang, Sha Lu, Xiqing Li, Liyan Xi, Yinying Kong
Summary: This study explored the establishment of deep learning-based diagnostic models for onychomycosis in dermoscopy and found that the deep learning-based diagnosis models showed superior diagnostic accuracy for onychomycosis compared to dermatologists. The distinctive dermoscopic patterns of onychomycosis were identified, and the deep learning models were more accurate in diagnosing the condition.
Article
Immunology
Hongfang Liu, Jiufeng Sun, Minying Li, Wenying Cai, Yangxia Chen, Yinghui Liu, Huan Huang, Zhenmou Xie, Weiying Zeng, Liyan Xi
Summary: This study investigated the epidemiological, clinical, and laboratory characteristics of CBM in Guangdong, China. The findings revealed that CBM patients were mostly elderly with a long duration of the disease and a higher prevalence in males. The most common clinical manifestation was the verrucous form. Antifungal susceptibility tests showed low minimum inhibitory concentrations for certain drugs. Combination therapy with itraconazole and terbinafine was commonly used for treatment. Cytokine profile analysis indicated impaired immune response in CBM cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Minying Li, Huan Huang, Jun Liu, Xiaohui Zhang, Qian Li, Dongmei Li, Mingfen Luo, Xiaoyue Wang, Weiying Zeng, Jiufeng Sun, Hongfang Liu, Liyan Xi
Summary: The C-terminal thioesterase (TE) in F. monophora plays a crucial role in maintaining the fully function of pks1, impacting melanin synthesis and metabolism, and consequently affecting the growth and virulence of F. monophora.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Xuelin Wu, Yanqing Hu, Yan Lu, Xiuling Ke, Kangxing Liu, Xianyi Zhou, Yongxuan Hu
Summary: This study compared the clinical efficacy of cantharidin cream, CO2 laser, and liquid nitrogen cryotherapy in the treatment of plantar warts. The results showed that the cantharidin cream group had the highest resolution rate of warts, indicating it could be an alternative treatment for Verruca plantaris.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Infectious Diseases
Xuelin Wu, Yongxuan Hu
Summary: Cutaneous fungal infections are common and cause distress to patients. Conventional treatments have issues with drug resistance, and there is a need for safer and more effective alternatives. Recent studies have shown the effectiveness of photodynamic therapy in treating fungal infections without severe adverse effects.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Dermatology
Li Lin, Junhao Huang, Junyue Fang, Jiahao Li, Wenying Cai, Jing Zhang, Sha Lu
Summary: This study classified 48 clinical isolates of sporothrix and tested their susceptibility to seven antifungal agents. The results showed that terbinafine and luliconazole were the most effective, followed by itraconazole and amphotericin B. Voriconazole, 5-flucytosine, and fluconazole had low efficacy. Overall, this study provides the first report on antifungal susceptibility and epidemiological correlation of sporothrix in southern China, and also the first evidence that sporothrix is sensitive to luliconazole.
Article
Mycology
Ying Tang, Wenying Cai, Li Lin, Jiahao Li, Hsingmei Liu, Liyan Xi, Sha Lu
Review
Dermatology
Xianzhong Zhu, Jianchi Ma, Bowen Zheng, Wenying Cai, Jiahao Li, Li Lin, Liyan Xi, Xiqing Li, Sha Lu
Summary: This article reports a case of cutaneous, subcutaneous, and disseminated phaeohyphomycosis caused by Exophiala spinifera in a Chinese male, who showed significant clinical improvement after receiving oral itraconazole and terbinafine treatment. A detailed review was conducted to evaluate the antifungal therapy for phaeohyphomycosis caused by E. spinifera.
Article
Infectious Diseases
Wenying Cai, Qianqian Ruan, Jiahao Li, Li Lin, Liyan Xi, Jiufeng Sun, Sha Lu
Summary: This study investigated the clinical characteristics, pathogen spectrum, and drug resistance of deep fungal infection in a hospital in Guangzhou, China. The main causative agents were Candida species. Echinocandins were the first choice for clinical therapy, followed by 5-fluorocytosine and amphotericin B. Caution should be taken when using azole antifungals in infections caused by Candida glabrata and Candida tropicalis.
INFECTION AND DRUG RESISTANCE
(2023)