Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Viet-Hung Do, P. Prabhu, Yinghao Li, Wenjie Xie, Pinit Kidkhunthod, Guangzhao Wang, Xin Wang, Jong-Min Lee
Summary: Transition metal nitrides with atomically thin Os nanoclusters confined on 2D 6-MoN exhibit enhanced catalytic performance, particularly in hydrogen evolution, due to optimized surface electron configurations and abundant active sites.
Review
Biochemistry & Molecular Biology
Kacper Poblocki, Joanna Drzezdzon, Tomasz Kostrzewa, Dagmara Jacewicz
Summary: Photodynamic therapy (PDT) is an alternative cancer treatment method that utilizes photosensitizers to convert light emission into radical oxygen-derived species (ROS), and can interact with compounds such as metal organic frameworks (MOFs). The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs, affecting the amount of ROS generated, quantum emission efficiency, and phototoxic index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Xiaoli Cheng, Qiang Cao, Yuhui Hua, Xu Cheng, Zhenwei Chu, Guomei He, Jiangxi Chen
Summary: The synthesis of cyclopropaosmabenzenes, which consist of an aromatic osmacyclopropene and an aromatic osmabenzene unit, was reported in this study. The complexes were obtained by reacting OsCl2(PPh3)3 with enediynes E-HC---CCH=C(SiMe3)C---CR (R = p-tol, Ph) in the presence of PPh3, followed by protonation with HCl. Both experimental observations and theoretical calculations support the σ-aromaticity (in the osmacyclopropene unit) and π-aromaticity (in the osmabenzene unit) of the cyclopropaosmabenzenes.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Stefan Latis, Christoph Marschner, Judith Baumgartner, Sharon Prince, Supratim Biswas, Suparna Chakraborty, Kimberly G. Garcia, Ron M. A. Heeren, Sebastiaan Van Nuffel, Burgert Blom
Summary: This study reports the synthesis and characterisation of piano-stool triphenylstibine and triphenylarsine arene complexes, and their in vitro cytotoxic evaluation on breast cancer cell lines. The tin containing complexes demonstrate remarkable activity and selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Zhenwei Chu, Guomei He, Chuan Shi, Yuhui Hua, Yaxi Huang, Jiangxi Chen, Hujun Xie, Guochen Jia
Summary: In this study, the synthesis and characterization of aromatic chloroosmacyclopentatrienes have been reported, which represent the first structurally confirmed metallaaromatic with a chlorine atom in its framework. Single-crystal X-ray diffraction studies show that these planar chloroosmacyclopentatrienes possess a very short Os-ClC distance suggesting M=ClC bond character.
NATIONAL SCIENCE REVIEW
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Krzysztof Kucinski, Marcin Gruszczynski, Grzegorz Hreczycho
Summary: A new catalytic reaction method has been developed to selectively transform disulfides and diselenides into their silicon and germanium counterparts, without the use of thiolate ions. Further experiments demonstrated the synthetic potential of the obtained silicon sulfide compounds.
Article
Chemistry, Physical
Dawid Zych
Summary: This study focuses on the theoretical investigations of mono- and dinuclear complexes, utilizing density functional theory calculations to understand their optical properties and physical parameters. The results have significant implications for the field of chemistry and materials science.
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: Neutral heteroleptic trinuclear coordination cages with a well-defined small spherical endocavity composed of electron-deficient bowl frameworks, three coordination-induced neutral polar C-H donors, and a phenyl motif were self-assembled via a one-pot approach. The endocavity selectively accommodates fluoride in the presence of other halides.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Li Wei, Rajesh Kushwaha, Anyi Dao, Zhongxian Fan, Samya Banerjee, Huaiyi Huang
Summary: A novel axisymmetric bis-tridentate Ir(iii) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity against drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 was investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Janice R. Aldrich-Wright
Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.
