Article
Microbiology
Barbara A. Brown-Elliott, Richard J. Wallace
Summary: Nontuberculous mycobacteria (NTM) infections, especially caused by Mycobacterium avium complex (MAC) and M. abscessus species, are increasing worldwide. This study tested the in vitro activity of a new tetracycline derivative, eravacycline, against 110 clinical isolates of NTM. The results showed that eravacycline was active against rapidly growing Mycobacterium species, including M. abscessus. However, its activity against slowly growing Mycobacterium species was limited.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Barbara A. Brown-Elliott, Richard J. Wallace
Summary: This study evaluated the in vitro potency of the new tetracycline derivative omadacycline against NTM, showing high activity against most RGM species. MIC testing against RGM revealed over 90% resistance to tetracycline in the isolates tested.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Sara Daneshfar, Azar Dokht Khosravi, Mohammad Hashemzadeh
Summary: This study aimed to identify M. simiae isolates and assess their drug resistance. The results showed that M. simiae is highly resistant to antibiotics with high resistance rates. Therefore, species identification and antibiotic susceptibility testing are essential before treatment.
Article
Biochemistry & Molecular Biology
Gisela Canedo-Marroquin, Jorge A. Soto, Catalina A. Andrade, Susan M. Bueno, Alexis M. Kalergis
Summary: The human respiratory syncytial virus (hRSV) can impair pulmonary immune surveillance mechanisms and promote secondary mycobacterial colonization. Immunization can modulate the expression of HO-1 on immune and epithelial cells, which may contribute to the repair of pulmonary tissue.
Article
Microbiology
Ruoyan Ying, Jinghui Yang, Xiaocui Wu, Fangyou Yu, Wei Sha
Summary: Given the increasing prevalence of NTM diseases and their natural resistance to multiple antibiotics, it is necessary to test the susceptibility of different NTM species to drugs from the MYCO test system and new applied drugs. This study analyzed 241 NTM clinical isolates and found that most of the SGM strains were susceptible to certain antibiotics, while the RGM strains were susceptible to different antibiotics. In addition, epidemiological cutoff values were determined for CLO and BDQ. The study concluded that BDQ and CLO show effective activity against different NTM species in vitro, making them potential treatments for NTM diseases.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Abderrahmane Errami, Jamila El Baghdadi, Fatima Ailal, Ibtihal Benhsaien, Jalila El Bakkouri, Leila Jeddane, Noureddine Rada, Noufissa Benajiba, Khaoula Mokhantar, Kaoutar Ouazahrou, Sanae Zaidi, Laurent Abel, Jean-Laurent Casanova, Stephanie Boisson-Dupuis, Jacinta Bustamante, Ahmed Aziz Bousfiha
Summary: We studied the genetic predisposition to mycobacterial diseases in Moroccan kindreds through clinical, immunological, and genetic analysis. The study revealed a Mendelian susceptibility to mycobacterial disease (MSMD) in these families, leading to severe tuberculosis and complications of BCG vaccination. Systematic genetic studies are necessary in the presence of these infections, and BCG vaccination should be delayed in newborn siblings until a genetic predisposition to mycobacteria is excluded.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Huiyun Zhang, Wenya Hua, Siran Lin, Yu Zhang, Xinchang Chen, Shiyong Wang, Jiazhen Chen, Wenhong Zhang
Summary: This study evaluated the susceptibility of clinical isolates of NTM to TZD, indicating that TZD has greater in vitro potency than LZD and shows synergistic effects with various antibiotics against NTM, suggesting it may be an important component of multi-drug treatment regimens.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Yiting Wang, Wencong He, Ping He, Huiwen Zheng, Yanlin Zhao
Summary: This study investigated differences in antimicrobial susceptibility of Mycobacterium abscessus complex (MABC) subsp. massiliense and subsp. abscessus, finding that multilocus variable number tandem repeat (VNTR) typing may provide valuable information for predicting resistance phenotype.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Respiratory System
Ho Namkoong, Yosuke Omae, Takanori Asakura, Makoto Ishii, Shoji Suzuki, Kozo Morimoto, Yosuke Kawai, Katsura Emoto, Andrew J. Oler, Eva P. Szymanski, Mitsunori Yoshida, Shuichi Matsuda, Kazuma Yagi, Isano Hase, Tomoyasu Nishimura, Yuka Sasaki, Takahiro Asami, Tetsuya Shiomi, Hiroaki Matsubara, Hisato Shimada, Junko Hamamoto, Byung Woo Jhun, Su-Young Kim, Hee Jae Huh, Hong-Hee Won, Manabu Ato, Kenjiro Kosaki, Tomoko Betsuyaku, Koichi Fukunaga, Atsuyuki Kurashima, Herve Tettelin, Hideki Yanai, Surakameth Mahasirimongkol, Kenneth N. Olivier, Yoshihiko Hoshino, Won-Jung Koh, Steven M. Holland, Katsushi Tokunaga, Naoki Hasegawa
Summary: This study identified rs109592 in the CHP2 locus as a susceptibility marker for pulmonary MAC disease.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Infectious Diseases
Yuwei Vivian Tsai, Caroline Derrick, Ismaeel Yunusa, Sharon Weissman, Majdi N. Al-Hasan, Julie Ann Justo, Paul Brandon Bookstaver
Summary: Nontuberculous mycobacterial (NTM) infections pose treatment challenges and limited data exists on treatment outcomes in U.S. adults. This retrospective study analyzed a cohort of NTM-infected adults and found Mycobacterium avium intracellulare complex and Mycobacterium abscessus to be the most prevalent isolates. Only 35% of patients received treatment, with a favorable outcome observed in 61.4% of cases. Multiple changes in antimicrobial therapy were associated with unfavorable outcomes, highlighting the importance of interdisciplinary collaboration to improve treatment outcomes in NTM infections.