Article
Chemistry, Multidisciplinary
Valentin Fuchs, Klaudia Cseh, Michaela Hejl, Petra Vician, Benjamin Neuditschko, Samuel M. Meier-Menches, Lukas Janker, Andrea Bileck, Natalie Gajic, Julia Kronberger, Martin Schaier, Sophie Neumayer, Gunda Koellensperger, Christopher Gerner, Walter Berger, Michael A. Jakupec, Michael S. Malarek, Bernhard K. Keppler
Summary: A series of highly lipophilic Cp-substituted molybdenocenes with different bioactive chelating ligands were synthesized and characterized. They showed significantly increased cytotoxic potency compared to non-Cp-substituted counterparts. In vivo experiments demonstrated tumor growth inhibition for the most active complex containing the thioflavone ligand, along with significant regulation of tubulin-associated and mitochondrial inner membrane proteins.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Olga V. Kuznetsova, Bernhard K. Keppler, Andrei R. Timerbaev
Summary: This study developed a unified protocol for the preparation of seawater samples for ICP-MS analysis of nanoparticles, which involved acidification and ultrafiltration to stabilize the particles and facilitate metal analysis. High-resolution ICP-MS method was used to achieve very low limits of detection.
Article
Pharmacology & Pharmacy
Janos P. Meszaros, Wolfgang Kandioller, Gabriella Spengler, Alexander Prado-Roller, Bernhard K. Keppler, Eva A. Enyedy
Summary: This study introduces half-sandwich Rh complexes that can be activated in the acidic, extracellular pH of tumor tissue, reducing the side effects and improving the efficacy of chemotherapy.
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Tim Gruene, Alexander Prado-Roller, Sandra Arandelovic, Johannes Reynisson, Vladimir B. B. Arion
Summary: A series of latonduine derivatives were synthesized and characterized using spectroscopic and mass spectrometry techniques. The molecular structures of some compounds were confirmed by X-ray diffraction or electron diffraction. The antiproliferative activity of these compounds in different cancer cells and normal cells was evaluated by MTT assays.
Article
Chemistry, Multidisciplinary
Philipp Spiess, Ana Sirvent, Irmgard Tiefenbrunner, Jules Sargueil, Anthony J. Fernandes, Ana Arroyo-Bondia, Ricardo Meyrelles, David Just, Alexander Prado-Roller, Saad Shaaban, Daniel Kaiser, Nuno Maulide
Summary: p-Toluenesulfonyl (Tosyl) and nitrobenzenesulfonyl (Nosyl) are widely used sulfonyl protecting groups for amines in organic synthesis. However, p-toluenesulfonamides are difficult to remove in multistep synthesis, while nitrobenzenesulfonamides are not stable under various reaction conditions. In this study, we introduce a new sulfonamide protecting group called Nms, which overcomes these limitations and shows superiority in terms of stability and cleavability.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Yvonne Lerchbammer-Kreith, Michaela Hejl, Petra Vician, Michael A. Jakupec, Walter Berger, Mathea S. Galanski, Bernhard K. Keppler
Summary: Based on their drug delivery properties and activity against tumors, PAMAM dendrimers were combined with platinum(IV) complexes to improve anticancer treatment. The conjugates showed faster reduction behavior compared to the platinum(IV) complexes and exhibited significantly increased cytotoxic activity in human cell lines. In vivo experiments demonstrated tumor growth inhibition and prolonged animal survival.
Article
Pharmacology & Pharmacy
Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. K. Keppler, Christian R. R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Summary: Platinum compounds are effective treatment options for various cancer types, but their use is limited by side effects and drug resistance. A new multi-targeted platinum(IV) prodrug, cisPt(PhB)(2), has shown promising anticancer activity and the ability to overcome drug resistance mechanisms. The drug's mode of action is influenced by cellular fatty acid metabolism and mitochondrial activity. Specifically, it is more effective against cisplatin-resistant cancer cells with Warburg-like properties. This orally applicable prodrug has the potential to improve cancer treatment outcomes.
Article
Chemistry, Multidisciplinary
Alexander Kastner, Hemma Schueffl, Patrick A. Yassemipour, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: Platinum(IV) prodrugs are promising alternatives to platinum(II) anticancer therapeutics. This study investigated the reactivity and synthetic usability of a platinum(IV) complex with hydrolyzable equatorial ligands, and successfully synthesized stable platinum(IV) complexes suitable for long-circulating tumor-targeting strategies. Additionally, platinum(IV) complexes with equatorial maleimides were synthesized, showing prolonged plasma half-life and improved anticancer activity compared to oxaliplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Paper & Wood
Yuko Yoneda, Toshinari Kawada, Markus Bacher, Alexander Prado-Roller, Hubert Hettegger, Antje Potthast, Alfred D. French, Thomas Rosenau
Summary: Cellulose model compounds are widely used in cellulose research to study the polymer's properties. By synthesizing methyl 4-O-methyl beta-D-glucopyranoside derivatives with different substitution patterns, the solid-state structures of these compounds were determined using X-ray diffraction. Solid-state C-13 NMR measurements confirmed the influence of packing arrangement on the chemical shifts of the substituted carbons.
Correction
Biochemistry & Molecular Biology
Mathea Sophia Galanski, Michael A. Jakupec, Bernhard K. Keppler
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Xiao Liu, Dominik Wenisch, Philipp Dahlke, Paul M. Jordan, Michael A. Jakupec, Christian R. Kowol, Phil Liebing, Oliver Werz, Bernhard K. Keppler, Wolfgang Weigand
Summary: In recent decades, the close connection between inflammation and cancer has been recognized, leading to extensive studies on joint strategies involving chemotherapeutic and anti-inflammatory agents. In this study, novel Pt(IV) complexes based on cisplatin and oxaliplatin were synthesized, incorporating non-steroidal anti-inflammatory drugs (NSAIDs) and their carboxyl ester analogues. Certain cisplatin-based Pt(IV) complexes 22-30 exhibited increased cytotoxicity in human cancer cell lines compared to the Pt(II) drug. Complex 26, containing two aceclofenac moieties, displayed potent anticancer effects combined with anti-inflammatory properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Klaudia Cseh, Iker Berasaluce, Valentin Fuchs, Alexandra Banc, Andreas Schweikert, Alexander Prado-Roller, Michaela Hejl, Debora Wernitznig, Gunda Koellensperger, Michael A. Jakupec, Wolfgang Kandioller, Michael S. Malarek, Bernhard K. Keppler
Summary: This paper describes the synthesis, characterization and biological activity of tungstenocenes with different biologically active chelates, such as (O,O-), (S,O-) and (N,O-). The complexes were analyzed using various techniques, including NMR, mass spectrometry, spectroscopy and X-ray diffraction. Their stability, electrochemical behavior, cytotoxicity and mode of action were investigated. The results showed that complexes containing (S,O-) chelates exhibited higher activity than those with (O,O-) and (N,O-) chelates. Notably, two complexes with a W-S or W-O bond showed different distribution patterns and strong inhibitory effects in tumor spheroid models.
Article
Biochemistry & Molecular Biology
Martin Schaier, Enrico Falcone, Tomas Prstek, Bertrand Vileno, Sonja Hager, Bernhard K. Keppler, Petra Heffeter, Gunda Koellensperger, Peter Faller, Christian R. Kowol
Summary: Thiosemicarbazones (TSCs) are biologically active compounds that have potential anticancer activity by chelating iron and targeting ribonucleotide reductase. Recent findings suggest that the stability and reduction properties of copper complexes are essential for the action of specific TSC derivatives. This study investigated the interaction between TSCs and human serum albumin (HSA) as a potential source of copper, and found that TSCs specifically chelate copper from HSA and form ternary HSA conjugates.
Article
Chemistry, Inorganic & Nuclear
Thomas Maier, Judith Wutschitz, Natalie Gajic, Michaela Hejl, Klaudia Cseh, Sebastian Mai, Michael A. Jakupec, Mathea S. Galanski, Bernhard K. Keppler
Summary: This study analyzed the unexpected reaction of (1R,2R)-(cyclohexane-1,2-diamine)dichloridoplatinum(II) with maleic acid and synthesized a series of derivatives with different lipophilicity. The results showed low cytotoxicity and no interaction with DNA for these compounds, indicating their lower reactivity compared to oxaliplatin.
DALTON TRANSACTIONS
(2023)