Article
Microbiology
Irena Reil, Silvio Spicic, Ljubo Barbic, Sanja Duvnjak, Gordan Kompes, Miroslav Benic, Dora Stojevic, Zeljko Cvetnic, Jurica Arapovic, Maja Zdelar-Tuk
Summary: This study demonstrates the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly growing NTM strains, which can pose a zoonotic threat to humans. The high prevalence of antibiotic resistance in these strains highlights the challenges in their treatment.
Article
Nuclear Science & Technology
D. Boeyaert, S. Wiesen, M. Wischmeier, W. Dekeyser, S. Carli, L. Wang, F. Ding, K. Li, Y. Liang, M. Baelmans
Summary: Energy dissipation in the plasma edge is crucial for future tokamaks, and neon seeding has a favorable effect by significantly reducing the target heat flux and divertor temperature during discharges. Interpretive edge plasma simulations with suitable coefficients for anomalous transport have shown good agreement with experimental data, supporting ongoing transport analysis.
NUCLEAR MATERIALS AND ENERGY
(2021)
Article
Microbiology
Stephen Adonai Leon-Icaza, Salimata Bagayoko, Romain Verge, Nino Iakobachvili, Chloe Ferrand, Talip Aydogan, Celia Bernard, Angelique Sanchez Dafun, Marlene Murris-Espin, Julien Mazieres, Pierre Jean Bordignon, Serge Mazeres, Pascale Bernes-Lasserre, Victoria Rame, Jean-Michel Lagarde, Julien Marcoux, Marie-Pierre Bousquet, Christian Chalut, Christophe Guilhot, Hans Clevers, Peter J. Peters, Virginie Molle, Geanncarlo Lugo-Villarino, Kaymeuang Cam, Laurence Berry, Etienne Meunier, Celine Cougoule
Summary: Although Mabs infection can induce oxidative stress, pharmacological activation of antioxidant pathways can better control Mabs growth and reduce its virulence. Genetic and pharmacological inhibition of CFTR is associated with improved Mabs growth and increased virulence. Pharmacological activation of antioxidant pathways can inhibit Mabs growth and improve efficacy when combined with cefoxitin.
Article
Microbiology
Skye R. S. Fishbein, Francesca G. Tomasi, Ian D. Wolf, Charles L. Dulberger, Albert Wang, Hasmik Keshishian, Luke Wallace, Steven A. Carr, Thomas R. Ioerger, E. Hesper Rego, Eric J. Rubin
Summary: The mycobacteria's resistance to antibiotic therapy is partly due to their ability to build proteins into a multilayer cell wall, which is crucial for maintaining cell integrity and antibiotic susceptibility. Loss of the LepA gene affects the abundance of membrane proteins, including the outer membrane porin MspA, influencing antibiotic tolerance.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Infectious Diseases
Jun Wang, Wei Jing, Jin Shi, Fengmin Huo, Yuanyuan Shang, Fen Wang, Naihui Chu, Yu Pang
Summary: This study evaluated the in vitro susceptibility of Q203 against Mycobacterium tuberculosis and major pathogenic nontuberculous mycobacterial species. Q203 demonstrated excellent activity against MDR- and XDR-TB isolates, but exhibited high MIC values for NTM isolates. The presence of a 10-amino acid insertion in QcrBs of M. avium and M. intracellulare may explain their natural resistance to Q203.
MICROBIAL DRUG RESISTANCE
(2021)